Age and ageing最新文献

{"title":"Association between transitional care in acute care hospitals and ambulatory care sensitive condition-related readmission.","authors":"Ako Machida,Noriko Morioka,Mutsuko Moriwaki,Kazuhiro Abe,Chihiro Takahashi,Kenshi Hayashida,Masayo Kashiwagi","doi":"10.1093/ageing/afaf247","DOIUrl":"https://doi.org/10.1093/ageing/afaf247","url":null,"abstract":"BACKGROUNDLittle is known about how ambulatory care sensitive condition (ACSC)-related readmissions can be reduced in acute care settings.OBJECTIVEThis study examined the association between transitional care for hospitalised older patients with ACSC and ACSC-related readmissions.METHODSThis retrospective observational cohort study included patients aged 65 years and older admitted with ACSC as the primary diagnosis from 1 April 2022 to 31 January 2023, using linked data from the Diagnosis Procedure Combination and the medical functions of the hospital beds database. The primary outcomes were cumulative readmissions within 1-7, 1-14, 1-21, 1-30 and 1-60 days, analysed using inverse probability treatment weighting regression models.RESULTSAmong 85 582 patients from 711 hospitals, 39 916 (46.6%) were female, with a median age of 82 years (interquartile range: 75-88); 57 127 (66.8%) patients received transitional care. The overall readmission rates were 2.9%, 6.0%, 8.7%, 11.4% and 17.5% among total hospitalisations within 7, 14, 21, 30 and 60 days, respectively. Overall, transitional care was associated with reduced odds of ACSC-related readmission, with odds ratios ranging from 0.72 (95% CI: 0.65-0.78) within 7 days to 0.91 (95% CI: 0.87-0.95) within 60 days. The association between transitional care and readmission varied by ACSC category. In chronic ACSC, the association was strongest for 7-day readmission, followed by a downward trend. In acute and vaccine-preventable ACSC, the association was strongest for 7-day readmission but levelled off after 21 days.CONCLUSIONSTransitional care in acute care hospitals may be associated with a reduced risk of early readmissions due to ACSC when older patients are hospitalised.","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"34 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145018205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Housing quality and related housing environmental factors associated with falls in older adults: results from the longitudinal ageing study in India.","authors":"Hongtao Cheng, Lu Shao, Tingting Xie, Jie Jiang, Boya Mi, Bei Wu, Jun-E Zhang","doi":"10.1093/ageing/afaf260","DOIUrl":"https://doi.org/10.1093/ageing/afaf260","url":null,"abstract":"<p><strong>Background: </strong>Falls are a significant cause of morbidity, disability, and mortality amongst older adults worldwide, with approximately one-third of Indian older adults experiencing falls annually. Despite extensive research on individual-level risk factors, the relationship between housing quality and fall risk remains understudied. This study examined the relationship between housing quality and falls.</p><p><strong>Methods: </strong>We analysed data from 30 632 adults aged ≥60 years from the longitudinal ageing study in India (2017-2018). Housing quality was assessed using five indicators (housing materials, sanitation, water access, cooking fuel, electricity) categorised as good (scores 0-1), moderate (scores 2-3), or poor (scores 4-5). Related environmental factors included lack of separate bedrooms/kitchens, indoor air pollutants, and household dampness. Self-reported falls >2 years were analysed using generalised linear mixed models with adjustment for sociodemographic, health, and lifestyle factors.</p><p><strong>Results: </strong>Participants had a median age of 67 years (interquartile range: 63, 73) with 52.0% female. After full adjustment, the housing quality index showed significant association with falls [odds ratio (OR) = 1.17, 95% confidence interval (CI): 1.13-1.21 per unit increase, P < .001]. Compared to good housing quality, moderate (OR = 1.32, 95% CI: 1.20-1.45) and poor (OR = 1.76, 95% CI: 1.56-1.98) housing quality were associated with a higher fall risk. Four housing quality indicators (poor sanitation, inadequate water access, solid fuel use, lack of electricity) and related housing environment factors (lack of separate bedrooms/kitchen, indoor air pollutants, household dampness) were all independently associated with increased fall risk.</p><p><strong>Conclusions: </strong>Poor housing quality significantly increases fall risk in older Indians, suggesting housing interventions may be effective fall prevention strategies.</p>","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"54 9","pages":""},"PeriodicalIF":7.1,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy of nonpharmacological interventions for preventing postoperative delirium in hospitalized older adults: a systematic review and network meta-analysis.","authors":"Chia-Chi Hsiao, Chia-Jou Lin, Faizul Hasan, Debby Syahru Romadlon, Victoria Traynor, Soni Roy Kurniawan Hulu, Hsiao-Yean Chiu","doi":"10.1093/ageing/afaf264","DOIUrl":"https://doi.org/10.1093/ageing/afaf264","url":null,"abstract":"<p><strong>Background: </strong>Postoperative delirium (POD) is the most common surgical complication. Although numerous studies have demonstrated the effectiveness of multicomponent interventions in preventing delirium among medical patients, the most effective nonpharmacological strategies for reducing the incidence of POD remains unclear. This study aimed to compare the effects of component-based and treatment-based nonpharmacological interventions on POD prevention in hospitalized older adults.</p><p><strong>Methods: </strong>A network meta-analysis was conducted using three databases from inception to February 1, 2024. Only randomized controlled trials evaluating nonpharmacological interventions versus usual care or other interventions for POD prevention in surgical older adults were included. A random-effects network meta-analysis assessed the comparative effectiveness of interventions.</p><p><strong>Results: </strong>Nineteen studies involving 4340 hospitalized older adults were included. Component-based analysis showed that multicomponent interventions were the most effective for reducing POD compared to usual care (odds ratio [OR] = 0.48, 95% confidence interval [CI] = 0.35-0.66). Treatment-based analysis identified that multicomponent interventions comprising six elements-physical activity, reorientation, clinical adjustment, sensory stimulation, environmental control and relaxation promotion-most effectively reduced POD incidence (OR = 0.11, 95% CI = 0.04-0.33).</p><p><strong>Conclusions: </strong>This network meta-analysis, drawing on both direct and indirect evidence, suggests that multicomponent nonpharmacological interventions are the most effective strategies for reducing POD incidence in hospitalized older adults. Specifically, interventions incorporating physical activity, reorientation, clinical adjustment, sensory stimulation, environmental control and relaxation promotion significantly lowered the risk of POD. These findings support the adoption of comprehensive multicomponent interventions as a first-line approach for POD prevention in surgical older adult populations.</p>","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"54 9","pages":""},"PeriodicalIF":7.1,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of 2-year cocoa extract supplementation on inflammaging biomarkers in older US adults: findings from the COcoa Supplement and Multivitamin Outcomes Study randomised clinical trial.","authors":"Sidong Li, Rikuta Hamaya, Haidong Zhu, Allison Clar, Pamela M Rist, Ying Huang, JoAnn E Manson, Howard D Sesso, Yanbin Dong","doi":"10.1093/ageing/afaf269","DOIUrl":"10.1093/ageing/afaf269","url":null,"abstract":"<p><strong>Objective: </strong>To examine the long-term effect of cocoa flavanols on inflammaging biomarkers in the COcoa Supplement and Multivitamin Outcomes Study (COSMOS).</p><p><strong>Methods: </strong>COSMOS is a large, randomised, double-blind, placebo-controlled, 2 × 2 factorial trial testing the effects of a cocoa extract supplement (containing 500 mg cocoa flavanols/day, including 80 mg (-)-epicatechin) among women aged ≥65 years and men aged ≥60 years. This ancillary study measured five widely used serum inflammaging biomarkers, including three pro-inflammatory markers (high-sensitivity C-reactive protein [hsCRP], interleukin-6, tumour necrosis factor-α), one anti-inflammatory cytokine (interleukin-10) and one pleotropic cytokine (interferon-γ [IFN-γ]) in a random sample of 598 participants with biospecimens collected at baseline, Year 1, and Year 2.</p><p><strong>Results: </strong>The mean age was 70.0 ± 5.6 years, and 49.8% were female. Cocoa extract supplementation significantly decreased hsCRP levels compared with placebo, with a between-group difference in yearly percentage change relative to baseline levels of -8.4% (95% CI, -14.1% to -2.3%; nominal P = .008; Holm-adjusted P value = .039). Moreover, cocoa extract increased IFN-γ with a 6.8% (95% CI, 1.5% to 12.2%, nominal P = .011; Holm-adjusted P value = .043) difference in yearly percentage change versus placebo. The effects of cocoa extract on other inflammatory markers were not significant (all adjusted P values >.05).</p><p><strong>Conclusion: </strong>Cocoa extract supplementation significantly decreased hsCRP, supporting a role in modulating the chronic inflammaging process as a potential mechanism underlying its cardio-protective effects, including a 27% reduction in cardiovascular disease death in the COSMOS trial. The biological effect of increased IFN-γ by cocoa extract warrants further exploration.</p>","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"54 9","pages":""},"PeriodicalIF":7.1,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145084687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic effects of exercise, cognitive training and vitamin D on gait performance and falls in mild cognitive impairment-secondary outcomes from the SYNERGIC trial.","authors":"Frederico Pieruccini-Faria, Surim Son, Guangyong Zou, Quincy J Almeida, Laura E Middleton, Nick W Bray, Maxime Lussier, J Kevin Shoemaker, Mark Speechley, Teresa Liu-Ambrose, Amer M Burhan, Richard Camicioli, Karen Z H Li, Sarah Fraser, Nicolas Berryman, Louis Bherer, Manuel Montero-Odasso","doi":"10.1093/ageing/afaf242","DOIUrl":"10.1093/ageing/afaf242","url":null,"abstract":"<p><strong>Background: </strong>Older adults with mild cognitive impairment (MCI) have a higher risk of gait impairments and falls; yet, the effects of multimodal interventions, including combinations of exercises with cognitive training, on improving their mobility remain unclear.</p><p><strong>Objectives: </strong>To investigate the synergistic effects of aerobic-resistance exercise combined with cognitive training, with or without vitamin D supplementation, on gait performance and falls risk in older adults with MCI.</p><p><strong>Methods: </strong>The effect of 20 weeks of aerobic-resistance exercise, cognitive training, and Vitamin D supplementation (10 000 IU 3×/week) on gait and falls in older adults with MCI was evaluated in the SYNERGIC trial, using a fractional factorial design. Assessments were conducted at baseline, 6-month endpoint (after intervention) and 12-month endpoint (follow-up). Eligible participants were between the ages of 65 and 84 years with MCI enrolled from 19 September 2016 to 7 April 2020. Main outcomes of interest for gait performance were gait speed and gait variability changes, whilst for falls were incidental falls and incidental injurious falls.</p><p><strong>Results: </strong>Amongst 161 participants, the four exercise-based arms improved gait speed (+7.5 cm/s, P < .001) and reduced falls (incidence rate ratios (IRR) = 0.65, 95% confidence interval (CI): 0.32-1.42, P = .25) and injurious falls (IRR = 0.38, 95% CI: 0.15-1.05, P = .05) at 6-month endpoint. Falls reduction reached statistical significance (IRR = 0.28, 95% CI: 0.13-0.64, P = .002) at 12-month endpoint. Exercises combined with cognitive training showed the greatest gains in gait speed at 6-month endpoint (P < .001) and in reducing falls at 12-month endpoint (IRR = 0.24, 95% CI: 0.05-0.77, P = .02) compared to the control. Vitamin D did not enhance outcomes and increased gait variability, a marker of instability.</p><p><strong>Conclusion: </strong>Aerobic-resistance exercise combined with sequential computerised cognitive training improved gait performance at 6 months and decreased the risk of falls and injuries at 12 months in older adults with MCI. The addition of vitamin D did not produce benefits.</p>","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"54 9","pages":""},"PeriodicalIF":7.1,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12445844/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145084724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editor's view: age and ageing-a home for reports on trials.","authors":"Sophie Alexandra Hay, Terence J Quinn","doi":"10.1093/ageing/afaf262","DOIUrl":"https://doi.org/10.1093/ageing/afaf262","url":null,"abstract":"","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"54 9","pages":""},"PeriodicalIF":7.1,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145102614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Association between hypoglycaemic drug de-intensification, mortality and hospital admission in older adults with type 2 diabetes: a cohort study emulating a target trial.","authors":"","doi":"10.1093/ageing/afaf263","DOIUrl":"10.1093/ageing/afaf263","url":null,"abstract":"","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"54 9","pages":""},"PeriodicalIF":7.1,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145005758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dexmedetomidine and postoperative dementia risk in older patients.","authors":"Mingyang Sun, Shaihao Fu, Tian Mao, Wei Li, Shaoxuan Cai, Xiaojuan Xie, Wan-Ming Chen, Szu-Yuan Wu, Jiaqiang Zhang","doi":"10.1093/ageing/afaf258","DOIUrl":"https://doi.org/10.1093/ageing/afaf258","url":null,"abstract":"<p><strong>Background: </strong>Postoperative cognitive decline (POCD) and dementia are significant risks in older patients after surgery. Dexmedetomidine, an α2-adrenergic agonist, has shown neuroprotective properties in preclinical models, but its role in preventing dementia in postoperative patients remains unexplored.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study using data from Taiwan's National Health Insurance Research Database from 2012 to 2020. The cohort included 59 194 older patients (≥70 years) who underwent hip fracture surgery. Patients were categorised based on postoperative dexmedetomidine use. The primary outcome was the incidence of dementia, including Alzheimer's disease (ad) and vascular dementia (VaD), assessed using multivariable Cox regression models adjusted for confounders. Competing risk analysis was also performed.</p><p><strong>Results: </strong>Patients administered dexmedetomidine postoperatively had a significantly lower risk of dementia compared to those who did not receive the drug [adjusted hazard ratio (aHR) 0.53, 95% confidence interval (CI) 0.45-0.60]. The reduction in ad risk was more pronounced (aHR 0.38, 95% CI 0.30-0.47) compared to VaD (aHR 0.58, 95% CI 0.49-0.68). These effects persisted after adjusting for confounders, including age, sex, comorbidities, and socioeconomic factors.</p><p><strong>Conclusions: </strong>This study is the first to provide clinical evidence supporting dexmedetomidine's potential in reducing dementia risk, particularly ad, in older postoperative patients. Further randomised trials are needed to confirm these findings and determine the optimal use of dexmedetomidine in postoperative care. If validated, dexmedetomidine could become a critical strategy in reducing the long-term cognitive burden in ageing populations.</p>","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"54 9","pages":""},"PeriodicalIF":7.1,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145084719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Creating a home away from home: a resident-centred systematic review and meta-synthesis of ideal nursing home qualities from the perspectives of cognitively intact residents.","authors":"Celine Joy Jing Hsia Gan, Ivana Felicia Angkawijaya, Ziqiang Li, Yong-Shian Goh","doi":"10.1093/ageing/afaf265","DOIUrl":"https://doi.org/10.1093/ageing/afaf265","url":null,"abstract":"<p><strong>Background: </strong>A home-like environment is crucial for the well-being of nursing home residents, promoting autonomy, comfort and social connection. This review addresses gaps in understanding factors shaping cognitively intact nursing home residents' perceptions of a home-like environment. By synthesising the best available evidence, it identifies and describes key characteristics of an ideal home-like nursing home environment from the perspectives of cognitively intact residents.</p><p><strong>Methods: </strong>A meta-synthesis was conducted, involving the search of eight databases, comprehensively searched through 10 December 2024, to identify studies exploring residents' perceptions of home-like environments in nursing homes. Inclusion criteria focused on qualitative studies with residents aged 50 and above. Thematic synthesis identified recurring themes across studies.</p><p><strong>Results: </strong>Nineteen studies published between 2002 and 2024, which encapsulated the 1368 residents' perspectives, met the inclusion criteria and were included in the review. Four key themes developed through thematic analysis: (i) Psychological: sense of recognition, autonomy and control, coping and adaptation, emotional comfort; (ii) Social: interaction with staff, relationship with residents, family connectedness and social activities; (iii) Built environment: private space, communal spaces, personalisation, aesthetic and ambience and outdoor spaces; (iv) Organisational: staffing challenges, respectful care practices, scheduled activities and dining and food choices.</p><p><strong>Discussion: </strong>Findings highlighted that autonomy, meaningful social connections and personalised environments are essential for fostering a home-like setting for long-term residents. Institutional constraints hinder this, highlighting the need for policies embedding autonomy into routines, staff training and design, with flexible, personalised and culturally attuned care practices that respect residents' preferences.</p>","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"54 9","pages":""},"PeriodicalIF":7.1,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barriers and improvements of respiratory aspiration risk management in older patients from multiple perspectives: a qualitative study.","authors":"Shuojin Fu, Yanling Wang, Ruifu Kang, Ling Tong, Shuai Jin, Chunhong Li, Qian Xiao, Yaqin Zhang","doi":"10.1093/ageing/afaf256","DOIUrl":"https://doi.org/10.1093/ageing/afaf256","url":null,"abstract":"<p><strong>Background: </strong>Aspiration, the entry of food, fluids, saliva or gastric contents into the airway, is common in older adults and may lead to pneumonia or even death. Multidisciplinary management has the opportunity to help prevent aspiration in older patients. However, implementation in clinical practice remains problematic. By investigating the perspectives of stakeholders, comprehensive barriers and improvements measures can be identified to help manage aspiration risk.</p><p><strong>Method: </strong>Doctors, therapists, nurses, patients and their caregivers were recruited from wards in three tertiary hospitals. Semi-structured interviews were conducted to explore participants' views and experiences on the implementation of aspiration risk management. Data were analysed using content analysis.</p><p><strong>Results: </strong>Data from 62 participants revealed barriers and improvements measures in aspiration risk management in older patients: Barriers: (i) Patient-related barriers, related to cognition, physical condition, compliance and caregiver burden; (ii) Healthcare-related barriers, including insufficient professional competence, lack of personalised guidance and education and limited communication; (iii) Support system and environmental barriers, including insufficient collaboration, limited processes, insufficient technical support and uneven hospital management attention. Improvements measures: (i) Hybrid management model of online and offline integration; (ii) Clear role definition across multiple roles; (iii) Visualization or quantification of aspiration display; (iv) Personalised and dynamic aspiration management strategies; (v) Strengthening communication and trust to improve adherence; (vi) Emotional support and supervision by caregivers.</p><p><strong>Conclusion: </strong>All major stakeholders faced some challenges, and it was necessary to strengthen teamwork, make good use of new technology support and enhance humanistic care to help stakeholders manage aspiration risk in older patients.</p>","PeriodicalId":7682,"journal":{"name":"Age and ageing","volume":"54 9","pages":""},"PeriodicalIF":7.1,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}