Revue francaise des maladies respiratoires最新文献_第3页

[Markers of lymphocyte activation in interstitial pulmonary disease]. [间质性肺疾病淋巴细胞活化的标志物]。

Revue francaise des maladies respiratoires Pub Date : 1983-01-01

J F Mornex, G Cordier, J P Revillard

{"title":"[Markers of lymphocyte activation in interstitial pulmonary disease].","authors":"J F Mornex, G Cordier, J P Revillard","doi":"","DOIUrl":"","url":null,"abstract":"A lymphocytic alveolitis is a common stage in a number of types of interstitial pneumonia where the lymphocytes accumulate in the alveoli and play a major pathogenic role by the regulation or activation of the inflammatory reaction, controlling the outcome either to healing, chronicity or fibrosis. A study of lymphocytes obtained by broncho-alveolar lavage enables the study of different parameters whose functional value is discussed from information derived form in vitro models. These models show the need for activating signals acting in a sequential manner on cells whose function and mode of response are remarkably varied. Three successive phases may be defined during activation: first a \"membrane\" stage with changes in the lipid (in the metabolism of arachidonic acid) and kinetic framework, a second phase corresponds to the beginning of \"blastic transformation\" with the production of lymphocytes, an increase in the protein content and RNA (phase G1), then a third stage of DNA synthesis (phase S-G2) preceding cell division; it is necessary to have new markers of differentiation. The joint study of the phases of cell cycles and the antigenic expression of differentiation, identified by monoclonal antibodies within a heterogeneous population nowadays benefit from techniques of cytofluorimetry. The methods combined with a measure of mediators produced (interleukins) or the non-specific markers of activation by macrophages ought to lead to a definition of initial stages of the clinical immunology of alveolitis. Finally these methods permit the development of cellular immunopharmacology which to open the possibilities of new forms of treatment.","PeriodicalId":76480,"journal":{"name":"Revue francaise des maladies respiratoires","volume":"11 4","pages":"293-300"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17257062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Value of determining plasma INH during antitubercular treatment. Retrospective analysis of 204 cases]. 血浆INH测定在抗结核治疗中的价值。204例回顾性分析]。

Revue francaise des maladies respiratoires Pub Date : 1983-01-01

J C Cheminat, M Paire, J Lavarenne, C Ducarrouge, C Molina

{"title":"[Value of determining plasma INH during antitubercular treatment. Retrospective analysis of 204 cases].","authors":"J C Cheminat, M Paire, J Lavarenne, C Ducarrouge, C Molina","doi":"","DOIUrl":"","url":null,"abstract":"The acetylator phenotype of 204 tuberculous patients was assessed (152 men and 52 women aged between 15 and 90). The INH dose was adjusted according to Vivien's protocol, measuring the index of inactivation of Isoniazid I3, three hours after the oral dose. In fixing the transition zone of I3 at 0.50 the distribution between slow and rapid acetylators was 53% and 47% respectively. There was no difference for sex, age or ethnic group. The dosage used according to this protocol varied greatly, going from 1.64 mg/kg/day to 13.3 mg/kg/day with a mean value of 2.74 mg/kg/day for slow acetylators and 6.13 mg/kg/day for rapid acetylators. The usual dose advised is 5 mg/kg/day, which may lead equally to over or under treatment though the former is more likely in our experience. Adjusting the dosage is an important feature in good tolerance of the treatment: indeed only 4 of 86 subjects whose dosage has been adjusted showed elevated transaminases, whereas 34 of 118 patients had raised transaminases in the control group on a standard dose before the adjusted treatment was introduced. The difference was significant between the two groups.","PeriodicalId":76480,"journal":{"name":"Revue francaise des maladies respiratoires","volume":"11 6","pages":"867-73"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17724366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Endocavitary drainage (Monaldi's technic) in the treatment of pulmonary abscess]. [腔内引流术治疗肺脓肿]。

Revue francaise des maladies respiratoires Pub Date : 1983-01-01

J Vergeret, P Dabadie, M Dupon, P Maurette, A Taytard, R Chevais

{"title":"[Endocavitary drainage (Monaldi's technic) in the treatment of pulmonary abscess].","authors":"J Vergeret, P Dabadie, M Dupon, P Maurette, A Taytard, R Chevais","doi":"","DOIUrl":"","url":null,"abstract":"The technique of intracavitary aspiration introduced by Monaldi in 1938 in the treatment of tuberculous cavities and then applied by him in the treatment of lung abscesses was forgotten for nearly 30 years. The advent of antibiotics and their success explain its abandonment. It may take an important place again in the treatment of difficult cases, as a last resort, after failure of properly conducted classical medical treatment. A study of 20 hospitalised patients in an intensive care unit presenting with severe pulmonary abscesses demonstrates this point. After recalling the causes, the therapeutic difficulties and the complications of these abscesses, the authors describe the medications, the method of endocavitary drainage and the technical problems posed by its use in patients often artificially ventilated. The absence of any major dangers inherent in using this technique is also discussed. Finally the short (one month) and long term (20 months) results were analysed. Three deaths occurred during the initial period, although largely explained by associated lesions in these patients. The other 17 patients, of whom 11 were followed up for more than six months, had a satisfactory outcome from the respiratory stand-point. The disappearance of all signs of infection was constantly obtained and in only four patients the bullous cavities persisted. The authors conclude by attesting the efficacy of the technique and its low risk often in the most critically ill patients.","PeriodicalId":76480,"journal":{"name":"Revue francaise des maladies respiratoires","volume":"11 3","pages":"201-7"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17927712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Long-term prognosis of chronic bronchitis following the first episode of acute respiratory decompensation]. 慢性支气管炎首次急性呼吸失代偿发作后的长期预后。

Revue francaise des maladies respiratoires Pub Date : 1983-01-01

M Gaertner, N Chau, E Ludwiczak, J M Polu, P Sadoul

引用次数: 0

[Chronic respiratory insufficiency in children]. [儿童慢性呼吸功能不全]。

Revue francaise des maladies respiratoires Pub Date : 1983-01-01

C Gaultier

引用次数: 0

[Why, when and how to treat sarcoidosis?]. [为什么，何时以及如何治疗结节病?]

Revue francaise des maladies respiratoires Pub Date : 1983-01-01

G Huchon