{"title":"Impact of Updated Invasive Right Ventricular and Pulmonary Hemodynamics on Long-Term Outcomes in Patients With Mitral Valve Transcatheter Edge-to-Edge Repair","authors":"Giulia Masiero MD , Federico Arturi MD , Elisa Boscolo Soramio MD , Luca Nai Fovino MD, PhD , Tommaso Fabris MD , Francesco Cardaioli MD , Andrea Panza MD , Giulia Lorenzoni MD, PhD , Massimo Napodano MD, PhD , Chiara Fraccaro MD, PhD , Giuseppe Tarantini MD, PhD","doi":"10.1016/j.amjcard.2024.11.010","DOIUrl":"10.1016/j.amjcard.2024.11.010","url":null,"abstract":"<div><div>Right-sided cardiac catheterization (RHC) is selectively recommended in mitral valve transcatheter edge-to-edge <strong>(</strong>M-TEER) workup because right ventricle (RV) hemodynamic parameters predict adverse outcomes. This study examines the impact of RV hemodynamics and the prognostic value of the 2022 European Society of Cardiology (ESC) pulmonary hypertension definitions on outcomes after M-TEER. Of 152 patients treated with M-TEER for symptomatic severe mitral regurgitation (MR) between December 2014 and February 2024 at our tertiary center, 71 underwent elective RHC before the procedure. The primary outcomes assessed were all-cause mortality and a composite of heart failure hospitalization and death at the longest available follow-up. In a cohort of 152 mostly male patients (64%) with a median age of 79 years who were treated for symptomatic severe MR, 71 underwent elective RHC. The causes were categorized as degenerative (47%), functional ventricular (41%), and atrial (12%). Pulmonary hypertension (PH) was common, with 74% showing mean pulmonary artery pressure (mPAP) >20 mm Hg and 39% with pulmonary vascular resistance (PVR) >2 Wood Units. Success rates were high, with technical, device, and procedural success at 97%, 88%, and 84%, respectively. At a median follow-up of 681 days, all-cause mortality was 50%, and the composite outcome (death or heart failure hospitalizations) occurred in 61%. Key hemodynamic parameters, including mPAP, PVR, and the tricuspid annular plane systolic excursion/systolic pulmonary artery pressure ratio, were independently linked to mortality risk. Kaplan-Meier analysis found significant associations with mPAP >20 mm Hg and pulmonary capillary wedge pressure >15 mm Hg for long-term mortality, whereas the 2022 ESC PH thresholds showed greater sensitivity, correlating with increased mortality risk. In patients with severe MR who undergo M-TEER, most RV invasive hemodynamic parameters are linked to adverse long-term outcomes, with mPAP, PVR, and the tricuspid annular plane systolic excursion/systolic pulmonary artery pressure ratio identified as independent predictors of mortality. Despite the study's limited sample size, the updated ESC PH definitions enhance prognostic assessment.</div></div>","PeriodicalId":7705,"journal":{"name":"American Journal of Cardiology","volume":"234 ","pages":"Pages 99-106"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142685791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cardiovascular Prognosis in Limb Ischemia Patients With Heart Failure and Systolic Dysfunction Following Major Amputation","authors":"Takuma Takada MD, PhD , Eiji Shibahashi MD, PhD , Shun Hasegawa MD , Ayano Yoshida MD, PhD , Makoto Kishihara MD , Shonosuke Watanabe MD , Shota Shirotani MD, PhD , Takuro Abe MD , Masashi Nakao MD, PhD , Junichi Yamaguchi MD, PhD , Kentaro Jujo MD, PhD","doi":"10.1016/j.amjcard.2024.12.031","DOIUrl":"10.1016/j.amjcard.2024.12.031","url":null,"abstract":"<div><div>Chronic limb-threatening ischemia (CLTI), the severest stage of peripheral artery disease, frequently necessitates amputation. In CLTI patients, heart failure with reduced ejection fraction (HFrEF) markedly raises mortality risk, with increased peripheral vascular resistance contributing to this exacerbation. This investigation aimed to assess the impact of major amputation (MA) on the cardiovascular (CV) prognosis in CLTI patients with HFrEF by lowering peripheral vascular resistance. Conducting a retrospective, observational analysis at a single center, a total of 60 patients with CLTI and HFrEF (EF < 50%) who underwent endovascular therapy (EVT) at our institution were assessed. We compared CV outcomes in CLTI patients with HFrEF who received MA (<em>n</em> = 17) to those who did not (<em>n</em> = 43) after undergoing EVT. During the follow-up period, which median 641 (IQR: 245 to 1,734) days post-EVT, a composite primary endpoint of CV death or hospitalization for HF was observed. During the study period, 19 patients (32%) were admitted for HF or died as a consequence of CV events. Kaplan-Meier analysis revealed a significantly reduced incidence of the primary endpoint in the MA cohort (log-rank test: p = 0.035). Adjustments for age and sex showed MA was significantly linked to improved CV prognosis (HR: 0.19; 95% confidence interval: 0.04 to 0.87). A nonsignificant trend toward decreased overall mortality was noted in the MA group, with infections being the predominant cause of death across both groups. In conclusion, in CLTI patients with HFrEF, MA might be linked to reduced CV events, proposing it as a potential definitive strategy for improving CV outcomes in this high-risk population.</div></div>","PeriodicalId":7705,"journal":{"name":"American Journal of Cardiology","volume":"240 ","pages":"Pages 17-23"},"PeriodicalIF":2.3,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142920542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohamad B. Moumneh MD , Mohammed A. Quader MD , Nicholas R. Teman MD , Daniel Tang MD , Liam Ryan MD , Raymond J. Strobel MD, MSc , Mark Joseph MD , Michael Mazzeffi MD , Zachary M. Gertz MD , Michael C. Kontos MD , Ramesh Singh MD , Alan Spier MD , Eric Sarin MD , Abdulla A. Damluji MD, PhD, MBA
{"title":"Clinical Outcomes for Postinfarct Ventricular Septal Defect Repair in a Large State-Wide Surgical Registry","authors":"Mohamad B. Moumneh MD , Mohammed A. Quader MD , Nicholas R. Teman MD , Daniel Tang MD , Liam Ryan MD , Raymond J. Strobel MD, MSc , Mark Joseph MD , Michael Mazzeffi MD , Zachary M. Gertz MD , Michael C. Kontos MD , Ramesh Singh MD , Alan Spier MD , Eric Sarin MD , Abdulla A. Damluji MD, PhD, MBA","doi":"10.1016/j.amjcard.2024.12.028","DOIUrl":"10.1016/j.amjcard.2024.12.028","url":null,"abstract":"<div><div>Ventricular septal defect (VSD) is a life-threatening complication occurring after delayed presentation of acute myocardial infarction (AMI). We assessed clinical characteristics based on mortality following surgical repair of post-AMI VSD and evaluated trends of mortality, mechanical circulatory support (MCS) device use, and surgical approach. We included all patients who had surgical VSD repair following AMI who were included in a regional quality collaborative from May 2008 through January 2020. The primary outcome was in-hospital mortality. A univariate logistic regression model was utilized for each clinical variable on in-hospital mortality, while a multivariable model was used on age and variables that showed significant association (p <0.05) in the univariable model. Of the 79 patients who received repair, 32 (41%) were ≥70 years, 49 (62%) were male, and 28 (35%) died. The preoperative mean ejection fraction was 35%. Cardiogenic shock (CS) was observed in 53% (alive vs dead: 39% vs 79%, p = 0.001), while 6% required cardiopulmonary resuscitation (alive vs dead: 2% vs 14%, p = 0.05). MCS devices including extracorporeal membrane oxygenation were used in 22% (alive vs dead: 4% vs 54%, p <0.001). Emergent surgery was performed in 37% (alive vs dead: 18% vs 71%, p <0.001), concomitant aortic valve replacement in 10% (alive vs dead: 11% vs 9%, p = 0.029), and delayed intervention (beyond 7 days) in 44% (alive vs dead: 57% vs 21%, p = 0.002). Intraoperatively, blood products were used in 49% (alive vs dead: 45% vs 57%, p = 0.005). Following repair, 22% suffered from renal failure (alive vs dead: 19% vs 48%, p = 0.021). Patients who experienced delayed intervention had higher survival rates probably related to survival bias. Patients who suffered in-hospital mortality were more likely to have CS and to require MCS. Improvement in patient selection by a “Heart Team” approach and new therapeutic options are needed as part of advanced care for mechanical complications of AMI.</div></div>","PeriodicalId":7705,"journal":{"name":"American Journal of Cardiology","volume":"240 ","pages":"Pages 64-67"},"PeriodicalIF":2.3,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Federica Agnello MD , Calogero Russo PharmD , Giulia Laterra MD , Salvatore Ingala MD , Stefania Saragoni BSc , Mario Giuffrida PharmD , Paola Maria Greca PharmD , Francesco La Tona MD , Noemi Rinaldi MD , Ilaria Gagliano MD , Carmela Nappi MSc , Alessandro Ghigi MSc , Maria Cappuccilli BSc, PhD , Luca Degli Esposti PhD , Lorenzo Scalia MD , Emanuele Cassarà MD , Marco Barbanti MD
{"title":"The Integrated Multidisciplinary Pathway for Large-Scale Management of Dyslipidemia in High-Risk Patients (ENNA) Project: Rationale and Project Design","authors":"Federica Agnello MD , Calogero Russo PharmD , Giulia Laterra MD , Salvatore Ingala MD , Stefania Saragoni BSc , Mario Giuffrida PharmD , Paola Maria Greca PharmD , Francesco La Tona MD , Noemi Rinaldi MD , Ilaria Gagliano MD , Carmela Nappi MSc , Alessandro Ghigi MSc , Maria Cappuccilli BSc, PhD , Luca Degli Esposti PhD , Lorenzo Scalia MD , Emanuele Cassarà MD , Marco Barbanti MD","doi":"10.1016/j.amjcard.2024.12.027","DOIUrl":"10.1016/j.amjcard.2024.12.027","url":null,"abstract":"<div><div>Atherosclerotic cardiovascular disease is a leading cause of morbidity and mortality globally, significantly influenced by modifiable risk factors, particularly hypercholesterolemia. Despite the availability of effective lipid-reducing drugs, achieving the low-density lipoprotein cholesterol (LDL-C) target levels remains a significant challenge in clinical practice, contributing to persistently high rates of cardiovascular events. The intEgrated multidiscipliNary pathway for large-scale maNagement of dyslipidemiA in high-risk patients (ENNA) Project was designed to address the alarming rates of suboptimal lipid management in patients at high and very-high risk in the province of Enna, Sicily. This program aims to optimize LDL-C control through an integrated care model that fosters collaboration among pharmacists, general practitioners, and cardiologists, ultimately promoting a patient-centered approach to therapy. The patients who are eligible are identified using data-driven methods through prescription claims, laboratory results, and hospital discharge data, facilitated by local pharmacies. General practitioners play a crucial role as the primary care providers for initiating or optimizing lipid-reducing therapy, whereas cardiologists are involved in managing more complex cases requiring specialized intervention. The primary objective of the ENNA Project is to increase the percentage of patients at great risk in whom LDL-C targets are achieved, improving overall lipid management and therapeutic adherence.</div></div>","PeriodicalId":7705,"journal":{"name":"American Journal of Cardiology","volume":"240 ","pages":"Pages 71-75"},"PeriodicalIF":2.3,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142891657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
He Jiao MM , Xiankun Liu MD , Yiming Bai MD , Lin Cong MM , Yunpeng Bai MD , Zhigang Guo MD
{"title":"Gender Differences in Acute Type A Aortic Dissection: A Comprehensive Review and Meta-Analysis","authors":"He Jiao MM , Xiankun Liu MD , Yiming Bai MD , Lin Cong MM , Yunpeng Bai MD , Zhigang Guo MD","doi":"10.1016/j.amjcard.2024.12.023","DOIUrl":"10.1016/j.amjcard.2024.12.023","url":null,"abstract":"<div><div>We aimed to undertake a meta-analysis of cohort studies to evaluate gender-based differences for patients with acute type A aortic dissection. A systematic search was performed across PubMed, Embase, and Cochrane Library (2000 to 2023) for studies reporting gender-related discrepancies in clinical presentation, in-hospital management, and/or outcomes. Study effects were assessed using mean difference or risk ratio (RR) as aggregated estimates. Besides, individual patient-level data on survival were reestablished to form gender-related Kaplan–Meier curves to evaluate long-term survival outcome. The study protocol was registered in PROSPERO (ID: CRD42024524125). The 21 studies were analyzed, comprising 6,728 women and 12,839 men. Women had lower risks of postoperative acute kidney injury (RR 0.85; 95% confidence interval [CI] 0.72 to 1.00, p = 0.049) and reoperation (RR 0.89; 95% CI 0.81 to 0.99, p = 0.024) but a higher perioperative mortality (RR 1.11; 95% CI 1.03 to 1.18, p = 0.005) than men. In addition, the overall survival was poorer in women (p <0.001), with 10-year survival rates of 66.5% for men and 60.0% for women. In conclusion, acute type A aortic dissection presents gender differences, with women facing higher perioperative and long-term mortality despite lower acute kidney injury and reoperation risks, suggesting a need for tailored management and prevention strategies.</div></div>","PeriodicalId":7705,"journal":{"name":"American Journal of Cardiology","volume":"240 ","pages":"Pages 1-12"},"PeriodicalIF":2.3,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142891649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Long-Term Outcomes of True Versus Nontrue Coronary Bifurcation Lesions Treated With Bioresorbable Polymer Sirolimus-Eluting Ultimaster Stent Under Intravascular Imaging Guidance","authors":"Nobuki Matsuna MD, Shoichi Kuramitsu MD, PhD, Yutaka Tadano MD, Takuro Sugie MD, Umihiko Kaneko MD, Hisanori Yui MD, PhD, Takuya Shimizu MD, PhD, Shigeyoshi Miura MD, Ken Kobayashi MD, Daitaro Kanno MD, Yoshifumi Kashima MD, Tsutomu Fujita MD","doi":"10.1016/j.amjcard.2024.12.025","DOIUrl":"10.1016/j.amjcard.2024.12.025","url":null,"abstract":"<div><div>Limited evidence exists regarding the long-term outcomes of true versus nontrue coronary bifurcation lesions (CBLs) treated with current-generation drug-eluting stents and intravascular imaging guidance. The Sapporo Cardiovascular Clinic (SCVC) registry was a prospective, single-center, all-comers registry enrolling 1,727 consecutive patients treated with bioresorbable polymer sirolimus-eluting stent under complete imaging guidance. From this registry, 440 patients with CBLs (25.5%) were analyzed. Patients were categorized into the true and nontrue CBL groups according to the Medina classification (n = 234 and 206, respectively). The primary end point was the cumulative incidence of target vessel failure (TVF) (a composite of cardiac death, target vessel-related myocardial infarction, and clinically driven target vessel revascularization). The 1-stent strategy was predominantly chosen for the true and nontrue CBL groups (93.9% and 96.2%, respectively). During the median follow-up of 5.4 years, the cumulative incidence of TVF did not differ between true and nontrue CBL groups after adjustment for baseline differences (5-year incidence 22.0% vs 17.7%, adjusted hazard ratio 1.27, 95% confidence interval 0.79 to 2.05, p = 0.32). Although the Medina 0.0.1 lesions were very rare (1.1%), they had the highest rate of TVF among the Medina subtypes. Final kissing balloon inflation technique was associated with a lower incidence of TVF (p = 0.036). In conclusion, imaging-guided percutaneous coronary intervention with bioresorbable polymer sirolimus-eluting stent resulted in comparable long-term clinical outcomes between true and nontrue CBLs, primarily using the 1-stent technique.</div></div>","PeriodicalId":7705,"journal":{"name":"American Journal of Cardiology","volume":"239 ","pages":"Pages 57-63"},"PeriodicalIF":2.3,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142891651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Intervening on Partial Anomalous Pulmonary Venous Return Without Leaving a Trace Ready for a Minimally Invasive Future?","authors":"Georges Ephrem","doi":"10.1016/j.amjcard.2024.12.026","DOIUrl":"10.1016/j.amjcard.2024.12.026","url":null,"abstract":"","PeriodicalId":7705,"journal":{"name":"American Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142891650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ashraf Samhan MD , Danish Saleh MD, PhD , Ellis Y. Kim MD, PhD , Mo Hu MS , Kayla Mueller BSN, RN , Abigail Garza BSN, RN , Elizabeth Schormann MPH , Parmeen Bindra MS, MBA , Baljash Cheema MD, MSCI, MSAI , Dominic E. Fullenkamp MD, PhD , Abigail S. Baldridge DrPH , Jyothy J. Puthumana MD , James D. Flaherty MD , Lubna Choudhury MD, MRCPI
{"title":"Comparison of Alcohol Septal Ablation With Mavacamten in Obstructive Hypertrophic Cardiomyopathy","authors":"Ashraf Samhan MD , Danish Saleh MD, PhD , Ellis Y. Kim MD, PhD , Mo Hu MS , Kayla Mueller BSN, RN , Abigail Garza BSN, RN , Elizabeth Schormann MPH , Parmeen Bindra MS, MBA , Baljash Cheema MD, MSCI, MSAI , Dominic E. Fullenkamp MD, PhD , Abigail S. Baldridge DrPH , Jyothy J. Puthumana MD , James D. Flaherty MD , Lubna Choudhury MD, MRCPI","doi":"10.1016/j.amjcard.2024.12.024","DOIUrl":"10.1016/j.amjcard.2024.12.024","url":null,"abstract":"<div><div>Obstructive hypertrophic cardiomyopathy (HCM) is associated with significant morbidity attributed to left ventricular outflow tract (LVOT) obstruction. Although alcohol septal ablation (ASA) is an established interventional treatment, mavacamten, a novel cardiac myosin inhibitor, has emerged as a noninvasive pharmacologic alternative. Understanding the comparative efficacy of these 2 treatments is important for optimizing patient care. This single-center retrospective study assessed the hemodynamic and functional changes in adult patients with obstructive HCM treated with ASA (n = 58) or mavacamten (n = 36) from July 2012 to May 2024. Outcomes, including changes in LVOT gradient, left ventricular ejection fraction, mitral regurgitation (MR) severity, and New York Heart Association (NYHA) class, were collected at baseline, 16 weeks, and after 32 weeks of treatment. ASA and mavacamten were associated with over 70% reductions in Valsalva-induced LVOT gradient and MR after 32 weeks. The maximal effect of ASA on LVOT gradient was observed at 16 weeks, whereas mavacamten's peak effect was noted after 32 weeks. MR severity improved similarly in both cohorts (p <0.01). Patients who underwent ASA had a poorer baseline NYHA functional class than their counterparts; however, each treatment significantly improved LVOT gradients (p <0.001) and average NYHA class after 32 weeks (p <0.001). The average left ventricular ejection fraction was comparable at baseline and after 32 weeks between the 2 groups. Patients treated with ASA were older than those treated with mavacamten (68.5 vs 60.8 years, p <0.001). In patients with obstructive HCM, ASA and mavacamten yield significant and comparable improvements in hemodynamics and functional status after 32 weeks.</div></div>","PeriodicalId":7705,"journal":{"name":"American Journal of Cardiology","volume":"239 ","pages":"Pages 51-56"},"PeriodicalIF":2.3,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142891648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sahib Singh, Udaya S Tantry, Young-Hoon Jeong, Paul A Gurbel
{"title":"The Importance of Time from Event in Assessing Mortality in Patients With ST-Segment Elevation Myocardial Infarction and Non-ST-Segment Elevation Myocardial Infarction.","authors":"Sahib Singh, Udaya S Tantry, Young-Hoon Jeong, Paul A Gurbel","doi":"10.1016/j.amjcard.2024.12.022","DOIUrl":"10.1016/j.amjcard.2024.12.022","url":null,"abstract":"","PeriodicalId":7705,"journal":{"name":"American Journal of Cardiology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142880788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}