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[Graft versus host disease with fatal outcome after administration of filtered erythrocyte concentrates]. [经过滤红细胞浓缩物治疗后的移植物抗宿主病的致命后果]。
Beitrage zur Infusionstherapie = Contributions to infusion therapy Pub Date : 1992-01-01
M U Heim, R Munker, H Sauer, B Wolf-Hornung, H Knabe, E Holler, M Böck, W Mempel
{"title":"[Graft versus host disease with fatal outcome after administration of filtered erythrocyte concentrates].","authors":"M U Heim,&nbsp;R Munker,&nbsp;H Sauer,&nbsp;B Wolf-Hornung,&nbsp;H Knabe,&nbsp;E Holler,&nbsp;M Böck,&nbsp;W Mempel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Transfusion-associated graft-versus-host disease (TA-GVHD) resulting from the engraftment of competent lymphocytes contained in blood products has been well described in immunocompromised patients and more recently in immunocompetent patients. Prophylactic irradiation of blood products prior to transfusion is the most efficient way to prevent TA-GVHD. Standard blood bank measures to reduce mononuclear cell contamination in red blood cell units, such as freezing, washing and filtration, may reduce the number of viable lymphocytes to prevent immunizations. However, it is unknown whether the depletion of leukocytes with these techniques would decrease the risk of TA-GVHD. In this report we describe the first case of TA-GVHD following transfusion of filtrated red blood cells given to a patient receiving cytotoxic therapy for Hodgkin's disease.</p>","PeriodicalId":77034,"journal":{"name":"Beitrage zur Infusionstherapie = Contributions to infusion therapy","volume":"30 ","pages":"178-81"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12459056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The 'critical hematocrit': a figure differing from patient to patient. “临界红细胞压积”:一个因人而异的数字。
Beitrage zur Infusionstherapie = Contributions to infusion therapy Pub Date : 1992-01-01
P Lundsgaard-Hansen
{"title":"The 'critical hematocrit': a figure differing from patient to patient.","authors":"P Lundsgaard-Hansen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In my opinion, the problem of a 'critical hematocrit' can be summarized in five contentions: First, it is inadmissible to label any single hemoglobin or hematocrit value as being generally acceptable, the reason being, second, that the adequate values differ between patients and sometimes also between various stages of their individual course--for instance during the intra- and the postoperative period. Third, a hemoglobin or hematocrit within the normal range constitutes a natural buffer against encroachments upon the oxygen supply from non-Hb causes. Intentional manipulation of this buffer requires a careful assessment of potential benefits vs. risks. Fourth, a patient in otherwise perfect condition tolerates a hemoglobin or hematocrit below 10 g/dl or 30%, respectively, down to approximately 8 g/dl or 25%- but tolerance is not necessarily equivalent to an optimum. And fifth, the patient most dependent on his 'hemoglobin buffer' is the individual who has to overcome troubles without the monitoring facilities of an intensive care unit, for instance in the peripheral hospital equipped only for primary care.</p>","PeriodicalId":77034,"journal":{"name":"Beitrage zur Infusionstherapie = Contributions to infusion therapy","volume":"30 ","pages":"208-15; discussion 247-64"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12459063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Differentiation of leukocytes in thrombocyte concentrates by APAAP staining]. [血小板浓缩物中白细胞的apap染色分化]。
Beitrage zur Infusionstherapie = Contributions to infusion therapy Pub Date : 1992-01-01
M Müller-Steinhardt, H Klüter, H Kirchner
{"title":"[Differentiation of leukocytes in thrombocyte concentrates by APAAP staining].","authors":"M Müller-Steinhardt,&nbsp;H Klüter,&nbsp;H Kirchner","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The preparation of platelet concentrates (PC) from pooled buffy coats has raised concern as to whether activation of lymphocytes might take place during the period of storage. Therefore it appears to be essential to investigate the degree of leukocyte contamination and identify the subtypes of these cells. Especially lymphocytes are of relevance as they may induce either a mixed lymphocyte reaction (MLR), the production of cytokines or a graft-versus-host reaction. As the number of leukocytes is very low we adopted the alkaline phosphatase-antialkaline phosphatase (APAAP) technique to determine the composition of leukocytes. We used mouse monoclonal antibodies to specifically stain T lymphocytes, B lymphocytes, monocytes, HLA-DR-positive cells and NK cells. All subtypes could easily be identified and their relative amounts were determined. In samples from 15 PCs the percentages of T lymphocytes, B lymphocytes, monocytes, NK cells and HLA-DR-positive cells was 40.3, 6.4, 18.9, 7.2 and 17.1% of total leukocytes, respectively. The standard deviation ranged between 2 and 5%. We highly recommend this technique, which is a very sensitive method to determine leukocyte contamination in PC.</p>","PeriodicalId":77034,"journal":{"name":"Beitrage zur Infusionstherapie = Contributions to infusion therapy","volume":"30 ","pages":"127-30"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12459150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[New possibilities in diagnosing hemolytic disease of newborn infants]. [新生儿溶血病诊断的新可能性]。
Beitrage zur Infusionstherapie = Contributions to infusion therapy Pub Date : 1992-01-01
K Fischer, A Poschmann, A Grundmann, S Asmussen
{"title":"[New possibilities in diagnosing hemolytic disease of newborn infants].","authors":"K Fischer,&nbsp;A Poschmann,&nbsp;A Grundmann,&nbsp;S Asmussen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The diagnosis and management of HDN relies on measurement of maternal anti-D, amniotic fluid analysis and fetal blood sampling by chordiocentesis. However, amniocentesis and chordiocentesis have substantial risks of fetomaternal hemorrhage and subsequent increase in maternal anti-D. In addition to quantitation the functional activity of maternal anti-D has been determined by measuring the interaction of red blood cells sensitized by maternal serum in monocyte-monolayer assays. We assessed the functional activity of anti-D by titration of the sensitized red blood cells using selected sera with rheumatoid factor (RF) as human anti-IgG. First experiments using monoclonal anti-D showed a good correlation between erythrophagocytosis and RF titers. The bilirubin-protein ratio in amniotic fluid may be of great value in predicting the severity of HDN, as shown in 94 cases with severe and 39 cases with moderate disease. Amniotic fluid analysis is complicated by the presence of hemoglobin; we developed a computer program to solve this problem. To improve the serological diagnosis of ABO incompatibility, we measured IgG-anti-A, B in 1,392 maternal and newborn sera applying a sensitive gel test with Coombs serum. Furthermore, we determined the hemolytic activity of anti-A, B by microscopic observation of the morphological changes of red blood cells.</p>","PeriodicalId":77034,"journal":{"name":"Beitrage zur Infusionstherapie = Contributions to infusion therapy","volume":"30 ","pages":"431-5"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12459156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Granulocyte-specific and HLA antibodies in pregnancy: incidence and clinical value]. 妊娠期粒细胞特异性抗体和HLA抗体:发病率及临床价值
Beitrage zur Infusionstherapie = Contributions to infusion therapy Pub Date : 1992-01-01
J Bux, K D Jung, G Mueller-Eckhardt, C Mueller-Eckhardt
{"title":"[Granulocyte-specific and HLA antibodies in pregnancy: incidence and clinical value].","authors":"J Bux,&nbsp;K D Jung,&nbsp;G Mueller-Eckhardt,&nbsp;C Mueller-Eckhardt","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Postpartum sera of 1,016 unselected women were examined for granulocyte-specific and HLA antibodies. A total of 11 out of 1,016 sera (1.1%) were only reactive with neutrophils. Cytotoxic HLA antibodies were detected in 24%, noncytotoxic HLA antibodies in 4.8% of the sera. All antibodies belonged to the IgG 1 and IgG 3 subclasses. NA1 and NB1 specificity were each determined in one serum, two sera contained NA2-specific antibodies. After 1 year all antibodies were no more detectable. As none of the newborns from immunized mothers developed neutropenia, the incidence of alloimmune neonatal neutropenia seems to be lower than 0.1%.</p>","PeriodicalId":77034,"journal":{"name":"Beitrage zur Infusionstherapie = Contributions to infusion therapy","volume":"30 ","pages":"446-9"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12459160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Heparin-associated thrombocytopenia: successful therapy of patients after prospective selection of a compatible heparinoid with the heparin-induced platelet activation test]. [肝素相关性血小板减少症:通过肝素诱导的血小板活化试验前瞻性选择相容的类肝素后患者的成功治疗]。
Beitrage zur Infusionstherapie = Contributions to infusion therapy Pub Date : 1992-01-01
A Greinacher, I Michels, C Mueller-Eckhardt
{"title":"[Heparin-associated thrombocytopenia: successful therapy of patients after prospective selection of a compatible heparinoid with the heparin-induced platelet activation test].","authors":"A Greinacher,&nbsp;I Michels,&nbsp;C Mueller-Eckhardt","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Diagnosis of HAT type II and treatment of thromboembolic complications in these patients are difficult. Recently we have developed the heparin-induced platelet activation (HIPA) assay which allows a rapid confirmation of the tentative diagnosis of HAT type II. In vitro studies with sera of 25 patients revealed cross-reactivity to the LMW heparins Fragmin, Fraxiparin and Clexane whereas a LMW heparinoid, Org 10172 (Orgaran), did not. In a prospective study this heparinoid was selected for 10 HAT patients, for whom further parenteral anticoagulation was required. In 7 of these patients who received LMW heparins prior to laboratory investigations low platelet counts persisted under treatment with LMW heparins and 2 patients developed additional thromboembolic complications. Upon treatment with Org 10172 platelet counts normalized in 9 patients, in 1 patient thrombocytopenia was unrelated to parenteral anticoagulation, in 1 patient platelet count normalized after discontinuation of Org 10172. We conclude that the HIPA assay allows the laboratory diagnosis of HAT type II and the selection of a compatible heparin or heparinoid for further parenteral anticoagulation.</p>","PeriodicalId":77034,"journal":{"name":"Beitrage zur Infusionstherapie = Contributions to infusion therapy","volume":"30 ","pages":"408-12"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12459209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Diagnosis of the presence of SGPT in blood donors]. [献血者SGPT的诊断]。
Beitrage zur Infusionstherapie = Contributions to infusion therapy Pub Date : 1992-01-01
R Grunenberg, J Krüger
{"title":"[Diagnosis of the presence of SGPT in blood donors].","authors":"R Grunenberg,&nbsp;J Krüger","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Presampling determination for hemoglobin has been pursued for a long time, but now it is becoming possible to examine further parameters such as SGPT (ALT). The SGPT predonation testing is best performed with the Reflotron system (Fa. Boehringer Mannheim) since whole blood samples drawn into capillary tube can be used. Between 1985 and 1988 1.35-1.75% of an average of 22,000 whole blood donations were found to have SGPT levels above the accepted cutoff (> 30 IU/l, 25 degrees C). The cost per test using the UV kinetics and the overall expenses of unusable collections were compared with the cost of SGPT predonation testing. An average of DM 20,000.-per year has been saved. Therefore prescreening of SGPT in blood banking is a highly cost-effective approach.</p>","PeriodicalId":77034,"journal":{"name":"Beitrage zur Infusionstherapie = Contributions to infusion therapy","volume":"30 ","pages":"73-4"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12459218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recombinant antigens in viral diagnosis. 病毒诊断中的重组抗原。
Beitrage zur Infusionstherapie = Contributions to infusion therapy Pub Date : 1992-01-01
R Vornhagen, A Baur, G Jahn, W Hinderer, H Nebel-Schickel, J Horn, H Wolf, H H Sonneborn
{"title":"Recombinant antigens in viral diagnosis.","authors":"R Vornhagen,&nbsp;A Baur,&nbsp;G Jahn,&nbsp;W Hinderer,&nbsp;H Nebel-Schickel,&nbsp;J Horn,&nbsp;H Wolf,&nbsp;H H Sonneborn","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>DNA fragments coding for a variety of different viral antigens have been cloned and expressed in Escherichia coli. Selected purified recombinant antigens were used for detection of specific antibodies by means of the ELISA technique. This approach has been used for the development of four different ELISAs for the detection of HIV- and EBV-specific antibodies.</p>","PeriodicalId":77034,"journal":{"name":"Beitrage zur Infusionstherapie = Contributions to infusion therapy","volume":"30 ","pages":"78-81"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12459220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Prevalence of Borrelia burgdorferi antibodies in Hamburg blood donors]. [汉堡献血者伯氏疏螺旋体抗体的流行]。
Beitrage zur Infusionstherapie = Contributions to infusion therapy Pub Date : 1992-01-01
T Weiland, P Kühnl, R Laufs, J Heesemann
{"title":"[Prevalence of Borrelia burgdorferi antibodies in Hamburg blood donors].","authors":"T Weiland,&nbsp;P Kühnl,&nbsp;R Laufs,&nbsp;J Heesemann","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>One thousand regular blood donors of the Department of Transfusion Medicine at the University Hospital in Hamburg were screened for antibodies against the Lyme disease spirochete, B. burgdorferi. 7.2% were initially reactive in the enzyme immunoassay, 37.5% of which were confirmed by immunoblot. The seroprevalence of anti-B. burgdorferi antibodies thus is 2.7% in Hamburg blood donors. 25 of 27 positive donors received a physical exam, which did not reveal any symptoms of acute or chronic Lyme disease. 24 of these 25 donors were tested for B. burgdorferi-specific DNA in urine by polymerase chain reaction, which came out negative in all cases. Introduction of B. burgdorferi antibody screening is not regarded an effective means to prevent transfusion-transmitted Lyme disease.</p>","PeriodicalId":77034,"journal":{"name":"Beitrage zur Infusionstherapie = Contributions to infusion therapy","volume":"30 ","pages":"92-5"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12459223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Examination of a Berlin blood donation branch for antibodies to hepatitis C virus with the anti-HCV test and for circulating HCV-RNA using polymerase chain reaction]. [用抗丙型肝炎病毒试验检查柏林献血分支的丙型肝炎病毒抗体和用聚合酶链反应检查循环的丙型肝炎病毒rna]。
Beitrage zur Infusionstherapie = Contributions to infusion therapy Pub Date : 1992-01-01
R Zimmermann, V König, J Bauditz, T Zeiler, J Zingsem, H G Heuft, U Hopf, D Huhn, R Eckstein
{"title":"[Examination of a Berlin blood donation branch for antibodies to hepatitis C virus with the anti-HCV test and for circulating HCV-RNA using polymerase chain reaction].","authors":"R Zimmermann,&nbsp;V König,&nbsp;J Bauditz,&nbsp;T Zeiler,&nbsp;J Zingsem,&nbsp;H G Heuft,&nbsp;U Hopf,&nbsp;D Huhn,&nbsp;R Eckstein","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hepatitis C virus (HCV) is responsible for the majority of cases of transfusion-related hepatitis. We performed a first-generation anti-HCV EIA in 665 repeat and 168 first-time blood donors from Berlin. 4.7 and 4.2%, respectively, showed at least one indeterminate or positive result. We further looked for HCV genome in the plasma of 20 donors with reactive anti-HCV-EIA doing a polymerase chain reaction (nested PCR). The control group consisted of 20 patients with chronic hepatitis C. The PCR was negative in all examined blood donors, but was positive in 17 of 20 controls. These findings raise the question, if a positive anti-HCV test correlates with infectiosity.</p>","PeriodicalId":77034,"journal":{"name":"Beitrage zur Infusionstherapie = Contributions to infusion therapy","volume":"30 ","pages":"38-41"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12459337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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