{"title":"[Short scientific report. Vitamin C lessens superoxide anion(O2)-induced bronchial constriction].","authors":"G Becher, K Winsel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An in vivo model of acute lung damage provoked by free oxygen radicals in guinea pigs was introduced. Bronchial and pulmonary response was induced by tracheal instillation of Xanthine-Oxidase (XO)-Xanthine solution. The response was measured as a decrease of tidal volume during unchanged artificially ventilation. It was found that ascorbic acid pretreatment was effective to diminish the XO-induced reaction.</p>","PeriodicalId":76840,"journal":{"name":"Zeitschrift fur Erkrankungen der Atmungsorgane","volume":"173 1","pages":"100-4"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13695795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Surgery of large bullous emphysema--functional results].","authors":"O Lembcke","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Forty eight patients suffering from a bulla compressing the rest of the lung tissue were examined before and after the resection of the bulla with the aim to estimate the degree of functional improvement and to find out criteria of indication for surgical treatment. The follow-up examinations included the clinical symptoms, functional data and the size of the bulla in an early phase and a late phase. The size of the bulla was determined on the basis of chest x-ray by planimetry. The analysis of preoperative and postoperative functional data (bodyplethysmography, spirometry, blood gas analysis, ergometry, measurement of pulmonary artery pressure) were performed in consideration of the surgical method and the presence of chronic obstructive lung disease. The comparison of the preoperative and postoperative values showed an improvement of the respiratory function, the gas exchange and the degree of dyspnea. The size of the bulla and the degree of the functional restriction are the decisive criteria for surgical treatment.</p>","PeriodicalId":76840,"journal":{"name":"Zeitschrift fur Erkrankungen der Atmungsorgane","volume":"173 3","pages":"205-14"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13836412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[BCG vaccination in low risk tuberculosis; first experiences after the suspension of BCG vaccination of newborns in Czechoslovakia].","authors":"L Trnka, D Danková","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>With the steadily declining risk of tuberculosis infection in CSR the question arose whether vaccination of infants remains worthwhile considering not only resources spent but also complications to vaccination vis-a-vis benefits derived. A prospective study has been designed in which BCG vaccination of newborns is discontinued in an area with 30,000 newborns yearly. In the period from April 1, 1986 to January 31, 1988 there were not vaccinated 43,428 children (84.8% of the newborns). The collaboration of mothers was good. The one year old non-vaccinated children were tested with 2 TU PPD RT 23 with Tween 80. The distribution of positive tuberculin reactions appears unimodal, relatively large reactions being absent. 8 children had reactions with 6 or more mm induration. That corresponds to a risk of infection of 0.04%. The project continues in the research area and might be extended to another area.</p>","PeriodicalId":76840,"journal":{"name":"Zeitschrift fur Erkrankungen der Atmungsorgane","volume":"173 1","pages":"60-2"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13938952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Injector units for special use areas during normal and high frequency jet ventilation--flow technic studies].","authors":"R Geske, T M Treu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Two injector units for special use during normo- and high-frequency jet ventilation are presented. Their pressure-volume-characteristics were analysed and theoretically consolidated. There is a good correlation between measurements and theory. Hence the jet ventilation is easier and dangerous incidents are avoidable.</p>","PeriodicalId":76840,"journal":{"name":"Zeitschrift fur Erkrankungen der Atmungsorgane","volume":"172 3","pages":"244-54"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13939111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E Harzendorf, E Müller, H Voigt, M Bomm, A Oddoy, G Merker, E Danzmann
{"title":"[Experiences with the use of oscillating high frequency ventilation].","authors":"E Harzendorf, E Müller, H Voigt, M Bomm, A Oddoy, G Merker, E Danzmann","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Our investigations have demonstrated that the effect of oscillatory high-frequency ventilation (HFO) on gas exchange in dogs is directly proportional to the oscillatory flow amplitude VM. Because of the equation: VM = PM/Z, gas exchange is increasing with rising oscillatory amplitude of the ventilation pressure PM and decreasing with rising impedance Z of the respiratory system. This system consists of endotracheal tube and the lungs of the dog investigated. The impedance Z = square root of R2 + X2 (resistance R and reactance X) achieves a minimal value near at the resonant frequency (reactance X = 0, in healthy intubated dogs near at 5 Hz) and increases with rising oscillatory frequency. Thus the oscillatory high-frequency ventilation is most effective near to the resonant frequency of the respiratory system. The results presented allow the conclusion that the application of high-frequency ventilation can be optimized by monitoring the respiratory mechanics parameters.</p>","PeriodicalId":76840,"journal":{"name":"Zeitschrift fur Erkrankungen der Atmungsorgane","volume":"172 3","pages":"265-71"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13939112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Smoking behavior of workers--occupational disability and economic sequelae. A prospective study].","authors":"J Kozák","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A prospective study concerning the influence of smoking on duration and frequency of certified sickness absence due to illness or accident and due to respiratory diseases in particular was carried out in a production plant from 1981 to 1984. The results show, that the mean duration of sickness absence due to illness and accident during a year is not in relation to smoking habit. The frequency of sickness absence due to illness and accident as well as to respiratory disease in smokers was significantly higher (p less than 0.05) than in non-smokers. The frequency of visits of male smokers at surgery hours was assessed to be significantly higher in relation to male non-smokers; in females we found an inverted relation. Higher frequency of smokers sickness absence could be expressed in economic terms.</p>","PeriodicalId":76840,"journal":{"name":"Zeitschrift fur Erkrankungen der Atmungsorgane","volume":"173 3","pages":"229-37"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13766646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Epidemiologic cross-sectional study of the prevalence of chronic bronchitis and lung function disorders in swine breeders and milkers].","authors":"E Barthel, K Krecklow","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In an epidemiological cross-sectional study the influence of occupation in swine production confinements on development of chronic bronchitis and lung function impairments was investigated. The study population comprised 307 swine confinement workers and 165 cattle workers without significant differences in age distribution and smoking habits. For evaluation of respiratory symptoms a standardized questionnaire was used. The following lung function tests were carried out: FVC, FEV1, RV, MEF25, MEF50, PEF and Raw. Regarding the prevalence of chronic bronchitis and lung function impairments no statistically significant differences were found between the two groups. Indeed swine confinement workers indicated a distinct trend to a higher prevalence of chronic bronchitis in correlation to the duration of employment. Workers in swine confinement buildings with more than 10 y exposure showed significantly worse mean values of the measured lung function parameters and significantly more frequent pathological lung function values than the control group of cattle workers.</p>","PeriodicalId":76840,"journal":{"name":"Zeitschrift fur Erkrankungen der Atmungsorgane","volume":"172 2","pages":"143-9"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13927906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hypoxia and the pulmonary circulation: a brief review.","authors":"G R Barer","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hypoxia constricts small pulmonary arteries. Local hypoxia regulates blood flow/ventilation ratios, while general hypoxia elevates pulmonary artery pressure (Ppa). There is a continuum of responses from flow reduction to Ppa elevation dependent on the proportion of lung involved. Stimulus-response curves to hypoxia show the effect is maximal within the physiological range and resemble that for the carotid body. In widespread lung disease so much of the lung becomes hypoxic, that blood flow/ventilation matching fails, hypoxaemia and pulmonary hypertension follow. In chronic hypoxia structural changes take place which maintain a high pressure even when hypoxia is removed; small arterioles become muscularized and there is right ventricular hypertrophy and polycythaemia. Animal models of hypoxic pulmonary hypertension have brought some understanding of the growth processes involved and shown that several drugs will prevent these changes. The reactivity of the restructured pulmonary vessels in chronic hypoxia is altered.</p>","PeriodicalId":76840,"journal":{"name":"Zeitschrift fur Erkrankungen der Atmungsorgane","volume":"173 2","pages":"109-15"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13826159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[The effect of climatic and meteorologic factors on bronchial hyperreactivity and the course of bronchial asthma diseases and their potential significance in asthma prevention: hypotheses, methodologic approaches and initial results].","authors":"J Slapke, B Vucelic, C Schütt, S Müller","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Bronchial hyperresponsiveness (BHR) as the main condition for the development of asthma may be modulated either by intrinsic or by extrinsic stimuli as well as by climatic and meteorologic factors. Proinflammatory mediators in combination with alterations of airway mucosa induce or amplify BHR. Upper airway viral infections, exposure to allergens in atopic subjects, chronic hyperplastic changes of the upper airways, airway irritants and analgesics are supposed to be the most likely asthma triggers in predisposed children and adults. There is the suggestion that BHR can be improved not only by treatment with steroidal and nonsteroidal antiinflammatory drugs but also by maritime climatotherapy. The latter could be the result not only of the reduction of inhalative irritants, e.g. of allergen concentration, but also by the involvement or more complex mechanisms. Possible theoretic approaches and hypotheses regarding the mode of action of maritime climatic cures are discussed. First preliminary results obtained in a mediterranean region have demonstrated a negative impact of metereologic events like passages of cold weather fronts or increase of wind velocity on the course of asthma disease. An improvement of BHR assessed by histamine challenge test has been observed at the end of climatotherapy in the Baltic sea area. Prospective studies about asthma prevention in subjects at risk with BHR and atopy that have been starting should contribute to the evaluation of the therapeutic effects and the prognostic importance of maritime climatotherapy for getting exact scientific indications for climatotherapy in patients with bronchial asthma.</p>","PeriodicalId":76840,"journal":{"name":"Zeitschrift fur Erkrankungen der Atmungsorgane","volume":"173 2","pages":"116-26"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13826160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H Scharkoff, H Landmann, S Merkel, H Köhler, H D Jung
{"title":"[Recommendations for the therapy of atypical immunization courses and complications of BCG vaccination (Position: April, 1988)].","authors":"H Scharkoff, H Landmann, S Merkel, H Köhler, H D Jung","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>After introduction of the \"direct\" BCG-vaccination of the 16 years old youngsters in 1981 a small increase of atypical reactions and complications of the vaccination was probable. References and experiences about different therapy methods of these atypical reactions and complications gave rise to recommend uniform guide-lines for definition, diagnostic and therapy.</p>","PeriodicalId":76840,"journal":{"name":"Zeitschrift fur Erkrankungen der Atmungsorgane","volume":"173 1","pages":"96-9"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13938957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}