African Journal of Biochemistry Research最新文献

Effect of conditions in the production of highly soluble powder from tomatoes using microbial enzyme preparation 利用微生物酶制剂生产番茄高溶性粉末的条件影响

African Journal of Biochemistry Research Pub Date : 2024-02-29 DOI: 10.5897/ajbr2024.1182

Hirata Ryuichi, Kojima Koji, Teramoto Yuji, Saigusa Noriaki

引用次数: 0

Physicochemical properties and fatty acid composition of freshly prepared palm oil 新制棕榈油的理化性质及脂肪酸组成

African Journal of Biochemistry Research Pub Date : 2023-07-31 DOI: 10.5897/ajbr2023.1167

Ndidi Nwachoko, Udiomine B. Akuru, Inyingi A. Green, Reward M. Kpaanadee, T. Odinga, C. O. Egbunefu

引用次数: 0

Physicochemical parameters of Blighia sapida (K.D. Koenig) oil extracted in Togo 多哥产白螺旋藻油理化参数研究

African Journal of Biochemistry Research Pub Date : 2022-11-30 DOI: 10.5897/ajbr2022.1158

Nabéde Aklesso, Sina Haziz, Souho Tiatou, Mélila Mamatchi, T. Farid, A. Adolphe, Ouadja Batcha, B. Lamine, Amouzou Kou’santa

引用次数: 1

Effects of Quantitative Trait Loci (QTLs) of BCL11A and HBS1L-MYB genes on clinical-biological variability of sickle cell disease in a Senegalese pediatric population BCL11A和HBS1L-MYB基因数量性状位点(qtl)对塞内加尔儿童镰状细胞病临床生物学变异的影响

African Journal of Biochemistry Research Pub Date : 2022-11-30 DOI: 10.5897/ajbr2022.1154

Fatoumata Tall, E. H. Ndour, M. Djité, Oumou K. Barry, P. Kandji, P. M. Gueye, A. Cissé, P. L. Sall

引用次数: 0

Prevalence and associated risk factors of Vitamin D deficiency in children under five years of age, at the Diamniadio Childrens Hospital in Senegal 塞内加尔Diamniadio儿童医院5岁以下儿童维生素D缺乏症患病率及相关风险因素

African Journal of Biochemistry Research Pub Date : 2022-10-31 DOI: 10.5897/ajbr2022.1152

Ba Abou, Fatou Coly Najah, Basse Idrissa, Hadji Ibrahima Kane El, Awa Ka Penda, Soumboundou Mamadou, Thiam Souleymane, Samba Abdourahmane, Ndiaye Arame, Yaya Soumah Idrissa, Diedhiou Fatou, Cissé Fatou, Djité Moustapha, Oumou Kesso Barry Néné, M. Pape, Madiéye Gueye Papa, Diallo Fatou, Ramatoulaye Diagne Gueye Ndéye

引用次数: 0

Investigation into the intake of a popular polyherbal drug (Jalin Herbal Mannex Liquid) on selected biochemical indices of male wister rats 研究了常用复方药物加林甘露液对雄性大鼠部分生化指标的影响

African Journal of Biochemistry Research Pub Date : 2022-10-31 DOI: 10.5897/ajbr2022.1150

E. D. Kpomah, E. M. Arhoghro

{"title":"Investigation into the intake of a popular polyherbal drug (Jalin Herbal Mannex Liquid) on selected biochemical indices of male wister rats","authors":"E. D. Kpomah, E. M. Arhoghro","doi":"10.5897/ajbr2022.1150","DOIUrl":"https://doi.org/10.5897/ajbr2022.1150","url":null,"abstract":"Jalin Herbal Mannex Liquid (JHML) is a polyherbal formulation from honey, Panax ginseng, Liriosma ovate, and Lepidium mehenil, intended for enhanced sexual performance and improve sperm count in men. JHML was studied via its effect on body weight, biochemical indices and histopathology of the testes. Twenty healthy Wistar rats of 120 -150 g weight were allotted into groups A and B., of ten rats each, group A (control), were given 2 mL/kg B.W of tap water, group B were dosed with 2 mL/kg B.W of JHML for four weeks with the animals allowed access to feed and water ad-libitum. Blood were obtained through heart perforation, kidney and testes were excised, washed with normal buffered saline. Results from the investigation indicated that JHML had androgenic properties with marked significant increase (p˂0.05) in body weight of rats administered with JHML. Significant increase (p˂0.05) was observed in LH, FSH, testosterone and with a concomitant significant decrease (p˂0.05) in PRL. The JHML caused non-significant decrease (p>0.05) on triglycerides and cholesterol but with positive significant effect (p ˂ 0.05) on LDL and HDL. No significant changes (p>0.05) on creatinine, urea, uric acid and serum electrolytes. Testicular sections of rats treated with JHML exhibited normal features, seminiferous epithelium and interstitial tissues with active spermatogene sis. The significant increase (p˂0.05) in testosterone, LH, FSH with a concomitant significant decrease (p˂0.05) in PRL may account for its sex invigorating potential, the non-significant changes observed in some biochemical indices of the rats showed that JHML is relatively safe at the studied dose.","PeriodicalId":7631,"journal":{"name":"African Journal of Biochemistry Research","volume":"146 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73726583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antioxidants and antigenotoxic properties of Rhizopus oligosporus fermented cassava (Manihot esculenta Crantz) 低孢根霉发酵木薯的抗氧化及抗基因毒性研究

African Journal of Biochemistry Research Pub Date : 2022-09-30 DOI: 10.5897/ajbr2022.1153

O. E. Egoamaka, Ezedom Theresa, A. A. Akpovwehwee, Aganbi Eferhire, Amata Alex-Ifo, J. T. Nyerhovwo

引用次数: 9

The anti-inflammatory activities of twelve Nigerian medicinal plants: Inhibition of NfkB, activation of Nrf2, and antioxidant content 12种尼日利亚药用植物的抗炎活性:抑制NfkB、激活Nrf2和抗氧化剂含量

African Journal of Biochemistry Research Pub Date : 2022-01-31 DOI: 10.5897/ajbr2021.1134

Dorothy VanderJagt, Lucy Hunsaker, S. Otimenyin, M. O. Uguru

{"title":"The anti-inflammatory activities of twelve Nigerian medicinal plants: Inhibition of NfkB, activation of Nrf2, and antioxidant content","authors":"Dorothy VanderJagt, Lucy Hunsaker, S. Otimenyin, M. O. Uguru","doi":"10.5897/ajbr2021.1134","DOIUrl":"https://doi.org/10.5897/ajbr2021.1134","url":null,"abstract":"Chronic non-communicable diseases are responsible for a large majority of deaths worldwide. These include cardiovascular and respiratory diseases, diabetes and cancer. Inflammation has been reported to be involved in the initiation or progression of these conditions. Populations in developing or low to middleincome countries often rely on traditional medicine using locally available herbs and plants for their medical care. This study examined the anti-inflammatory potential of aqueous extracts of twelve medicinal plants used in Nigeria. The antioxidant activity was estimated using the total radical-trapping antioxidant parameter (TRAP) and ferric reducing ability (FRAP) assays. The abilities to inhibit nuclear factor kappa light chain enhancer of activated B cells (NfkB), a key regulator of the inflammatory response, and to activate nuclear factorE2 related factor 2 (Nrf2), a transcription factor that regulates cellular antioxidant defense systems, were determined using in vitro cell based assays. Extracts of Erythrina senegalensis (leaves), Sclerocarya birrea (bark), Boswellia dalzielli (leaves and bark), Pseudrocedrila kotschyi (bark), Sterculia setigera (stem bark), and Sarcocephalus esculentus (bark) contained the highest levels of antioxidant activity. Extracts that showed the greatest inhibition of NfkB were S. esculentus (bark), 91.8%; E. senegalensis (leaves), 81.4%; S. birrea (stem bark), 77.5%; and S. setigera (stem bark), 75.5%. B. dalzielli (leaves) and Xylopia aethiopica (leaves) gave 7.4 and 7.7 fold activation of Nrf2, respectively. These were comparable to activation by sulphorophane.","PeriodicalId":7631,"journal":{"name":"African Journal of Biochemistry Research","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81422041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of hyperuricemia and metabolic syndrome in type 2 diabetes mellitus patients in Dakar 达喀尔地区2型糖尿病患者高尿酸血症与代谢综合征的关系

African Journal of Biochemistry Research Pub Date : 2021-10-31 DOI: 10.5897/ajbr2020.1111

Oumou Kesso Barry Néné, Djité Moustapha, M. Pape, Hadji Malick Ndour El, Assane Ndour Michel, Diédhiou Demba, Fatou Gueye-tall, Palanga Koboyo Alix, Marieme Thioune Ndeye, Fatou Coly Najah, Doupa Dominique, Ndour-Mbaye Maimouna, C. Aynina, Amadou Diop Pape, Lopez-Sall Philomène, Madiéye Gueye Papa

{"title":"Association of hyperuricemia and metabolic syndrome in type 2 diabetes mellitus patients in Dakar","authors":"Oumou Kesso Barry Néné, Djité Moustapha, M. Pape, Hadji Malick Ndour El, Assane Ndour Michel, Diédhiou Demba, Fatou Gueye-tall, Palanga Koboyo Alix, Marieme Thioune Ndeye, Fatou Coly Najah, Doupa Dominique, Ndour-Mbaye Maimouna, C. Aynina, Amadou Diop Pape, Lopez-Sall Philomène, Madiéye Gueye Papa","doi":"10.5897/ajbr2020.1111","DOIUrl":"https://doi.org/10.5897/ajbr2020.1111","url":null,"abstract":"The association between hyperuricemia and metabolic syndrome (MS) has been reported in many studies. The authors performed this cross-sectional study to determine the association between hyperuricemia and the MS among diabetic patients in Dakar. Type 2 diabetic patients received as part of their follow-up at the Marc Sankalé Center of Abass Ndao Hospital in Dakar were enrolled. For each patient, blood samples and 24 h urine collection were performed. Hyperuricemia was defined for uric acid concentrations > 416 µmol/l in men and > 357 µmol/l in women and the MS was evaluated according to WHO criteria. Statistical analysis was done using the XLSTAT 2019 software. A total of 153 type 2 diabetic patients were included with an average age of 56.63 years. Thirty-one percent (31%) of patients had metabolic syndrome and 32% of them had hyperuricemia. Significant correlations were found between serum uric acid and some components of the MS including triglyceride levels (r = 0.25, p = 0.002), microalbuminuria (r = 0.19, p = 0.018), and fasting glucose (r = - 0.22, p = 0.005). The authors found that hyperuricemia is frequent in patients with MS and this could be considered as a biomarker associated with the presence of this syndrome.","PeriodicalId":7631,"journal":{"name":"African Journal of Biochemistry Research","volume":"78 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75524863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Study of isoforms of nicotinamide adenine dinucleotide phosphate oxidase of the heart in a model of rats fed on several vegetable oils 几种植物油喂养大鼠心脏模型烟酰胺腺嘌呤二核苷酸磷酸氧化酶异构体的研究

African Journal of Biochemistry Research Pub Date : 2021-10-31 DOI: 10.5897/ajbr2021.1128

K. Gervais, Jover Bernard, Badia Eric, Djohan Ferdinand, Reynaud Fabrice, Dere, Luc, Niamke Germaine, Chantal Gauze, M. Absalome, Adeoti F Mansour, -. Camara, C. Massara, Cristol Jean Paul

{"title":"Study of isoforms of nicotinamide adenine dinucleotide phosphate oxidase of the heart in a model of rats fed on several vegetable oils","authors":"K. Gervais, Jover Bernard, Badia Eric, Djohan Ferdinand, Reynaud Fabrice, Dere, Luc, Niamke Germaine, Chantal Gauze, M. Absalome, Adeoti F Mansour, -. Camara, C. Massara, Cristol Jean Paul","doi":"10.5897/ajbr2021.1128","DOIUrl":"https://doi.org/10.5897/ajbr2021.1128","url":null,"abstract":"Palm oil has long been incriminated in obesity, and this obesity would be responsible for the development of cardiac fibrosis, several authors have evoked the role of free radicals in the pathophysiological mechanism of the fibrotic response linked to obesity; the aim of this study was therefore to evaluate the profile of NOX2 in the development of cardiac fibrosis in rats subjected to a diet rich in the fat of several vegetable oils, in this case palm oil. A total of forty young male Wistar rats were subjected to several diets (soybean, red and branched palm oil, olive and lard). After twelve weeks of experimentation, the rats were sacrificed after anaesthesia, and the parameters of oxidative stress, inflammation and the level of interstitial fibrosis of the heart were assessed. Our study showed that red palm oil consumption did not lead to overexpression of oxidative stress parameters and inflammatory RNA markers. The expression of myocardial nicotine adenine dinucleotide phosphate oxidase did not change in rats consuming red palm oil compared to the control diet. However, consumption of palm olein, olive and lard resulted in a significant change in myocardial nicotine adenine dinucleotide phosphate oxidase activity. This study seems to show that red palm oil, because of its richness in antioxidants, would be less deleterious for the heart. ANOVA, followed by Tukey Kramer's multiple comparison test. Statistical analyzes of the data were performed with StatView software (SAS Institute, Cary, NC, USA). The differences observed were considered significant for a p value <0.05. The Bravais-Pearson correlation test was used to evaluate linear regressions; the closer the values are to 1 (in absolute value), the stronger the relationship.","PeriodicalId":7631,"journal":{"name":"African Journal of Biochemistry Research","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85120659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0