Padiatrie und Padologie. Supplementum最新文献

[Psychosomatic aspects of non-epileptic seizures]. [非癫痫发作的身心方面]。

Padiatrie und Padologie. Supplementum Pub Date : 1984-01-01

B Mangold

引用次数: 0

[Child and environment. Mental health and psychosomatic aspects]. 儿童与环境。心理健康和身心方面]。

Padiatrie und Padologie. Supplementum Pub Date : 1980-01-01

引用次数: 0

[A new antigonadotropin in the treatment of precocious puberty and pubertal gynaecomastia (author's transl)]. [一种新的抗促性腺激素治疗性早熟和青春期女性乳房发育症[作者译]。

Padiatrie und Padologie. Supplementum Pub Date : 1977-01-01

W Swoboda, E Turnheim, H Frisch, J Spona

{"title":"[A new antigonadotropin in the treatment of precocious puberty and pubertal gynaecomastia (author's transl)].","authors":"W Swoboda, E Turnheim, H Frisch, J Spona","doi":"","DOIUrl":"","url":null,"abstract":"A synthetic steroid compound derived from testosteron (isoxazol-ethisterone), Danazol, with gonadotropin-depressing activity, was used in the treatment of 4 cases of idiopathis sexual precocity (age 2 1/2 to 4 years) and in 10 cases of severe pubertal gynaecomastia. In sexual precocity the suppression of menstruation as well as of breast-enlargement was good, while the suppression of acceleration of longitudinal growth and bone maturation was inferior compared with cyproteron-acetate. In most boys with gynaecomastia a marked regression of breast enlargement occurred within a few weeks or months. With the dosage used (200-300 mg/day in the sexual precocity patients, 300-400 mg in the gynaecomastia patients) the changes in plasma hormone levels (LH, FSH, progesterone, estradiol, testosterone) were within a non significant range. Depression of testosterone seemed to be a rather regular finding. No untoward side-effects of the medication were noticed in the 14 patients studied. In summary, Danazol did not show any advantages compared with the compounds used in the treatment of isosexual precocity sofar. In contrast, the drug proved to have useful effects in pubertal gynecomastia, a condition which in severe degrees certainly deserves medical treatment.","PeriodicalId":76299,"journal":{"name":"Padiatrie und Padologie. Supplementum","volume":" 5","pages":"109-20"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11415820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypothalamic control of the mammalian sexual maturation. 哺乳动物性成熟的下丘脑控制。

Padiatrie und Padologie. Supplementum Pub Date : 1977-01-01 DOI: 10.1007/978-3-7091-8491-2_10

D Gupta

{"title":"Hypothalamic control of the mammalian sexual maturation.","authors":"D Gupta","doi":"10.1007/978-3-7091-8491-2_10","DOIUrl":"https://doi.org/10.1007/978-3-7091-8491-2_10","url":null,"abstract":"The attainment of sexual maturity is a complex process which requires maturation and interaction not only of gonads and reproductive tract but also of the pituitary and essentially of the neuroendocrine mechanisms which ultimately control gonadotropin secretion. One of the more attractive hypotheses of the sexual maturation presumes the existence of the sensitivity threshold of the regulating system to the negative feedback signal, which differentiates immaturity from maturity. As the subject matures this declines. In an attempt to examine further the maturational alterations of the male hypothalamo-pituitary-gonadal axis, investigations were carried out with regard to simultaneous changes of blood LH, FSH, testosterone and dihydrotestosterone levels during the course of 24 hr; augmentation of pituitary and blood LH and FSH concentrations under the stimulus of LH-RH as a function of time and age; synthesis and release of LH and FSH in the testosterone-blocked animals at various stages of sexual maturation; and in vitro biotransformation of testosterone to its 5 alpha-reduced metabolites by the pituitaries as a function of age. Evidence from the experimental data could be interpreted as a decrement of the feedback set-points during sexual maturatio as reflected by the transition of the responses obtained under various experimental signals. In parallel to these observations, new evidence was presented regarding not only quantitative but qualitative changes in the pituitary gonadotropins as response to the negative and positive feedback signals. This leads to new thinking with regard to the hypothesis of differential sensitivity.","PeriodicalId":76299,"journal":{"name":"Padiatrie und Padologie. Supplementum","volume":" 5","pages":"83-102"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11547371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Application of glass capillary gas chromatography to the study of urinary steroid excretion in normal children and in patients with various endocrinopathies. 应用玻璃毛细管气相色谱法研究正常儿童及各种内分泌疾病患者尿类固醇排泄。

Padiatrie und Padologie. Supplementum Pub Date : 1977-01-01 DOI: 10.1007/978-3-7091-8491-2_3

W M Teller, J Homoki

引用次数: 1

Biochemical determinants in Gender identity. 性别认同的生化决定因素。

Padiatrie und Padologie. Supplementum Pub Date : 1977-01-01 DOI: 10.1007/978-3-7091-8491-2_9

W Hamilton, P H Chapman

{"title":"Biochemical determinants in Gender identity.","authors":"W Hamilton, P H Chapman","doi":"10.1007/978-3-7091-8491-2_9","DOIUrl":"https://doi.org/10.1007/978-3-7091-8491-2_9","url":null,"abstract":"The purpose of this communication is to report cognate studies which suggest that the nature of the peripheral metabolism of testosterone may impart gender direction to thought construction and motive. In patients with the complete testicular feminizing syndrome [4], the XO/XY syndrome [4], female trans-sexualism [4] and testicular agenesis [5] HCG-tests of 3 days duration were performed, and plasma and urinary testosterone, urinary excretion of 5 alpha-androstane, 3 alpha, 17 beta-diol (5 alpha-diol), 5 beta-androstane, 3 alpha, 17 beta-diol (5 beta-diol) and epiandrosterone before and after stimulation were measured. In addition steroid transformation was examined by incubation studies with human fetal brain tissue. The results of the latter method presented here are in agreement with published work. It seems clear therefore that the peripheral levels of androgens, oestrogens and their metabolites combine with cerebral steroid transformation, metabolism and possible also synthesis in order to establish gender identity. Exploration of the role of peripheral hormones as stimulators of both gender identity and gender function has dictated the need for a new approach to therapy for gender abnormalities in psyche and soma.","PeriodicalId":76299,"journal":{"name":"Padiatrie und Padologie. Supplementum","volume":" 5","pages":"69-81"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12099603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Hypergonadotrophic male pseudohermaphroditism due to complete 17-alpha-hyroxylase deficiency. 促性腺功能亢进性男性假两性畸形，完全缺乏17- α羟化酶。

Padiatrie und Padologie. Supplementum Pub Date : 1977-01-01 DOI: 10.1007/978-3-7091-8491-2_11

W K Waldhäusl, K Herkner, P Bratusch-Marrain, H Haydl, P Nowotny

引用次数: 1

[Transient hypoaldosteronism. A case report]. (瞬态hypoaldosteronism。[病例报告]。

Padiatrie und Padologie. Supplementum Pub Date : 1977-01-01

F Haschke, L Hohenauer, K Parth, H Zimprich

引用次数: 0

Response of gonadotropins to stimulation with luteinizing hormone -- releasing hormone (LH-RH) in children with precocious puberty before, during and following therapy with cyproterone acetate or an ethisterone derivate. 性早熟儿童促性腺激素对促黄体生成素释放激素(LH-RH)刺激的反应在醋酸环丙孕酮或乙酯酮衍生物治疗之前、期间和之后

Padiatrie und Padologie. Supplementum Pub Date : 1977-01-01 DOI: 10.1007/978-3-7091-8491-2_13

H Frisch, P Kemeter, I Steinert

{"title":"Response of gonadotropins to stimulation with luteinizing hormone -- releasing hormone (LH-RH) in children with precocious puberty before, during and following therapy with cyproterone acetate or an ethisterone derivate.","authors":"H Frisch, P Kemeter, I Steinert","doi":"10.1007/978-3-7091-8491-2_13","DOIUrl":"https://doi.org/10.1007/978-3-7091-8491-2_13","url":null,"abstract":"9 children with precocious puberty were treated over a period of 6 months to 6 3/12 years with Cyproteron acetate or an Ethisterone derivate. LH-RH tests with radioimmunological estimations of LH and FSH were performed before therapy was begun, during and after completion of treatment. In children with untreated precocious puberty the mean basal LH levels were the same as in normal prepubertal children but the increase and the peak values after i.v. LH-RH were found to be considerably greater than in normals. In the treated patients this stimulatable LH release was suppressed; after completion of therapy it was again elevated. The basal FSH levels in untreated children were elevated; however the increase and the peak values were comparable to the collective norm. Results were not altered considerably by therapy, however these parameters were given elevated after completion of therapy. Despite the marked suppression of stimulatable LH by therapy acceleration of bone age is practically not affected. After completion of therapy this drug-induced suppression of gonadotropines is promptly reversible.","PeriodicalId":76299,"journal":{"name":"Padiatrie und Padologie. Supplementum","volume":" 5","pages":"121-8"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11415821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Somatomedin and growth hormone in psychosocial dwarfism. 生长激素和生长激素在心理侏儒症中的作用。

Padiatrie und Padologie. Supplementum Pub Date : 1977-01-01 DOI: 10.1007/978-3-7091-8491-2_1

P Saenger, L S Levine, E Wiedemann, E Schwartz, S Korth-Schutz, J Pareira, B Heinig, M I New

{"title":"Somatomedin and growth hormone in psychosocial dwarfism.","authors":"P Saenger, L S Levine, E Wiedemann, E Schwartz, S Korth-Schutz, J Pareira, B Heinig, M I New","doi":"10.1007/978-3-7091-8491-2_1","DOIUrl":"https://doi.org/10.1007/978-3-7091-8491-2_1","url":null,"abstract":"The diagnosis of psychosocial dwarfism (PSD) was made in a 7 year old boy upon admission to the hospital. In the period following admission, he grew at a slightly accelerated rate of 0.6 cm in 24 days (extrapolated growth rate--9.1 cm/yr); his caloric intake was 1663 calories/day (147 cal/kg/day), stimulable growth hormone was 5.9 ng/ml and somatomedin activity was in the hypopituitary range (0.24, 0.05 U/ml). In the following period of marked catch-up growth of 8.6 cm in 102 days (extrapolated growth rate 30.8 cm/yr), his caloric intake decreased significantly to 1514 cal/day (106 cal/kg/day, 0.005 less than p less than 0.01), stimulable growth hormone in this period was 13.6 ng/ml and somatomedin activity normalized (0.98 U/ml). While under continued observation, with separation from his favorite nurse, his growth velocity dropped significantly to the rate immediately following admission, but there was no change in his stimulable growth hormone or in somatomedin activity. With the return of his favorite nurse, he resumed his previous rapid catch-up growth with no change in caloric intake (p equals not significant), growth hormone level, or somatomedin activity. Upon transient return to his depriving home, his growth rate decreased to 1.4 cm in 70 days (extrapolated growth rate 7.2 cm/yr); growth hormone remained in the normal range. Somatomedin activity was in the low normal range (0.57 U/ml) and rose to high normal activity (1.31 U/ml) as rapid catch-up growth resumed after he had been readmitted. We conclude from these data that: 1. Serum somatomedin in longstanding untreated PSD may be in the hypopituitary range. 2. Markedly fluctuating growth rates during recovery in this patient with PSD were not due to changes in caloric nutrition, growth hormone release or somatomedin activity, but to an as yet unidentified factor affecting growth during emotional stress.","PeriodicalId":76299,"journal":{"name":"Padiatrie und Padologie. Supplementum","volume":" 5","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12101219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17