Proceedings of the Royal Society of Medicine最新文献

{"title":"Alkaptonuria.","authors":"T. Sussman","doi":"10.32388/cxucf8","DOIUrl":"https://doi.org/10.32388/cxucf8","url":null,"abstract":"","PeriodicalId":76359,"journal":{"name":"Proceedings of the Royal Society of Medicine","volume":"62 5 1","pages":"485"},"PeriodicalIF":0.0,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48010754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aphakia.","authors":"D. Lobascher, M. O’riordan","doi":"10.32388/1n7nac","DOIUrl":"https://doi.org/10.32388/1n7nac","url":null,"abstract":"","PeriodicalId":76359,"journal":{"name":"Proceedings of the Royal Society of Medicine","volume":"68 1 1","pages":"54"},"PeriodicalIF":0.0,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44854645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal Vein Occlusion","authors":"","doi":"10.32388/g557kx","DOIUrl":"https://doi.org/10.32388/g557kx","url":null,"abstract":"","PeriodicalId":76359,"journal":{"name":"Proceedings of the Royal Society of Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69630793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sclerema Neonatorum","authors":"","doi":"10.32388/76wt07","DOIUrl":"https://doi.org/10.32388/76wt07","url":null,"abstract":"","PeriodicalId":76359,"journal":{"name":"Proceedings of the Royal Society of Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69625140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Hypoparathyroidism","authors":"","doi":"10.32388/za5ib6","DOIUrl":"https://doi.org/10.32388/za5ib6","url":null,"abstract":"Owner Observations Abrupt or gradual onset of intermittent neurologic or neuromuscular signs; excitement or exercise may initiate or perpetuate signs: • Seizures or tetany. • Muscle tremors, fasciculations, or twitching. • Facial rubbing. • Stilted gait or ataxia. • Prolapsed nictitating membranes (cats). • Anorexia. • Weakness or lethargy. • Panting. • Disorientation, abnormal behavior, or aggression. • Polyuria/polydipsia.","PeriodicalId":76359,"journal":{"name":"Proceedings of the Royal Society of Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69644572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transplacental carcinogenesis.","authors":"P. Magee","doi":"10.32388/rvq131","DOIUrl":"https://doi.org/10.32388/rvq131","url":null,"abstract":"","PeriodicalId":76359,"journal":{"name":"Proceedings of the Royal Society of Medicine","volume":"68 10 1","pages":"655-7"},"PeriodicalIF":0.0,"publicationDate":"2020-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45710030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tertiary Syphilis.","authors":"J. H. Sequeira","doi":"10.32388/m88kko","DOIUrl":"https://doi.org/10.32388/m88kko","url":null,"abstract":"","PeriodicalId":76359,"journal":{"name":"Proceedings of the Royal Society of Medicine","volume":"2 Dermatol Sect 1","pages":"153-4"},"PeriodicalIF":0.0,"publicationDate":"2020-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44878826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Pathogenicity and Transcriptome Analysis of Methicillin-Resistant <i>Staphylococcus aureus</i> in Response to Water Extract of <i>Galla chinensis</i>.","authors":"Shizhou Wu, Yunjie Liu, Hui Zhang, Lei Lei","doi":"10.1155/2019/3276156","DOIUrl":"10.1155/2019/3276156","url":null,"abstract":"<p><strong>Aim: </strong>Antibiotic abuse contributes to the emergence of methicillin-resistant <i>Staphylococcus aureus</i> (MRSA). It is increasingly important to screen new antimicrobial agents for the management of MRSA infections. <i>G. chinensis,</i> a nontoxic Chinese herbal medicine, is considered a potential antibacterial agent. The aim of this study was to investigate the bactericidal effects of the aqueous extracts of <i>G. chinensis</i> on MRSA. The potential mechanisms of <i>G. chinensis</i> aqueous extract inhibition of the pathogenicity of MRSA <i>in vivo</i> are also discussed.</p><p><strong>Methods: </strong><i>G. chinensis</i> aqueous extract was prepared and its antimicrobial activities were examined by determining its minimum inhibitory concentration (MIC). Biofilm biomass was determined by scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM). RNA sequencing (RNA-seq) was used to evaluate differentially expressed functional pathways in MRSA treated with <i>G. chinensis</i> aqueous extract. We validated the role of <i>G. chinensis</i> aqueous extract in the invasive ability and pathogenicity of MRSA <i>in vivo</i> using a rat infectious model.</p><p><strong>Results: </strong>The results indicated that MRSA was sensitive to the <i>G. chinensis</i> aqueous extracts at concentration of 31.25<i>μ</i>g/mL. <i>G. chinensis</i> extract led to a reduction in dextran-dependent aggregation and biofilm formation in MRSA. Based on the transcriptome analysis, <i>G. chinensis</i> aqueous extracts significantly downregulated the gene expression related to biofilm formation and carbohydrate metabolism. <i>G. chinensis</i> aqueous extract inhibited the invasive ability and the pathogenicity of MRSA <i>in vivo</i>.</p><p><strong>Conclusion: </strong>The antimicrobial properties of <i>G. chinensis</i> aqueous extract are likely related to its modulation of MRSA biofilm formation and carbohydrate metabolism. <i>G. chinensis</i> aqueous extract is a promising supplementary therapy to lessen or eliminate the use of antibiotics and is a potential tool for the management of MRSA infections.</p>","PeriodicalId":76359,"journal":{"name":"Proceedings of the Royal Society of Medicine","volume":"13 Laryngol Sect 1","pages":"3276156"},"PeriodicalIF":0.0,"publicationDate":"2019-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86852131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pityriasis Rosea.","authors":"E. Little","doi":"10.1891/9780826195197.0139","DOIUrl":"https://doi.org/10.1891/9780826195197.0139","url":null,"abstract":"","PeriodicalId":76359,"journal":{"name":"Proceedings of the Royal Society of Medicine","volume":"8 Dermatol Sect 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42339780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lichen Planus.","authors":"S. E. Dore","doi":"10.1891/9780826195197.0117","DOIUrl":"https://doi.org/10.1891/9780826195197.0117","url":null,"abstract":"","PeriodicalId":76359,"journal":{"name":"Proceedings of the Royal Society of Medicine","volume":"13 Dermatol Sect 1","pages":"77-8"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47785756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}