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Effects of hippocampal lesions on ethanol intake in mice. 小鼠海马损伤对乙醇摄入的影响。
Progress in biochemical pharmacology Pub Date : 1981-01-01
J N Pasley, E W Powell
{"title":"Effects of hippocampal lesions on ethanol intake in mice.","authors":"J N Pasley,&nbsp;E W Powell","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effects of bilateral electrolytic hippocampal lesions on voluntary ethanol selection were examined in five groups (n = 10 each) of male mice. Mice sustained lesions in the dorsal hippocampus (DH), central hippocampus (CH), ventral hippocampus (VH), were sham-operated (SH) or left unoperated. CH mice exhibited a preference for ethanol compared with all other groups (p less than 0.01). In a second experiment, ethanol preference threshold and 24-hour drinking patterns were examined in CH and SH mice. These data revealed a higher preference threshold in CH mice, but not difference in drinking activity periods compared with controls. The central hippocampal area may be important in ethanol ingestive behavior in mice.</p>","PeriodicalId":76365,"journal":{"name":"Progress in biochemical pharmacology","volume":"18 ","pages":"196-204"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18213478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of ethanol on spontaneous and stimulated growth hormone secretion. 乙醇对自发和刺激生长激素分泌的影响。
Progress in biochemical pharmacology Pub Date : 1981-01-01
G P Redmond
{"title":"Effect of ethanol on spontaneous and stimulated growth hormone secretion.","authors":"G P Redmond","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Growth hormone (GH) regulates not only somatic growth but also carbohydrate, protein and lipid metabolism. Altered secretory states resulting from alcohol use could have pathogenetic significance. The pattern of spontaneous GH secretion in man is reviewed and previously published human studies on ethanol and GH examined to develop a coherent formulation of the nature of ethanol effects on GH secretion. The weight of the evidence suggests that ethanol suppresses GH secretion. Studies using the rat indicates that the dose-response relationship is of a threshold nature, with doses of 3 g/kg or greater abolishing spontaneous secretion. The possible role of diminished GH secretion in the pathogenesis of the fetal alcohol syndrome is discussed.</p>","PeriodicalId":76365,"journal":{"name":"Progress in biochemical pharmacology","volume":"18 ","pages":"58-74"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17336886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Voluntary ethanol consumption by female offspring from alcoholic and control Sinclair (S-1) miniature dams. 酒精和对照辛克莱(S-1)微型水坝雌性后代的自愿乙醇消耗。
Progress in biochemical pharmacology Pub Date : 1981-01-01
M E Tumbleson, J D Dexter, C C Middleton
{"title":"Voluntary ethanol consumption by female offspring from alcoholic and control Sinclair (S-1) miniature dams.","authors":"M E Tumbleson,&nbsp;J D Dexter,&nbsp;C C Middleton","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76365,"journal":{"name":"Progress in biochemical pharmacology","volume":"18 ","pages":"179-89"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18213476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Marihuana and alcohol: perinatal effects on development of male reproductive functions in mice. 大麻和酒精:围产期对小鼠雄性生殖功能发育的影响。
Progress in biochemical pharmacology Pub Date : 1981-01-01
S Dalterio, A Bartke, K Blum, C Sweeney
{"title":"Marihuana and alcohol: perinatal effects on development of male reproductive functions in mice.","authors":"S Dalterio,&nbsp;A Bartke,&nbsp;K Blum,&nbsp;C Sweeney","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Marihuana and alcohol have been reported to exert a wide range of effects on reproductive functions in man and laboratory animals. Decreased testosterone levels, suppression of pituitary gonadotropin release, impaired fertility and sexual dysfunction have been observed in adult males exposed to either of these substances. The present studies examined the effects of perinatal exposure to ETOH and THC alone or in combination on the development or reproductive functions in mice. Testes weights and plasma testosterone levels were reduced in adult males perinatally exposed to these substances, alone or in combination. Seminal vesicle weights were reduced only in the THC-exposed mice, while kidney weights were decreased by either ETOH or THC exposure. In ETOH plus THC-exposed animals, plasma LH was reduced while FSH levels were increased. In response to castration, gonadotropin levels were elevated in mice perinatally exposed to THC. In vitro responsiveness to gonadotropin stimulation, as indicated by testosterone production by decapsulated testes, was significantly inhibited in tissue obtained from ETOH-exposed males. Although no simple interactions were observed, it is evident that THC and ETOH, either alone or in combination, can affect the development of male reproductive functions in mice.</p>","PeriodicalId":76365,"journal":{"name":"Progress in biochemical pharmacology","volume":"18 ","pages":"143-54"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17336250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Voluntary ethanol consumption, as a function of estrus, in adult Sinclair (S-1) miniature sows. 成年辛克莱(S-1)微型母猪的自愿酒精消耗，作为发情的功能。
Progress in biochemical pharmacology Pub Date : 1981-01-01
M E Tumbleson, J D Dexter, P Van Cleve
{"title":"Voluntary ethanol consumption, as a function of estrus, in adult Sinclair (S-1) miniature sows.","authors":"M E Tumbleson,&nbsp;J D Dexter,&nbsp;P Van Cleve","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76365,"journal":{"name":"Progress in biochemical pharmacology","volume":"18 ","pages":"190-5"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18213477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endocrinological aspects of alcoholism. 酒精中毒的内分泌方面。
Progress in biochemical pharmacology Pub Date : 1981-01-01
{"title":"Endocrinological aspects of alcoholism.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76365,"journal":{"name":"Progress in biochemical pharmacology","volume":"18 ","pages":"1-232"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18324904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hypothalamic-pituitary-gonadal function in liver disease. 肝病的下丘脑-垂体-性腺功能。
Progress in biochemical pharmacology Pub Date : 1981-01-01
D H Van Thiel
{"title":"Hypothalamic-pituitary-gonadal function in liver disease.","authors":"D H Van Thiel","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76365,"journal":{"name":"Progress in biochemical pharmacology","volume":"18 ","pages":"24-34"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18324910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroendocrinological implications of alcoholism. 酒精中毒的神经内分泌影响
Progress in biochemical pharmacology Pub Date : 1981-01-01
A K Rawat
{"title":"Neuroendocrinological implications of alcoholism.","authors":"A K Rawat","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76365,"journal":{"name":"Progress in biochemical pharmacology","volume":"18 ","pages":"35-57"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17185287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute and chronic effects of maternal ethanol administration on the ovine maternal-fetal unit. 母体乙醇给药对羊母胎单位的急性和慢性影响。
Progress in biochemical pharmacology Pub Date : 1981-01-01
J C Rose, J W Strandhoy, P J Meis
{"title":"Acute and chronic effects of maternal ethanol administration on the ovine maternal-fetal unit.","authors":"J C Rose,&nbsp;J W Strandhoy,&nbsp;P J Meis","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The purpose of this study was to examine, in the pregnant ewe and its fetus, some of the physiological consequences of acute and chronic ethanol exposure. Ethanol was infused intravenously (2 g/kg/day over 2 h) to pregnant ewes from day 100 of pregnancy to term. Control animals received isocaloric infusions of 5% dextrose. Animals were pair-fed and allowed water ad lib. Maternal (n = 5) systolic, diastolic, and mean blood pressures and heart rate rose significantly by 1 h after starting ethanol, whereas fetal (n = 4) blood pressure and heart rate did not change during ethanol infusion. Maternal ethanol infusion produced a significant rise (p less than 0.01) in both fetal (n = 8) and maternal (n = 10) plasma cortisol levels. Peak blood ethanol concentration was significantly higher in the ewe (240 +/- 6 mg.dl-1, n = 7) than in the fetus (190 +/- 9 mg.dl-1, n = 6) at the end of the 2-hour infusion. Maternal rate of elimination after ethanol infusion was terminated was 40 mg.dl-1 per hour, while fetal elimination was 10 mg.dl-1 per hour. Body weights and crown-rump lengths of fetuses from 0.82 to 1.0 gestation were significantly less in ethanol-treated animals than in age-matched control animals. Fetal plasma thyroxine and triiodothyronine increments following thyrotrophin-releasing hormone administration were significantly less in alcohol-treated than in control animals. Thus, chronic exposure to ethanol during the latter part of gestation impaired fetal growth and altered fetal endocrine function in these animals.</p>","PeriodicalId":76365,"journal":{"name":"Progress in biochemical pharmacology","volume":"18 ","pages":"1-14"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17849864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroendocrine effects of fetal alcohol exposure. 胎儿酒精暴露对神经内分泌的影响。
Progress in biochemical pharmacology Pub Date : 1981-01-01
A N Taylor, B J Branch, N Kokka
{"title":"Neuroendocrine effects of fetal alcohol exposure.","authors":"A N Taylor,&nbsp;B J Branch,&nbsp;N Kokka","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>While the actions of alcohol on endocrine function in adults are well-documented, the effects of fetal exposure to alcohol on neuroendocrine function in neonates and adults are only beginning to be investigated. Recent reports are reviewed which demonstrate effects of fetal alcohol exposure on pituitary-adrenal function, GH secretion, thyroxine levels and sexual differentiation in newborn rodents. Our studies of the long-term effects of fetal and early postnatal exposure to alcohol on pituitary-adrenal and body temperature responses to a challenge dose of ethanol in adult rats are described. Both responses are enhanced in prenatally, but not in postnatally exposed rats, indicating that the effects of fetal alcohol exposure on physiological systems, such as the endocrine and thermoregulatory systems, persist to adulthood. Based on apparent similarities in the somatic and cerebral deficits which occur following fetal alcohol exposure and neonatal corticosteroid treatment, a hypothesis is developed for the role of alcohol-induced activation of the HPA axis during gestation in the adverse effects of fetal alcohol exposure.</p>","PeriodicalId":76365,"journal":{"name":"Progress in biochemical pharmacology","volume":"18 ","pages":"99-110"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18079279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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