A Baculard, G Morgant, C Gaultier, M Boule, G Tournier
{"title":"[Sustained-action oral theophylline in the asthmatic child. Clinical, pharmacokinetic and respiratory function studies].","authors":"A Baculard, G Morgant, C Gaultier, M Boule, G Tournier","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Twenty children aged between 5 and 16 suffering from severe asthma were treated with long acting oral theophylline. The minimum duration of treatment was three months and the maximum 12 months. Clinical, pharmacokinetic and pulmonary function studies were made. With a mean dose of 8.75 mg/kg, morning and evening, the theophylline blood levels on the 4th day of treatment (4 hours after the morning dose) were 12.3 +/- 4.36 mg/l. Those taken 4 hours after the evening dose 9.41 +/- 3.75 mg/l, suggesting a circadian rhythm for theophylline blood levels. The importance if fever is stressed in relationship to blood levels, which were increased by 67-100% with fevers of 38.5-39 degrees C. Treatment was very beneficial in 53% of cases. Respiratory function studies were performed in 13 children. After 4 days of treatment there was a significant decrease in airflow obstruction and hypoxemia However, despite carefully adjusted treatment, functional disturbances persisted, in particular hyperinflation.</p>","PeriodicalId":76480,"journal":{"name":"Revue francaise des maladies respiratoires","volume":"11 6","pages":"833-46"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17724365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[The cell populations of the lower lung and their response to stress. Interrelations between cells and secretions of inflammation mediators in the distal air spaces].","authors":"P Godard, J Clot, F B Michel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Broncho-alveolar cells (BAC) act as defence means in the lower respiratory tract and acinus; equally they determine the evolution of inflammatory phenomena, whatsoever its cause. Alveolar macrophages (AM) play an important role in the regulation of the immune response and presentation of antigen to lymphocytes. In the alveolar microclimate AM exert a suppressor effect. AM can be equally considered as true inflammatory cells, either through their own mediators or through the skewed pattern of cellular recruitment. Among these cells polymorphonuclear cells and eosinophils, present in small numbers in broncho-alveolar lavage (BAL) may be encountered in a number of pathological conditions. Finally, free mast cells probably play an important role in the induction of the inflammatory reaction in the distal air spaces.</p>","PeriodicalId":76480,"journal":{"name":"Revue francaise des maladies respiratoires","volume":"11 4","pages":"275-84"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17470348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[French Society of Tuberculosis and Respiratory Diseases. Membership list (1983)].","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76480,"journal":{"name":"Revue francaise des maladies respiratoires","volume":"11 2 Suppl","pages":"1-35"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17405729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Short-term chemotherapy of tuberculosis. Cooperative French trial].","authors":"S Pretet","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A cooperative french trial in the treatment of pulmonary tuberculosis has compared the efficacy and the tolerance of daily antituberculous regimes, one of short duration of 18 weeks (HRSZ/HRZ), the other of standard duration of 9 months (HRE). Of 204 patients included in the trial 180 were analysed. No significant difference was found between the two regimes regarding either biological tolerance or clinical outcome. Four relapses were seen within 24 months of the onset of treatment, two in each regime, which shows that 18 weeks treatment is ethically acceptable. Such short course therapy is useful in those patients who would sometimes find prolonged therapy difficult or would be likely to abandon treatment prematurely.</p>","PeriodicalId":76480,"journal":{"name":"Revue francaise des maladies respiratoires","volume":"11 6","pages":"859-66"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17426393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Resistance of the Koch bacillus to antibacillary agents in the Department of the Lower Rhine].","authors":"J Cooreman, G Burghard, J Grosset","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The aim of this work was to study drug resistance of M. tuberculosis to Streptomycin (SM), Isoniazid (INH), Ethambutol (EMB) and Rifampicin (RMP) in the department of the Bas-Rhin from 1971 to 1978. On 2,995 original culture plates which were positive, 1,561 antibiograms were performed at the C.E.R.P. The proportion of those tested has increased over the years from 27.8% in 1971 to 80.6% in 1978 because of the increasing number of laboratories participating in the study. The research is based on 1,511 cultures of M. tuberculosis and the population was split into two groups: 1,386 untreated subjects or treated for less than 15 days (primary resistance) and 125 subjects who had already been treated (acquired resistance). Over all the years, primary resistance to at least one drug was 6.9%. Primary resistance to SM was 3.0%, to INH 2.2% and to both 1.4% (the levels of primary resistance to EMB and RMP were practically nil). Acquired resistance to at least one of these antibiotics was 16.0% with the same order as for primary resistance: resistance to SM alone = 7.2%, to INH alone 4.0% and both together 2.4%. The proportions were greater than for primary resistance but concerned fewer subjects as only 8% of the population had been previously treated. There were no cases of primary or acquired resistance to Rifampicin alone.</p>","PeriodicalId":76480,"journal":{"name":"Revue francaise des maladies respiratoires","volume":"11 5","pages":"699-704"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17479084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Current progress and new or unrecognized risks in occupational respiratory pathology. Pneumoconiosis in coal miners. Epidemiologic and experimental approach].","authors":"C Amoudru","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In a brief historical review the author shows that the delayed recognition of coal miners pneumoconiosis as an independent nosological entity was mainly due to an insufficiently experimentally orientated approach before 1940. The principal characteristics of the french endemic are described: a slow decline in incidence yet a continued elevated prevalence, due to the increased life span of the sufferers; the late appearance of the first radiological manifestations, most often after the working life of a Miner; a disparity of the endemic levels between mining regions without the reasons being fully elucidated. Finally the principal lines of current research are recalled which take account of new data on epidemiology and modern dust analysis processes as well as information collected in man using recent biological techniques.</p>","PeriodicalId":76480,"journal":{"name":"Revue francaise des maladies respiratoires","volume":"11 4","pages":"355-70"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17659710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E Chailleux, D Dupas, C Geraut, C Moigneteau, R Pariente
{"title":"[Respiratory pathology of isocyanates].","authors":"E Chailleux, D Dupas, C Geraut, C Moigneteau, R Pariente","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Isocyanates are chemical compounds used in making polyurethane (for flexible or rigid foam, paint, varnish, glue and textiles). In strong concentrations isocyanates are powerful irritants producing chemical bronchopulmonary lesions. In weak doses they are responsible for occupational asthma and more rarely allergic alveolitis. Long term exposure to isocyanates may produce a deterioration in pulmonary function in asymptomatic patients. The pathophysiology of isocyanate asthma remains uncertain: immunological data remains contradictory while isocyanates have been shown to have a Betablocking effect. The maximum allowable concentration in the working environment, at present proposed in the U.S.A. is 0.005 ppm.</p>","PeriodicalId":76480,"journal":{"name":"Revue francaise des maladies respiratoires","volume":"11 5","pages":"635-44"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17712783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Problems posed by tuberculosis in the world in 1982].","authors":"P Chaulet, N A Khaled, R Amrane","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>One hundred years after the discovery of the tubercle bacillus the struggle against tuberculosis still poses numerous problems on a world scale. Each year, 10 million new cases appear: nearly five million are highly contagious; 95% of these cases come from developing countries. The official notification system currently in force is imperfect but a reckoning of the annual infection risk, from a methodical enquiry into tuberculous disease gives exact information on the size of the problem and its evolutionary time scale in each country. This is the best epidemiological index currently available. The technical problems of the struggle against tubercle are resolved in theory: the selective detection of groups at risk, centered on a network of bacteriology laboratories enables identification of all the sources of infection; chemotherapy, becoming safer and safer, with a duration reduced to 6 or 9 months at the maximum and curing practically 100% of the patients; properly performed BCG vaccination reduces the risk of infantile tuberculosis. Operational problems remain the most serious. The greatest difficulties are seen in countries with the highest prevalence: they are linked to a global shortage of resources but also at times a poor utilisation of the resources available. A concerted international action could render antituberculous drugs and the appropriate sanitary technology to all countries. With a judicious use of available information and means each country could today achieve an effective national antituberculous programme.</p>","PeriodicalId":76480,"journal":{"name":"Revue francaise des maladies respiratoires","volume":"11 2","pages":"79-110"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17907859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Technics and results in respiratory kinesitherapy of chronic obstructive bronchopneumopathies].","authors":"M Gimenez","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The rehabilitation of patients with chronic airflow obstruction consists of a number of complementary treatments, one of which is respiratory physiotherapy (KR). Breathing exercises (RE), bronchial drainage and controlled coughing are all part of current techniques in physiotherapy. As problems with the rhythm of breathing are frequently encountered in patients with chronic pulmonary disease, their correction is attempted with KR. In order to acquire a new, more efficient breathing pattern, training in simple every day measures is used (such as talking, reading watching TV, walking, climbing stairs, etc.) or techniques using mechanical devices, including inventive spirometers and magnetometers. With a few exceptions, most of the studies show an immediate objective benefit on blood gases and alveolar ventilation, due to a reduced respiratory rate and increased tidal volume. Although dynamic ventilatory work increases, neither the pulmonary haemodynamics nor energy expenditure are altered as judged by oxygen consumption during RE. The long term results are contradictory and more difficult to interpret. Many studies have noted a clinical and functional improvement with fewer relapses and hospital admissions; these studies often lack adequate controls and the clinical state is not always precisely defined; nor whether associated therapy has been changed or not. Other studies have given negative results, and lately the causes of these failures have been better defined. There is insufficient theoretical and practical training of KR at all medical levels, an absence of uniformity in the KR rehabilitation teams, and treatment courses which are both too few in number and too short in duration. An appreciation of these points of criticism should make for greater objectivity in the future analysis of pulmonary rehabilitation.</p>","PeriodicalId":76480,"journal":{"name":"Revue francaise des maladies respiratoires","volume":"11 4","pages":"525-43"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17929664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}