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Polyethers. 聚醚。
Biotechnology (Reading, Mass.) Pub Date : 1995-01-01 DOI: 10.1016/b978-0-7506-9095-9.50025-3
A W Birch, J A Robinson
{"title":"Polyethers.","authors":"A W Birch, J A Robinson","doi":"10.1016/b978-0-7506-9095-9.50025-3","DOIUrl":"https://doi.org/10.1016/b978-0-7506-9095-9.50025-3","url":null,"abstract":"","PeriodicalId":77041,"journal":{"name":"Biotechnology (Reading, Mass.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19662813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Chloramphenicol. 氯霉素。
Biotechnology (Reading, Mass.) Pub Date : 1995-01-01 DOI: 10.1016/b978-0-7506-9095-9.50028-9
L C Vining, C Stuttard
{"title":"Chloramphenicol.","authors":"L C Vining, C Stuttard","doi":"10.1016/b978-0-7506-9095-9.50028-9","DOIUrl":"https://doi.org/10.1016/b978-0-7506-9095-9.50028-9","url":null,"abstract":"","PeriodicalId":77041,"journal":{"name":"Biotechnology (Reading, Mass.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/b978-0-7506-9095-9.50028-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19662815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Peptidolactones. 肽内酯。
Biotechnology (Reading, Mass.) Pub Date : 1995-01-01 DOI: 10.1016/b978-0-7506-9095-9.50013-7
U Keller
{"title":"Peptidolactones.","authors":"U Keller","doi":"10.1016/b978-0-7506-9095-9.50013-7","DOIUrl":"https://doi.org/10.1016/b978-0-7506-9095-9.50013-7","url":null,"abstract":"","PeriodicalId":77041,"journal":{"name":"Biotechnology (Reading, Mass.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19662887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Glycopeptides. 糖肤。
Biotechnology (Reading, Mass.) Pub Date : 1995-01-01 DOI: 10.1016/b978-0-7506-9095-9.50017-4
M J Zmijewski, J T Fayerman
{"title":"Glycopeptides.","authors":"M J Zmijewski, J T Fayerman","doi":"10.1016/b978-0-7506-9095-9.50017-4","DOIUrl":"https://doi.org/10.1016/b978-0-7506-9095-9.50017-4","url":null,"abstract":"","PeriodicalId":77041,"journal":{"name":"Biotechnology (Reading, Mass.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19662891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Lantibiotics. Lantibiotics。
Biotechnology (Reading, Mass.) Pub Date : 1995-01-01 DOI: 10.1016/b978-0-7506-9095-9.50018-6
M J Gasson
{"title":"Lantibiotics.","authors":"M J Gasson","doi":"10.1016/b978-0-7506-9095-9.50018-6","DOIUrl":"https://doi.org/10.1016/b978-0-7506-9095-9.50018-6","url":null,"abstract":"","PeriodicalId":77041,"journal":{"name":"Biotechnology (Reading, Mass.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19662892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Mechanism-based screening for the discovery of novel antifungals. 基于机制的筛选发现新型抗真菌药物。
Biotechnology (Reading, Mass.) Pub Date : 1994-01-01 DOI: 10.1016/b978-0-7506-9003-4.50012-5
D R Kirsch, B J DiDomenico
{"title":"Mechanism-based screening for the discovery of novel antifungals.","authors":"D R Kirsch, B J DiDomenico","doi":"10.1016/b978-0-7506-9003-4.50012-5","DOIUrl":"https://doi.org/10.1016/b978-0-7506-9003-4.50012-5","url":null,"abstract":"","PeriodicalId":77041,"journal":{"name":"Biotechnology (Reading, Mass.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/b978-0-7506-9003-4.50012-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18749597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Mechanism-based screens in the discovery of chemotherapeutic antibacterials. 基于机制的筛选在发现化疗抗菌素中的作用。
Biotechnology (Reading, Mass.) Pub Date : 1994-01-01 DOI: 10.1016/b978-0-7506-9003-4.50014-9
S Kadam
{"title":"Mechanism-based screens in the discovery of chemotherapeutic antibacterials.","authors":"S Kadam","doi":"10.1016/b978-0-7506-9003-4.50014-9","DOIUrl":"https://doi.org/10.1016/b978-0-7506-9003-4.50014-9","url":null,"abstract":"<p><p>Numerous assays have been developed over the last 40 years for the detection of novel antibacterial metabolites. I have discussed many of the successful strategies and suggested some potential targets. Although the trend toward mechanism-based assays is relatively recent, it is clear that they have had a profound impact on screening in drug discovery. Often a mechanism-based assay requires construction of specific strains and verification of the antibacterial role of the selected target. Since the conception and development of a mechanism-based screen depends upon knowledge of the specific target and perhaps a compound that affects that target, it is implicit that mode of action studies on compounds discovered through random screening may subsequently lead to new mechanistic assays. While serendipity continues to play a crucial role in any screen, target-directed assays appear to be a worthwhile approach in antibacterial screening.</p>","PeriodicalId":77041,"journal":{"name":"Biotechnology (Reading, Mass.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/b978-0-7506-9003-4.50014-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18749599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Potential of fungi in the discovery of novel, low-molecular weight pharmaceuticals. 真菌在发现新型低分子量药物方面的潜力。
Biotechnology (Reading, Mass.) Pub Date : 1994-01-01 DOI: 10.1016/b978-0-7506-9003-4.50009-5
M M Dreyfuss, I H Chapela
{"title":"Potential of fungi in the discovery of novel, low-molecular weight pharmaceuticals.","authors":"M M Dreyfuss,&nbsp;I H Chapela","doi":"10.1016/b978-0-7506-9003-4.50009-5","DOIUrl":"https://doi.org/10.1016/b978-0-7506-9003-4.50009-5","url":null,"abstract":"","PeriodicalId":77041,"journal":{"name":"Biotechnology (Reading, Mass.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/b978-0-7506-9003-4.50009-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18749608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 319
The discovery of drugs from higher plants. 从高等植物中发现药物。
Biotechnology (Reading, Mass.) Pub Date : 1994-01-01 DOI: 10.1016/b978-0-7506-9003-4.50010-1
A D Kinghorn
{"title":"The discovery of drugs from higher plants.","authors":"A D Kinghorn","doi":"10.1016/b978-0-7506-9003-4.50010-1","DOIUrl":"https://doi.org/10.1016/b978-0-7506-9003-4.50010-1","url":null,"abstract":"","PeriodicalId":77041,"journal":{"name":"Biotechnology (Reading, Mass.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/b978-0-7506-9003-4.50010-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18749609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 42
Modern spectroscopic approaches to structure elucidation. 结构解析的现代光谱学方法。
Biotechnology (Reading, Mass.) Pub Date : 1994-01-01 DOI: 10.1016/b978-0-7506-9003-4.50020-4
O D Hensens
{"title":"Modern spectroscopic approaches to structure elucidation.","authors":"O D Hensens","doi":"10.1016/b978-0-7506-9003-4.50020-4","DOIUrl":"https://doi.org/10.1016/b978-0-7506-9003-4.50020-4","url":null,"abstract":"","PeriodicalId":77041,"journal":{"name":"Biotechnology (Reading, Mass.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18749607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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