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Journal of clinical pathology. Supplement (Association of Clinical Pathologists)最新文献

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Plasma lipids and atherosclerosis. 血脂和动脉粥样硬化。
Journal of clinical pathology. Supplement (Association of Clinical Pathologists) Pub Date : 1973-01-01 DOI: 10.1136/jcp.s1-5.1.43
L A Carlson
{"title":"Plasma lipids and atherosclerosis.","authors":"L A Carlson","doi":"10.1136/jcp.s1-5.1.43","DOIUrl":"https://doi.org/10.1136/jcp.s1-5.1.43","url":null,"abstract":"Hyperlipidaemia may be defined as the presence of excess lipid in the blood. It may be classified according to the nature of the lipids which are increased. A classification of hyperlipidaemia based on the fasting levels of cholesterol and triglyceride allows of three possible abnormal groups, which are shown in table I together with the corresponding classification according to Fredrickson as modified in the World Health Organization Memorandum (1970). The Fredrickson system is based on lipoprotein analyses and has six classes compared","PeriodicalId":75995,"journal":{"name":"Journal of clinical pathology. Supplement (Association of Clinical Pathologists)","volume":"5 ","pages":"43-7"},"PeriodicalIF":0.0,"publicationDate":"1973-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/jcp.s1-5.1.43","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15619689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Hypolipoproteinaemia. 低脂蛋白血症。
Journal of clinical pathology. Supplement (Association of Clinical Pathologists) Pub Date : 1973-01-01 DOI: 10.1136/jcp.s1-5.1.53
J K Lloyd
{"title":"Hypolipoproteinaemia.","authors":"J K Lloyd","doi":"10.1136/jcp.s1-5.1.53","DOIUrl":"https://doi.org/10.1136/jcp.s1-5.1.53","url":null,"abstract":"Hypolipoproteinaemia, resulting from deficiency of one or more of the major serum lipoprotein fractions, may be due to a primary genetically determined condition or may occur as a secondary manifestation in another disease state (table I). This paper will be confined to a discussion of the primary disorders which, although rare, have contributed greatly to our understanding of the normal function of the serum lipoproteins.","PeriodicalId":75995,"journal":{"name":"Journal of clinical pathology. Supplement (Association of Clinical Pathologists)","volume":"5 ","pages":"53-8"},"PeriodicalIF":0.0,"publicationDate":"1973-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/jcp.s1-5.1.53","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15619690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Secondary hyperlipidaemia. 二级hyperlipidaemia。
Journal of clinical pathology. Supplement (Association of Clinical Pathologists) Pub Date : 1973-01-01 DOI: 10.1136/jcp.s1-5.1.68
A Chait
{"title":"Secondary hyperlipidaemia.","authors":"A Chait","doi":"10.1136/jcp.s1-5.1.68","DOIUrl":"https://doi.org/10.1136/jcp.s1-5.1.68","url":null,"abstract":"The secondary hyperlipidaemias occur remarkably frequently, and the underlying cause of high serum lipid levels will often be missed if it is not actively sought. Diagnosis is important because the lipid abnormality responds to treatment of the primary disorder in most cases; notable exceptions to this, however, are the hyperlipidaemias associated with gout and chronic renal failure. The conditions regularly associated with hyperlipidaemias are listed in the table. There is no lipoprotein pattern which is specific for any one of these, and almost any pattern may occur in every condition; the pattern may even vary from time to time in the same patient.","PeriodicalId":75995,"journal":{"name":"Journal of clinical pathology. Supplement (Association of Clinical Pathologists)","volume":"5 ","pages":"68-71"},"PeriodicalIF":0.0,"publicationDate":"1973-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/jcp.s1-5.1.68","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15681268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Classification of lipoproteins and lipoprotein disorders. 脂蛋白和脂蛋白紊乱的分类。
Journal of clinical pathology. Supplement (Association of Clinical Pathologists) Pub Date : 1973-01-01 DOI: 10.1136/jcp.s1-5.1.26
B Lewis
{"title":"Classification of lipoproteins and lipoprotein disorders.","authors":"B Lewis","doi":"10.1136/jcp.s1-5.1.26","DOIUrl":"https://doi.org/10.1136/jcp.s1-5.1.26","url":null,"abstract":"","PeriodicalId":75995,"journal":{"name":"Journal of clinical pathology. Supplement (Association of Clinical Pathologists)","volume":"5 ","pages":"26-31"},"PeriodicalIF":0.0,"publicationDate":"1973-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/jcp.s1-5.1.26","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15458939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Plasma triglyceride metabolism. 血浆甘油三酯代谢。
Journal of clinical pathology. Supplement (Association of Clinical Pathologists) Pub Date : 1973-01-01 DOI: 10.1136/jcp.s1-5.1.5
D S Robinson
{"title":"Plasma triglyceride metabolism.","authors":"D S Robinson","doi":"10.1136/jcp.s1-5.1.5","DOIUrl":"https://doi.org/10.1136/jcp.s1-5.1.5","url":null,"abstract":"Knowledge of the way in which triglyceride is trans- ported in the blood and of the factors that influence the transport process is essential for a proper under- standing of the overall distribution of lipids in the plasma that is observed in health and disease. The following account deals with triglyceride transport in normal individuals and provides a basis for com- parison with states of abnormal lipid metabolism. more polar lipids and macromolecules known lipoproteins.","PeriodicalId":75995,"journal":{"name":"Journal of clinical pathology. Supplement (Association of Clinical Pathologists)","volume":"5 ","pages":"5-10"},"PeriodicalIF":0.0,"publicationDate":"1973-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/jcp.s1-5.1.5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15458941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Diet and triglyceride metabolism. 饮食和甘油三酯代谢。
Journal of clinical pathology. Supplement (Association of Clinical Pathologists) Pub Date : 1973-01-01 DOI: 10.1136/jcp.s1-5.1.22
I Macdonald
{"title":"Diet and triglyceride metabolism.","authors":"I Macdonald","doi":"10.1136/jcp.s1-5.1.22","DOIUrl":"https://doi.org/10.1136/jcp.s1-5.1.22","url":null,"abstract":"Triglyceride forms the major store of energy in the body and it is only recently that the role of the triglyceride metabolism has been considered to be other than harmless. A vast accumulation of triglyceride as adipose tissue has been long known to increase the stress and strain of other aspects of the individual's physiology because of the physical problems it creates. More recently it has become apparent that obesity is associated with biochemical problems, and a closer look at triglyceride metabolism indicates that there exist more subtle and possibly more sinister implications in these associated disorders of triglyceride metabolism. It is widely known from obesity and starvation studies that diet plays a major role in triglyceride metabolism, certainly in the quantitative sense, but there is the possibility that the quality of the diet can exert less striking, but nevertheless important, influences on triglyceride metabolism.","PeriodicalId":75995,"journal":{"name":"Journal of clinical pathology. Supplement (Association of Clinical Pathologists)","volume":"5 ","pages":"22-5"},"PeriodicalIF":0.0,"publicationDate":"1973-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/jcp.s1-5.1.22","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15619688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Evidence for a defect in fatty acid uptake by adipose tissue of patients with hypertriglyceridaemia. 高甘油三酯血症患者脂肪组织脂肪酸摄取缺陷的证据。
Journal of clinical pathology. Supplement (Association of Clinical Pathologists) Pub Date : 1973-01-01 DOI: 10.1136/jcp.s1-5.1.48
L A Carlson, G Walldius, A G Olsson
{"title":"Evidence for a defect in fatty acid uptake by adipose tissue of patients with hypertriglyceridaemia.","authors":"L A Carlson,&nbsp;G Walldius,&nbsp;A G Olsson","doi":"10.1136/jcp.s1-5.1.48","DOIUrl":"https://doi.org/10.1136/jcp.s1-5.1.48","url":null,"abstract":"Professor Robinson has described the importance of lipoprotein lipase (clearing factor lipase) for the initial phase in the clearance of plasma triglycerides, whether exogenous and present as chylomicrons or endogenous and present as very-low-density lipoprotein (VLDL). It acts by splitting off the fatty acids which are then taken up by the cells. Our interest in hypertriglyceridaemia was extended to the later phases of the clearance process as a result of an unusual case described below. Case A.A. was a man aged 50 with massive hypertriglyceridaemia, with plasma levels sometimes exceeding 150 mmol/12 (approximately 12 500 mg/100 ml) compared with the normal of about 1-2 mmol/l. Initially, fasting plasma looked like cream and most of the triglyceride was present in the chylomicrons, ie, in particles with Sf>400, but there was also elevation of the VLDL with Sf< 400 (table I). The hyperlipidaemia is thus best classified","PeriodicalId":75995,"journal":{"name":"Journal of clinical pathology. Supplement (Association of Clinical Pathologists)","volume":"5 ","pages":"48-52"},"PeriodicalIF":0.0,"publicationDate":"1973-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/jcp.s1-5.1.48","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15377797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
The enterohepatic circulation of bile acids as they relate to lipid disorders. 与脂质紊乱有关的胆汁酸的肠肝循环。
Journal of clinical pathology. Supplement (Association of Clinical Pathologists) Pub Date : 1973-01-01 DOI: 10.1136/jcp.s1-5.1.59
R H Dowling
{"title":"The enterohepatic circulation of bile acids as they relate to lipid disorders.","authors":"R H Dowling","doi":"10.1136/jcp.s1-5.1.59","DOIUrl":"https://doi.org/10.1136/jcp.s1-5.1.59","url":null,"abstract":"Bile acids' play a fundamental role in lipid metabolism. They solubilize the products of lipolysis thereby facilitating digestion of triglycerides and the absorption of monoglycerides and fatty acids, and their presence is mandatory for the absorption of cholesterol and the fat-soluble vitamins. The enterohepatic circulation of bile acids ensures that adequate concentrations of these biological detergents are available when needed in the intestinal lumen. This paper, therefore, begins by reviewing the normal enterohepatic circulation of bile acids as illustrated by studies in the rhesus monkey. The influence of diet and particularly of dietary fat on this circulation is then discussed with emphasis on some further recent studies in the monkey which suggest a possible mechanism for the hypocholesterolaemic action of polyunsaturated fats. Finally, some effects of interrupting the bile acid enterohepatic circulation are considered. These include the development of hyperoxaluria and occasionally renal oxalate stone formation, and the formation of a bile supersaturated with cholesterol and the subsequent development of cholesterol gallstones.","PeriodicalId":75995,"journal":{"name":"Journal of clinical pathology. Supplement (Association of Clinical Pathologists)","volume":"5 ","pages":"59-67"},"PeriodicalIF":0.0,"publicationDate":"1973-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/jcp.s1-5.1.59","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15308611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 22
The pathogenesis of atherosclerosis. 动脉粥样硬化的发病机制。
Journal of clinical pathology. Supplement (Association of Clinical Pathologists) Pub Date : 1973-01-01 DOI: 10.1136/jcp.s1-5.1.38
C W Adams
{"title":"The pathogenesis of atherosclerosis.","authors":"C W Adams","doi":"10.1136/jcp.s1-5.1.38","DOIUrl":"https://doi.org/10.1136/jcp.s1-5.1.38","url":null,"abstract":"Duguid (1946, 1952) extended Rokitansky's earlier observations by suggesting that encrustation of fine platelet deposits and films of fibrin on the endothelium provokes an inflammatory response that results in organization by scarring. This view has been modified by supposing that local fibrinolytic activity in the arterial wall may control the equilibrium between encrustation and solution of fibrin (Astrup, 1959). Although Duguid's mechanism does not in itself explain how lipid enters the arterial wall, a subsequent suggestion is that vasoactive compounds from encrusted platelets increase endothelial permeability and thus permit lipid to enter (Mustard, 1967, 1970; Constantinides and Robinson, 1969).","PeriodicalId":75995,"journal":{"name":"Journal of clinical pathology. Supplement (Association of Clinical Pathologists)","volume":"5 ","pages":"38-42"},"PeriodicalIF":0.0,"publicationDate":"1973-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/jcp.s1-5.1.38","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15377796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Enzyme kinetics and its relevance to enzyme assay. 酶动力学及其与酶分析的相关性。
Journal of clinical pathology. Supplement (Association of Clinical Pathologists) Pub Date : 1970-01-01 DOI: 10.1136/jcp.s1-4.1.14
J H Wilkinson
{"title":"Enzyme kinetics and its relevance to enzyme assay.","authors":"J H Wilkinson","doi":"10.1136/jcp.s1-4.1.14","DOIUrl":"https://doi.org/10.1136/jcp.s1-4.1.14","url":null,"abstract":"The reversible oxidation of lactate by lactate dehydrogenase (EC 1-1 1-27), pH7-4 pyruvate + NADH + H+ 't lactate + NAD+, pH 9 2 may be regarded as a typical enzyme reaction which can proceed in either direction according to whether pyruvate or lactate is provided as substrate. When the reaction is started by the addition of either substrate in the presence of the appropriate coenzyme, pH, temperature, etc, it proceeds quite rapidly at first. However, as substrate or coenzyme is consumed and the products accumulate, the rate gradually slows until an equilibrium is reached at which the forward and reverse reactions proceed at the same rate (Fig. 1).","PeriodicalId":75995,"journal":{"name":"Journal of clinical pathology. Supplement (Association of Clinical Pathologists)","volume":"4 ","pages":"14-21"},"PeriodicalIF":0.0,"publicationDate":"1970-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/jcp.s1-4.1.14","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15451411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
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