Aging (Milan, Italy)最新文献_第3页

Evaluation of complex activities in daily living of elderly Japanese with visual impairment. 日本老年视力障碍患者日常复杂活动的评价。

Aging (Milan, Italy) Pub Date : 1999-04-01

K Nakamura, A Otomo, A Maeda, S Kikuchi, Y Motohashi, M Tanaka, H Nakadaira, M Yamamoto

引用次数: 0

Coexistence of lowered mood and cognitive impairment of elderly people in five birth cohorts. 5个出生队列中老年人情绪低落和认知障碍的共存

Aging (Milan, Italy) Pub Date : 1999-04-01

S Arve, R S Tilvis, A Lehtonen, J Valvanne, S Sairanen

引用次数: 0

Is age a negative prognostic indicator in HIV infection or AIDS? 年龄是HIV感染或艾滋病的阴性预后指标吗?

Aging (Milan, Italy) Pub Date : 1999-02-01

M J Keller, J M Hausdorff, L Kyne, J Y Wei

{"title":"Is age a negative prognostic indicator in HIV infection or AIDS?","authors":"M J Keller, J M Hausdorff, L Kyne, J Y Wei","doi":"","DOIUrl":"","url":null,"abstract":"To better understand disease progression in older persons with human immunodeficiency virus (HIV infection or acquired immunodeficiency syndrome (AIDS), we studied patients aged 50 years and older hospitalized with a diagnosis of HIV infection or AIDS between January 1985 and October 1995. Data collected included demographics, opportunistic infections, comorbid disease, neurologic dysfunction, and antiretroviral therapy. A total of 86 patients with a mean age of 54.3 years was identified. Pneumocystis carinii pneumonia was the most frequent opportunistic infection (43%). Hypertension was the most common previous medical condition (38%). Other comorbid disease was present in less than 15% of the subjects. Fifty-seven patients (66%) had neurologic impairment, with 30 requiring treatment for delirium. In these 30, 23 (77%) had anemia, infection, or both. The median length of survival following the diagnosis of AIDS was 18.5 months, for HIV it was 48 months. The median survival following the diagnosis of AIDS in patients who received antiretroviral therapy was 22 months compared with 11 months for those who did not receive antiretroviral therapy (p < 0.0004). Multivariable analysis found that antiretroviral therapy was the only independent predictor of survival after the diagnosis of AIDS. In contrast to previous studies, the present findings suggest that older age may not necessarily be associated with more rapid disease progression and reduced survival times in persons with HIV infection or AIDS. In those patients with delirium, many may have readily treatable conditions (anemia and/or infection). The absence of significant comorbid disease and the access to antiretroviral therapy may be in part responsible for the longer survival times obtained in this cohort compared to that reported previously.","PeriodicalId":76984,"journal":{"name":"Aging (Milan, Italy)","volume":"11 1","pages":"35-8"},"PeriodicalIF":0.0,"publicationDate":"1999-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21206598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dehydroepiandrosterone sulfate, diseases and mortality in a general aged population. 硫酸脱氢表雄酮与一般老年人群的疾病和死亡率。

Aging (Milan, Italy) Pub Date : 1999-02-01

R S Tilvis, M Kähönen, M Härkönen

{"title":"Dehydroepiandrosterone sulfate, diseases and mortality in a general aged population.","authors":"R S Tilvis, M Kähönen, M Härkönen","doi":"","DOIUrl":"","url":null,"abstract":"Dehydroepiandrosterone sulfate (DHEAS) was measured in a five-year follow-up study of random persons of three age cohorts (75-, 80-, and 85-years, N = 571) in order to investigate its associations with clinical diseases and their risk indicators, as well as its prognostic significance in old age. DHEAS was higher in men (3.1 mumol/L) than in women (1.9 mumol/L) in the 75-year age group. It decreased in men up 85 years. Compared to healthy men, DHEAS was lower in men with a history of or manifest vascular diseases, presence of dementia, diabetes mellitus, malignancies and musculoskeletal disorders, but was similar in all these disease groups. No differences were found in women. DHEAS did not relate to cardioechographic findings, cardiovascular risk factors or predictors of impaired survival prognosis. After controlling for age, DHEAS tended to be lower in the non-surviving than in the surviving men (2.28 mumol/L vs 2.65 mumol/L, p = 0.065). After controlling for disease, DHEAS did not predict increased risk of all-cause or cardiovascular mortality during the 5-year follow-up. In this study, gender differences in DHEAS persisted up to the age of 75 years. Low plasma DHEAS appears to be a secondary phenomenon rather than a specific risk indicator of common diseases in old age.","PeriodicalId":76984,"journal":{"name":"Aging (Milan, Italy)","volume":"11 1","pages":"30-4"},"PeriodicalIF":0.0,"publicationDate":"1999-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21206597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antioxidant systems in rat lens as a function of age: effect of chronic administration of vitamin E and ascorbate. 大鼠晶状体中抗氧化系统随年龄的变化:长期服用维生素E和抗坏血酸的影响。

Aging (Milan, Italy) Pub Date : 1999-02-01

A Campisi, C Di Giacomo, A Russo, V Sorrenti, G Vanella, R Acquaviva, G Li Volti, A Vanella

引用次数: 0

Bitter taste threshold and its relation to number of circumvallate papillae in the elderly. 老年人苦味阈值及其与周围乳头数的关系。

Aging (Milan, Italy) Pub Date : 1999-02-01

A Mavi, O Ceyhan

引用次数: 0

Lack of association of anabolic hormone status and muscle strength with regional and whole body bone mineral density in healthy men aged 60-79 years. 在60-79岁的健康男性中，合成代谢激素状态和肌肉力量与局部和全身骨密度缺乏关联。

Aging (Milan, Italy) Pub Date : 1999-02-01

D R Taaffe, C S Cooper, L Holloway, C Duret, R Marcus

{"title":"Lack of association of anabolic hormone status and muscle strength with regional and whole body bone mineral density in healthy men aged 60-79 years.","authors":"D R Taaffe, C S Cooper, L Holloway, C Duret, R Marcus","doi":"","DOIUrl":"","url":null,"abstract":"This study investigated the capacity of muscle strength and anabolic hormone status to predict regional and whole body bone mineral density (BMD) in older men. Fifty-two healthy men aged 60-79 years served as subjects. BMD of the lumbar spine, proximal femur, upper and lower limbs, and whole body was assessed by dual X-ray absorptiometry. Dynamic muscle strength for several upper and lower body muscle groups was determined by the one-repetition maximum and isometric grip strength by dynamometry. Anabolic hormone status was assessed by the ratio of testosterone (T) to sex hormone binding globulin (SHBG), given as the free androgen index (FAI), and the ratio of insulin-like growth factor I (IGF-I) to IGF binding protein-3 (IGFBP-3). Age was associated with declines in dynamic strength and the log FAI. In stepwise regression analysis, only body mass was an independent predictor of whole body and upper limb BMD (R2 = 0.13), and hip adductor strength predicted the Ward's triangle (R2 = 0.14). For lumbar spine BMD, triceps extensor strength was significantly correlated (r = 0.36, p < 0.01), while no strength or hormonal variable was associated with the femoral neck, trochanter, or lower limb. The lack of association between muscle strength and BMD was generally unaltered after controlling for hormone status and body mass. There was no difference in BMD when analyzed by tertiles of log FAI or IGF-I/IGFBP-3 or by tertiles of muscle strength. These results suggest that in healthy community-dwelling men in the seventh and eighth decade, muscle strength and hormonal status are not significant contributors to regional or whole body BMD.","PeriodicalId":76984,"journal":{"name":"Aging (Milan, Italy)","volume":"11 1","pages":"4-11"},"PeriodicalIF":0.0,"publicationDate":"1999-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21206594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heart fatty acid unsaturation and lipid peroxidation, and aging rate, are lower in the canary and the parakeet than in the mouse. 金丝雀和长尾小鹦鹉的心脏脂肪酸不饱和、脂质过氧化和衰老率低于小鼠。

Aging (Milan, Italy) Pub Date : 1999-02-01

R Pamplona, M Portero-Otín, D Riba, F Ledo, R Gredilla, A Herrero, G Barja

{"title":"Heart fatty acid unsaturation and lipid peroxidation, and aging rate, are lower in the canary and the parakeet than in the mouse.","authors":"R Pamplona, M Portero-Otín, D Riba, F Ledo, R Gredilla, A Herrero, G Barja","doi":"","DOIUrl":"","url":null,"abstract":"Despite their high metabolic rates, birds have a much higher maximum longevity (MLSP) than mammals of similar body size, and thus represent ideal models for identifying longevity characteristics not linked to low metabolic rates. This study shows that the fatty acid double bond content of both canary (MLSP = 24 years) and parakeet (MLSP = 21 years) hearts is intrinsically lower than in mouse (MLSP = 3.5 years) heart. This is caused by a redistribution between types of unsaturated fatty acids, mainly due to a lower content of the most highly unsaturated docosahexaenoic acid (22:6n-3) in the two birds in relation to the mammal. The lower double bond content leads to a lower sensitivity to lipid peroxidation, and to a lower level of in vivo lipid peroxidation in the heart of parakeets and canaries than in that of mice. Similar results have been previously found comparing liver mitochondria of rats and pigeons and tissues of different mammalian species. All these results taken together suggest that a low degree of fatty acid unsaturation is a general characteristic of longevous homeothermic vertebrate animals, both when they have low metabolic rates (mammals of large body size) or high metabolic rates (the studied birds); this constitutive trait protects their tissues and organelles against free radical mediated lipid peroxidation, and can contribute to their slow aging rate.","PeriodicalId":76984,"journal":{"name":"Aging (Milan, Italy)","volume":"11 1","pages":"44-9"},"PeriodicalIF":0.0,"publicationDate":"1999-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21206600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased medical attention needed for frail elderly initially admitted to the emergency department for lack of community support. 由于缺乏社区支持，最初入住急诊科的体弱老年人需要更多的医疗照顾。

Aging (Milan, Italy) Pub Date : 1999-02-01

S Elmståhl, C Wahlfrid

{"title":"Increased medical attention needed for frail elderly initially admitted to the emergency department for lack of community support.","authors":"S Elmståhl, C Wahlfrid","doi":"","DOIUrl":"","url":null,"abstract":"The demographic changes in society with growing numbers of elderly subjects will inevitably increase admission rates to acute emergency departments (AMU). Early discharge might augment emergency readmissions due to a relapse in medical conditions. Our aim was to study precipitating factors in frail elderly patients who got the diagnosis \"lack of community support\" after initial medical examination at an AMU, as well as discharge rates and one-year mortality. The study population was 380 cases of 18,015 patients attending the AMU at a city hospital during one year. Inclusion criteria were age above 65 years, and given the diagnosis \"lack of community support\" by a physician, defined as no other etiological or symptom diagnosis after an initial medical examination, and in some cases 24 to 48-hours observation. All but three medical records were checked. Reduced ability to eat, drink and walk prior to admission were noted among 22 to 58% of cases. Two thirds of the patients needed further medical care as inpatients, and physical medical causes were identified in 85% of the cases (mean number 3 causes); infectious diseases, cardiovascular diseases, dementia and trauma were the most prevalent factors. The median hospital stay was 14 days, and 10% had been discharged from the hospital the week prior to admission. The one-year mortality was 34%. The deceased had more precipitating physical causes, and were more often admitted to medical wards, but fewer had been referred to a senior consultant at the time of admission than survivors, adjusted for age (14% vs 42%, p < 0.05). Multiple medical conditions were noted in the majority of patients admitted to an emergency department with reduced abilities to cope with basic activities of daily life, even though a preliminary examination stated lack of social support as the underlying cause. The need for better medical attention seems important, especially for patients discharged directly home from an emergency department.","PeriodicalId":76984,"journal":{"name":"Aging (Milan, Italy)","volume":"11 1","pages":"56-60"},"PeriodicalIF":0.0,"publicationDate":"1999-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21205988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cell culture aging: insights for cell aging in vivo? 细胞培养衰老:对体内细胞衰老的见解?

Aging (Milan, Italy) Pub Date : 1999-02-01

V J Cristofalo

引用次数: 0