{"title":"[The role of cholinergic regulation and stabilization of myocardial structures in the adaptive protection of the heart].","authors":"F Z Meerson, V I Kuznetsov, V A Saltykova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>It was found that rat immobilization in small-size cages leb to physiological changes. On day 1 it was a stress-reaction that resulted in decreases of the fibrillation threshold and arrhythmia resistance. On day 5 it was an increase in the vagal tone that caused noticeable atropine-relieved bradycardia. The fibrillation level returned to the baseline. Heart resistance to ischemic and reperfusion arrhythmias increased drastically as compared to the control level. On day 15 the vagal effect declined to reach the baseline; in spite of this heart tolerance to reperfusion arrhythmias further increased. This was followed by enhanced resistance of isolated hearts of the adapted animals to the reperfusion paradox and tonic concentrations of epinephrine and Ca2+, which indicated the formation of the phenomenon of adaptation stabilization of cardiac structures. After termination of the 5-day stressogenic exposure the cholinergic stress-limiting protection of the heart disappeared rapidly, i. e. within 12 hours. The protective effect of the adaptation stabilization phenomenon, which developed during 15 days of the stressogenic exposure, proved to be more stable and persisted during 15 days after its cessation. It is concluded that, based on the coordination of short-term central and long-term cellular mechanisms, the animal body develops optimal adaptation that emerges rapidly and persists for an adequately long period of time. The step-by-step replacement of central mechanisms with cellular ones provides high reliability and efficiency of the protection of the heart and the entire body from extended environmental effects.</p>","PeriodicalId":76078,"journal":{"name":"Kosmicheskaia biologiia i aviakosmicheskaia meditsina","volume":"25 2","pages":"36-43"},"PeriodicalIF":0.0,"publicationDate":"1991-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13030112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Medical problems of the automated control of astronauts' health].","authors":"R M Baevskiĭ","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A typical structure of an automatic complex for dynamic medical monitoring of the health status of crewmembers in space is described. Algorithms of medical data processing and data imaging are discussed. Approaches to automatic diagnosis of functional states are presented. Advanced automatic systems related to medical support of future flights to Mars are described.</p>","PeriodicalId":76078,"journal":{"name":"Kosmicheskaia biologiia i aviakosmicheskaia meditsina","volume":"25 2","pages":"21-6"},"PeriodicalIF":0.0,"publicationDate":"1991-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13030250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N L Delone, Iu V Seleznev, N A Egolina, Iu I Voronkov, V G Solonichenko, V V Antipov
{"title":"[Study of heterochromatin of metaphasic chromosomes in cultured lymphocytes of astronauts using C-stain].","authors":"N L Delone, Iu V Seleznev, N A Egolina, Iu I Voronkov, V G Solonichenko, V V Antipov","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76078,"journal":{"name":"Kosmicheskaia biologiia i aviakosmicheskaia meditsina","volume":"25 2","pages":"58"},"PeriodicalIF":0.0,"publicationDate":"1991-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12878534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A I Grigor'ev, V B Noskov, O Iu At'kov, B V Afonin, Iu V Sukhanov, V I Lebedev, T A Boĭko
{"title":"[Status of water-electrolyte homeostasis and the systems of hormonal regulation during 237-day space flight].","authors":"A I Grigor'ev, V B Noskov, O Iu At'kov, B V Afonin, Iu V Sukhanov, V I Lebedev, T A Boĭko","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>On mission days 216-219 two crewmembers collected urine and recorded their food and water consumption during three days on end. The cosmonaut-physician withdrew blood samples from the vein and finger. In addition, he made venipuncture to himself and drew blood. Urine and blood samples were frozen and returned to the ground for analysis. In spite of individual variations of each cosmonaut, they all showed a trend for water and sodium retention which was provided by adequate hormonal rearrangement, i. e. increased production of ADH and aldosterone. No disorders in calcium and phosphorus metabolism were seen. Immediately postflight the cosmonauts displayed typical changes in fluid-electrolyte balance and renal function that suggested body dehydration and adjustment to Earth's gravity.</p>","PeriodicalId":76078,"journal":{"name":"Kosmicheskaia biologiia i aviakosmicheskaia meditsina","volume":"25 2","pages":"15-8"},"PeriodicalIF":0.0,"publicationDate":"1991-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13030248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Anthropo-ecological aspects of occupational health and various biochemical approaches to the problem of its evaluation in workers in high risk occupations].","authors":"I P Bobrovnitskiĭ, V A Ponomarenko","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This paper presents the concept of occupational health of man, interpreted as the process of maintenance and development of regulatory properties of the body and his physical, psychic and social well-being, which provide high reliability of his professional activities, professional longevity and maximal lifetime. The paper discusses the main areas of biochemical investigations to evaluate occupational health of the flying personnel, which include identification of correlates between biochemical or immune changes and pathological or premorbid states, that reduce tolerance to environmental effects, as well as study of functional specificities related to the reserves and mechanisms of implementation of adaptive capabilities of the human body. It gives detailed biochemical data derived from pilots with neurotic problems and biochemical indicators of stress tolerance measured during exposure to +Gz acceleration, angular acceleration, hyperthermia, hypoxia, and exercise.</p>","PeriodicalId":76078,"journal":{"name":"Kosmicheskaia biologiia i aviakosmicheskaia meditsina","volume":"25 2","pages":"31-6"},"PeriodicalIF":0.0,"publicationDate":"1991-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13030251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Effectiveness of laser acupuncture in the preservation of the structure of the skeletal muscles during long-term hypokinesia].","authors":"N G Samoĭlov","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76078,"journal":{"name":"Kosmicheskaia biologiia i aviakosmicheskaia meditsina","volume":"25 2","pages":"61-3"},"PeriodicalIF":0.0,"publicationDate":"1991-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13032211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I A Popova, E G Vetrova, L A Rustam'ian, E A Nosova
{"title":"[Carbohydrate and lipid metabolites and blood serum enzymes in humans during graded exercise test in long-term anti-orthostatic hypokinesia].","authors":"I A Popova, E G Vetrova, L A Rustam'ian, E A Nosova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Exercise tests were carried out before as well as on days 128 and 248 of a 370-day head-down tilt study. The test subjects, who took part in the study, were divided into two groups that used different regimens of countermeasures (drugs and exercise). During exercise tests the following serum parameters were measured: lactate, pyruvate, glucose, triglycerides, nonesterified fatty acids, lactate dehydrogenase, alpha-hydroxybutyrate dehydrogenase, malate dehydrogenase, creatine phosphokinase. Decrease or delayed increase in the concentration of energy substrates (nonesterified fatty acids and triglycerides) after a standard exercise test is a metabolic manifestation of deconditioning changes induced by head-down tilting. Insufficient supply of a working human body with readily utilizable lipid substrates causes inadequate activation of energy forming enzymes and excessive buildup of metabolites, i. e. lactate and pyruvate. The efficacy of corrective and prophylactic measures was verified by biochemical data.</p>","PeriodicalId":76078,"journal":{"name":"Kosmicheskaia biologiia i aviakosmicheskaia meditsina","volume":"25 2","pages":"50-4"},"PeriodicalIF":0.0,"publicationDate":"1991-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13030120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Dynamics of hematocrit values in humans during space flights of varying duration].","authors":"V B Noskov, V V Kravchenko, Batenchuk-Tusko","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76078,"journal":{"name":"Kosmicheskaia biologiia i aviakosmicheskaia meditsina","volume":"25 2","pages":"59"},"PeriodicalIF":0.0,"publicationDate":"1991-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13032203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I E Kalninia, R K Bluma, A S Ushakov, V N Sominskiĭ
{"title":"[Changes in serotonin and histamine levels in human blood after 370-day anti-orthostatic hypokinesia].","authors":"I E Kalninia, R K Bluma, A S Ushakov, V N Sominskiĭ","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Ten healthy men took part in a 360-day antiorthostatic hypokinesia study. They were subdivided into two equal groups that differed in terms of time when they started using counter-measures: Group A began exercising on the first day of exposure and Group B on bed rest day 120. As compared to the baseline, the test subjects showed a decrease of serotonin (Ser) and histamine (HA). The only exception was HA increase on bed rest day 50 in the Group A subjects. The difference in Ser and HA concentrations in Group A and B subjects was insignificant on bed rest days 110 through 350. On the 60th day after the study Ser and HA concentrations did not yet return to norm. These observations indicate that changes in the serotonin- and histaminergic systems cannot be compensated within the above period of time.</p>","PeriodicalId":76078,"journal":{"name":"Kosmicheskaia biologiia i aviakosmicheskaia meditsina","volume":"25 2","pages":"54-5"},"PeriodicalIF":0.0,"publicationDate":"1991-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13030114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Reaction of various components of the erythrocyte system to periodic action of submaximal loads].","authors":"I G Dlusskaia, N A Gaĭdamakin, R K Kiselev","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>During repeated exposures of rats to hypergravity two stages of catabolic and adaptive developments in red blood were distinguished. The first stage that lasted about a week was characterized by decrease of resistance and hemolysis of red blood cells, hemosiderosis in the spleen, circulation hypoxia in the liver. The second stage was characterized by the predominance of adaptive processes, viz. increased activity of red blood cells, enhanced erythropoiesis in the spleen pulp, and appearance of highly active hepatocytes.</p>","PeriodicalId":76078,"journal":{"name":"Kosmicheskaia biologiia i aviakosmicheskaia meditsina","volume":"25 2","pages":"47-50"},"PeriodicalIF":0.0,"publicationDate":"1991-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13030117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}