Archives of virology. Supplementum最新文献_第9页

Surveillance of BSE. 监测疯牛病。

Archives of virology. Supplementum Pub Date : 2000-01-01 DOI: 10.1007/978-3-7091-6308-5_11

D. Heim, J. Wilesmith

引用次数: 16

Pathogenesis of natural scrapie in sheep. 绵羊天然痒病的发病机制。

Archives of virology. Supplementum Pub Date : 2000-01-01 DOI: 10.1007/978-3-7091-6308-5_5

L. Keulen, B. Schreuder, M. Vromans, J. Langeveld, M. Smits

引用次数: 204

The glycoproteins of Marburg and Ebola virus and their potential roles in pathogenesis. 马尔堡病毒和埃博拉病毒的糖蛋白及其在发病机制中的潜在作用。

Archives of virology. Supplementum Pub Date : 1999-01-01 DOI: 10.1007/978-3-7091-6425-9_11

H Feldmann, V E Volchkov, V A Volchkova, H D Klenk

{"title":"The glycoproteins of Marburg and Ebola virus and their potential roles in pathogenesis.","authors":"H Feldmann, V E Volchkov, V A Volchkova, H D Klenk","doi":"10.1007/978-3-7091-6425-9_11","DOIUrl":"https://doi.org/10.1007/978-3-7091-6425-9_11","url":null,"abstract":"Filoviruses cause systemic infections that can lead to severe hemorrhagic fever in human and non-human primates. The primary target of the virus appears to be the mononuclear phagocytic system. As the virus spreads through the organism, the spectrum of target cells increases to include endothelial cells, fibroblasts, hepatocytes, and many other cells. There is evidence that the filovirus glycoprotein plays an important role in cell tropism, spread of infection, and pathogenicity. Biosynthesis of the glycoprotein forming the spikes on the virion surface involves cleavage by the host cell protease furin into two disulfide linked subunits GP1 and GP2. GP1 is also shed in soluble form from infected cells. Different strains of Ebola virus show variations in the cleavability of the glycoprotein, that may account for differences in pathogenicity, as has been observed with influenza viruses and paramyxoviruses. Expression of the spike glycoprotein of Ebola virus, but not of Marburg virus, requires transcriptional editing. Unedited GP mRNA yields the nonstructural glycoprotein sGP, which is secreted extensively from infected cells. Whether the soluble glycoproteins GP1 and sGP interfere with the humoral immune response and other defense mechanisms remains to be determined.","PeriodicalId":77010,"journal":{"name":"Archives of virology. Supplementum","volume":"15 ","pages":"159-69"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/978-3-7091-6425-9_11","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21333935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 118

Retroviruses: ancient and modern. 逆转录病毒:古代和现代。

Archives of virology. Supplementum Pub Date : 1999-01-01 DOI: 10.1007/978-3-7091-6425-9_12

R A Weiss, D Griffiths, Y Takeuchi, C Patience, P J Venables

引用次数: 17

Foot-and-mouth disease and beyond: vaccine design, past, present and future. 口蹄疫及其他疾病:疫苗设计，过去，现在和未来。

Archives of virology. Supplementum Pub Date : 1999-01-01 DOI: 10.1007/978-3-7091-6425-9_13

F Brown

{"title":"Foot-and-mouth disease and beyond: vaccine design, past, present and future.","authors":"F Brown","doi":"10.1007/978-3-7091-6425-9_13","DOIUrl":"https://doi.org/10.1007/978-3-7091-6425-9_13","url":null,"abstract":"The first experimental vaccines against foot-and-mouth disease were made in 1925 by Vallee, Carre and Rinjard using formaldehyde inactivation of tongue tissue from cattle infected with the virus. This method was essentially unaltered until the late 1940s when the important experiments by Frenkel in Holland showed that the quantities of virus required for vaccine production could be obtained from fragments of tongue epithelium incubated in vitro following infection with the virus. This major step made possible the comprehensive vaccination programmes which followed in Western Europe and which, in turn, resulted in the elimination of the disease from that part of the world by 1989. This spectacular success has led many to question whether other kinds of vaccine are required to control the disease worldwide. Such reservations ignore the danger to the environment associated with the growth of large amounts of virus. This can never be a zero-risk situation. Consequently, a vaccine which is not based on infectious virus as starting material has many attractions from safety considerations alone. In addition, a vaccine based on more fundamental considerations would not only be more aesthetically satisfying but could possibly provide an understanding at the molecular level of antigenic variation, still a problem in the control of the disease. The advances in our knowledge of the structure of the virus and the fragments which elicit a protective immune response now allow us to envisage a vaccine which does not require infectious virus and which protects against the multiple serotypes of the agent. Since antigenic variation is still a major problem in the control of the disease by vaccination, such a product would have important advantages over the current vaccines.","PeriodicalId":77010,"journal":{"name":"Archives of virology. Supplementum","volume":"15 ","pages":"179-88"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/978-3-7091-6425-9_13","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21333937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Learning from our foes: a novel vaccine concept for influenza virus. 向敌人学习:一种新的流感病毒疫苗概念。

Archives of virology. Supplementum Pub Date : 1999-01-01 DOI: 10.1007/978-3-7091-6425-9_9

P Palese, T Muster, H Zheng, R O'Neill, A Garcia-Sastre

引用次数: 18

Immune modulation by proteins secreted from cells infected by vaccinia virus. 受牛痘病毒感染的细胞分泌的蛋白质对免疫的调节。

Archives of virology. Supplementum Pub Date : 1999-01-01 DOI: 10.1007/978-3-7091-6425-9_8

G L Smith, J A Symons, A Alcamí

引用次数: 25

The post-Loeffler-Frosch era: contribution of German virologists. 后吕弗勒-弗罗施时代:德国病毒学家的贡献。

Archives of virology. Supplementum Pub Date : 1999-01-01 DOI: 10.1007/978-3-7091-6425-9_4

R Rott

{"title":"The post-Loeffler-Frosch era: contribution of German virologists.","authors":"R Rott","doi":"10.1007/978-3-7091-6425-9_4","DOIUrl":"https://doi.org/10.1007/978-3-7091-6425-9_4","url":null,"abstract":"This presentation dealt with the contributions of German virologists in the rapid development of virology following the Loeffler-Frosch era. Thereby, only research was included which was undertaken within German institutions, even though guest scientists from other countries or international cooperative efforts have in some cases contributed to the work. Contributions to the field of veterinary virology were not considered here, since this topic was treated separately during this centennial symposium. The overview includes contributions of the very early period when interest was focussed mainly on the determination of the physicochemical properties of the fast growing number of newly detected viruses, and of the pioneering period when fundamental discoveries of the nature of viruses were made. The concepts that derived from those studies made the development of modern virology possible. Some highlights of the present period were presented describing the findings of selected virus families. This part was followed by a description of the results which were relevant to problems of how viruses become pathogens, and the role of the immune response to virus infections. Finally, attention was drawn to the contributions of molecular studies which became important not only for the field of virology but also for life sciences in general.","PeriodicalId":77010,"journal":{"name":"Archives of virology. Supplementum","volume":"15 ","pages":"43-61"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21333972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Life beyond eradication: veterinary viruses in basic science. 根除之外的生命:基础科学中的兽医病毒。

Archives of virology. Supplementum Pub Date : 1999-01-01 DOI: 10.1007/978-3-7091-6425-9_7

L W Enquist

引用次数: 23

The legacy of Friedrich Loeffler--the Institute on the Isle of Riems. Friedrich Loeffler的遗产——Riems岛上的研究所。

Archives of virology. Supplementum Pub Date : 1999-01-01 DOI: 10.1007/978-3-7091-6425-9_3

W Wittmann

{"title":"The legacy of Friedrich Loeffler--the Institute on the Isle of Riems.","authors":"W Wittmann","doi":"10.1007/978-3-7091-6425-9_3","DOIUrl":"https://doi.org/10.1007/978-3-7091-6425-9_3","url":null,"abstract":"When starting the experiments on foot and mouth disease on the Isle of Riems in October 1910, Friedrich Loeffler could continue investigations that had been interrupted in 1907 by ministerial order. Loeffler's appointment to Berlin in 1913 and his sudden death in 1915 lead to the temporary cessation of work on the Riems. With high personal creativity and many years of seminal influence, Otto Waldmann carried Loeffler's ideas further, in the selection of themes and research strategy, making the Riems a world famous place of research. Some essential elements have determined life and research on the island for decades: the development of measures against epidemics, the conception of their application, the extension of research to new diseases of economic significance, the close contacts with the veterinary practice at all times, the presentation of results to experts and the stimulating discussions in the laboratory. I will try to briefly draw a bow covering the decades of different social conditions to the present and to suggest that Loeffler's ideas, which have been improved with the years, can affect many a current decision, even though differentiated individually.","PeriodicalId":77010,"journal":{"name":"Archives of virology. Supplementum","volume":"15 ","pages":"25-42"},"PeriodicalIF":0.0,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21333971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0