UCLA forum in medical sciences最新文献

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Virological studies of amyotrophic lateral sclerosis: an overview. 肌萎缩性侧索硬化症的病毒学研究综述。
UCLA forum in medical sciences Pub Date : 1976-01-01
R T Johnson
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引用次数: 0
Lower motor neuron disease in wild mice caused by indigenous type C virus and search for a similar etiology in human amyotrophic lateral sclerosis. 由本地C型病毒引起的野生小鼠下运动神经元疾病,并在人类肌萎缩侧索硬化症中寻找类似的病因。
UCLA forum in medical sciences Pub Date : 1976-01-01
M B Gardner, S Rasheed, V Klement, R W Rongey, J C Brown, R Dworsky, B E Henderson
{"title":"Lower motor neuron disease in wild mice caused by indigenous type C virus and search for a similar etiology in human amyotrophic lateral sclerosis.","authors":"M B Gardner,&nbsp;S Rasheed,&nbsp;V Klement,&nbsp;R W Rongey,&nbsp;J C Brown,&nbsp;R Dworsky,&nbsp;B E Henderson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In certain genetically susceptible populations of wild mice a progressive motor neuron disease with a long latent period is caused by indigenous type C leukemia virus. Neuronal damage appears to be due primarily to a direct neurotropic effect of the virus and not to an immunogenic mechanism. The disease can be prevented by antiviral genetic means. Search for a similar virus in humans with ALS has been negative.</p>","PeriodicalId":76774,"journal":{"name":"UCLA forum in medical sciences","volume":" 19","pages":"217-34"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11408595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural substrate of protein synthesis and transport in spinal motor neurons. 脊髓运动神经元中蛋白质合成和转运的结构底物。
UCLA forum in medical sciences Pub Date : 1976-01-01
D L Price, J W Griffin
{"title":"Structural substrate of protein synthesis and transport in spinal motor neurons.","authors":"D L Price,&nbsp;J W Griffin","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76774,"journal":{"name":"UCLA forum in medical sciences","volume":" 19","pages":"1-32"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11288106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The control of motor nerve growth. 运动神经生长的控制。
UCLA forum in medical sciences Pub Date : 1976-01-01
L W Duchen
{"title":"The control of motor nerve growth.","authors":"L W Duchen","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76774,"journal":{"name":"UCLA forum in medical sciences","volume":" 19","pages":"69-85"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11408596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The physiology of alpha motoneurons and their synaptic input in relation to the problem of amyotrophic lateral sclerosis. 运动神经元的生理学及其突触输入与肌萎缩性侧索硬化症的关系。
UCLA forum in medical sciences Pub Date : 1976-01-01
R E Burke
{"title":"The physiology of alpha motoneurons and their synaptic input in relation to the problem of amyotrophic lateral sclerosis.","authors":"R E Burke","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76774,"journal":{"name":"UCLA forum in medical sciences","volume":" 19","pages":"119-33"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11238725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physiological properties of vertebrate nerve cells in tissue culture. 脊椎动物神经细胞在组织培养中的生理特性。
UCLA forum in medical sciences Pub Date : 1975-01-01 DOI: 10.1016/b978-0-12-139050-1.50011-2
M A Dichter
{"title":"Physiological properties of vertebrate nerve cells in tissue culture.","authors":"M A Dichter","doi":"10.1016/b978-0-12-139050-1.50011-2","DOIUrl":"https://doi.org/10.1016/b978-0-12-139050-1.50011-2","url":null,"abstract":"<p><p>Vertebrate neurons in tissue culture are providing us with a new model system for studying the complex events which occur during neuronal differentiation, synaptogenesis, and neural network formation. It is already apparent that dissociated embryo neurons are capable of differentiating both morphologically and physiologically along predetermined lines in the absence of external influences. These neurons can form new connections with one another but retain some specificity in their selections. Both simple and complex neural networks can be seen. At the present time, the development of the invitro model system is just being explored. The potential value of a system of this kind at a variety of investigative levels should be appreciated. Questions of a fundamental nature in neurobiology, such as how synapses form, what rules govern such interaction, how cells recognize one another, and the nature of the basic two-, three-, or four-cell circuits that comprise the more complex neurons tissue can be approached with this system. Studies of the neurons and synapses themselves can lead to a more basic understanding of vertebrate nervous system functioning. The development of certain pathophysiological processes and the effects of neuroactive drugs on vertebrate neurons may be studied at the cellular level. Finally, the basic mechanism of some genetic abnormalities which produce abnormal nervous structure and function may be more easily determined in a simplified in vitro model than in the intact central nervous system. The value of any model is not inherent in the elegance of the model itseld, but only in its ability to suggest answers to fundamental questions about the system being modeled. Many fundamental questions about brain mechanisms in mental retardation remain unanswered. Perhaps some day the model of nerve cells in tissue culture will bring us closer to the answers to these questions.</p>","PeriodicalId":76774,"journal":{"name":"UCLA forum in medical sciences","volume":" 18","pages":"101-14"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11391274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Studies on the molecular defect in galactosemia. 半乳糖血症分子缺陷的研究。
UCLA forum in medical sciences Pub Date : 1975-01-01 DOI: 10.1016/b978-0-12-139050-1.50034-3
T A Tedesco
{"title":"Studies on the molecular defect in galactosemia.","authors":"T A Tedesco","doi":"10.1016/b978-0-12-139050-1.50034-3","DOIUrl":"https://doi.org/10.1016/b978-0-12-139050-1.50034-3","url":null,"abstract":"<p><p>The galactose metabolic pathway and some of the consequences of deficient galactokinase or gal-1-P uridyltransferase activity have been discussed. The existence of CRM in transferase deficiency galactosemia is presented as evidence that this disease is the result of a structural gene mutation. The finding of both quantitative and qualitative variation in transferase CRM among different galactosemic patients argues that genetic heterogeneity exists within this group. Data supporting a Ping-Pong mechanism of action for human transferase reaction is proposed.</p>","PeriodicalId":76774,"journal":{"name":"UCLA forum in medical sciences","volume":" 18","pages":"467-77"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11391277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The futility of comparative IQ research. 比较智商研究的无用性。
UCLA forum in medical sciences Pub Date : 1975-01-01 DOI: 10.1016/b978-0-12-139050-1.50031-8
J Garcia
{"title":"The futility of comparative IQ research.","authors":"J Garcia","doi":"10.1016/b978-0-12-139050-1.50031-8","DOIUrl":"https://doi.org/10.1016/b978-0-12-139050-1.50031-8","url":null,"abstract":"","PeriodicalId":76774,"journal":{"name":"UCLA forum in medical sciences","volume":" 18","pages":"421-42"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11999518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Neurophysiological and anatomical interrelationships of the basal ganglia. 基底神经节的神经生理和解剖关系。
UCLA forum in medical sciences Pub Date : 1975-01-01 DOI: 10.1016/b978-0-12-139050-1.50017-3
N A Buchwald, C D Hull, M S Levine
{"title":"Neurophysiological and anatomical interrelationships of the basal ganglia.","authors":"N A Buchwald,&nbsp;C D Hull,&nbsp;M S Levine","doi":"10.1016/b978-0-12-139050-1.50017-3","DOIUrl":"https://doi.org/10.1016/b978-0-12-139050-1.50017-3","url":null,"abstract":"","PeriodicalId":76774,"journal":{"name":"UCLA forum in medical sciences","volume":" 18","pages":"187-203"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12284928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Discussion: Development of postsynaptic potentials recorded from immature neurons in kitten visual cortex. 讨论:幼猫视觉皮层未成熟神经元突触后电位的发展。
UCLA forum in medical sciences Pub Date : 1975-01-01 DOI: 10.1016/b978-0-12-139050-1.50016-1
C D Hull, D R Fuller
{"title":"Discussion: Development of postsynaptic potentials recorded from immature neurons in kitten visual cortex.","authors":"C D Hull,&nbsp;D R Fuller","doi":"10.1016/b978-0-12-139050-1.50016-1","DOIUrl":"https://doi.org/10.1016/b978-0-12-139050-1.50016-1","url":null,"abstract":"","PeriodicalId":76774,"journal":{"name":"UCLA forum in medical sciences","volume":" 18","pages":"179-84"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12376012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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