American Journal of Advanced Drug Delivery最新文献_第3页

Functionalization of Polymeric Nanoparticles for Drug Delivery Across the BloodâBrain Barrier 高分子纳米颗粒在血-脑屏障药物传递中的功能化

American Journal of Advanced Drug Delivery Pub Date : 2020-01-01 DOI: 10.21767/2321-547X.8.1.33

Jyoti Rawat

{"title":"Functionalization of Polymeric Nanoparticles for Drug Delivery Across the BloodâBrain Barrier","authors":"Jyoti Rawat","doi":"10.21767/2321-547X.8.1.33","DOIUrl":"https://doi.org/10.21767/2321-547X.8.1.33","url":null,"abstract":"The blood–brain barrier (BBB) is made out of cerebrum endothelial cells, pericytes, and astrocytes, which assemble a tight cell obstruction. Restorative (macro)molecules can't travel through the BBB in their free structure. This constraint is skirted by apolipoprotein E (ApoE)âÂÂfunctionalized polymeric nanoparticles (NPs) that can move drugs (e.g., dalargin, loperamide, doxorubicin, and nerve development factor) over the BBB by means of low density lipoprotein (LDL) receptorâÂÂmediated transcytosis. Covering with polysorbate 80 or poloxamer 188 encourages ApoE adsorption onto polymeric NPs empowering acknowledgment by LDL receptors of cerebrum endothelial cells. This impact is even upgraded when NPs are legitimately covered with ApoE without surfactant grapple. Also, covalent coupling of ApoE to NPs that bear receptive gatherings on their surface prompts altogether improved cerebrum take-up while keeping away from the utilization of surfactants. In this Progress Report a few in vitro BBB models utilizing mind endothelial cells or cocultures with astrocytes/pericytes/glioma cells are portrayed, which give bits of knowledge in regards to the capacity of a m","PeriodicalId":7704,"journal":{"name":"American Journal of Advanced Drug Delivery","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85819673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Steroidal molecules as swiftly acting therapeutics 类固醇分子作为速效治疗药物

American Journal of Advanced Drug Delivery Pub Date : 2020-01-01 DOI: 10.21767/2321-547X.8.1.34

Jyoti Rawat

引用次数: 0

Development and Evaluation of a Shea Butter Based Cream Containing Essential Oils from the Leaves of Ocimum gratissimum Lamiaceae), a Plant with Antifungal Activity 具有抗真菌活性的木果油基乳木果油乳霜的研制与评价

American Journal of Advanced Drug Delivery Pub Date : 2020-01-01 DOI: 10.21767/2321-547X.8.1.30

Koffi

引用次数: 0

Anti-cancer and Anti-oxidant Potencies of Cuscuta reflexa Roxb. Plant Extracts 菟丝子的抗癌和抗氧化作用。植物提取物

American Journal of Advanced Drug Delivery Pub Date : 2020-01-01 DOI: 10.36648/2321-547X.8.1.31

I. Ali, M. Suhail, Mohd Fazil, B. Ahmad, A. Sayeed, Mohd Farooq Naqshb, A. Azam

{"title":"Anti-cancer and Anti-oxidant Potencies of Cuscuta reflexa Roxb. Plant Extracts","authors":"I. Ali, M. Suhail, Mohd Fazil, B. Ahmad, A. Sayeed, Mohd Farooq Naqshb, A. Azam","doi":"10.36648/2321-547X.8.1.31","DOIUrl":"https://doi.org/10.36648/2321-547X.8.1.31","url":null,"abstract":"All around the world, the percentage of deaths due to cancer is continuously increasing-the greatest devastation of deaths. Among all medications, Unani medicines are boon for human beings to treat cancer with no or least side effects. About 80% rural population use natural products for primary health care. Cuscuta reflexa Roxb. (family Cuscutaceae) is utilized in traditional medicines for curing cancer and other diseases, and it is considered as the most significant plant in the Unani medicinal system. The extracts of Cuscuta reflexa Roxb. were obtained to measure the anticancer activity with H-1299 and MCF-7 cancer cell lines. Soxhlet extraction was utilized for stem and seeds. The anticancer activity of fractions of each extract obtained by using Flash chromatography was also checked. Besides, the antioxidant activity of each fraction was also checked. DNA binding study supported the results obtained during whole process. The cellular death was detected utilizing ELISA. The results indicated that extracts of Cuscuta reflexa Roxb. exhibited strong anticancer activities as compared to the fractions of each extract. Cuscuta reflexa Roxb. extracts indicated noteworthy cytotoxicity against human H-1299 and (lung cancer) MCF-7 cancer cells (breast cancer). The extract of this plant may be given to the patients having lung cancer and breast cancer.","PeriodicalId":7704,"journal":{"name":"American Journal of Advanced Drug Delivery","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87387679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Flakka: A Designer Drug with Deadly Consequences Flakka:一种具有致命后果的设计药物

American Journal of Advanced Drug Delivery Pub Date : 2018-01-01 DOI: 10.21767/2321-547X.1000021

L. Hendricks, R. Ashmore, Samuel K. Bore

引用次数: 0

Preparation and In vitro Evaluation of Enteric Coated Oral Vancomycin Hydrochloride Sustained Release Formulation with Mucoadhesive Properties 肠溶包衣口服盐酸万古霉素黏附缓释片的制备及体外评价

American Journal of Advanced Drug Delivery Pub Date : 2018-01-01 DOI: 10.21767/2321-547X.1000029

Lana Alsharkas, Vijayaraj Kumar Palanirajan, Y. Wei

{"title":"Preparation and In vitro Evaluation of Enteric Coated Oral Vancomycin Hydrochloride Sustained Release Formulation with Mucoadhesive Properties","authors":"Lana Alsharkas, Vijayaraj Kumar Palanirajan, Y. Wei","doi":"10.21767/2321-547X.1000029","DOIUrl":"https://doi.org/10.21767/2321-547X.1000029","url":null,"abstract":"Clostridium difficile is a species of gram-positive bacteria thought to infect patients with weakened immune response resulting in colitis. Oral vancomycin hydrochloride is given four times a day to treat Clostridium difficile colitis and is commercially available in the form of capsule and solution. Patient’s compliance is the main issue in this treatment due to the multiple dosing frequencies. Accordingly, replacement of such dose regimen with a once daily dosage will enhance patient compliance. In this study, mucoadhesive vancomycin hydrochloride tablets were prepared with the use of chitosan to exert a local effect in the colon. Sustained release property was also imparted by chitosan. Enteric coating with Eudragit® S 100 was applied to prevent the sticking of chitosan tablets in the stomach and small intestine and deliver the tablets intact to the colon. The prepared tablets were evaluated for In vitro drug release for 24 hours and compared with the marketed formulation. The formulation was found to release in a sustained manner in pH 7.4 buffer allowing the colon delivered oral vancomycin hydrochloride to be a promising formulation in the development of a once daily treatment for Clostridium difficile colitis.","PeriodicalId":7704,"journal":{"name":"American Journal of Advanced Drug Delivery","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73560763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A Critical Therapeutic Target to Inhibit Apoptosisin Relevant Heart Failure: An Overview 抑制凋亡相关心力衰竭的关键治疗靶点:综述

American Journal of Advanced Drug Delivery Pub Date : 2018-01-01 DOI: 10.21767/2321-547X.1000027

Akriti Nepala, Sufia Yasmeenb, Fahad Akhtarc, Nirmala Kojua, Qu Aina, Cao Teng-Lia, Zhang Xiu-Xiua, Li Qinga, Chen Ding-Dinga

{"title":"A Critical Therapeutic Target to Inhibit Apoptosisin Relevant Heart Failure: An Overview","authors":"Akriti Nepala, Sufia Yasmeenb, Fahad Akhtarc, Nirmala Kojua, Qu Aina, Cao Teng-Lia, Zhang Xiu-Xiua, Li Qinga, Chen Ding-Dinga","doi":"10.21767/2321-547X.1000027","DOIUrl":"https://doi.org/10.21767/2321-547X.1000027","url":null,"abstract":"Heart failure (HF) is the ultimate trail anteceded by different genetics and categorized by impaired cardiac remodeling where heart chambers gradually expand and contractile function declines. Apoptosis is a well-thought-out system that gestures cells to self-destruct for cell renewal or to switch abnormal cell growth. The stability of cardiomyocytes is acknowledged using an essential method for the advancement of HF. Apoptosis possibly will remain in control on behalf of a substantial quantity of cardiomyocytes death in the sequence of acute myocardial infarction (MI) as well as advanced damage of persisting cells among the failing hearts. Indicating that distinctive apoptosis and the prospective ability knows how to remain lured in cardiomyocytes next to the investigational circumstances of beneficial mediation to inhibit apoptosis remnants as notorious. Promisingly apoptosis shows a starring protagonist in the reperfusion of tissue impairment, which has prophylactic, pathological and useful inferences. Numerous studies concluded that the progression of HF along with the apoptotic inhibitor is cardio protective and can prevent HF. This review article aims to deliberate lessons mainly to identify potential therapeutic targets in the cardiac muscles, as well as mechanisms of apoptosis in MI which is primarily intended for the upcoming treatment and inhibition of HF.","PeriodicalId":7704,"journal":{"name":"American Journal of Advanced Drug Delivery","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89373242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial T Cell Mimetics to Combat Melanoma Tumor Growth. 人工 T 细胞模拟物对抗黑色素瘤肿瘤生长

American Journal of Advanced Drug Delivery Pub Date : 2018-01-01

Shilpaa Mukundan, Dongli Guan, Amy Singleton, Yunlong Yang, Matthew Li, Biju Parekkadan

{"title":"Artificial T Cell Mimetics to Combat Melanoma Tumor Growth.","authors":"Shilpaa Mukundan, Dongli Guan, Amy Singleton, Yunlong Yang, Matthew Li, Biju Parekkadan","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Despite recent breakthroughs in melanoma treatment with anti-PD-1 immunotherapy, innovative approaches are needed to improve off-target effects. In this study, we report a T cell mimetic microparticle delivery of soluble PD1 aiming at providing a carrier substrate for future combinatorial and targeting efforts. Microparticles of sizes varying from (5 μm to-7 μm) were conjugated with soluble mouse or human PD-1 through nearly irreversible binding between streptavidin and biotin. PD-1 conjugated microparticles (PDMPs) suppressed 3-dimensional tumor growth of human A375 and mouse B16-F10 melanoma cells compared to control microparticles conjugated with the Fc portion of human IgG1 (IgG1MPs). This can be attributed to competitive inhibition by PDMPs on a melanoma cell-intrinsic PD-1/PD-L1 pathway. A single, local administration of mPDMPs in a B16-F10 mouse melanoma model inhibited tumor growth significantly compared to control IgMPs at the same dose. CD45+ immune cells were found to infiltrate tumors treated with mPDMPs as a mechanism for tumor control. These results collectively suggest that PDMPs can target the melanoma cell-intrinsic PD-1/PD-L1 pathway and that these artificial T cell mimetics can be the scaffold for further improvements in anti-tumor immunotherapy.</p>","PeriodicalId":7704,"journal":{"name":"American Journal of Advanced Drug Delivery","volume":"6 1","pages":"21-32"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126372/pdf/nihms-983472.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36476270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quercetin Loaded Nanostructured Lipid Carriers for Nose to Brain Delivery: In Vitro and In Vivo Studies 槲皮素负载的纳米结构脂质载体用于鼻到脑输送:体外和体内研究

American Journal of Advanced Drug Delivery Pub Date : 2018-01-01 DOI: 10.21767/2321-547X.1000022

N. L. Patil, H. Mahajan

引用次数: 10

Effect of Progesterone with Vitamin E on Pregnancy in Young Rabbit Does 黄体酮与维生素E对幼兔妊娠的影响

American Journal of Advanced Drug Delivery Pub Date : 2018-01-01 DOI: 10.21767/2321-547X.1000028

A. Salem, H. A. Hussein, Y. Gomaa, F. Allam

{"title":"Effect of Progesterone with Vitamin E on Pregnancy in Young Rabbit Does","authors":"A. Salem, H. A. Hussein, Y. Gomaa, F. Allam","doi":"10.21767/2321-547X.1000028","DOIUrl":"https://doi.org/10.21767/2321-547X.1000028","url":null,"abstract":"Progesterone (P4) and vitamin E (Vitamin E) are important in early stage of pregnancy especially in young does. The goal was to investigate effect of injection of P4, Vitamin E and their integration on pregnancy enhancement, embryo dimensions and P4 concentration in young does. 24 animals were divided into 4 equal groups: control group, P4 group (each doe was injected i.m with single dose of 1.0 mg long-acting P4 two days post-mating), Vitamin E group (each doe was injected i.m with 20 IU Vitamin E/kg BW every 3 days from mating to mid-pregnancy and P4+Vitamin E group. All does were ultrasono-graphically examined at days 7,10,12,14,16,18,20 and 22 of pregnancy. Results revealed that P4 and P4+Vitamin E treatment facilitated establishment of pregnancy on day 7 of pregnancy more than the control and Vitamin E alone. Amniotic vesicles diameters on day 12 and fetal length on days 14 and 16 were greater (P<0.05) in P4 and P4+Vitamin E groups. On days 18-22, fetus length was significantly larger in P4 group. P4 concentrations at first week and mid-pregnancy were significantly greater in P4 group followed by P4+Vitamin E. Conclusion: P4 and P4+Vitamin E enhanced the early stage of pregnancy during the first parity of rabbit does.","PeriodicalId":7704,"journal":{"name":"American Journal of Advanced Drug Delivery","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87972629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0