Effect of estrogens and progestins on the cervix uteri.

Abstract

High doses of estrogen may increase the occurrence of cervical cancer in mice but not in the rat, dog, or rhesus monkey. Available data do not demonstrate that estrogens increase the frequency of cervical cancer in women. Thus, studies in the mouse did not predict correctly for women. The effects of progestins and oral contraceptives on the cervix of various species are also reviewed.