Journal of toxicology and environmental health. Supplement最新文献_第3页

Interaction of estrogen and prolactin in spontaneous mammary tumorigenesis of the mouse. 雌激素和催乳素在小鼠自发性乳腺肿瘤发生中的相互作用。

Journal of toxicology and environmental health. Supplement Pub Date : 1976-01-01

C W Welsch

{"title":"Interaction of estrogen and prolactin in spontaneous mammary tumorigenesis of the mouse.","authors":"C W Welsch","doi":"","DOIUrl":"","url":null,"abstract":"Daily treatment for 12 months of young nulliparous C3H mice with 0.1 mg 2-bromo-alpha-ergocryptine (CB-154), an effective suppressor of prolactin secretion, significantly reduced and in some instances virtually eliminated the incidence of spontaneous mammary tumors. The CB-154-treated mice had normal body weight gains and normal estrous cycles. Ovariectomy of young nulliparous C3H mice also reduced mammary tumor incicence, but appeared to be slightly less effective than treatment with the ergot. Chronic administration of 17beta-estradiol for 12-19 months (via drinking water) to young nulliparous intact or ovariectomized-hysterectomized C3H mice significantly increased mammary tumor incidence. Concurrent administration of 0.1 mg CB-154 to the estrogen-treated mice significantly reduced the incidence of mammary tumors when compared with mice treated with the steroid alone. Chronic sc administration (0.1 mg/mouse, twice weekly for 20 months) of Enovid to young, nulliparous, intact C3H mice significantly increased mammary tumor incidence, whereas concurrent administration of 0.1 mg CB-154 to the Enovid-treated mice significantly reduced the incidence of these tumors. Thus significant inhibition of spontaneous or estrogen- or Enovid-induced mammary tumorigenesis by concurrent drug-induced prolactin suppression has been demonstrated in these studies.","PeriodicalId":76061,"journal":{"name":"Journal of toxicology and environmental health. Supplement","volume":"1 ","pages":"161-75"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12217354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of estrogens and progestins on the cervix uteri. 雌激素和黄体酮对子宫颈的影响。

Journal of toxicology and environmental health. Supplement Pub Date : 1976-01-01

V A Drill

引用次数: 0

Circulating levels of prolactin and growth hormone and natural incidence of mammary tumors in mice. 泌乳素和生长激素的循环水平与小鼠乳腺肿瘤的自然发病率。

Journal of toxicology and environmental health. Supplement Pub Date : 1976-01-01

Y N Sinha, C B Salocks, W P VanderLaan

引用次数: 0

Metabolism of diethylstilbestrol by rat liver: a preliminary report. 己烯雌酚在大鼠肝脏代谢的初步研究。

Journal of toxicology and environmental health. Supplement Pub Date : 1976-01-01

L L Engel, J Weidenfield, G R Merriam

引用次数: 0

Steroid-binding proteins of the mammary gland and their clinical significance in breast cancer. 乳腺类固醇结合蛋白及其在乳腺癌中的临床意义。

Journal of toxicology and environmental health. Supplement Pub Date : 1976-01-01

J L Wittliff, R G Mehta, P A Boyd, J E Goral

{"title":"Steroid-binding proteins of the mammary gland and their clinical significance in breast cancer.","authors":"J L Wittliff, R G Mehta, P A Boyd, J E Goral","doi":"","DOIUrl":"","url":null,"abstract":"Differentiation and development of the mammary gland are influenced by estrogens, glucocorticoids, and progesterone. Specific binding sites for each of these classes of steroid hormones have been characterized in vivo and in cell-free preparations of lactating mammary gland of the rat. These properties were compared with those of steroid-binding proteins in the R3230AC and dimethylbenz[a]anthracene-induced mammary tumors of the rat and of human breast carcinomas. The binding components that were protein in nature were more concentrated in tissue from lactating than from virgin or pregnant rats. The steroid-binding capacities of mammary tumors were highly variable. Using a dextran-coated charcoal procedure, the rate constants of 3H-ligand association with specific binding sites were temperature dependent. Ligand specificity indicated that [3H]estradoil-17beta(3H-E) binding was inhibited only by estrogens, whereas [3H]triamcinolone acetonide (3 H-TA) was blocked by glucocorticoid/s and progesterone. Likewise, [3H]progesterone (3H-P) binding was inhibited by progestins and certain glucocorticoids. Incubation of minced mammary gland with 3H-steroid in the presence and absence of unlabeled competitor demonstrated specific binding sites in cytoplasm that were translocated to nuclei in a tempreature-dependent fashion. Using a steroid-exchange procedure both DEX and TA inhibited 3H-P binding to exchangeable sites that were loaded previously with unlabeled progesterone. These data suggest that certain glucocorticoid and progesterone binding sites were translocated simultaneously to nuclei. Administration in vivo of either 3H-E or 3H-TA indicated binding in cytoplasm and subsequent translocation to nuclei.","PeriodicalId":76061,"journal":{"name":"Journal of toxicology and environmental health. Supplement","volume":"1 ","pages":"231-56"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11403742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progesterone-receptor mediation of chromatin RNA transcription in a cell-free system. 无细胞系统中黄体酮受体介导的染色质RNA转录。

Journal of toxicology and environmental health. Supplement Pub Date : 1976-01-01

W T Schrader, R J Schwartz, R W Kuhn, R E Buller, B W O'Malley

引用次数: 0