Bioprocess technology最新文献

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Microbial biofilms and biofilm reactors. 微生物生物膜和生物膜反应器。
Bioprocess technology Pub Date : 2018-10-03 DOI: 10.1201/9781315138954-6
B. Peyton, W. G. Characklis
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引用次数: 6
Matrices and activation methods for cell adhesion/immobilization studies. 用于细胞粘附/固定化研究的基质和活化方法。
Bioprocess technology Pub Date : 2018-10-03 DOI: 10.1201/9781315138954-7
W. Scouten
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引用次数: 4
Cell adhesion in animal cell culture: physiological and fluid-mechanical implications. 动物细胞培养中的细胞粘附:生理和流体力学意义。
Bioprocess technology Pub Date : 2018-10-03 DOI: 10.1201/9781315138954-3
Manfred R. Koller, E. Papoutsakis
{"title":"Cell adhesion in animal cell culture: physiological and fluid-mechanical implications.","authors":"Manfred R. Koller, E. Papoutsakis","doi":"10.1201/9781315138954-3","DOIUrl":"https://doi.org/10.1201/9781315138954-3","url":null,"abstract":"We have reviewed the general forces through which cells interact with substrata in their first nonspecific contact. The complex, fast-emerging biology of specific cell adhesion and the structure of the extracellular matrix were reviewed in substantial detail, and the most updated conceptual model of biological cell adhesion was assembled from past efforts and new literature data. The chemistries of the various possible substrata for cell adhesion have been reviewed extensively in the past, and here only a brief summary was presented, with particular emphasis on the materials for traditional and porous microcarriers. The fascinating molecular and cellular implications of cell adhesion were reviewed in detail to establish that cell adhesion and the extracellular matrix provide more than structural support for the cells and their assemblies, and that in fact they constitute fundamental regulators of cell function, metabolism, and differentiation. We reviewed the fluid-mechanical mechanisms of cell damage in microcarrier systems and provided experimental evidence for the importance of the cell-adhesion quality in the ability of cells to withstand fluid forces in bioreactors. We provided evidence that the interplay of cell adhesion and fluid forces is likely to produce cell responses more complex than that of simple life and death, and we suggested that such responses are awaiting investigation and exploration for new applications and culturing possibilities. We also reviewed the experimental evidence on the importance of cell adhesion in cell and microcarrier aggregation and discussed the implications of such aggregation on the culturing environment and the operation of bioreactors. Finally, we discussed the possible implications of cell adhesion as it relates to the developing field of tissue engineering, using the example of bone marrow culture, which involves a large variety of cells and constitutes one of the most complex cell culture systems.","PeriodicalId":77040,"journal":{"name":"Bioprocess technology","volume":"20 1","pages":"61-110"},"PeriodicalIF":0.0,"publicationDate":"2018-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41658314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Cell aggregation and sedimentation. 细胞聚集和沉淀。
Bioprocess technology Pub Date : 2018-10-03 DOI: 10.1201/9781315138954-5
R. Davis
{"title":"Cell aggregation and sedimentation.","authors":"R. Davis","doi":"10.1201/9781315138954-5","DOIUrl":"https://doi.org/10.1201/9781315138954-5","url":null,"abstract":"The aggregation of cells into clumps or flocs has been exploited for decades in such applications as biological wastewater treatment, beer brewing, antibiotic fermentation, and enhanced sedimentation to aid in cell recovery or retention. More recent research has included the use of cell aggregation and sedimentation to selectively separate subpopulations of cells. Potential biotechnological applications include overcoming contamination, maintaining plasmid-bearing cells in continuous fermentors, and selectively removing nonviable hybridoma cells from perfusion cultures.","PeriodicalId":77040,"journal":{"name":"Bioprocess technology","volume":"20 1","pages":"135-85"},"PeriodicalIF":0.0,"publicationDate":"2018-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48925907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Matrices and activation methods for cell adhesion/immobilization studies. 细胞粘附/固定研究的基质和活化方法。
Bioprocess technology Pub Date : 1995-01-01
W H Scouten
{"title":"Matrices and activation methods for cell adhesion/immobilization studies.","authors":"W H Scouten","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77040,"journal":{"name":"Bioprocess technology","volume":"20 ","pages":"233-65"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18766622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fundamentals of bioreactor design. 生物反应器设计基础。
Bioprocess technology Pub Date : 1995-01-01
J C Merchuk, J A Asenjo
{"title":"Fundamentals of bioreactor design.","authors":"J C Merchuk, J A Asenjo","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77040,"journal":{"name":"Bioprocess technology","volume":"21 ","pages":"139-205"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18766625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gene expression in recombinant Streptomyces. 重组链霉菌的基因表达。
Bioprocess technology Pub Date : 1995-01-01
R H Baltz
{"title":"Gene expression in recombinant Streptomyces.","authors":"R H Baltz","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77040,"journal":{"name":"Bioprocess technology","volume":"22 ","pages":"309-81"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18768727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbial biofilms and biofilm reactors. 微生物生物膜和生物膜反应器。
Bioprocess technology Pub Date : 1995-01-01
B M Peyton, W G Characklis
{"title":"Microbial biofilms and biofilm reactors.","authors":"B M Peyton,&nbsp;W G Characklis","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Scientists and engineers have realized the industrial and environmental significance of biofilm accumulation and activity. The ability to predict and control biofilm formation has led to less fouling and corrosion in industrial systems and a better understanding of biofilm importance in natural aquatic systems. Understanding the fundamental processes contributing to biofilm formation is beneficial to anyone involved with natural or industrial systems where biofilms may play a significant role in determining variables such as bulk water quality, toxic compound biodegradation, or product quality.</p>","PeriodicalId":77040,"journal":{"name":"Bioprocess technology","volume":"20 ","pages":"187-231"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18766621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immobilized animal cell bioreactors. 固定化动物细胞生物反应器。
Bioprocess technology Pub Date : 1995-01-01
M S Croughan, T W Chiou, D I Wang
{"title":"Immobilized animal cell bioreactors.","authors":"M S Croughan,&nbsp;T W Chiou,&nbsp;D I Wang","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77040,"journal":{"name":"Bioprocess technology","volume":"21 ","pages":"377-411"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18766628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Organism selection. 生物的选择。
Bioprocess technology Pub Date : 1995-01-01
F J Castillo
{"title":"Organism selection.","authors":"F J Castillo","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":77040,"journal":{"name":"Bioprocess technology","volume":"21 ","pages":"13-45"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18766624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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