AGE Pub Date : 2016-06-01 Epub Date: 2016-05-18 DOI: 10.1007/s11357-016-9924-z

Kylie Kavanagh, Richelle N Brown, Ashley T Davis, Beth Uberseder, Edison Floyd, Bianca Pfisterer, Carol A Shively

{"title":"Microbial translocation and skeletal muscle in young and old vervet monkeys.","authors":"Kylie Kavanagh, Richelle N Brown, Ashley T Davis, Beth Uberseder, Edison Floyd, Bianca Pfisterer, Carol A Shively","doi":"10.1007/s11357-016-9924-z","DOIUrl":"https://doi.org/10.1007/s11357-016-9924-z","url":null,"abstract":"Intestinal barrier dysfunction leads to microbial translocation (MT) and inflammation in vertebrate and invertebrate animal models. Age is recently recognized as a factor leading to MT, and in some human and animal model studies, MT was associated with physical function. We evaluated sarcopenia, inflammation, MT biomarkers, and muscle insulin sensitivity in healthy female vervet monkeys (6-27 years old). Monkeys were fed consistent diets and had large and varied environments to facilitate physical activity, and stable social conditions. Aging led to sarcopenia as indicated by reduced walking speeds and muscle mass, but general metabolic health was similar in older monkeys (n = 25) as compared to younger ones (n = 26). When older monkeys were physically active, their MT burden approximated that in young monkeys; however, when older monkeys were sedentary, MT burden was dramatically increased. MT levels were positively associated with inflammatory burden and negatively associated with skeletal muscle insulin sensitivity. Time spent being active was positively associated with insulin sensitivity as expected, but this relationship was specifically modified by the individual monkey's MT, not inflammatory burden. Our data supports clinical observations that MT interacts with physical function as a factor in healthy aging. ","PeriodicalId":7632,"journal":{"name":"AGE","volume":"38 3","pages":"58"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11357-016-9924-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34393183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Relation between aerobic fitness and brain structures in amnestic mild cognitive impairment elderly. 有氧健身与失忆性轻度认知障碍老年人大脑结构的关系。

AGE Pub Date : 2016-06-01 Epub Date: 2016-04-23 DOI: 10.1007/s11357-016-9912-3

Camila Vieira Ligo Teixeira, Thiago J R Rezende, Marina Weiler, Mateus H Nogueira, Brunno M Campos, Luiz F L Pegoraro, Jessica E Vicentini, Gabriela Scriptore, Fernando Cendes, Marcio L F Balthazar

{"title":"Relation between aerobic fitness and brain structures in amnestic mild cognitive impairment elderly.","authors":"Camila Vieira Ligo Teixeira, Thiago J R Rezende, Marina Weiler, Mateus H Nogueira, Brunno M Campos, Luiz F L Pegoraro, Jessica E Vicentini, Gabriela Scriptore, Fernando Cendes, Marcio L F Balthazar","doi":"10.1007/s11357-016-9912-3","DOIUrl":"10.1007/s11357-016-9912-3","url":null,"abstract":"Mild cognitive impairment (aMCI) is a clinical condition, with high risk to develop Alzheimer's disease. Physical exercise may have positive effect on cognition and brain structure in older adults. However, it is still under research whether these influences are true on aMCI subjects with low Ab_42 and high total tau in cerebrospinal fluid (CSF), which is considered a biomarker for AD. Therefore, we aimed to investigate a possible relation between aerobic fitness (AF) and gray matter (GM) volume and AF and white matter (WM) integrity in aMCI with a CSF biomarker. Twenty-two participants with aMCI acquired the images on a 3.0-T MRI. AF was assessed by a graded exercise test on a treadmill. Voxel-based morphometry and tract-based spatial statistic methods were used to analyze the GM volume and WM microstructural integrity, respectively. We correlated AF and GM volume and WM integrity in aMCI (p < 0.05, FWE corrected, cluster with at least five voxels). There was a positive relation between AF and GM volume mostly in frontal superior cortex. In WM integrity, AF was positively correlated with fractional anisotropy and negatively correlated with mean diffusivity and radial diffusivity, all in the same tracts that interconnect frontal, temporal, parietal, and occipital areas (longitudinal fasciculus, fronto-occipital fasciculus, and corpus callosum). These results suggest that aerobic fitness may have a positive influence on protection of brain even in aMCI CSF biomarker, a high-risk population to convert to AD. ","PeriodicalId":7632,"journal":{"name":"AGE","volume":"38 3","pages":"51"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005905/pdf/11357_2016_Article_9912.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34424825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Higher levels of phosphorylated Y1472 on GluN2B subunits in the frontal cortex of aged mice are associated with good spatial reference memory, but not cognitive flexibility. 老年小鼠额叶皮层GluN2B亚基上较高水平的Y1472磷酸化与良好的空间参考记忆有关，但与认知灵活性无关。

AGE Pub Date : 2016-06-01 Epub Date: 2016-04-19 DOI: 10.1007/s11357-016-9913-2

Daniel R Zamzow, Val Elias, Varinia A Acosta, Emily Escobedo, Kathy R Magnusson

{"title":"Higher levels of phosphorylated Y1472 on GluN2B subunits in the frontal cortex of aged mice are associated with good spatial reference memory, but not cognitive flexibility.","authors":"Daniel R Zamzow, Val Elias, Varinia A Acosta, Emily Escobedo, Kathy R Magnusson","doi":"10.1007/s11357-016-9913-2","DOIUrl":"https://doi.org/10.1007/s11357-016-9913-2","url":null,"abstract":"The N-methyl-D-aspartate receptor (NMDAr) is particularly vulnerable to aging. The GluN2B subunit of the NMDAr, compared to other NMDAr subunits, suffers the greatest losses of expression in the aging brain, especially in the frontal cortex. While expression levels of GluN2B mRNA and protein in the aged brain are well documented, there has been little investigation into age-related posttranslational modifications of the subunit. In this study, we explored some of the mechanisms that may promote differences in the NMDAr complex in the frontal cortex of aged animals. Two ages of mice, 3 and 24 months, were behaviorally tested in the Morris water maze. The frontal cortex and hippocampus from each mouse were subjected to differential centrifugation followed by solubilization in Triton X-100. Proteins from Triton-insoluble membranes, Triton-soluble membranes, and intracellular membranes/cytosol were examined by Western blot. Higher levels of GluN2B tyrosine 1472 phosphorylation in frontal cortex synaptic fractions of old mice were associated with better reference learning but poorer cognitive flexibility. Levels of GluN2B phosphotyrosine 1336 remained steady, but there were greater levels of the calpain-induced 115 kDa GluN2B cleavage product on extrasynaptic membranes in these old good learners. There was an age-related increase in calpain activity, but it was not associated with better learning. These data highlight a unique aging change for aged mice with good spatial learning that might be detrimental to cognitive flexibility. This study also suggests that higher levels of truncated GluN2B on extrasynaptic membranes are not deleterious to spatial memory in aged mice. ","PeriodicalId":7632,"journal":{"name":"AGE","volume":"38 3","pages":"50"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11357-016-9913-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34474088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Increased levels of hyper-stable protein aggregates in plasma of older adults. 老年人血浆中超稳定蛋白聚集体水平升高。

AGE Pub Date : 2016-06-01 Epub Date: 2016-05-14 DOI: 10.1007/s11357-016-9919-9

Ke Xia, Hannah Trasatti, James P Wymer, Wilfredo Colón

{"title":"Increased levels of hyper-stable protein aggregates in plasma of older adults.","authors":"Ke Xia, Hannah Trasatti, James P Wymer, Wilfredo Colón","doi":"10.1007/s11357-016-9919-9","DOIUrl":"https://doi.org/10.1007/s11357-016-9919-9","url":null,"abstract":"Proteins that misfold into hyper-stable/degradation-resistant species during aging may accumulate and disrupt protein homeostasis (i.e., proteostasis), thereby posing a survival risk to any organism. Using the method diagonal two-dimensional (D2D) SDS-PAGE, which separates hyper-stable SDS-resistant proteins at a proteomics level, we analyzed the plasma of healthy young (<30 years) and older (60-80 years) adults. We discovered the presence of soluble SDS-resistant protein aggregates in the plasma of older adults, but found significantly lower levels in the plasma of young adults. We identified the inflammation-related chaperone protein haptoglobin as the main component of the hyper-stable aggregates. This observation is consistent with the growing link between accumulations of protein aggregates and aging across many organisms. It is plausible higher amounts of SDS-resistant protein aggregates in the plasma of older adults may reflect a compromise in proteostasis that may potentially indicate cellular aging and/or disease risk. The results of this study have implications for further understanding the link between aging and the accumulation of protein aggregates, as well as potential for the development of aging-related biomarkers. More broadly, this novel application of D2D SDS-PAGE may be used to identify, quantify, and characterize the degradation-resistant protein aggregates in human plasma or any biological system. ","PeriodicalId":7632,"journal":{"name":"AGE","volume":"38 3","pages":"56"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11357-016-9919-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34392587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Common SIRT1 variants modify the effect of abdominal adipose tissue on aging-related lung function decline. 常见的SIRT1变异改变了腹部脂肪组织对衰老相关肺功能下降的影响。

AGE Pub Date : 2016-06-01 Epub Date: 2016-04-28 DOI: 10.1007/s11357-016-9917-y

Ivan Curjuric, Medea Imboden, Pierre-Olivier Bridevaux, Margaret W Gerbase, Margot Haun, Dirk Keidel, Ashish Kumar, Marco Pons, Thierry Rochat, Tamara Schikowski, Christian Schindler, Arnold von Eckardstein, Florian Kronenberg, Nicole M Probst-Hensch

{"title":"Common SIRT1 variants modify the effect of abdominal adipose tissue on aging-related lung function decline.","authors":"Ivan Curjuric, Medea Imboden, Pierre-Olivier Bridevaux, Margaret W Gerbase, Margot Haun, Dirk Keidel, Ashish Kumar, Marco Pons, Thierry Rochat, Tamara Schikowski, Christian Schindler, Arnold von Eckardstein, Florian Kronenberg, Nicole M Probst-Hensch","doi":"10.1007/s11357-016-9917-y","DOIUrl":"https://doi.org/10.1007/s11357-016-9917-y","url":null,"abstract":"Lung function is an independent predictor of mortality and serves as an aging marker in never smokers. The protein sirtuin-1 of gene SIRT1 has profound anti-inflammatory effects and regulates metabolic pathways. Its suggested longevity effects on lower organisms remain poorly studied in humans. In 1132 never smokers of the population-based SAPALDIA cohort, we investigated associations between single nucleotide polymorphisms (SNPs; rs730821, rs10997868, rs10823116) of SIRT1 and aging-related lung function decline over 11 years in terms of change in forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), FEV1/FVC ratio, and forced expiratory flow between 25 and 75 % of FVC (FEF25-75) using multiple linear regression models. Interactions between the SIRT1 SNPs and adiposity parameters (body mass index (BMI), its change and weight gain) were tested by including multiplicative interaction terms into the models. SIRT1 polymorphisms exhibited no main effects, but modified the association between obesity measures and FEV1/FVC and FEF25-75 decline (p = 0.009-0.046). Per risk allele, FEV1/FVC decline was accelerated up to -0.5 % (95 % CI -1.0 to 0 %) and -0.7 % (-1.3 to -0.2 %) over interquartile range increases in BMI (2.4 kg/m(2)) or weight (6.5 kg), respectively. For FEF25-75 decline, corresponding estimates were -57 mL/s (-117 to 4 mL/s) and -76 mL/s (-1429 to -9 mL/s). Interactions were not present in participants with genetically lowered C-reactive protein concentrations. Genetic variation in SIRT1 might therefore affect lung function and human longevity by modifying subclinical inflammation arising from abdominal adipose tissue. ","PeriodicalId":7632,"journal":{"name":"AGE","volume":"38 3","pages":"52"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11357-016-9917-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34500324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Telomere attrition in beta and alpha cells with age. 随着年龄增长，细胞端粒磨损。

AGE Pub Date : 2016-06-01 Epub Date: 2016-05-24 DOI: 10.1007/s11357-016-9923-0

Yoshiaki Tamura, Naotaka Izumiyama-Shimomura, Yoshiyuki Kimbara, Ken-Ichi Nakamura, Naoshi Ishikawa, Junko Aida, Yuko Chiba, Yoko Matsuda, Seijiro Mori, Tomio Arai, Mutsunori Fujiwara, Steven S S Poon, Tatsuro Ishizaki, Atsushi Araki, Kaiyo Takubo, Hideki Ito

{"title":"Telomere attrition in beta and alpha cells with age.","authors":"Yoshiaki Tamura, Naotaka Izumiyama-Shimomura, Yoshiyuki Kimbara, Ken-Ichi Nakamura, Naoshi Ishikawa, Junko Aida, Yuko Chiba, Yoko Matsuda, Seijiro Mori, Tomio Arai, Mutsunori Fujiwara, Steven S S Poon, Tatsuro Ishizaki, Atsushi Araki, Kaiyo Takubo, Hideki Ito","doi":"10.1007/s11357-016-9923-0","DOIUrl":"https://doi.org/10.1007/s11357-016-9923-0","url":null,"abstract":"We have reported telomere attrition in β and α cells of the pancreas in elderly patients with type 2 diabetes, but it has not been explored how the telomere lengths of these islet cells change according to age in normal subjects. To examine the telomere lengths of β and α cells in individuals without diabetes across a wide range of ages, we conducted measurement of the telomere lengths of human pancreatic β and α cells obtained from 104 autopsied subjects without diabetes ranging in age from 0 to 100 years. As an index of telomere lengths, the normalized telomere-centromere ratio (NTCR) was determined for β (NTCRβ) and α (NTCRα) cells by quantitative fluorescence in situ hybridization (Q-FISH). We found NTCRβ and NTCRα showed almost the same levels and both decreased according to age (p < 0.001 for both). NTCRs decreased more rapidly with age and were more widely distributed (p = 0.036 for NTCRβ, p < 0.001 for NTCRα) in subjects under 18 years of age than in subjects over 18 years. There was a positive correlation between NTCRβ and NTCRα only among adult subjects (p < 0.001). In conclusion, the telomeres of β and α cells become shortened with normal aging process. ","PeriodicalId":7632,"journal":{"name":"AGE","volume":"38 3","pages":"61"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11357-016-9923-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34576170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

ECG low QRS voltage and wide QRS complex predictive of centenarian 360-day mortality 心电图低QRS电压和宽QRS复合体预测百岁老人360天死亡率

AGE Pub Date : 2016-04-01 DOI: 10.1007/s11357-016-9907-0

J. Szewieczek, Z. Gąsior, J. Duława, T. Francuz, Katarzyna Legierska, Agnieszka Batko-Szwaczka, B. Hornik, M. Janusz-Jenczeń, I. Włodarczyk, K. Wilczyński

引用次数: 5

Developing physical frailty specifications for investigation of frailty pathways in older people. 为调查老年人的衰弱途径制定身体衰弱规范。

AGE Pub Date : 2016-04-01 Epub Date: 2016-04-08 DOI: 10.1007/s11357-016-9903-4

Yew Y Ding

{"title":"Developing physical frailty specifications for investigation of frailty pathways in older people.","authors":"Yew Y Ding","doi":"10.1007/s11357-016-9903-4","DOIUrl":"https://doi.org/10.1007/s11357-016-9903-4","url":null,"abstract":"Different frailty definitions are suitable for different purposes. When investigating its key multidimensional predictors and effects, narrower definitions of frailty that exclude these elements may be more desirable. For this purpose, candidate physical frailty specifications are constructed and then evaluated on their construct and concurrent validity. For 4638 participants aged 65 to 89 years from wave 2 (2004) of the English Longitudinal Study of Ageing, confirmatory factor analysis is performed to create physical frailty specifications with four indicators (slowness, weakness, exhaustion, and weight loss) and with three indicators (slowness, weakness, and either exhaustion or weight loss). Using derived factor scores, their convergent, discriminant, and concurrent validity are compared. For specifications with four indicators and with three indicators including exhaustion, slowness contributes dominantly to the physical frailty factor. However, with three indicators including weight loss, weakness contributes most. Where represented, weight loss only contributes minimally. Higher factor scores are significantly associated with chronic diseases, functional impairment, and poor self-rated health, although less so for the third specification. Factor scores for the first two specifications have low correlation with psychological and social frailty while those for the third have negligible correlation. Factor scores increase with higher Frailty Index although again less so for the third specification. Minor differences are seen across gender. On account of their convergent, discriminatory, and concurrent validity, physical frailty specifications with four indicators and with three indicators including exhaustion hold promise for use in investigation of frailty pathways involving multidimensional predictors and effects. ","PeriodicalId":7632,"journal":{"name":"AGE","volume":"38 2","pages":"47"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11357-016-9903-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34386950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Joint effect of gene-physical activity and the interactions among CRP, TNF-α, and LTA polymorphisms on serum CRP, TNF-α levels, and handgrip strength in community-dwelling elders in Taiwan - TCHS-E 基因-体能活动的联合作用及CRP、TNF-α和LTA多态性对台湾社区老年人血清CRP、TNF-α水平和握力的相互作用- TCHS-E

AGE Pub Date : 2016-04-01 DOI: 10.1007/s11357-016-9909-y

Chia-Ing Li, Tsai-Chung Li, Li-Na Liao, C. Liu, Chuan-Wei Yang, Chih-Hsueh Lin, Jen-Hao Hsiao, Nai-Hsin Meng, Wen-Yuan Lin, Fang-Yang Wu, Cheng-Chieh Lin

引用次数: 9

Manual aiming in healthy aging: does proprioceptive acuity make the difference? 健康老龄化中的手动瞄准:本体感觉敏锐度有影响吗?

AGE Pub Date : 2016-04-01 DOI: 10.1007/s11357-016-9908-z

W. Helsen, Florian Van Halewyck, O. Levin, M. Boisgontier, Ann Lavrysen, D. Elliott

引用次数: 28

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