Developments in ophthalmology最新文献_第10页

Optical Coherence Tomography Angiography of Type 2 Neovascularization in Age-Related Macular Degeneration. 年龄相关性黄斑变性2型新生血管的光学相干断层血管造影。

Developments in ophthalmology Pub Date : 2016-01-01 DOI: 10.1159/000442777

E. Souied, A. El Ameen, O. Semoun, A. Miere, G. Querques, S. Cohen

{"title":"Optical Coherence Tomography Angiography of Type 2 Neovascularization in Age-Related Macular Degeneration.","authors":"E. Souied, A. El Ameen, O. Semoun, A. Miere, G. Querques, S. Cohen","doi":"10.1159/000442777","DOIUrl":"https://doi.org/10.1159/000442777","url":null,"abstract":"Well-defined choroidal neovascularization, known as type 2 neovascularization (NV) or classic NV, is the least representative phenotype of exudative age-related macular degeneration. Clinical aspects of type 2 NV have been widely described in the literature, and to date fluorescein angiography remains the gold standard for imaging age-related macular degeneration at initial presentation. Optical coherence tomography angiography (OCT-A) can be used to image vessels based on flow characteristics without any dye injection. Type 2 NV can be visualized using OCT-A with very typical patterns. A neovascular membrane appears as either a medusa-shaped complex or a glomerulus-shaped lesion in the outer retina and the choriocapillaris layer. Furthermore, in the choriocapillaris layer, the external borders of the lesion appear as a dark ring in most cases, and one or more central feeder vessels that extend deeply into the more profound choroidal layers are visible. Identification of type 2 NV is easily feasible for any clinician using OCT-A, especially in areas where there are normally no vessels, like in subretinal space, if the interpretation rules are respected.","PeriodicalId":77107,"journal":{"name":"Developments in ophthalmology","volume":"56 1","pages":"52-6"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000442777","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64987885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 31

Optical Coherence Tomography Angiography Study of Choroidal Neovascularization Early Response after Treatment. 治疗后脉络膜新生血管早期反应的光学相干断层血管造影研究。

Developments in ophthalmology Pub Date : 2016-01-01 DOI: 10.1159/000442782

B. Lumbroso, M. Rispoli, M. Savastano, Yali Jia, O. Tan, David Huang

引用次数: 38

Sirolimus for Retinal and Uveitic Diseases. 西罗莫司用于视网膜和葡萄膜疾病。

Developments in ophthalmology Pub Date : 2016-01-01 Epub Date: 2015-10-26 DOI: 10.1159/000438951

Aniruddha Agarwal, Nithya Rajagopalan, Muhammad Hassan, Mohammad Ali Sadiq, Mohamed K Soliman, Rubbia Afridi, Yasir Jamal Sepah, Quan Dong Nguyen

{"title":"Sirolimus for Retinal and Uveitic Diseases.","authors":"Aniruddha Agarwal, Nithya Rajagopalan, Muhammad Hassan, Mohammad Ali Sadiq, Mohamed K Soliman, Rubbia Afridi, Yasir Jamal Sepah, Quan Dong Nguyen","doi":"10.1159/000438951","DOIUrl":"https://doi.org/10.1159/000438951","url":null,"abstract":"<p><p>Chronic inflammation plays an important role in the pathogenesis of ocular diseases such as diabetic retinopathy, uveitis and age-related macular degeneration. Activation and proliferation of naïve T cells may result in pathological changes responsible for significant visual morbidity. Sirolimus (earlier termed rapamycin) is a novel drug that inhibits cellular kinases and, thereby, inhibits T-cell proliferation. Preclinical studies in experimental models have shown promising results with the use of this pharmacological agent in various ocular conditions. Subsequently, early phase I/II studies have provided encouraging safety and efficacy data. This chapter focuses on the mechanisms of action, preclinical study results and data from human clinical trials of sirolimus in human eye diseases. Key highlights from ongoing phase III clinical trials are also provided. Sirolimus, thus, appears to be an important addition to the armamentarium of steroid-sparing therapeutic agents that act on various steps in the inflammatory pathway.</p>","PeriodicalId":77107,"journal":{"name":"Developments in ophthalmology","volume":"55 ","pages":"276-81"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000438951","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34184509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Future Perspectives: Agents on the Horizon. 未来展望:地平线上的代理人。

Developments in ophthalmology Pub Date : 2016-01-01 Epub Date: 2015-10-26 DOI: 10.1159/000439037

Jose R Maya, Mohammad Ali Sadiq, Aniruddha Agarwal, Peter K Kaiser, Glenn L Stoller, Yasir Jamal Sepah, Quan Dong Nguyen

引用次数: 1

Optical Coherence Tomography Angiography Using the Optovue Device. 使用Optovue设备的光学相干断层血管造影。

Developments in ophthalmology Pub Date : 2016-01-01 DOI: 10.1159/000442770

David Huang, Yali Jia, Simon S. Gao, B. Lumbroso, M. Rispoli

{"title":"Optical Coherence Tomography Angiography Using the Optovue Device.","authors":"David Huang, Yali Jia, Simon S. Gao, B. Lumbroso, M. Rispoli","doi":"10.1159/000442770","DOIUrl":"https://doi.org/10.1159/000442770","url":null,"abstract":"Optovue AngioVue system technology for optical coherence tomography (OCT) angiography is based on the AngioVue Imaging System (Optovue, Inc., Freemont, CA), using split-spectrum amplitude-decorrelation angiography (SSADA) algorithm. This algorithm was developed to minimize scanning time. It detects motion in blood vessel lumen by measuring the variation in reflected OCT signal amplitude between consecutive cross-sectional scans. The novelty of SSADA lies in how the OCT signal is processed to enhance flow detection and reject axial bulk motion noise. Specifically, the algorithm splits the OCT image into different spectral bands, thus increasing the number of usable image frames. Each new frame has a lower axial resolution that is less susceptible to axial eye motion caused by blood pulsation. Optovue AngioVue system technology allows quantitative analysis. It provides numerical data about flow area and non-flow area. It can also generate a flow density map. These metrics may serve as biomarkers in diagnosis and for tracking disease progression or treatment response. Flow area: the software will calculate the drawn area and vessel area in mm(2). It allows for comparison of all measurements for a given participant. Non-flow area: the software shows the non-perfused areas by mouse click selection. Ischemic areas will be shown in yellow. These areas may be saved and matched with others in the study. Flow density tool is able to measure the percentage of vascular areas on en face angiograms. This analysis is based on an ETDRS grid centered on the macula as with the thickness map. This tool works both on inner and outer vascular plexus.","PeriodicalId":77107,"journal":{"name":"Developments in ophthalmology","volume":"56 1","pages":"6-12"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000442770","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64987671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 134

Swept-Source Optical Coherence Tomography Angio™ (Topcon Corp, Japan): Technology Review. 扫描源光学相干层析成像Angio™(Topcon公司，日本):技术评论。

Developments in ophthalmology Pub Date : 2016-01-01 DOI: 10.1159/000442771

P. Stanga, E. Tsamis, A. Papayannis, Francesco Stringa, Tim Cole, A. Jalil

{"title":"Swept-Source Optical Coherence Tomography Angio™ (Topcon Corp, Japan): Technology Review.","authors":"P. Stanga, E. Tsamis, A. Papayannis, Francesco Stringa, Tim Cole, A. Jalil","doi":"10.1159/000442771","DOIUrl":"https://doi.org/10.1159/000442771","url":null,"abstract":"Optical coherence tomography (OCT) angiography (OCTA) is a novel, noninvasive, three-dimensional imaging technique that allows for the visualization of intravascular flow in the microvasculature. Swept-source OCT technology utilizes longer-wavelength infrared light than conventional spectral-domain OCT. This enables improved penetration into tissue and imaging through optical opacities and is invisible to the subject. Topcon has recently developed an innovative OCTA algorithm, OCTARA (OCTA Ratio Analysis), which benefits from being paired with swept-source OCT. OCTARA aims to provide improved detection sensitivity of low blood flow and reduced motion artifacts without compromising axial resolution. In this chapter, we describe the implementation of OCTARA with swept-source OCT technology, the technical specifications of acquisition (e.g. the number of scans, area of examination field, etc.) along with the algorithm's function and principles for analysis of B-scan data to achieve angiographic visualization. Examples of OCTA scans performed using the OCTARA algorithm and a comparison of these scans with images obtained using other technologies are also presented.","PeriodicalId":77107,"journal":{"name":"Developments in ophthalmology","volume":"56 1","pages":"13-7"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000442771","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64987791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 128

Optical Coherence Tomography Angiography of Fibrosis in Age-Related Macular Degeneration. 年龄相关性黄斑变性纤维化的光学相干断层血管造影。

Developments in ophthalmology Pub Date : 2016-01-01 DOI: 10.1159/000442783

E. Souied, A. Miere, S. Cohen, O. Semoun, G. Querques

{"title":"Optical Coherence Tomography Angiography of Fibrosis in Age-Related Macular Degeneration.","authors":"E. Souied, A. Miere, S. Cohen, O. Semoun, G. Querques","doi":"10.1159/000442783","DOIUrl":"https://doi.org/10.1159/000442783","url":null,"abstract":"PURPOSE To describe the optical coherence tomography angiography (OCTA) features of subretinal fibrosis in the context of exudative age-related macular degeneration. METHODS Patients diagnosed exudative age-related macular degeneration presenting with subretinal fibrosis were imaged by conventional multimodal imaging and OCTA. The patients were divided into the following two groups: group A, for eyes with active exudative features over the last 6 months, and group B, for eyes without any sign of exudation for >6 months. RESULTS In almost all of the patients, a high-flow network was detected inside of the fibrotic scar. We divided the vascular networks into the following three patterns: the pruned vascular tree, tangled network and vascular loop patterns. Furthermore, two types of low-flow structures, for which we coined the terms large flow void and dark halo, were observed. Both active and inactive lesions demonstrated the abovementioned patterns either individually or together. No difference was found between the two groups in the prevalent vascular network pattern of low-flow areas. CONCLUSION OCTA of subretinal fibrosis revealed a perfused, abnormal vascular network, as well as collateral architectural changes in the outer retina and the choriocapillaris layer, in the majority of the studied eyes. These features are associated with both active and inactive fibrotic choroidal neovessels.","PeriodicalId":77107,"journal":{"name":"Developments in ophthalmology","volume":"56 1","pages":"86-90"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000442783","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64988359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Optical Coherence Tomography Angiography of Diabetic Retinopathy. 糖尿病视网膜病变的光学相干断层血管造影。

Developments in ophthalmology Pub Date : 2016-01-01 DOI: 10.1159/000442801

F. Bandello, Eleonora Corbelli, A. Carnevali, L. Pierro, G. Querques

引用次数: 40

Neuroprotection and Retinal Diseases. 神经保护和视网膜疾病。

Developments in ophthalmology Pub Date : 2016-01-01 Epub Date: 2015-10-26 DOI: 10.1159/000434703

Yannis M Paulus, J Peter Campbell

引用次数: 5

Routes for Drug Delivery to the Retina: Topical, Transscleral, Suprachoroidal and Intravitreal Gas Phase Delivery. 视网膜给药途径:局部、经巩膜、脉络膜上和玻璃体内气相给药。

Developments in ophthalmology Pub Date : 2016-01-01 Epub Date: 2015-10-26 DOI: 10.1159/000431193

Norihiro Yamada, Timothy W Olsen

引用次数: 12