Current topics in medical mycology最新文献

{"title":"Ultrastructural correlates of antimycotic treatment.","authors":"M Borgers","doi":"10.1007/978-1-4612-3730-3_1","DOIUrl":"https://doi.org/10.1007/978-1-4612-3730-3_1","url":null,"abstract":"","PeriodicalId":77092,"journal":{"name":"Current topics in medical mycology","volume":"2 ","pages":"1-39"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/978-1-4612-3730-3_1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14416347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peptide transport in Candida albicans: implications for the development of antifungal agents.","authors":"F Naider, J M Becker","doi":"10.1007/978-1-4612-3730-3_5","DOIUrl":"https://doi.org/10.1007/978-1-4612-3730-3_5","url":null,"abstract":"","PeriodicalId":77092,"journal":{"name":"Current topics in medical mycology","volume":"2 ","pages":"170-98"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/978-1-4612-3730-3_5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14416348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Soluble polysaccharides of Cryptococcus neoformans.","authors":"R Cherniak","doi":"10.1007/978-1-4612-3730-3_2","DOIUrl":"https://doi.org/10.1007/978-1-4612-3730-3_2","url":null,"abstract":"","PeriodicalId":77092,"journal":{"name":"Current topics in medical mycology","volume":"2 ","pages":"40-54"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14416355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melanins and their importance in pathogenic fungi.","authors":"M H Wheeler, A A Bell","doi":"10.1007/978-1-4612-3730-3_10","DOIUrl":"https://doi.org/10.1007/978-1-4612-3730-3_10","url":null,"abstract":"","PeriodicalId":77092,"journal":{"name":"Current topics in medical mycology","volume":"2 ","pages":"338-87"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/978-1-4612-3730-3_10","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14416353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytochrome P450 of fungi: primary target for azole antifungal agents.","authors":"Y Yoshida","doi":"10.1007/978-1-4612-3730-3_11","DOIUrl":"https://doi.org/10.1007/978-1-4612-3730-3_11","url":null,"abstract":"<p><p>Cytochromes of fungi are essentially similar to those of animals. Cytochromes of fungi constitute two electron transport systems occurring in mitochondria and the endoplasmic reticulum. The former system, called the respiratory chain, contributes to cellular respiration and ATP generation, whereas the later system, named the microsomal electron transport system, is responsible for biosynthesis of several cellular components. The oxidative metabolism of lanosterol, that is included in the biosynthetic pathway of ergosterol, is one of the important functions of the microsomal electron transport system, which is catalyzed by P450(14DM). Many azole antifungal agents avidly combine with P450(14DM) and inhibit the oxidative removal of C-32 (the 14 alpha-demethylation) of lanosterol. This inhibition causes depletion of ergosterol and accumulation of 14-methylsterols in the membrane of fungal cells. Such change in sterol composition disturbs membrane function and results in growth inhibition and death of the fungal cells. Accordingly, P450(14DM) is considered as the primary target for azole antifungal agents. Cytochrome P450, which mediates the 14 alpha-demethylation of lanosterol, is also present in mammalian cells. Mammalian cells contain various species of cytochrome P450 which are responsible for many important cellular metabolic functions. If azole antifungal agents inhibit mammalian cytochrome P450 too, their systemic use may result in potentially significant adverse reactions. The high selectivity of azole antifungal agents for fungal P450(14DM) will be necessary for their systemic application. Binding ability of an azole antifungal agent to P450(14DM) is predominantly determined by the substituent at N-1 of the azole group, and the substituent must interact with the substrate site of the cytochrome. Extensive modification of the N-1 substituents and the screening of newly developed compounds with respect to the selectivity to fungal P450(14DM) with some conventional methods will be necessary. For this project, a biochemical understanding of cytochrome P450 and other cytochromes is important.</p>","PeriodicalId":77092,"journal":{"name":"Current topics in medical mycology","volume":"2 ","pages":"388-418"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/978-1-4612-3730-3_11","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14416354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tinea imbricata.","authors":"R J Hay","doi":"10.1007/978-1-4612-3730-3_3","DOIUrl":"https://doi.org/10.1007/978-1-4612-3730-3_3","url":null,"abstract":"","PeriodicalId":77092,"journal":{"name":"Current topics in medical mycology","volume":"2 ","pages":"55-72"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/978-1-4612-3730-3_3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14416356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphogenetic transformation of fungi.","authors":"M G Shepherd","doi":"10.1007/978-1-4612-3730-3_8","DOIUrl":"https://doi.org/10.1007/978-1-4612-3730-3_8","url":null,"abstract":"","PeriodicalId":77092,"journal":{"name":"Current topics in medical mycology","volume":"2 ","pages":"278-304"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14416351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of coccidioidomycosis.","authors":"D Pappagianis","doi":"10.1007/978-1-4612-3730-3_6","DOIUrl":"https://doi.org/10.1007/978-1-4612-3730-3_6","url":null,"abstract":"<p><p>Coccidioides immitis naturally occurs in the soil and air of certain areas of the New World. These are generally arid to semiarid areas that have relatively modest rainfall, mild winters, and prolonged hot seasons. Coccidioidomycosis is usually a disease of human and nonhuman residents of these areas; but visitors may develop the disease after entering these areas and returning home long distances from the endemic areas. Inhalation (rarely percutaneous introduction) of arthroconidia of C. immitis leads to usually benign but occasionally severe and even fatal infection. Recovery from or asymptomatic infection leads to resistance to reinfection. Exposure to soil (dust) means that certain occupations are more likely to be exposed to C. immitis. Persistence of the organism in the soil means that infections will be encountered in the future, particularly as long as susceptible newcomers continue to enter endemic areas. Those who have been infected and recovered generally will be resistant to later infection, although exacerbation may occur as a result of superimposed immunosuppression.</p>","PeriodicalId":77092,"journal":{"name":"Current topics in medical mycology","volume":"2 ","pages":"199-238"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14416349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural cell-mediated resistance against Cryptococcus neoformans: a possible role for natural killer (NK) cells.","authors":"J W Murphy","doi":"10.1007/978-1-4613-9547-8_5","DOIUrl":"https://doi.org/10.1007/978-1-4613-9547-8_5","url":null,"abstract":"","PeriodicalId":77092,"journal":{"name":"Current topics in medical mycology","volume":"1 ","pages":"135-54"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15032616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermatophyte antigens and cell-mediated immunity in dermatophytosis.","authors":"T Kaaman","doi":"10.1007/978-1-4613-9547-8_4","DOIUrl":"https://doi.org/10.1007/978-1-4613-9547-8_4","url":null,"abstract":"","PeriodicalId":77092,"journal":{"name":"Current topics in medical mycology","volume":"1 ","pages":"117-34"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/978-1-4613-9547-8_4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15032615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}