Society of General Physiologists series最新文献

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Regulatory interactions between calcium ATPases and phospholamban. 钙三磷酸腺苷酶与磷蛋白之间的调节相互作用。
D H MacLennan, T Toyofuku
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引用次数: 0
Myotonias due to CLC-1 chloride channel mutations. 由CLC-1氯离子通道突变引起的肌强直。
T J Jentsch, C Lorenz, M Pusch, K Steinmeyer
{"title":"Myotonias due to CLC-1 chloride channel mutations.","authors":"T J Jentsch, C Lorenz, M Pusch, K Steinmeyer","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76550,"journal":{"name":"Society of General Physiologists series","volume":"50 ","pages":"149-59"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18681367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment of cystic fibrosis based on understanding CFTR. 基于对CFTR的理解治疗囊性纤维化。
A E Smith
{"title":"Treatment of cystic fibrosis based on understanding CFTR.","authors":"A E Smith","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76550,"journal":{"name":"Society of General Physiologists series","volume":"50 ","pages":"139-47"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18681366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of the skeletal muscle ryanodine receptor (RYR1) gene in malignant hyperthermia and central core disease. 骨骼肌ryanodine受体(RYR1)基因在恶性高热和中枢核心疾病中的作用。
D H MacLennan, M S Phillips
{"title":"The role of the skeletal muscle ryanodine receptor (RYR1) gene in malignant hyperthermia and central core disease.","authors":"D H MacLennan, M S Phillips","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76550,"journal":{"name":"Society of General Physiologists series","volume":"50 ","pages":"89-100"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18681374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New potassium channel gene families in flies and mammals: from mutants to molecules. 苍蝇和哺乳动物的新钾通道基因家族:从突变体到分子。
B Ganetzky, J W Warmke, G Robertson, L Pallanck
{"title":"New potassium channel gene families in flies and mammals: from mutants to molecules.","authors":"B Ganetzky, J W Warmke, G Robertson, L Pallanck","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76550,"journal":{"name":"Society of General Physiologists series","volume":"50 ","pages":"29-39"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18681369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural models of Na+, Ca2+, and K+ channels. Na+, Ca2+和K+通道的结构模型。
H R Guy, S R Durell
{"title":"Structural models of Na+, Ca2+, and K+ channels.","authors":"H R Guy,&nbsp;S R Durell","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The structure determination of voltage-gated channels by the combination of molecular modeling and mutagenesis experiments is a long term, iterative process. As such, the models should be considered as a work in progress, with changes expected as more data becomes available. The primary role of the models is that they assimilate the known data and provide ideas for further experiments to elucidate the real structures. Although the models presented here have already gone through two or three cycles of development and testing, many aspects remain tentative. Perhaps the most significant result so far is that the P segment was experimentally confirmed to form the ion-selective part of the channel. In a subsequent cycle of testing and modeling, the specific residues responsibility for Na+ and Ca2+ selectivity have been identified and the selectivity filter of K+ channels is now predicted to be formed by the side chains, but rather by the carbonyl oxygens of the conserved Gly-Tyr-Gly sequence backbone. As another example, the 9p residue of the P segment of K+ channels was originally modeled as either being buried in the protein or accessible channels was originally modeled as either being buried in the protein or accessible from inside the cell only. However, once mutation of this residue to histidine was found to affect blockade by extracellular TEA, protons, Zn2+ and histidine reagents (DeBiasi et al., 1993), the models were updated to have this and the hydrophilic residues in the first part of P form a helix that comprises part of the extracellular, outer vestibular of the pore. While this motif was used also for Na+ and Ca2+ pore models (see Fig. 2) where the putative helices are amphipathic, it remains to be verified. Modeling of the size and shape of the outer vestibule of K+ channels was also aided by the data for the binding of CTX in the extracellular entrance to the pore. Similarly, experiments with peptide toxins such as mu and omega conotoxins may prove useful in modeling the outer vestibules of the Na+ and/or Ca2+ channels. While important advances have been made, it is important to realize that these approaches are still very new. In the future we are likely to see improvements on both the theoretical and experimental sides which will greatly advance the process.(ABSTRACT TRUNCATED AT 400 WORDS)</p>","PeriodicalId":76550,"journal":{"name":"Society of General Physiologists series","volume":"50 ","pages":"1-16"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18679438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nucleotide domains in transport ATPases: structure-function and relationship to disease. 转运三磷酸腺苷酶的核苷酸结构域:结构-功能及其与疾病的关系。
P J Thomas, Y H Ko, P Shenbagamurthi, P L Pedersen
{"title":"Nucleotide domains in transport ATPases: structure-function and relationship to disease.","authors":"P J Thomas,&nbsp;Y H Ko,&nbsp;P Shenbagamurthi,&nbsp;P L Pedersen","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76550,"journal":{"name":"Society of General Physiologists series","volume":"50 ","pages":"17-28"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18681368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlating ion channels with disease using genetic linkage analysis. 利用遗传连锁分析将离子通道与疾病联系起来。
G R Cutting
{"title":"Correlating ion channels with disease using genetic linkage analysis.","authors":"G R Cutting","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76550,"journal":{"name":"Society of General Physiologists series","volume":"50 ","pages":"161-8"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18551906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Muscular dysgenesis the role of calcium channels in muscle development. 肌肉发育不良:钙通道在肌肉发育中的作用。
N Chaudhari
{"title":"Muscular dysgenesis the role of calcium channels in muscle development.","authors":"N Chaudhari","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76550,"journal":{"name":"Society of General Physiologists series","volume":"50 ","pages":"115-23"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18679440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sodium channel mutations and disorders of excitation in human skeletal muscle. 人骨骼肌钠通道突变和兴奋障碍。
S Ji, A L George, R Horn, R L Barchi
{"title":"Sodium channel mutations and disorders of excitation in human skeletal muscle.","authors":"S Ji,&nbsp;A L George,&nbsp;R Horn,&nbsp;R L Barchi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76550,"journal":{"name":"Society of General Physiologists series","volume":"50 ","pages":"61-76"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18681372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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