MD, CMFM, FRACOG, FRCOG Caroline A. Crowther (Senior Lecturer)
{"title":"5 Prevention of preterm birth in multiple pregnancy","authors":"MD, CMFM, FRACOG, FRCOG Caroline A. Crowther (Senior Lecturer)","doi":"10.1016/S0950-3552(98)80040-0","DOIUrl":"10.1016/S0950-3552(98)80040-0","url":null,"abstract":"<div><p>Preterm birth is the greatest threat to the infants in a multiple pregnancy. This chapter focuses on strategies that aim to prevent preterm birth and concentrates on the evidence derived from randomized clinical trials and systematic review of randomized clinical trials. The options to avoid a multiple pregnancy are briefly considered. Interventions that aim to prolong pregnancy, including prophylactic cervical cerclage, prophylactic tocolysis, home uterine activity monitoring and hospitalization for bed rest, are critically appraised, as are interventions that aim to improve the outcome of preterm birth. Interventions that require additional evaluation are highlighted.</p></div>","PeriodicalId":77031,"journal":{"name":"Bailliere's clinical obstetrics and gynaecology","volume":"12 1","pages":"Pages 67-75"},"PeriodicalIF":0.0,"publicationDate":"1998-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0950-3552(98)80040-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20835987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
MRCOG, MRCPI Fiona Ní Chuileannáin (Clinical Research Fellow), BA, MBBS, BMedSci(Hons), DPhil(Oxon), FRACOG Shaun Brennecke (Professor and Director)
{"title":"4 Prediction of preterm labour in multiple pregnancies","authors":"MRCOG, MRCPI Fiona Ní Chuileannáin (Clinical Research Fellow), BA, MBBS, BMedSci(Hons), DPhil(Oxon), FRACOG Shaun Brennecke (Professor and Director)","doi":"10.1016/S0950-3552(98)80039-4","DOIUrl":"10.1016/S0950-3552(98)80039-4","url":null,"abstract":"<div><p>Various methods of predicting preterm labour in both singleton and multiple pregnancies have been studied including risk scoring systems, home uterine activity monitoring, cervical assessment and biochemical methods. In practice, risk scoring systems for preterm delivery perform poorly. Consensus in the literature regarding the usefulness of home uterine activity monitoring is lacking and well designed randomized controlled trials are required. Transvaginal ultrasound assessment of the cervix appears to have a role to play in the prediction of preterm labour. The presence of IFN in cervicovaginal fluid in the late second and early third trimesters is an important risk factor for preterm labour in asymptomatic women with multiple pregnancies. Preterm labour may be mediated in part by inflammatory cytokines. The measurement of these inflammatory cytokines in cervical secretions may also prove helpful in the prediction of preterm labour. It is anticipated that an improved ability to predict preterm labour in both singleton and multiple pregnancies will depend on increasing understanding of the condition's pathophysiology</p></div>","PeriodicalId":77031,"journal":{"name":"Bailliere's clinical obstetrics and gynaecology","volume":"12 1","pages":"Pages 53-66"},"PeriodicalIF":0.0,"publicationDate":"1998-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0950-3552(98)80039-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20835986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
MD Mark I. Evans (Charlotte B. Failing Professor and Vice Chairman), MD Roderick F. Hume Jr, MD Yuval Yaron, MD Ralph L. Kramer (Instructor), MD Mark P. Johnson (Assistant Professor)
{"title":"10 Multifetal pregnancy reduction","authors":"MD Mark I. Evans (Charlotte B. Failing Professor and Vice Chairman), MD Roderick F. Hume Jr, MD Yuval Yaron, MD Ralph L. Kramer (Instructor), MD Mark P. Johnson (Assistant Professor)","doi":"10.1016/S0950-3552(98)80045-X","DOIUrl":"10.1016/S0950-3552(98)80045-X","url":null,"abstract":"<div><p>Multifetal pregnancy reduction (MFPR) has become a mainstay of infertility therapy as its development has allowed physicians to become more aggressive in treating patients resistant to more conservative therapies. Over the course of the past decade, MFPR has become practised in a limited number of tertiary specialty centres, which have improved its performance and very substantially lowered its risks. The majority of physicians performing MFPR employ a transabdominal needle injection of potassium chloride into the fetal thorax. Risks for pregnancy losses of patients starting with triplets and/or quadruplets reduced to twins have improved over the past decade and are not substantially different from those in patients whose pregnancy began as twins. There have been no substantiated risks of coagulopathies or damage to surviving fetuses.</p></div>","PeriodicalId":77031,"journal":{"name":"Bailliere's clinical obstetrics and gynaecology","volume":"12 1","pages":"Pages 147-159"},"PeriodicalIF":0.0,"publicationDate":"1998-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0950-3552(98)80045-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20835904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pathology of uterine fibroids.","authors":"J. Crow","doi":"10.1097/00000441-190405000-00057","DOIUrl":"https://doi.org/10.1097/00000441-190405000-00057","url":null,"abstract":"The pathological appearances of uterine leiomyomas at macroscopic, histological and ultrastructural levels are described and illustrated. Features useful in the differential diagnosis from other uterine spindle cell lesions are included, and an outline is given of the variable features found in different studies of the effects of gonadotrophin hormone releasing hormone analogues on uterine leiomyomas.","PeriodicalId":77031,"journal":{"name":"Bailliere's clinical obstetrics and gynaecology","volume":"29 1","pages":"197-211"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76015134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Complications of ovarian stimulation.","authors":"H. Jacobs, R. Agrawal","doi":"10.1201/b16081-21","DOIUrl":"https://doi.org/10.1201/b16081-21","url":null,"abstract":"We review three complications of ovarian stimulation, namely ovarian hyperstimulation syndrome, thromboembolic disease in relation to fertility treatment and multiple pregnancy. Current views on the ovarian hyperstimulation syndrome emphasize its association with the presence of polycystic ovaries. We review here the pathophysiological background of this association and focus on the central role of vascular endothelial growth factor (VEGF). Overexpression of VEGF in the polycystic ovary is thought to contribute to its characteristic multifollicular response to gonadotrophic stimulation. Release of large amounts of VEGF into the circulation is thought to account for the development of the clinical syndrome of ovarian hyperstimulation. The implications of this understanding are explored and the clinical features of the condition and its management are described. Thromboembolic disease is increasingly recognized as a serious if rare complication of infertility treatment. The subject is reviewed here with special reference to two recently published and important papers. The most concerning complication of infertility treatment is multiple pregnancy. Few doctors seem to be aware of the dire statistics: every index of obstetric outcome is adversely affected. The survival, health and family circumstances of children born as the result of multifetal gestation are all impaired. Infertility patients need a clear understanding of the risks involved so that they can appreciate the need for intensive monitoring of ovarian stimulation. In our opinion a knowledge of the rate of multiple pregnancy is quite as important as knowing the clinic's 'success' rate.","PeriodicalId":77031,"journal":{"name":"Bailliere's clinical obstetrics and gynaecology","volume":"35 1","pages":"565-79"},"PeriodicalIF":0.0,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85785918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"2 Clinical value of tests for assessing male infertility","authors":"PhD Phillip L. Matson (Scientific Director)","doi":"10.1016/S0950-3552(97)80004-1","DOIUrl":"10.1016/S0950-3552(97)80004-1","url":null,"abstract":"<div><p>The laboratory assessment of the male partner of an infertile couple is an important aspect of the overall investigation of that couple. The laboratory tests are designed essentially to determine whether (a) the semen samples contain adequate numbers of normal motile sperm, and the sperm are able (b) to migrate to the site of fertilization and (c) to fertilize oocytes. Within this framework, tests can be viewed as being either descriptive, in terms of describing the ejaculate and sperm, or assessing functional qualities of the sperm. Irrespective of the nature of the test, it must satisfy simple criteria, namely being reproducible and able to discriminate between the fertile and infertile populations reliably. External quality assurance programmes now exist for semen analysis and allied techniques to help laboratories to standardize their reporting and to identify the source of possible errors.</p></div>","PeriodicalId":77031,"journal":{"name":"Bailliere's clinical obstetrics and gynaecology","volume":"11 4","pages":"Pages 641-654"},"PeriodicalIF":0.0,"publicationDate":"1997-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0950-3552(97)80004-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20607422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"8b The genetics of male infertility in relation to cystic fibrosis","authors":"PhD Willy Lissens (Head, Laboratory of Molecular Genetics), MD, PhD Inge Liebaers (Director)","doi":"10.1016/S0950-3552(97)80014-4","DOIUrl":"10.1016/S0950-3552(97)80014-4","url":null,"abstract":"<div><p>Absence, dysfunction or low levels of cystic fibrosis (CF) transmembrane conductance regulator (CFTR) protein result in a broad range of clinical manifestations with CF with pancreatic insufficiency at the severe end of the phenotypic spectrum and, at the other end, relatively mild clinical conditions, including several forms of male infertility. The condition of congenital bilateral absence of the vas deferens (CBAVD) is in 75–80% of the patients associated with defects in the <em>CFTR</em> gene. In the remaining patients, CBAVD is also associated with urinary tract malformations, and this form of CBAVD is not related to CF. Congenital unilateral absence of the vas deferens also seems to be associated with CF except when associated with renal abnormalities at the ipsilateral side of the absent vas. A possible role of the CFTR protein in the aetiology of infertility due to defects in sperm production and maturation has also been suggested recently. In contrast, Young's syndrome is probably not related to CF.</p><p>The relation between some conditions of male infertility and CF implies appropriate clinical examination of the patients, <em>CFTR</em> mutation analysis and genetic counselling. Because infertility can now in many cases be treated by artificial reproductive technology couples have an increased risk of having children with CF or infertility if the female partner is also a carrier of a <em>CFTR</em> mutation. Couples should be well informed about these risks and risk prevention including pre-implantation diagnosis. Follow-up studies of children born to these couples are mandatory, whether male infertility is linked to CF or not.</p></div>","PeriodicalId":77031,"journal":{"name":"Bailliere's clinical obstetrics and gynaecology","volume":"11 4","pages":"Pages 797-817"},"PeriodicalIF":0.0,"publicationDate":"1997-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0950-3552(97)80014-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20608513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
MD, PhD, FRACP H.W. Gordon Baker (Senior Research Fellow)
{"title":"4 Medical treatment for idiopathic male infertility: is it curative or palliative?","authors":"MD, PhD, FRACP H.W. Gordon Baker (Senior Research Fellow)","doi":"10.1016/S0950-3552(97)80006-5","DOIUrl":"10.1016/S0950-3552(97)80006-5","url":null,"abstract":"<div><p>Medical treatment of disorders of sperm production and function remains an important goal despite major advances in assisted reproductive technology. Effective treatments exist for genital tract obstruction, gonadotrophin deficiency, sperm autoimmunity, coital disorders and some impairments caused by toxins or illness. However, the majority of men seen for reduced sperm production or function do not have these conditions and the empirical treatments used in the past are probably ineffective. New therapeutic approaches derived from research on the causes and mechanisms of testicular dysfunction are needed and their curative effects must be established by well-designed controlled clinical trials.</p></div>","PeriodicalId":77031,"journal":{"name":"Bailliere's clinical obstetrics and gynaecology","volume":"11 4","pages":"Pages 673-689"},"PeriodicalIF":0.0,"publicationDate":"1997-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0950-3552(97)80006-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20607424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
MD, PhD Herman Tournaye (Lecturer and Clinical Consultant)
{"title":"7b Use of testicular sperm for the treatment of male infertility","authors":"MD, PhD Herman Tournaye (Lecturer and Clinical Consultant)","doi":"10.1016/S0950-3552(97)80011-9","DOIUrl":"10.1016/S0950-3552(97)80011-9","url":null,"abstract":"<div><p>Testicular biopsy has been widely used for the diagnosis of male infertility. Since the introduction of intracytoplasmic sperm injection (ICSI), sperm recovered from a testicular biopsy specimen can be successfully used for establishing pregnancies. Testicular spermatozoa may be recovered from testicular tissue in patients with excretory azoospermia but also in many patients with secretory azoospermia. In the latter patients spermatozoa may be recovered only after multiple excisional testicular biopsies, irrespective of follicle-stimulating hormone level, testicular size or medical history. Less invasive techniques such as percutaneous fine-needle aspiration have been introduced and may yield comparable success rates in patients with normal testicular function. The use of cryopreserved testicular spermatozoa may become an alternative to repeated surgery for obtaining testicular tissue for subsequent ICSI treatment cycles if larger series confirm the preliminary case reports. The introduction of the use of testicular spermatozoa for ICSI has raised new concerns because potentially genetically immature germ cells are being used from patients who may carry genetic defects causing their infertility problems.</p></div>","PeriodicalId":77031,"journal":{"name":"Bailliere's clinical obstetrics and gynaecology","volume":"11 4","pages":"Pages 753-762"},"PeriodicalIF":0.0,"publicationDate":"1997-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0950-3552(97)80011-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20608510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}