NeuropadiatriePub Date : 1979-11-01DOI: 10.1055/s-0028-1085339
I Lagenstein, R P Willig, D Kühne
{"title":"Cranial computed tomography (CCT) findings in children treated with ACTH and dexamethasone: first results.","authors":"I Lagenstein, R P Willig, D Kühne","doi":"10.1055/s-0028-1085339","DOIUrl":"https://doi.org/10.1055/s-0028-1085339","url":null,"abstract":"<p><p>8 children with different petit mal epilepsies were systematically treated with ACTH and dexamethasone. CCT examinations were performed before, during and after treatment. In all children severe cerebral changes. enlargement of ventricles and subarachnoid space developed during the initial phase of treatment with Depot-ACTH. Similar changes, but to a less severe degree, could be demonstrated during the phase of dexamethasone therapy thereafter. In all patients cerebral changes disappeared after hormonal treatment had ended. At this point many children had a developmental spurt, developmental relapses could not be observed. It is suggested that these reversible changes seen on CCT scans represent a form of morphological plasticity of brain structures. These results bear certain consequences as to the therapy of cerebral edema.</p>","PeriodicalId":76211,"journal":{"name":"Neuropadiatrie","volume":"10 4","pages":"370-84"},"PeriodicalIF":0.0,"publicationDate":"1979-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0028-1085339","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11446446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeuropadiatriePub Date : 1979-11-01DOI: 10.1055/s-0028-1085334
B Hagberg, M Kyllerman, G Steen
{"title":"Dyskinesia and dystonia in neurometabolic disorders.","authors":"B Hagberg, M Kyllerman, G Steen","doi":"10.1055/s-0028-1085334","DOIUrl":"https://doi.org/10.1055/s-0028-1085334","url":null,"abstract":"In neurological disorders with progressive dyskinetic and dystonic abnormalities, it is a difficult task for the neuropediatrician to make a correct diagnosis solely on the basis of the clinical symptoms and signs. Furthermore, the choice of suitable laboratory procedures for further investigation has become increasingly delicate owing to the continuously accumulating body of information about \"new\" metabolic diseases, metabolic pathways, enzymes, tests and loads. The purpose of this article is to make a survey of neurometabolic diseases in which dyskinesia or dystonia or both, are known to occur more or less frequently. It is not our ambition to cover these diseases completely, but it is hoped that this overview may be of some help in the diagnostic approach.","PeriodicalId":76211,"journal":{"name":"Neuropadiatrie","volume":"10 4","pages":"305-20"},"PeriodicalIF":0.0,"publicationDate":"1979-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0028-1085334","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11786489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeuropadiatriePub Date : 1979-11-01DOI: 10.1055/s-0028-1085338
L Curzi-Dascalova, M F Radvanyi, G Moriette, F Morel-Kahn, G Korn
{"title":"Respiratory variability according to sleep states during mechanical ventilation: a polygraphic study in a baby with bilateral diaphragmatic paralysis.","authors":"L Curzi-Dascalova, M F Radvanyi, G Moriette, F Morel-Kahn, G Korn","doi":"10.1055/s-0028-1085338","DOIUrl":"https://doi.org/10.1055/s-0028-1085338","url":null,"abstract":"<p><p>Polygraphic recordings were performed at 1 and 2 months of age in mechanically ventilated baby (25-27 insufflations per min) with bilateral diaphragmatic paralysis. The EEG and the sleep organisation were normal for the given age. The breathing patterns were state dependent. Autonomous breathing movements and phasic inspiratory intercostal EMG were present during both wakefulness and active sleep (AS). In quiet sleep (QS) the respiration was usually passive, completly dependent on the respirator. Small autonomous breathings can occur in some periods of QS, simultaneously with the appearance of numerous skin potential responses. These results are probably related to the differences between the respiratory control in QS and in AS.</p>","PeriodicalId":76211,"journal":{"name":"Neuropadiatrie","volume":"10 4","pages":"361-9"},"PeriodicalIF":0.0,"publicationDate":"1979-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0028-1085338","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11786491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeuropadiatriePub Date : 1979-11-01DOI: 10.1055/s-0028-1085335
F Goutières, M L Arsenio-Nunes, J Aicardi
{"title":"Mucolipidosis IV.","authors":"F Goutières, M L Arsenio-Nunes, J Aicardi","doi":"10.1055/s-0028-1085335","DOIUrl":"https://doi.org/10.1055/s-0028-1085335","url":null,"abstract":"<p><p>Five new cases of Mucolipidosis IV are related and the seven cases in the literature reviewed. Neurological signs of the disorder and the value of skin and conjuncitival biopsies for its diagnosis are emphasized. Arguments in favour of a recessive autosomic inheritance are brought forth. The disease does not affect exclusively Jewish people. In two cases absence of oligosacchariduria was demonstrated.</p>","PeriodicalId":76211,"journal":{"name":"Neuropadiatrie","volume":"10 4","pages":"321-31"},"PeriodicalIF":0.0,"publicationDate":"1979-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0028-1085335","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11446445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeuropadiatriePub Date : 1979-11-01DOI: 10.1055/s-0028-1085341
F Gullotta, L Pavone, F Mollica, S Grasso, C Valenti
{"title":"Krabbe's disease with unusual clinical and morphological features.","authors":"F Gullotta, L Pavone, F Mollica, S Grasso, C Valenti","doi":"10.1055/s-0028-1085341","DOIUrl":"https://doi.org/10.1055/s-0028-1085341","url":null,"abstract":"<p><p>A progressive encephalopathy appeared in two sibs aged 7 and 5 months. The children died at 23 respectively 29 months of age. Autopsy of the second child disclosed a severe demyelination involving the whole brain. Only few globoid cells were identified. Ultrastructural and biochemical investigations confirmed the diagnosis of Krabbe's disease.</p>","PeriodicalId":76211,"journal":{"name":"Neuropadiatrie","volume":"10 4","pages":"395-400"},"PeriodicalIF":0.0,"publicationDate":"1979-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0028-1085341","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11446447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeuropadiatriePub Date : 1979-11-01DOI: 10.1055/s-0028-1085337
K Watanabe, S Miyazaki, K Hara, M Kuroyanagi, T Yamamoto, M Ito, S Nakamura, H Yamada
{"title":"Neonatal EEG and computerized tomography.","authors":"K Watanabe, S Miyazaki, K Hara, M Kuroyanagi, T Yamamoto, M Ito, S Nakamura, H Yamada","doi":"10.1055/s-0028-1085337","DOIUrl":"https://doi.org/10.1055/s-0028-1085337","url":null,"abstract":"<p><p>The correlation between EEG and CT scan was studied in 57 full-term newborn infants with various neurological abnormalities, in order to clarify pathological processes underlying EEG abnormalities during the neonatal period. The relation between EEG and CT findings changes with the time elapsing after the acute phase of the perinatal brain insult. The same EEG pattern was associated with different CT findings of perinatal brain injury were usually associated with complete obliteration of cerebrospinal fluid spaces, a phenomenon considered to reflect severe brain swelling. Milkdly and minimally depressed EEGs in the acute phase were usually associated with localized decreased brain density, which is thought to represent localized edema. Moderately depressed background EEGs in the first week were associated with normal CT scans in most cases, although mild localized edema did not produce significant changes in the background EEG in some cases. In contrast to perinatal brain lesions, CT scans were not always well correlated with background EEGs in congenital cerebral dysplasia and intracranial hemorrhage, although the EEG was an useful adjunct to the CT scan in the diagnosis and prognostication of these disorders.</p>","PeriodicalId":76211,"journal":{"name":"Neuropadiatrie","volume":"10 4","pages":"348-60"},"PeriodicalIF":0.0,"publicationDate":"1979-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0028-1085337","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11786490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeuropadiatriePub Date : 1979-11-01DOI: 10.1055/s-0028-1085336
R Korinthenberg, D Palm, A Rübig, G Schellong
{"title":"EEG-changes during intensified induction-therapy of acute lymphoblastic leukemia.","authors":"R Korinthenberg, D Palm, A Rübig, G Schellong","doi":"10.1055/s-0028-1085336","DOIUrl":"https://doi.org/10.1055/s-0028-1085336","url":null,"abstract":"<p><p>In 49 children with acute lymphoblastic leukemia serial EEGs were performed during the course of treatment. Therapy in the first four weeks consisted of: Prednisone, vincristine, daunorubicine and L-asparaginase. In the second month 6-mercaptopurine, cytosin-arabinoside, cyclophosphamide, methotrexate-i. th. and cranial irradiation were administered. Maintenance-therapy consisted of 6-mercaptopurine, cyclophosphamide and methotrexate i.v. Before treatment only 24% of patients showed normal EEG-findings, whereas 57% presented sly induced by leukemic infiltrations and partly due to the impaired clinical state. At the end of the first phase of therapy, the combined toxicity of vincristine and L-asparaginase led to the finding of 23% severely and 37% moderately slowed EEGs. Slightly disturbed EEGs were found in 29% and normal ones in 11% of children. Regression occurred duirng the phase of CNS-prophylaxis. At its end 37% of recordings were normal and 57% slightly abnormal. After maintenance-therapy of 1/2 to 1 year duration, there were 65% normal findings. Moderate and severe disorders were no longer demonstrated. Paroxysmal activity developed twice, each during the first phase of therapy and accompnaying convulsions. In both cases we saw slowing of background-activity and signs of increased excitability still months after. In one of these patients, the probable cause was a vincristin-encephalopathy, the cause of the second case remained unknown. EEGs of two furtehr patients with rubella-encephalitis and subarachnoideal hemorrhage exhibited severe unspecific changes.</p>","PeriodicalId":76211,"journal":{"name":"Neuropadiatrie","volume":"10 4","pages":"332-47"},"PeriodicalIF":0.0,"publicationDate":"1979-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0028-1085336","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11508569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeuropadiatriePub Date : 1979-11-01DOI: 10.1055/s-0028-1085340
W Zaunbauer, P Huber
{"title":"[Angiography in posterior fossa extra-axial arachnoid cyst (author's transl)].","authors":"W Zaunbauer, P Huber","doi":"10.1055/s-0028-1085340","DOIUrl":"https://doi.org/10.1055/s-0028-1085340","url":null,"abstract":"<p><p>The clinical and roentgenographic findings in two patients with posterior fossa extra-axial cysts are presented, a detailed analysis of the angiographic findings of this congenital retrocerebellar leptomeningeal malformations reported and their differential diagnosis discussed.</p>","PeriodicalId":76211,"journal":{"name":"Neuropadiatrie","volume":"10 4","pages":"385-94"},"PeriodicalIF":0.0,"publicationDate":"1979-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0028-1085340","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11529804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeuropadiatriePub Date : 1979-08-01DOI: 10.1055/s-0028-1085329
T Hoppenbrouwers, D Jensen, J Hodgman, R Harper, M Sterman
{"title":"Respiration during the first six months of life in normal infants: II. The emergence of a circadian pattern.","authors":"T Hoppenbrouwers, D Jensen, J Hodgman, R Harper, M Sterman","doi":"10.1055/s-0028-1085329","DOIUrl":"https://doi.org/10.1055/s-0028-1085329","url":null,"abstract":"<p><p>The objective of the present study was to investigate the emergence of circadian patterns in respiratory rates. Twenty-five neurologically normal infants were monitored for 12-hours during the first week of life and at one, two, three, four and six months of age. Each minute of the recordings of EEG, eye movements, somatic activity, respiration, ECG and temperature was coded into Active sleep (AS), Quiet sleep (QS), Indeterminate (IN) and Awake (AW). The night was divided into four equal intervals and a computer program calculated the mean respiratory rate for each interval as a function of state and age. During the first week of life group means of respiratory rates increased linearly with each interval in all states. A circadian pattern with lowered respiratory rates between 10:00 p.m. and 1:00 a.m. emerged at different ages in different sleep states. This pattern was first seen at one month of age in AS and IN, and at three months in QS. It was also observed in AW at three months of age, suggesting that the circadian rhythm is not solely an expression of the sleep wakefulness cycle. Feeding patterns contributed to but did not explain these observations.</p>","PeriodicalId":76211,"journal":{"name":"Neuropadiatrie","volume":"10 3","pages":"264-80"},"PeriodicalIF":0.0,"publicationDate":"1979-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0028-1085329","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11786438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeuropadiatriePub Date : 1979-08-01DOI: 10.1055/s-0028-1085330
A Statz, D Wenzel, K Felgenhauer
{"title":"[Blood-cerebrospinal fluid barrier and the local immune response in the course of meningitis in childhood].","authors":"A Statz, D Wenzel, K Felgenhauer","doi":"10.1055/s-0028-1085330","DOIUrl":"https://doi.org/10.1055/s-0028-1085330","url":null,"abstract":"<p><p>The condition of the blood-CSF barrier can be evaluated by the simultaneous quantitation of marker proteins in serum and cerebrospinal fluid. The concentration ratios of albumin and alpha 2-macroglobulin, plotted versus the hydrodynamic radii are used as permeability parameter. There are wide ranging barrier disturbances during the early stages of meningitis. In mumps meningitis only slight disturbances were found, meanwhile in bacterial meningitis the barrier permeability was strongly increased. In both disease groups one may detect secretory fractions of both immunglobulins G and A. In some cases of mumps meningitis a prolonged humoral immune reaction was found.</p>","PeriodicalId":76211,"journal":{"name":"Neuropadiatrie","volume":"10 3","pages":"281-9"},"PeriodicalIF":0.0,"publicationDate":"1979-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0028-1085330","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11312278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}