Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna最新文献_第6页

Atrial septal defect and hyperhomocysteinemia: two culprits for a cryptogenic stroke. 房间隔缺损和高同型半胱氨酸血症:隐源性中风的两个罪魁祸首。

Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna Pub Date : 2004-10-01

Giuseppe Famularo, Giuseppe Paolo Pino, Giovanni Minisola

引用次数: 0

POEMS and calciphylaxis: a novel association? 诗歌和钙化:一种新的联系?

Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna Pub Date : 2004-10-01

Davide Rossi, Gianluca Gaidano

引用次数: 0

[Amoxicillin-clavulanic acid and oral anticoagulants: a possible dangerous association]. 阿莫西林-克拉维酸与口服抗凝剂:可能存在的危险关联。

Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna Pub Date : 2004-10-01

Cristiana Cauli, Lara Fenu, Andrea Perra, Francesco Marongiu

{"title":"[Amoxicillin-clavulanic acid and oral anticoagulants: a possible dangerous association].","authors":"Cristiana Cauli, Lara Fenu, Andrea Perra, Francesco Marongiu","doi":"","DOIUrl":"","url":null,"abstract":"We describe a 68-year-old male patient, treated with amoxicillin-clavulanic acid for 18 days and oral anticoagulants. He developed a cholestatic hepatitis with conjugated bilirubin of 11 mg/dL and a concomitant overdose of oral anticoagulants (INR 7). Nausea, vomiting, jaundice and large ecchymoses occurred 41 days after treatment with amoxicillin-clavulanic acid; the clinical manifestations resolved within 1 week and the liver tests returned to normal 48 days after therapy withdrawal. The mechanism of the amoxicillin-clavulanate-induced hepatitis is probably immunoallergic; this complication occurs mainly in subjects with a metabolic and/or immunologic idiosyncrasy. The pharmacokinetics of this antibiotic, which is not directly metabolized by cytochrome P450, may be affected by the concomitant use of drugs under cytochrome P450 control. When using amoxicillin-clavulanic acid, one should take into account its potential hepatic toxicity and possible interaction with oral anticoagulants. However, it appears to be crucial to follow the correct indications for both drugs. In fact, in the patient described above amoxicillin-clavulanic acid was wrongly administered as prophylaxis after a cutaneous biopsy of the nose. The same occurred with the oral anticoagulants prescribed to the patient for a single episode of paroxysmal atrial fibrillation which had occurred one year previously.","PeriodicalId":77002,"journal":{"name":"Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna","volume":"19 4","pages":"276-9"},"PeriodicalIF":0.0,"publicationDate":"2004-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25098210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Neonatal osteomyelitis--sequelae may manifest many years later]. [新生儿骨髓炎——后遗症可能在多年后显现]。

Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna Pub Date : 2004-10-01

Antonio Campelli

引用次数: 0

Brain Natriuretic Peptide 脑利钠肽

Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna Pub Date : 2004-08-25 DOI: 10.1007/978-3-540-38918-7_5298

蔦本尚慶, 堀江稔

引用次数: 86

[Iron overload disease: recent findings]. [铁超载疾病:最新发现]。

Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna Pub Date : 2004-07-01

Anna Licata, Virna Brucato, Vito Di Marco, Franco Barbaria, Antonio Craxì

{"title":"[Iron overload disease: recent findings].","authors":"Anna Licata, Virna Brucato, Vito Di Marco, Franco Barbaria, Antonio Craxì","doi":"","DOIUrl":"","url":null,"abstract":"Iron overload diseases are due to a progressive increase in total body iron stores that leads to deposition of iron in parenchymal organs and to subsequent damage to these organs. The commonest inherited form of iron overload is hereditary hemochromatosis (HH), an autosomal recessive disorder affecting the white population. Although in the western world and in northern Europe the majority of cases of HH are associated with an HFE gene mutation (C282Y and H63D), there are families with a familial iron overload disorder in whom neither the C282Y nor the H63D mutations were found. Recently, other forms of HH that are not related to HFE, but are due to mutations in genes coding iron transport proteins (ferroportin-1, TfR2, hepcidin) have been described. The clinical presentation of the disorder is highly variable, depending on the severity of iron overload. In fact, the inappropriate absorption and deposition of dietary iron may result in the development of hepatic and non-hepatic end-organ injury, leading to liver cirrhosis, hepatocellular carcinoma, diabetes, arthritis, skin pigmentation and cardiac diseases. HH and its sequelae are preventable with an early diagnosis and treatment. Patients with evidence of iron overload, a family history of HH or other risk factors should be screened by genotype testing for the HFE mutation. Nowadays, HH is recognized as being a complex genetic disease with probable significant environmental and genetic modifying factors, such as hepatitis C virus infection and alcohol abuse, and it has been shown that HFE mutations represent an independent risk factor for fibrosis and cirrhosis in chronic hepatitis C.","PeriodicalId":77002,"journal":{"name":"Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna","volume":"19 3","pages":"145-54"},"PeriodicalIF":0.0,"publicationDate":"2004-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24802707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Fever of unknown origin and monoclonal gammapathy with unclear significance. Report of 2 cases with different pathology and clinical course]. 原因不明的发热和单克隆γ病变，意义不明。2例不同病理及临床过程的报告]。

Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna Pub Date : 2004-07-01

Giuseppe Realdi, Fabrizio Fabris, Sandro Giannini, Maria Luigia Randi, Giuseppe Donà, Massimo Rugge

引用次数: 0

Immunoglobulin gene rearrangements and in vitro growth of stromal cells are prognostic indexes in B-chronic lymphocytic leukemia. 免疫球蛋白基因重排和基质细胞体外生长是b -慢性淋巴细胞白血病的预后指标。

Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna Pub Date : 2004-07-01

Pasquale Tripputi, Monica Bignotto, Daniela Cigognini, Caterina Pellegrini, Gianmarco Corneo

引用次数: 0

[Scientific medicine and alternative medicine: the problem of the separation line]. 【科学医学与替代医学:分界线的问题】。

Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna Pub Date : 2004-07-01

Giovanni Federspil, Roberto Vettor

引用次数: 0

The hungry bone: expected and unexpected. 饥饿的骨头:意料之中的和意料之外的。

Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna Pub Date : 2004-07-01

Alberto Angeli, Andrea Dovio

引用次数: 0