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Progress in biochemical pharmacology最新文献

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Relation between coronary heart disease and certain elements in water and diet. 冠心病与水和饮食中某些元素的关系。
Progress in biochemical pharmacology Pub Date : 1983-01-01
E Lanzola, G Turconi, M Allegrini, R de Marco, A Marinoni, P Miracca
{"title":"Relation between coronary heart disease and certain elements in water and diet.","authors":"E Lanzola, G Turconi, M Allegrini, R de Marco, A Marinoni, P Miracca","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76365,"journal":{"name":"Progress in biochemical pharmacology","volume":"19 ","pages":"80-8"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17880581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fetal alcohol syndrome. 胎儿酒精综合症。
Progress in biochemical pharmacology Pub Date : 1981-01-01
S K Varma, B B Sharma
{"title":"Fetal alcohol syndrome.","authors":"S K Varma, B B Sharma","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76365,"journal":{"name":"Progress in biochemical pharmacology","volume":"18 ","pages":"122-9"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18079273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alcoholism and reproduction. 酗酒和繁殖
Progress in biochemical pharmacology Pub Date : 1981-01-01
M W Heine
{"title":"Alcoholism and reproduction.","authors":"M W Heine","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A brief overview of the reproductive capacities of both men and women in alcoholism is presented. A historical evaluation indicates a resurgence of interest in this area. The effect of chronic alcohol consumption on both male fertility and potency is reported in conjunction with alcohol-mediated effects on the female subject. Emphasis is placed on pharmacokinetics, metabolism and drinking behavior of the alcoholic female. The adverse actions of some therapeutic drugs and chronic alcohol consumption is discussed in relationship to fetal alcohol syndrome and the accompanied mental and somatic abnormalities.</p>","PeriodicalId":76365,"journal":{"name":"Progress in biochemical pharmacology","volume":"18 ","pages":"75-82"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18079277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alcohol and the hypothalamus. 酒精和下丘脑
Progress in biochemical pharmacology Pub Date : 1981-01-01
L W Greene, C S Hollander
{"title":"Alcohol and the hypothalamus.","authors":"L W Greene,&nbsp;C S Hollander","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76365,"journal":{"name":"Progress in biochemical pharmacology","volume":"18 ","pages":"15-23"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17185286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fetal malnutrition: a possible cause of the fetal alcohol syndrome. 胎儿营养不良:胎儿酒精综合征的一个可能原因。
Progress in biochemical pharmacology Pub Date : 1981-01-01
G W Lin
{"title":"Fetal malnutrition: a possible cause of the fetal alcohol syndrome.","authors":"G W Lin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effects of ethanol ingestion during pregnancy on total folate levels in fetal tissues and on the concentrations of free amino acids in fetal and maternal plasma were examined in the rat. No differences were observed between the ethanol-fed and the control groups in total folates in fetal brain and liver. However, the concentration of fetal plasma histidine was reduced by 50% as a result of maternal ethanol consumption; the maternal plasma histidine level was not affected. It is suggested that fetal malnutrition in an essential amino acid, histidine, could impair fetal protein synthesis producing the fetal alcohol syndrome.</p>","PeriodicalId":76365,"journal":{"name":"Progress in biochemical pharmacology","volume":"18 ","pages":"115-21"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18324906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epididymal aldehyde dehydrogenase: a pharmacologic profile. 附睾醛脱氢酶:药理学特征。
Progress in biochemical pharmacology Pub Date : 1981-01-01
F S Messiha
{"title":"Epididymal aldehyde dehydrogenase: a pharmacologic profile.","authors":"F S Messiha","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The in vivo effect of various agents, with different pharmacologic properties, on cytosolic EP-ALDH was studied in the rat. Injection of a large dose of PYZ inhibited EP-ALDH 16 h after the injection. Short-term administration of a moderate daily dosage of PYZ also inhibited endogenous EP-ALDH from saline controls. Semichronic administration of a small daily dosage of DIS resulted in inhibition of EP-ALDH. Short-term administration of drugs with various pharmacologic profile produced little change in the specific activity of EP-ALDH. This is compared with an induction and an inhibition of T-ALDH as a function of treatment with an antiandrogen and an estrogenic drug, respectively. The results show lack of response of EP-ALDH towards pharmacologic intervention which may imply certain specificity for EP-ALDH.</p>","PeriodicalId":76365,"journal":{"name":"Progress in biochemical pharmacology","volume":"18 ","pages":"167-78"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18324907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subcellular fractionation of alcohol and aldehyde dehydrogenase in the rat testicles. 大鼠睾丸中乙醇和醛脱氢酶的亚细胞分离。
Progress in biochemical pharmacology Pub Date : 1981-01-01
F S Messiha
{"title":"Subcellular fractionation of alcohol and aldehyde dehydrogenase in the rat testicles.","authors":"F S Messiha","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The subcellular distribution of the enzymes primarily involved in the metabolism of ethanol and acetaldehyde were made in the rat testis and in the epididymis. The enzymes measured were alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). They were NAD-dependent, temperature sensitive and displaying maximal activity in the presence of pyrophosphate buffer at pH 9.8. Both enzymes were readily measurable in the 10% (w/v) testicular and epididymal homogenates. The ADH activity was mainly localized in the nuclear and in the cytosolic fractions of the testis compared to the absence of measurable ADH activity in the epididymis. Testicular ALDH was measurable in all subcellular preparations, i.e. in the nuclear, in the mitochondrial, in the cytosolic and in the microsomal fractions. Maximal testicular ALDH activity was determined in both the nuclear and the cytosolic components compared to a lower microsomal ALDH activity. Determination of Km shows that cytosolic ALDH possesses the lowest apparent Km as contrasted with a high value for the mitochondrial ALDH. Testicular cytosolic ADH but not ALDH was noncompetitively inhibited by 3-methoxytyramine, histamine and d-amphetamine in vitro.</p>","PeriodicalId":76365,"journal":{"name":"Progress in biochemical pharmacology","volume":"18 ","pages":"155-66"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18079275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of sex steroids on ethanol pharmacokinetics and autonomic reactivity. 性类固醇对乙醇药代动力学和自主反应性的影响。
Progress in biochemical pharmacology Pub Date : 1981-01-01
A R Zeiner, P S Kegg
{"title":"Effects of sex steroids on ethanol pharmacokinetics and autonomic reactivity.","authors":"A R Zeiner,&nbsp;P S Kegg","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Several lines of evidence indicate that female sex steroids, especially estrogen, interact with ethanol pharmacokinetics. Both animal and human studies are consistent in indicating that voluntary intake of alcohol decreases with increasing estrogen concentrations. Such effects are equivocal with progesterone and nonexistent with testosterone. There is some suggestion that estrogen modulates monoamine oxidase activity and via that mechanism alters sympathetic nervous system tone. Alterations in sympathetic nervous system tone, in turn, can alter gastric motility and absorption of alcohol from stomach and intestines. Several types of studies, both animal and human, indicate that high estrogen concentrations also impair ethanol metabolism. At present the exact mechanism of action for this effect is not known. Future studies investigating this aspect are indicated. At present the effect of sex steroids on performance and its interaction with alcohol do not show a clear relationship. There are contrary pieces of information both for and against the view that menstrual cycle, performance and alcohol interact.</p>","PeriodicalId":76365,"journal":{"name":"Progress in biochemical pharmacology","volume":"18 ","pages":"130-42"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18079274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prenatal effects of beverage alcohol on fetal growth. 饮料酒精对胎儿生长的产前影响。
Progress in biochemical pharmacology Pub Date : 1981-01-01
E L Abel
{"title":"Prenatal effects of beverage alcohol on fetal growth.","authors":"E L Abel","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76365,"journal":{"name":"Progress in biochemical pharmacology","volume":"18 ","pages":"111-4"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18324905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of ethanol on spontaneous and stimulated growth hormone secretion. 乙醇对自发和刺激生长激素分泌的影响。
Progress in biochemical pharmacology Pub Date : 1981-01-01
G P Redmond
{"title":"Effect of ethanol on spontaneous and stimulated growth hormone secretion.","authors":"G P Redmond","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Growth hormone (GH) regulates not only somatic growth but also carbohydrate, protein and lipid metabolism. Altered secretory states resulting from alcohol use could have pathogenetic significance. The pattern of spontaneous GH secretion in man is reviewed and previously published human studies on ethanol and GH examined to develop a coherent formulation of the nature of ethanol effects on GH secretion. The weight of the evidence suggests that ethanol suppresses GH secretion. Studies using the rat indicates that the dose-response relationship is of a threshold nature, with doses of 3 g/kg or greater abolishing spontaneous secretion. The possible role of diminished GH secretion in the pathogenesis of the fetal alcohol syndrome is discussed.</p>","PeriodicalId":76365,"journal":{"name":"Progress in biochemical pharmacology","volume":"18 ","pages":"58-74"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17336886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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