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Advances in second messenger and phosphoprotein research最新文献

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Chemoattractant receptor signaling: G protein-dependent and -independent pathways. 趋化剂受体信号:G蛋白依赖性和非依赖性途径。
Advances in second messenger and phosphoprotein research Pub Date : 1997-01-01 DOI: 10.1016/s1040-7952(97)80011-0
J L Milne, J Y Kim, P N Devreotes
{"title":"Chemoattractant receptor signaling: G protein-dependent and -independent pathways.","authors":"J L Milne, J Y Kim, P N Devreotes","doi":"10.1016/s1040-7952(97)80011-0","DOIUrl":"https://doi.org/10.1016/s1040-7952(97)80011-0","url":null,"abstract":"","PeriodicalId":76981,"journal":{"name":"Advances in second messenger and phosphoprotein research","volume":"31 ","pages":"83-104"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20276676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Mitochondrial alpha-ketoacid dehydrogenase kinases: a new family of protein kinases. 线粒体α -酮酸脱氢酶激酶:一个新的蛋白激酶家族。
Advances in second messenger and phosphoprotein research Pub Date : 1997-01-01
K M Popov, J W Hawes, R A Harris
{"title":"Mitochondrial alpha-ketoacid dehydrogenase kinases: a new family of protein kinases.","authors":"K M Popov,&nbsp;J W Hawes,&nbsp;R A Harris","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Four mitochondrial protein kinases have been cloned. These proteins represent a new family of protein kinases, related by sequence to the bacterial protein kinases but by function to the eukaryotic serine protein kinases. Arg288 is required for recognition by BCKDK of the phosphorylation site on the E1alpha subunit of the BCKDH complex. BCKDK inhibits the dehydrogenase activity of the BCKDH complex by introducing a negative charge into the active-site pocket of the E1 component. Protein starvation of rats induces an increase in the amount of BCKDK bound to the BCKDH complex. This causes inactivation of the BCKDH complex and conserves branched-chain amino acids for protein synthesis in the protein-starved state. Expression of the different PDK isoenzymes is tissue specific, and the different PDK isoenzymes are unique with respect to kinetic parameters for ATP and ADP and sensitivity to allosteric effectors (NADH, NAD+, coenzyme A, acetyl-CoA, pyruvate, and dichloroacetate). Preliminary experiments indicate that an increased amount of PDK2 protein partly explains the increase in PDK activity that occurs in rat liver in response to chemically induced diabetes.</p>","PeriodicalId":76981,"journal":{"name":"Advances in second messenger and phosphoprotein research","volume":"31 ","pages":"105-11"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20276677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interruption of specific guanylyl cyclase signaling pathways. 特定胍基环化酶信号通路的中断。
Advances in second messenger and phosphoprotein research Pub Date : 1997-01-01 DOI: 10.1016/s1040-7952(97)80018-3
Z Gao, P S Yuen, D L Garbers
{"title":"Interruption of specific guanylyl cyclase signaling pathways.","authors":"Z Gao,&nbsp;P S Yuen,&nbsp;D L Garbers","doi":"10.1016/s1040-7952(97)80018-3","DOIUrl":"https://doi.org/10.1016/s1040-7952(97)80018-3","url":null,"abstract":"","PeriodicalId":76981,"journal":{"name":"Advances in second messenger and phosphoprotein research","volume":"31 ","pages":"183-90"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20276683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Coupling transcription to signaling pathways: cAMP and nuclear factor cAMP-responsive element modulator. 信号通路的耦合转录:cAMP和核因子cAMP响应元件调制器。
Advances in second messenger and phosphoprotein research Pub Date : 1997-01-01
L Monaco, M Lamas, K Tamai, E Lalli, E Zazopoulos, L Penna, F Nantel, N S Foulkes, C Mazzucchelli, P Sassone-Corsi
{"title":"Coupling transcription to signaling pathways: cAMP and nuclear factor cAMP-responsive element modulator.","authors":"L Monaco,&nbsp;M Lamas,&nbsp;K Tamai,&nbsp;E Lalli,&nbsp;E Zazopoulos,&nbsp;L Penna,&nbsp;F Nantel,&nbsp;N S Foulkes,&nbsp;C Mazzucchelli,&nbsp;P Sassone-Corsi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76981,"journal":{"name":"Advances in second messenger and phosphoprotein research","volume":"31 ","pages":"63-74"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20276674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phosphatases as partners in signaling networks. 磷酸酶在信号网络中的作用。
Advances in second messenger and phosphoprotein research Pub Date : 1997-01-01 DOI: 10.1016/s1040-7952(97)80013-4
D L Brautigan
{"title":"Phosphatases as partners in signaling networks.","authors":"D L Brautigan","doi":"10.1016/s1040-7952(97)80013-4","DOIUrl":"https://doi.org/10.1016/s1040-7952(97)80013-4","url":null,"abstract":"","PeriodicalId":76981,"journal":{"name":"Advances in second messenger and phosphoprotein research","volume":"31 ","pages":"113-24"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20276678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The pseudosubstrate sequences alone are not sufficient for potent autoinhibition of cAMP- and cGMP-dependent protein kinases as determined by synthetic peptide analysis. 合成肽分析表明，假底物序列本身不足以对cAMP和cgmp依赖性蛋白激酶进行有效的自抑制。
Advances in second messenger and phosphoprotein research Pub Date : 1997-01-01 DOI: 10.1016/s1040-7952(97)80021-3
C E Poteet-Smith, J D Corbin, S H Francis
{"title":"The pseudosubstrate sequences alone are not sufficient for potent autoinhibition of cAMP- and cGMP-dependent protein kinases as determined by synthetic peptide analysis.","authors":"C E Poteet-Smith,&nbsp;J D Corbin,&nbsp;S H Francis","doi":"10.1016/s1040-7952(97)80021-3","DOIUrl":"https://doi.org/10.1016/s1040-7952(97)80021-3","url":null,"abstract":"","PeriodicalId":76981,"journal":{"name":"Advances in second messenger and phosphoprotein research","volume":"31 ","pages":"219-35"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20276686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Specificity in protein-tyrosine kinase signaling. 蛋白酪氨酸激酶信号传导的特异性。
Advances in second messenger and phosphoprotein research Pub Date : 1997-01-01 DOI: 10.1016/s1040-7952(97)80007-9
L C Cantley, Z Songyang
{"title":"Specificity in protein-tyrosine kinase signaling.","authors":"L C Cantley,&nbsp;Z Songyang","doi":"10.1016/s1040-7952(97)80007-9","DOIUrl":"https://doi.org/10.1016/s1040-7952(97)80007-9","url":null,"abstract":"","PeriodicalId":76981,"journal":{"name":"Advances in second messenger and phosphoprotein research","volume":"31 ","pages":"41-8"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20275570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Cyclic nucleotide-gated channels and calcium: an intimate relation. 环核苷酸门控通道与钙的密切关系。
Advances in second messenger and phosphoprotein research Pub Date : 1997-01-01 DOI: 10.1016/s1040-7952(97)80010-9
S Frings
{"title":"Cyclic nucleotide-gated channels and calcium: an intimate relation.","authors":"S Frings","doi":"10.1016/s1040-7952(97)80010-9","DOIUrl":"https://doi.org/10.1016/s1040-7952(97)80010-9","url":null,"abstract":"","PeriodicalId":76981,"journal":{"name":"Advances in second messenger and phosphoprotein research","volume":"31 ","pages":"75-82"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20276675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
G-protein-coupled receptors and their regulation: activation of the MAP kinase signaling pathway by G-protein-coupled receptors. g蛋白偶联受体及其调控:g蛋白偶联受体对MAP激酶信号通路的激活
Advances in second messenger and phosphoprotein research Pub Date : 1997-01-01
L M Luttrell, T van Biesen, B E Hawes, W J Koch, K M Krueger, K Touhara, R J Lefkowitz
{"title":"G-protein-coupled receptors and their regulation: activation of the MAP kinase signaling pathway by G-protein-coupled receptors.","authors":"L M Luttrell,&nbsp;T van Biesen,&nbsp;B E Hawes,&nbsp;W J Koch,&nbsp;K M Krueger,&nbsp;K Touhara,&nbsp;R J Lefkowitz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>G-protein-coupled receptors that mediate cellular responses to a variety of humoral, endothelial-, or platelet-derived substances are able to stimulate MAP kinase activity. In transfected model systems, G-protein-coupled receptors that couple to pertussis toxin-insensitive G proteins of the Gq/11 family mediate this activation predominantly via a PKC-dependent mechanism. In contrast, activation of MAP kinase by receptors that couple to pertussis toxin-sensitive Gi proteins is PKC-independent and requires downstream activation of the low-molecular-weight G protein, Ras. This pathway can be inhibited by coexpression of peptides that sequester Gbetagamma subunits, and is mimicked by overexpression of Gbetagamma subunits. This Ras-dependent MAP kinase activation requires tyrosine phosphorylation of \"docking proteins,\" including the shc adapter protein, and depends upon recruitment of Grb2/Sos1 complexes to the plasma membrane, thus resembling the pathway of MAP kinase activation employed by the receptor tyrosine kinases. Other molecules, including PI-3-kinases and phosphotyrosine phosphatases, probably also contribute to Gbetagamma-subunit-mediated assembly of a mitogenic signaling complex. Identification of the G-protein-coupled, receptor-regulated tyrosine kinase(s), and the means by which the mitogenic signaling complex is assembled at the plasma membrane, remain subjects of further study.</p>","PeriodicalId":76981,"journal":{"name":"Advances in second messenger and phosphoprotein research","volume":"31 ","pages":"263-77"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20276689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advances in the study of Ca2+/CaM-activated phosphodiesterases: expression and physiological functions. Ca2+/ cam活化磷酸二酯酶的表达及生理功能研究进展。
Advances in second messenger and phosphoprotein research Pub Date : 1997-01-01
A Z Zhao, C Yan, W K Sonnenburg, J A Beavo
{"title":"Recent advances in the study of Ca2+/CaM-activated phosphodiesterases: expression and physiological functions.","authors":"A Z Zhao,&nbsp;C Yan,&nbsp;W K Sonnenburg,&nbsp;J A Beavo","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76981,"journal":{"name":"Advances in second messenger and phosphoprotein research","volume":"31 ","pages":"237-51"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20276687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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