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Neuropatologia polska最新文献

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Role of electromyography in the diagnosis of motor neuron disorders. 肌电图在运动神经元疾病诊断中的作用。
Neuropatologia polska Pub Date : 1992-01-01
I Hausmanowa-Petrusewicz
{"title":"Role of electromyography in the diagnosis of motor neuron disorders.","authors":"I Hausmanowa-Petrusewicz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Programming of electromyographic examination in motor neuron diseases is discussed taking into account application of appropriate techniques. The difficulties of correct interpretation of results are stressed. The stages of disintegration and reintegration of affected motor units are described as well as compensatory changes of surviving motor units. A detailed description of EMG dynamics of amyotrophic lateral sclerosis, late post-polio syndrome and of childhood spinal muscular atrophy is given.</p>","PeriodicalId":76212,"journal":{"name":"Neuropatologia polska","volume":"30 3-4","pages":"187-97"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12514819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronic progressive axonal polyneuropathy simulating Guillain-Barré syndrome. 慢性进行性轴突多发性神经病模拟格林-巴-罗综合征。
Neuropatologia polska Pub Date : 1992-01-01
H Drac, M Babiuch
{"title":"Chronic progressive axonal polyneuropathy simulating Guillain-Barré syndrome.","authors":"H Drac,&nbsp;M Babiuch","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Six cases of chronic progressive and/or relapsing polyneuropathy are reported. All cases were idiopathic at the beginning of observation. Electrophysiological examination and biopsy of sural nerve in all cases as well as autopsy of spinal roots S1 in case 6 showed loss of fibers and axonal degeneration of myelinated fibers but neither active demyelination nor inflammatory cells were observed. Chronic progressive or relapsing idiopathic axonal polyneuropathy appear to be a distinct entity different from GBS. The term \"axonal GBS\" seems to be questionable.</p>","PeriodicalId":76212,"journal":{"name":"Neuropatologia polska","volume":"30 1","pages":"81-9"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12654055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
beta-Amyloid deposits within the cerebellum of persons older than 80 years of age. 80岁以上老人小脑内的β -淀粉样蛋白沉积。
Neuropatologia polska Pub Date : 1992-01-01
M Barcikowska, M Kujawa, H Wiśniewski
{"title":"beta-Amyloid deposits within the cerebellum of persons older than 80 years of age.","authors":"M Barcikowska,&nbsp;M Kujawa,&nbsp;H Wiśniewski","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The cerebellum, frontal cortex, hippocampal and parahippocampal regions of 100 patients older than 80 years, most of whom had died of stroke, were examined. Eighteen percent were diagnosed as clinically demented. On the specimens labeled previously with Thioflavin S and Bielschowsky method, immunohistochemical studies were performed with Fab (antigen-binding fragment) of the anti beta-amyloid antibody 4G8. Positive amyloid immunoreactivity was observed in the cerebrum in 71 of 100 cases, Cerebella of 31 subjects of 71 with cerebral amyloidosis also revealed amyloid deposits. They appeared in various morphological forms, such as diffuse plaques and focal subpial deposits, as well as classical and primitive neuritic plaques. Cases with amyloid in the cerebellum alone were not observed. Beta-amyloid deposits in the cerebellum were associated with a significant number of beta-amyloid plaques in the cerebrum, which showed other Alzheimer-type pathology, also in individuals without clinical symptoms of dementia. There was no correlation either between cerebellar amyloid deposits and clinical cerebellar symptoms or between the presence of diabetes mellitus, arterial hypertension, and neuropathological changes. A clear association of microglial cells with amyloid deposits in the cerebellum was demonstrated. In our experience, LN-1 and RCA-1 were not as suitable for formalin-fixed paraffin-embedded tissue, as was anti-ferritin. Negative staining for tau-1 and positive staining for anti-ubiquitin characterized neurites within primitive and classical plaques. No neurofibrillary pathology was detected in the cytoplasm of cerebellar neurons when we used anti tau-1 labeling.</p>","PeriodicalId":76212,"journal":{"name":"Neuropatologia polska","volume":"30 3-4","pages":"285-93"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12514060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of selected cytostatic drugs administration on the brain of young rabbits. 选择性细胞抑制药物给药对幼兔脑的影响。
Neuropatologia polska Pub Date : 1992-01-01
M Dambska, D Maślińska
{"title":"Effect of selected cytostatic drugs administration on the brain of young rabbits.","authors":"M Dambska,&nbsp;D Maślińska","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The aim of the study was to compare the effect of two selected cytostatic drugs (cyclophosphamide and vincristine) on the brain of young rabbits. The experimental models were similar to clinical administration of the examined drugs. Cyclophosphamide was given orally from the 5 to the 16th day of life and vincristine in a single intraperitoneal injection on the 8th day of life. Despite the assumed poor penetration of both drugs through the blood-brain barrier, both drugs induced changes in perivascular astrocytes. Other structural elements of the CNS exhibited lesions characteristic for the given drug: proliferation of endoplasmic membranes after cyclophosphamide administration and destruction of microtubules with proliferation of microfilaments after vincristine application.</p>","PeriodicalId":76212,"journal":{"name":"Neuropatologia polska","volume":"30 1","pages":"57-64"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12654053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cerebellar granular layer degeneration in small cell lung cancer: paraneoplastic cerebellopathy or artifact? 小细胞肺癌小脑颗粒层变性:副肿瘤小脑病还是伪影?
Neuropatologia polska Pub Date : 1992-01-01
M Barcikowska, E Kida, E Joachimowicz, A Siekierzyńska
{"title":"Cerebellar granular layer degeneration in small cell lung cancer: paraneoplastic cerebellopathy or artifact?","authors":"M Barcikowska,&nbsp;E Kida,&nbsp;E Joachimowicz,&nbsp;A Siekierzyńska","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The aim of our study was to ascertain whether granular cell degeneration represents uniquely an artifactual or a supravital event in patients with oat cell carcinoma. The material includes 52 cases of small cell lung cancer (SCLC). Formalin fixed and paraffin embedded representative cerebellar slides were stained routinely (HE, Klüver-Barrera), and some of them served as material for immunohistochemical study. The following antibodies were used: anti-ferritin, anti-GFAP, anti-IgG and anti-C3 complement fraction. Finally 5 cases out of our material could be diagnosed as paraneoplastic cerebellar degeneration (PCD), on the basis of lack of metastases within the CNS and concomitant intensive loss of Purkinje and granule cells. Clinically the cerebellar syndrome was disclosed in 3 cases. In the granular layer prevalence of microglial cell reaction was noted. GFAP-labeled astroglia were not demonstrated in the same intensity. Antisera to the C3 complement fraction showed moderate staining of Purkinje cell cytoplasm and in some cases also of granule cells. IgG immunostaining was disclosed in Purkinje cell cytoplasm and in 4 cases also in granule cell nuclei. The immunopathological changes presently observed and glial cell proliferation could be evidence for a nonartifactual origin of PCD.</p>","PeriodicalId":76212,"journal":{"name":"Neuropatologia polska","volume":"30 2","pages":"155-63"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12512356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Creutzfeldt-Jakob disease with tubulovesicular structures: an ultrastructural study. 克雅氏病伴管泡结构的超微结构研究。
Neuropatologia polska Pub Date : 1992-01-01
W Split, J Janusik, J Alwasiak, W Papierz, M Barcikowska, P P Liberski
{"title":"Creutzfeldt-Jakob disease with tubulovesicular structures: an ultrastructural study.","authors":"W Split,&nbsp;J Janusik,&nbsp;J Alwasiak,&nbsp;W Papierz,&nbsp;M Barcikowska,&nbsp;P P Liberski","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Tubulovesicular structures (TVS) have been consistently observed in brain tissue of the transmissible spongiform virus encephalopathies such as natural and experimental scrapie, bovine spongiform encephalopathy and experimentally induced Creutzfeldt-Jakob disease (CJD). TVS were recently demonstrated in 3 cases of naturally occurring CJD. We report here the presence of TVS in another human brain with CJD, as detected in all 3 specimens by thin section electron microscopy. Their occurrence in all types of spongiform encephalopathies, irrespective of the affected host and the strain of infectious agent, emphasizes their biological significance.</p>","PeriodicalId":76212,"journal":{"name":"Neuropatologia polska","volume":"30 3-4","pages":"295-305"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12514059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Does damage of perivascular astrocytes in multiple sclerosis plaques participate in blood-brain barrier permeability? 多发性硬化斑块血管周围星形胶质细胞损伤是否参与血脑屏障通透性?
Neuropatologia polska Pub Date : 1992-01-01
J Rafałowska, S Krajewski, E Dolińska, D Dziewulska
{"title":"Does damage of perivascular astrocytes in multiple sclerosis plaques participate in blood-brain barrier permeability?","authors":"J Rafałowska,&nbsp;S Krajewski,&nbsp;E Dolińska,&nbsp;D Dziewulska","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In six young and two senile MS cases perivascular astrocytes within demyelination lesions were evaluated immunocytochemically. The peroxidase-antiperoxidase method of Sternberger et al. (1970) was used for visualization of glial fibrillary acidic protein (GFAP). In all cases very weak immunoreactivity of perivascular astrocytes was noted. Accumulation of perivascular glial fibers, and infrequently their fragmentation were observed both within active and old demyelination plaques. Clasmatodendrosis, Rosenthal's fibers and prominent regressive changes of astrocyte perikarya were found only in old plaques. A lack of immunoreactivity of perivascular astrocytes was noted within old demyelination lesions. The background of the latter was often immunonegative to GFAP. It is suggested that secondary damage of perivascular astrocytes influences vascular permeability within demyelination lesions including old plaques.</p>","PeriodicalId":76212,"journal":{"name":"Neuropatologia polska","volume":"30 1","pages":"73-80"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12654054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuropathological changes in resected temporal lobe of patients with cryptogenic epilepsy. 隐源性癫痫患者颞叶切除后的神经病理改变。
Neuropatologia polska Pub Date : 1992-01-01
H Kroh, A Taraszewska, E Ruzikowski, J Bidziński, M J Mossakowski
{"title":"Neuropathological changes in resected temporal lobe of patients with cryptogenic epilepsy.","authors":"H Kroh,&nbsp;A Taraszewska,&nbsp;E Ruzikowski,&nbsp;J Bidziński,&nbsp;M J Mossakowski","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The study was performed on cerebral tissue resected during temporal lobectomy in 16 patients whose long-standing cryptogenic epilepsy did not submit to anticonvulsive drugs. Cases presenting definite etiological factors such as CNS trauma, infection or neoplasm were excluded. Neuropathological investigations disclosed microangiomas and focal vascular malformations in the meninges and tissue in 7 patients. Neuronal heterotopias in the white matter and of the white matter in the cortex were observed in 3 cases. Main cortical changes were: neuronal loss, chronic neuronal degeneration, perineuronal satellitosis, and GFAP-positive submeningeal gliosis, especially at the bottom of sulci, perivascular gliosis and laminar or diffuse gliosis. The changes in the hippocampus were most enhanced in the end-plate and in the sector H3 of the pyramidal layer. Astrocytic gliosis in the white matter presented distinct GFAP and S-100 immunostaining; the latter involved in some cases a wider area than the GFAP reaction. The above named changes are analysed with regard to the presumed epileptogenic factors and to the postepileptic damage.</p>","PeriodicalId":76212,"journal":{"name":"Neuropatologia polska","volume":"30 2","pages":"133-45"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12472435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hippocampal damage in vitro after different periods of oxygen deprivation. 不同缺氧时间对海马的体外损伤。
Neuropatologia polska Pub Date : 1992-01-01
E Matyja, E Kida
{"title":"Hippocampal damage in vitro after different periods of oxygen deprivation.","authors":"E Matyja,&nbsp;E Kida","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The dynamics and pattern of postanoxic ultrastructural changes in organotypic culture of rat hippocampus was studied. The experiments were performed on 14-day-old cultures of rat hippocampus exposed to pure nitrogen atmosphere for 10- and 20-minutes and processed for electron microscope 2 and 24 h, 3 and 7 days post anoxia. The earliest changes following 10-min anoxia consisted of marked swelling of mitochondria and Golgi complex of neurons. The presynaptic terminals were preferentially affected. The protoplasmic astrocytes revealed swelling of the cytoplasm whereas the fibrous ones were relatively well preserved. Longer, 20-min anoxia resulted in profound ultrastructural changes even after short survival time. The tissue culture model of anoxia allow to study the direct effect of oxygen deprivation on cell morphology independently of any vascular and/or vasogenic factors.</p>","PeriodicalId":76212,"journal":{"name":"Neuropatologia polska","volume":"30 3-4","pages":"231-43"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12514823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of short-term ischemia on the ultrastructure of hippocampal gyrus in Mongolian gerbil. III. Synapses in late stage of the pathological process. 短期缺血对蒙古沙鼠海马回超微结构的影响。3病理过程后期的突触。
Neuropatologia polska Pub Date : 1992-01-01
B Gajkowska, R Gadamski, M J Mossakowski
{"title":"Influence of short-term ischemia on the ultrastructure of hippocampal gyrus in Mongolian gerbil. III. Synapses in late stage of the pathological process.","authors":"B Gajkowska,&nbsp;R Gadamski,&nbsp;M J Mossakowski","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Electron microscope analysis of the CA1 Ammon's horn sector was performed in Mongolian gerbils three days after an incident of short-term ischemia of the forebrain. CA1 pyramidal neurons showed advanced disintegration. Some GABA-ergic interneurons revealed ultrastructural alteration of variable degree. The latter finding contradicts the generally helt view on the relative resistance of CA1 sector interneurons to the ischemic injury. Synapses localized in all cortical layers of the CA1 sector exhibited ultrastructural abnormalities involving both pre- and postsynaptic parts. They consisted in marked swelling and accumulation of unbound electron dense material, considered as calcium deposits. Presynaptic parts revealed additionally reduced number of synaptic vesicles and their abnormal distribution. Contrary to the early postischemic period, the most severe synaptic alterations appeared in stratum pyramidale, radiatum and oriens, involving both small dendritic branchings and their spines as well as large shafts of both basal and apical pyramidal dendrites. Synaptic alterations especially features of the postsynaptic damage correspond to those indicating excitotoxic neuronal lesions. Presynaptic alterations may indicate both cessation of neurotransmission function as well as direct ischemic damage. The presence of calcium deposition seems to favour the former possibility.</p>","PeriodicalId":76212,"journal":{"name":"Neuropatologia polska","volume":"30 1","pages":"13-28"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12654248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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