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Assessment of pinacidil in patients with primary Raynaud's phenomenon. pinacidil在原发性雷诺现象患者中的应用评估。
VASA. Supplementum Pub Date : 1992-01-01
E C Dompeling, A J Smit
{"title":"Assessment of pinacidil in patients with primary Raynaud's phenomenon.","authors":"E C Dompeling,&nbsp;A J Smit","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In fourteen patients with primary Raynaud's phenomenon we performed a double-blind, controlled study, comparing single doses of 12.5 and 25 mg of the potassium channel opener pinacidil with placebo and the active control nifedipine in randomised order. The main response criterium was the area under the curve (AUC) of the photoelectric plethysmography (PEP) during cooling and rewarming, performed 2-3 hours after administration of the study medication. Single doses of 12.5 and 25 mg pinacidil were shown not to be superior to placebo in respect of the AUC of PEP. Nifedipine, on the contrary, was significantly better than placebo. We conclude that no efficacy can be expected from the potassium channel opener pinacidil in the treatment of primary Raynaud's phenomenon. The efficacy of nifedipine cannot be explained from central rheological effects, as total blood viscosity was the same after pinacidil, nifedipine and placebo.</p>","PeriodicalId":76788,"journal":{"name":"VASA. Supplementum","volume":"34 ","pages":"34-7"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12698047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Laser Doppler blood flowmetry. Perinatal applications. 激光多普勒血流仪。围产期的应用程序。
VASA. Supplementum Pub Date : 1992-01-01
J G Aarnoudse
{"title":"Laser Doppler blood flowmetry. Perinatal applications.","authors":"J G Aarnoudse","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76788,"journal":{"name":"VASA. Supplementum","volume":"34 ","pages":"15-9"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12698244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Dose-dependent inhibition of plaque growth in the carotid artery by acetylsalicylic acid]. [剂量依赖性乙酰水杨酸抑制颈动脉斑块生长]。
VASA. Supplementum Pub Date : 1992-01-01
C Ranke, A Creutzig, H Hecker, K Alexander
{"title":"[Dose-dependent inhibition of plaque growth in the carotid artery by acetylsalicylic acid].","authors":"C Ranke,&nbsp;A Creutzig,&nbsp;H Hecker,&nbsp;K Alexander","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76788,"journal":{"name":"VASA. Supplementum","volume":"35 ","pages":"143-6"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12651799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rheological properties of blood in Raynaud's phenomenon. 雷诺现象中血液的流变特性。
VASA. Supplementum Pub Date : 1992-01-01
G Wichers, A J Smit, J van der Meer, A A Wouda, M R Halie
{"title":"Rheological properties of blood in Raynaud's phenomenon.","authors":"G Wichers,&nbsp;A J Smit,&nbsp;J van der Meer,&nbsp;A A Wouda,&nbsp;M R Halie","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Rheological tests were performed in four rigorously defined groups of patients with Raynaud's phenomenon: primary family-related (n = 21), primary family-unrelated (n = 30), 'possible scleroderma' (n = 26), and scleroderma (n = 19). Whole blood and plasma viscosity, and hematocrit were significantly higher in the 'possible scleroderma' group. We conclude that the contribution of central rheological abnormalities in the pathogenesis of Raynaud's phenomenon is limited.</p>","PeriodicalId":76788,"journal":{"name":"VASA. Supplementum","volume":"34 ","pages":"29-33"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12698046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Measuring model for intraoperative determination of vascular resistance in crural vascular surgery]. [术中测定小腿血管手术血管阻力的测量模型]。
VASA. Supplementum Pub Date : 1992-01-01
J Frank, U Scholz, V Henneken, C Bischoff-Everding, K de Jonge, E Hennig, W Hepp
{"title":"[Measuring model for intraoperative determination of vascular resistance in crural vascular surgery].","authors":"J Frank,&nbsp;U Scholz,&nbsp;V Henneken,&nbsp;C Bischoff-Everding,&nbsp;K de Jonge,&nbsp;E Hennig,&nbsp;W Hepp","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The measurement of the vascular outflow resistance during reconstructive vascular operations was applied since 1989 on 45 subjects with reliable results. This measurement is an aid for decision of additional treatment increasing the outflow, like a jump- or sequential bypass or a pharmacological therapy. The principle of measurement is based on the injection of a known volume of saline in the vessel and the integration of the intravascular pressure during this injection. In the prototype used, the pressure integration was performed by means of a modified analog/digital conversion method, hereby the results could be achieved directly as numerical values. Further an automatic, microcomputer based implementation of the outflow resistance measurement, showed remarkable improvements of accuracy in laboratory tests.</p>","PeriodicalId":76788,"journal":{"name":"VASA. Supplementum","volume":"36 ","pages":"18-24"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12698051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Antiphospholipid syndrome]. (Antiphospholipid综合症)。
VASA. Supplementum Pub Date : 1992-01-01
A Obernosterer, E Pilger, P Auer-Grumbach, R Tischler, A Doder, M Lafer, M Decrinis
{"title":"[Antiphospholipid syndrome].","authors":"A Obernosterer,&nbsp;E Pilger,&nbsp;P Auer-Grumbach,&nbsp;R Tischler,&nbsp;A Doder,&nbsp;M Lafer,&nbsp;M Decrinis","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76788,"journal":{"name":"VASA. Supplementum","volume":"37 ","pages":"43-4"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12649957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Long-term follow-up of patients with peripheral arterial occlusive disease after balloon dilatation in the femoropopliteal area]. 股腘区球囊扩张后外周动脉闭塞病患者的长期随访。
VASA. Supplementum Pub Date : 1992-01-01
M Lafer, M Decrinis, E Pilger, G Stark, A Obernosterer, R Tischler, A Doder, E G Klein, H Hausegger
{"title":"[Long-term follow-up of patients with peripheral arterial occlusive disease after balloon dilatation in the femoropopliteal area].","authors":"M Lafer,&nbsp;M Decrinis,&nbsp;E Pilger,&nbsp;G Stark,&nbsp;A Obernosterer,&nbsp;R Tischler,&nbsp;A Doder,&nbsp;E G Klein,&nbsp;H Hausegger","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76788,"journal":{"name":"VASA. Supplementum","volume":"37 ","pages":"52-3"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12649961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Heparin and plasminogen increase the thrombolytic potential in recanalization of peripheral arterial occlusions by local streptokinase]. [肝素和纤溶酶原增加局部链激酶对周围动脉闭塞再通的溶栓电位]。
VASA. Supplementum Pub Date : 1992-01-01
P Poredos, V Videcnik
{"title":"[Heparin and plasminogen increase the thrombolytic potential in recanalization of peripheral arterial occlusions by local streptokinase].","authors":"P Poredos,&nbsp;V Videcnik","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76788,"journal":{"name":"VASA. Supplementum","volume":"37 ","pages":"62-3"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12649965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Immunosuppression and cryopreservation of arterial allografts]. 异体动脉移植物的免疫抑制和低温保存。
VASA. Supplementum Pub Date : 1992-01-01
T Schmitz-Rixen, C Berwanger, A Löhe-Quast, K Addicks, R D Hilgers, H Pichlmaier
{"title":"[Immunosuppression and cryopreservation of arterial allografts].","authors":"T Schmitz-Rixen,&nbsp;C Berwanger,&nbsp;A Löhe-Quast,&nbsp;K Addicks,&nbsp;R D Hilgers,&nbsp;H Pichlmaier","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76788,"journal":{"name":"VASA. Supplementum","volume":"35 ","pages":"169-72"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12650282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The value of laser angioplasty in occlusions of the upper leg]. [激光血管成形术在上肢闭塞中的应用价值]。
VASA. Supplementum Pub Date : 1992-01-01
P E Huppert, H Seboldt, S H Duda, U Helber, C D Claussen, H E Hoffmeister
{"title":"[The value of laser angioplasty in occlusions of the upper leg].","authors":"P E Huppert,&nbsp;H Seboldt,&nbsp;S H Duda,&nbsp;U Helber,&nbsp;C D Claussen,&nbsp;H E Hoffmeister","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76788,"journal":{"name":"VASA. Supplementum","volume":"35 ","pages":"194-5"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12650294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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