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[Immunochemical characteristics of the population structure of antibody-producing cells in experimental influenza]. [实验性流感中产生抗体细胞群体结构的免疫化学特征]。
Vestnik Akademii meditsinskikh nauk SSSR Pub Date : 1991-01-01
A I Dukhin, I I Agafonova, B L Voĭtsekhovskiĭ
{"title":"[Immunochemical characteristics of the population structure of antibody-producing cells in experimental influenza].","authors":"A I Dukhin,&nbsp;I I Agafonova,&nbsp;B L Voĭtsekhovskiĭ","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The authors presented the results of population study of specific IgG-antibody-forming cells (AFC) in the pool of mice splenocytes performed in the time-course of simulated influenza with the help of experimental mathematical approach which permitted making a detailed observation of the functional structure of the population and analysing the changes in the spectrum of the AFC subpopulations in the time-course of viral disease. Mathematical simulation of the main stage of immunopointed identification of AFC on +nitrocellulose filters (NCF) permitted the verification of the ratio between the characteristic features of the spots on the NCF and the number and affinity of cell-secreting IgG antibodies. New data are obtained on the formation of the population of +virus-specific IgG-AFC which are featured by discreteness of the AFC +affinity ++ spectrum, cyclic changes in their activity and shifts in the stages of the AFC subpopulation activity. The authors substantiated the necessity to revise the existing theoretical models of the formation of humoral immune response to viral infections.</p>","PeriodicalId":76796,"journal":{"name":"Vestnik Akademii meditsinskikh nauk SSSR","volume":" 4","pages":"14-8"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13027431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Fibronectin and pregnancy]. [纤维连接蛋白与妊娠]。
Vestnik Akademii meditsinskikh nauk SSSR Pub Date : 1991-01-01
T V Sebko, V A Aliev
{"title":"[Fibronectin and pregnancy].","authors":"T V Sebko,&nbsp;V A Aliev","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Fibronectin is a high-molecular polyfunctional glycoprotein occurring in the majority of the body fluids and tissues. Various investigations have demonstrated that plasma fibronectin levels either fail to change, or increase with longer gestation during a normal pregnancy. The time course of changes in fibronectin levels has been found to become lower in the amniotic fluid during pregnancy, though its physiological role has not been defined in this case. In late gestosis, plasma fibronectin concentrations substantially rises as compared to those observed in normal pregnancy.</p>","PeriodicalId":76796,"journal":{"name":"Vestnik Akademii meditsinskikh nauk SSSR","volume":" 2","pages":"46-50"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13204376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Academician in exile (little-known pages on the life of S.S. Iudin, Academician of the USSR Academy of Sciences)]. [流亡院士(关于苏联科学院院士s·s·乌丁生平的鲜为人知的几页)]。
Vestnik Akademii meditsinskikh nauk SSSR Pub Date : 1991-01-01
A B Rusakov
{"title":"[Academician in exile (little-known pages on the life of S.S. Iudin, Academician of the USSR Academy of Sciences)].","authors":"A B Rusakov","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76796,"journal":{"name":"Vestnik Akademii meditsinskikh nauk SSSR","volume":" 2","pages":"62-4"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13204382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Immunosorption of individual HIV proteins and virions]. [单个HIV蛋白和病毒粒子的免疫吸附]。
Vestnik Akademii meditsinskikh nauk SSSR Pub Date : 1991-01-01
Iu M Lopukhin, V V Pavlenko, D V Kulaev, T K Liukova, D D Petrunin, E V Karamov, I A Rudneva
{"title":"[Immunosorption of individual HIV proteins and virions].","authors":"Iu M Lopukhin,&nbsp;V V Pavlenko,&nbsp;D V Kulaev,&nbsp;T K Liukova,&nbsp;D D Petrunin,&nbsp;E V Karamov,&nbsp;I A Rudneva","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Immunosorbents specifically binding native (gp160, gp120, gp41) and recombinant env proteins and HIV-I virions were synthesized on the basis of Sepharose 4B and Silica with immobilized ligands such as gamma-fraction of rabbit antiserum to HIV-I proteins and purified antibodies to env proteins of HIV-I. The possibility was shown of selective extraction of HIV-I virions and individual HIV proteins both in vitro and in vivo. The titer of virus antigens (in ELISA) after perfusion via an immunosorbent of patterns with a high content of virions and HIV-I proteins was 8 times as low as the starting titer (after perfusion via the control sorbent it was 2-fold decreased). Extracorporeal immunosorption in animals after intravenous injection of recombinant env protein permitted the latter's titer to be 5 times lower. After perfusion via the control sorbent the titer dropped by at least 20% as compared with the starting titer. The possibility of using immunosorption in multimodality therapy of AIDS is under discussion.</p>","PeriodicalId":76796,"journal":{"name":"Vestnik Akademii meditsinskikh nauk SSSR","volume":" 11","pages":"60-3"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12930502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The way of life of the population exposed to radiation as a health-forming factor]. [受辐射影响的人口的生活方式]。
Vestnik Akademii meditsinskikh nauk SSSR Pub Date : 1991-01-01
V P Ferents, V A Prilipko
{"title":"[The way of life of the population exposed to radiation as a health-forming factor].","authors":"V P Ferents,&nbsp;V A Prilipko","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76796,"journal":{"name":"Vestnik Akademii meditsinskikh nauk SSSR","volume":" 11","pages":"45-6"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12931311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Mechanisms of development of brain edema in neurosurgical pathology]. [神经外科病理学中脑水肿的发展机制]。
Vestnik Akademii meditsinskikh nauk SSSR Pub Date : 1991-01-01
E B Sirovskiĭ, V G Amcheslavskiĭ, V P Kulikovskiĭ, V D Tenedieva, S A Lobanov, M E Polonskaia, Iu N Pokid'ko
{"title":"[Mechanisms of development of brain edema in neurosurgical pathology].","authors":"E B Sirovskiĭ,&nbsp;V G Amcheslavskiĭ,&nbsp;V P Kulikovskiĭ,&nbsp;V D Tenedieva,&nbsp;S A Lobanov,&nbsp;M E Polonskaia,&nbsp;Iu N Pokid'ko","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>As many as 120 neurosurgical patients were examined after the excision of hemispheric gliomas, basal and subtentorial tumors. Based on an the computer-aided analysis biochemical and clinical data, attempts have been made to unify the mechanisms responsible for brain edema development in patients with neurosurgical pathology. In the early postoperative period, brain edema occurs in 95% of neurosurgical patients. Edema development, spreading and intensity depend on the site and nature of the primary pathological focus as well as on traumatism of surgical interventions. It is proved that edema is an original, biologically expedient brain response to its injury. This response manifests in hyperhydration of all tissues, with the maximum intensity being concentrated in the focus of injury. Specific (neurogenic neurohumoral) and nonspecific (biochemical, autoimmune, mechanical, and so forth) factors of brain edema development may be distinguished. The differences in the neurogenic and neurohumoral mechanisms by which brain edema develops may be accounted for by the topography of the focus of injury. The closer the pathological focus is to the stem and diencephalic structures, the more remarkable the action of neurogenous and neurohumoral factors and the more distinct the tendency toward edema generalization are. At the diencephalic level of injury, damaged are the structures responsible for central regulation of metabolism and trophicity of nerve cells. The neurogenously precipitated diffuse impairment of permeability of the cells entails their hyperhydration, which marks cellular (cytotoxic) edema. The subtentorial process that affects the vasomotor centre of the stem triggers the neurogenic diffuse alterations in the vascular tone, manifesting in an increase of permeability for water and plasma proteins which is characteristic of vasogenic edema.(ABSTRACT TRUNCATED AT 250 WORDS)</p>","PeriodicalId":76796,"journal":{"name":"Vestnik Akademii meditsinskikh nauk SSSR","volume":" 7","pages":"7-13"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12943655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Various aspects of using minor regulatory peptides in anesthesiology]. [在麻醉学中使用次要调节肽的各个方面]。
Vestnik Akademii meditsinskikh nauk SSSR Pub Date : 1991-01-01
V V Likhvantsev, V I Smirnova
{"title":"[Various aspects of using minor regulatory peptides in anesthesiology].","authors":"V V Likhvantsev,&nbsp;V I Smirnova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Dalargin is a Soviet synthetic analog of leu-enkephalin. It was used in a complex of anesthesiological protection (in the form of permanent infusion at a rate of 40-55 micrograms/kg/h) in 331 patients who suffered different operations on the heart, lungs and abdominal cavity. Potential mechanisms of the protective action of the drug were studied in experimental surgical distress. It was found advisable that dalargin may be included into combined general anesthesia to maintain intraoperative organ protection, to stabilize vital functions of the patient at the most crucial and traumatic stages of intervention, and to decrease requirements of narcotic analgetics. It is assumed that dalargin may interact with peripheral opiate receptors. The interaction is likely to be viewed as the main mechanism by which the protective properties of the drug are realized.</p>","PeriodicalId":76796,"journal":{"name":"Vestnik Akademii meditsinskikh nauk SSSR","volume":" 7","pages":"17-21"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12943711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Evaluation of hypoxia by studying the metabolism of purine compounds]. [通过研究嘌呤化合物的代谢来评价缺氧]。
Vestnik Akademii meditsinskikh nauk SSSR Pub Date : 1991-01-01
G A Riabov, S S Ladygin, Iu M Azizov, I N Pasenchik
{"title":"[Evaluation of hypoxia by studying the metabolism of purine compounds].","authors":"G A Riabov,&nbsp;S S Ladygin,&nbsp;Iu M Azizov,&nbsp;I N Pasenchik","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76796,"journal":{"name":"Vestnik Akademii meditsinskikh nauk SSSR","volume":" 7","pages":"3-7"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12943719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Nonspecific mitogenic factors of Mycoplasma: immunobiological properties]. 支原体的非特异性有丝分裂因子:免疫生物学特性。
Vestnik Akademii meditsinskikh nauk SSSR Pub Date : 1991-01-01
A V Pronin, L G Gorina
{"title":"[Nonspecific mitogenic factors of Mycoplasma: immunobiological properties].","authors":"A V Pronin,&nbsp;L G Gorina","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The readily extractable surface membrane proteins of M. arthritidis and sodium dodecyl sulfate-solubilized membrane components of M. fermentans were found to have the highest mitogenic action on the splenocytes from CBA mice and the least on those from C57BL/6 mice. The M. arthritidis mitogen (MAM) is an antigen-dependent T-cell mitogen that inhibits the specific proliferation of T cells, inducing their non-specific proliferation. Dextran sulfate-induced blockage of lymphocyte proliferation under the action of MAM was stimulated with interleukin-2, which suggests MAM-induced expression of receptors to interleukin-2 onto the surface of lymphocytes. A factor that has the activity of interleukin-1 and stimulates the proliferation of C57BL/6 murine thymocytes with phytohemagglutinin was found to liberate into a culture medium.</p>","PeriodicalId":76796,"journal":{"name":"Vestnik Akademii meditsinskikh nauk SSSR","volume":" 6","pages":"30-4"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13085406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Interactions between Mycoplasma and macrophages]. 支原体与巨噬细胞的相互作用。
Vestnik Akademii meditsinskikh nauk SSSR Pub Date : 1991-01-01
V V Neustroeva
{"title":"[Interactions between Mycoplasma and macrophages].","authors":"V V Neustroeva","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Examining the interaction of M. hominis, M. fermentans, and M. arthritidis with peritoneal macrophages of various strain mice has demonstrated that the interaction is related both to the mycoplasma and macrophage types. It has been found that M. arthritidis may multiply and persist for a long time in the macrophages, which is followed by morphological changes developed in the latter and by suppression of phagocytic activity.</p>","PeriodicalId":76796,"journal":{"name":"Vestnik Akademii meditsinskikh nauk SSSR","volume":" 6","pages":"34-6"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13085407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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