ASSOCIATION OF TOTAL AND DIFFERENTIAL WHITE BLOOD CELL COUNTS TO DEVELOPMENT OF TYPE 2 DIABETES IN MEXICAN AMERICANS IN CAMERON COUNTY HISPANIC COHORT.

Diabetes research (Edinburgh, Scotland) Pub Date : 2015-09-01 Epub Date: 2015-09-23 DOI:10.17140/DROJ-1-117

Kristina P Vatcheva, Susan P Fisher-Hoch, Mohammad H Rahbar, MinJae Lee, Rene L Olvera, Joseph B Mccormick

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Abstract

Objective: To evaluate the relationship between total and differential White Blood Cell (WBC) counts with time to transition to type 2 diabetes in Mexican Americans using prospective data from the Cameron County Hispanic Cohort (CCHC).

Results: Multivariable Cox proportional hazards regression models revealed that obese Mexican-American cohort participants whose total WBC or granulocyte count increased over time had 1.39 and 1.35 times higher risk respectively of transition to type 2 diabetes when compared to overweight participants. The granulocyte or total WBC count in participants with BMI≥35 were significant risk factors for transition to type 2 diabetes.

Conclusions: Increased total WBC and WBC differential counts, particularly lymphocytes and granulocytes, are associated with risk of transition to type 2 diabetes in obese Mexican Americans, after adjusting for other potential confounders. Screening and monitoring the WBC counts, including lymphocytes and granulocytes can help with monitoring potential transition to type 2 diabetes.

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卡梅伦县西班牙裔队列中的墨西哥裔美国人白细胞总数和差值与 2 型糖尿病发病的关系。

目的利用卡梅伦县西班牙裔队列（CCHC）的前瞻性数据，评估墨西哥裔美国人白细胞（WBC）总数和差异数与转为2型糖尿病的时间之间的关系：多变量考克斯比例危险回归模型显示，与超重参与者相比，白细胞总数或粒细胞计数随时间增加的肥胖墨西哥裔美国人队列参与者转变为2型糖尿病的风险分别高出1.39倍和1.35倍。BMI≥35的参与者的粒细胞或白细胞总数是转为2型糖尿病的重要风险因素：结论：在调整了其他潜在的混杂因素后，白细胞总数和白细胞差异计数（尤其是淋巴细胞和粒细胞）的增加与肥胖的墨西哥裔美国人转为 2 型糖尿病的风险有关。筛查和监测白细胞计数（包括淋巴细胞和粒细胞）有助于监测向2型糖尿病过渡的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Diabetes research (Edinburgh, Scotland)

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