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International pharmacopsychiatry最新文献

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Pharmacology of hypnotics. 催眠药理学。
International pharmacopsychiatry Pub Date : 1982-01-01
P Simon, I Boutelier
{"title":"Pharmacology of hypnotics.","authors":"P Simon,&nbsp;I Boutelier","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Sedative hypnotics belong to several chemical classes and thus have heterogeneous pharmacodynamic properties. Among various ways of approaches, conventional pharmacology using animal models allows one to define a common pharmacological profile. It still remains the best predictive tool of hypnotic efficacy in man. The study of discriminative properties is a useful extension of these conventional models. Electrophysiological and biochemical studies allow primarily to approach the problems of the sites and mechanisms of action, but only begin at the moment to lead to practical applications.</p>","PeriodicalId":75943,"journal":{"name":"International pharmacopsychiatry","volume":"17 Suppl 2 ","pages":"39-45"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17212224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent investigations on the mechanism of action of nomifensine. 诺米芬作用机制的研究进展。
International pharmacopsychiatry Pub Date : 1982-01-01 DOI: 10.1159/000468599
U Schacht, M Leven, H J Gerhards, P Hunt, J P Raynaud
{"title":"Recent investigations on the mechanism of action of nomifensine.","authors":"U Schacht,&nbsp;M Leven,&nbsp;H J Gerhards,&nbsp;P Hunt,&nbsp;J P Raynaud","doi":"10.1159/000468599","DOIUrl":"https://doi.org/10.1159/000468599","url":null,"abstract":"","PeriodicalId":75943,"journal":{"name":"International pharmacopsychiatry","volume":"17 Suppl 1 ","pages":"21-34"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000468599","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17246963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 25
Long-term study of fluvoxamine: a new rapid-acting antidepressant. 氟伏沙明的长期研究:一种新的速效抗抑郁药。
International pharmacopsychiatry Pub Date : 1982-01-01 DOI: 10.1159/000468564
H S Feldmann, H C Denber
{"title":"Long-term study of fluvoxamine: a new rapid-acting antidepressant.","authors":"H S Feldmann,&nbsp;H C Denber","doi":"10.1159/000468564","DOIUrl":"https://doi.org/10.1159/000468564","url":null,"abstract":"<p><p>This was a 1-year study of fluvoxamine in 31 depressed male and female patients with a history of chronic recurring depression of various types. Fluvoxamine has a rapid action with lifting of the mood often within 4-7 days, in a dosage range from 150 to 200 mg/day. Suicidal ideation in 8 patients disappeared within 5-6 days. There were few side effects. This new antidepressant seemed to be very effective especially in endogenous depression.</p>","PeriodicalId":75943,"journal":{"name":"International pharmacopsychiatry","volume":"17 2","pages":"114-22"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000468564","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17861472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
Longitudinal assessment of MAO-, COMT-, and DBH- activity in patients with bipolar depression.
International pharmacopsychiatry Pub Date : 1982-01-01 DOI: 10.1159/000468552
E Fähndrich, B Müller-Oerlinghausen, H Coper
{"title":"Longitudinal assessment of MAO-, COMT-, and DBH- activity in patients with bipolar depression.","authors":"E Fähndrich,&nbsp;B Müller-Oerlinghausen,&nbsp;H Coper","doi":"10.1159/000468552","DOIUrl":"https://doi.org/10.1159/000468552","url":null,"abstract":"<p><p>This study was carried out to determine whether the activity of regulatory enzymes for biogenic amines are state variables or trait variables for bipolar depression. The activity of MAO, COMT, and DBH in platelets, RBC and serum, respectively, was measured repeatedly in patients with bipolar depression and in matched control subjects. An increase in MAO activity was observed in patients compared to controls, while MAO activity was unrelated to the patient's psychopathological state. COMT activity was higher in female patients than in female controls and was lower in male patients than in male controls, but it failed to be related to the psychopathological state of patients. Relevant differences in serum DBH activity failed to occur either between patients and controls, or in patients during different states of their illness. The findings suggest that the activity of MAO and COMT are trait variables for bipolar depression, while DBH activity is neither a state variable nor a trait variable. it is discussed why only longitudinal studies in contrast to conventional cross-sectional assessments allow a distinction between state and trait variables.</p>","PeriodicalId":75943,"journal":{"name":"International pharmacopsychiatry","volume":"17 1","pages":"8-17"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000468552","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18029349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Pharmacokinetics of haloperidol decanoate. A 2-year follow-up. 癸酸氟哌啶醇的药代动力学。随访2年。
International pharmacopsychiatry Pub Date : 1982-01-01 DOI: 10.1159/000468580
A J Reyntigens, J J Heykants, R J Woestenborghs, Y G Gelders, T J Aerts
{"title":"Pharmacokinetics of haloperidol decanoate. A 2-year follow-up.","authors":"A J Reyntigens,&nbsp;J J Heykants,&nbsp;R J Woestenborghs,&nbsp;Y G Gelders,&nbsp;T J Aerts","doi":"10.1159/000468580","DOIUrl":"https://doi.org/10.1159/000468580","url":null,"abstract":"<p><p>Plasma haloperidol levels were assayed in 181 chronic schizophrenic inpatients, who were monthly injected intramuscularly with haloperidol decanoate. Steady state levels are reached after the third monthly injection and then remain constant, being associated with a remarkably stable control of the psychotic condition. Between two subsequent injections the haloperidol levels decrease gradually by about half their initial value. The haloperidol plasma levels strongly correlate with the injected doses of the decanoate form. For a single dose of 100 mg haloperidol decanoate monthly the minimal steady state value is about 4 ng/ml.</p>","PeriodicalId":75943,"journal":{"name":"International pharmacopsychiatry","volume":"17 4","pages":"238-46"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000468580","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18201858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 39
[Scale construction of the German version of the Comprehensive Psychopathological Rating Scale (CPRS)]. [德文精神病理综合评定量表(CPRS)的量表构建]。
International pharmacopsychiatry Pub Date : 1982-01-01 DOI: 10.1159/000468589
M Maurer, S Kuny, A Dittrich, B Woggon
{"title":"[Scale construction of the German version of the Comprehensive Psychopathological Rating Scale (CPRS)].","authors":"M Maurer,&nbsp;S Kuny,&nbsp;A Dittrich,&nbsp;B Woggon","doi":"10.1159/000468589","DOIUrl":"https://doi.org/10.1159/000468589","url":null,"abstract":"<p><p>170 hospitalised patients (96 schizophrenic, 71 depressive, and 3 manic) were examined during the German version of the CPRS. Based on factor analytical results four subscales ('manic syndrome', 'schizophrenic syndrome', 'depressive syndrome', and 'side-effects') and two second-order scales ('manic-depressive syndrome' and 'schizophrenic syndrome') were constructed. The first three subscales show a good reliability. The fourth subscale ('side-effects') has an insufficient internal consistency, mainly due to the small number of items (6). The two subscales 'schizophrenic syndrome' and 'depressive syndrome' and the two second-order scales can differentiate very well between schizophrenic and depressive syndromes. The validity of the first and fourth subscale could not be examined in this study.</p>","PeriodicalId":75943,"journal":{"name":"International pharmacopsychiatry","volume":"17 4","pages":"338-53"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000468589","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18201865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Zopiclone: sleep and performance studies in healthy man. 佐匹克隆:健康男性的睡眠和表现研究。
International pharmacopsychiatry Pub Date : 1982-01-01
A N Nicholson, B M Stone
{"title":"Zopiclone: sleep and performance studies in healthy man.","authors":"A N Nicholson,&nbsp;B M Stone","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Effects of 2.5, 5.0, 7.5, and 10.0 mg zopiclone on sleep and on performance the next day were studied in 6 healthy adult males aged between 21 and 33 years. The experiment was double-blind and placebo controlled. 5.0 and 10.0 mg zopiclone decreased the amount of awake activity and drowsy (stage 1) sleep over the first 6 h of sleep, but this effect was only present for the whole sleep period with the 10.0-mg dose. The duration and percentage of stage 3 sleep were increased with 7.5 mg. The 7.5- and 10.0-mg doses increased the combined duration of stages 2, 3, and 4 sleep over the first 6 h and over the whole night. The first period of rapid eye movement sleep was delayed with 7.5 mg, and with 10.0 mg the time spent in rapid eye movement sleep was reduced during the first 6 h of sleep, but not over the whole night. The number of substitutions in the digit symbol substitution test was decreased 9 h after ingestion of 7.5 and 10.0 mg, and the number of symbols copied reduced after 10.0 mg. The clinical dose range of zopiclone is likely to be up to 7.5 mg. The latter dose provides a useful hypnotic effect with minimal residual effects the next day, whilst 5.0 mg is appropriate for those involved in skilled tasks where even the most minor changes in performance during the early part of the next day must be avoided.</p>","PeriodicalId":75943,"journal":{"name":"International pharmacopsychiatry","volume":"17 Suppl 2 ","pages":"92-7"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18204208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of piracetam on extrapyramidal side effects induced by neuroleptic drugs. 吡拉西坦对抗精神病药物所致锥体外系不良反应的影响。
International pharmacopsychiatry Pub Date : 1982-01-01 DOI: 10.1159/000468574
J. Kabeš, J. Sikora, J. Pisvejc, L. Hanzlícek, V. Skondia
{"title":"Effect of piracetam on extrapyramidal side effects induced by neuroleptic drugs.","authors":"J. Kabeš, J. Sikora, J. Pisvejc, L. Hanzlícek, V. Skondia","doi":"10.1159/000468574","DOIUrl":"https://doi.org/10.1159/000468574","url":null,"abstract":"In a double-blind crossover placebo controlled trial the effectivity of piracetam in neuroleptic-induced extrapyramidal side effects was confirmed. 40 psychotic patients treated with neuroleptics in an average daily dose equal to 600 mg of chlorpromazine were included in this study. Akathisia, tremor, muscle rigidity and dyskinesia were evaluated on a 4-point scale. The patients were randomly divided into two subgroups--40 g of piracetam or placebo from identic ampoules were given i.v. with a crossover readministration after 60 min. The intensity of the extrapyramidal side effects was evaluated at 30-min intervals during 2 h. Piracetam was proved to be significantly effective in both subgroups, the onset of its action being between 30 and 60 min after i.v. administration. Possible interpretations of the observed piracetam effectivity are considered. Further trials with piracetam in neurologic complications during neuroleptic treatment, tardive dyskinesia included, are suggested.","PeriodicalId":75943,"journal":{"name":"International pharmacopsychiatry","volume":"17 3 1","pages":"185-92"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000468574","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65243528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 24
Rebound phenomena: results of a 10 years' (1970--1980) literature review. 反弹现象:一项10年(1970- 1980)文献回顾的结果。
International pharmacopsychiatry Pub Date : 1982-01-01 DOI: 10.1159/000468579
R Lupolover, H Dazzi, J Ward
{"title":"Rebound phenomena: results of a 10 years' (1970--1980) literature review.","authors":"R Lupolover,&nbsp;H Dazzi,&nbsp;J Ward","doi":"10.1159/000468579","DOIUrl":"https://doi.org/10.1159/000468579","url":null,"abstract":"A survey of the literature over 10 years (1970--1980) shows that the phenomenon of 'rebound' can appear after withdrawal of a large number of drugs belonging to various chemical classes and also, as a physiologic compensatory mechanism of the central nervous system, without drugs. Among the various drugs, benzodiazepine hypnotics are also mentioned in problems related to 'rebound' (insomnia, anxiety). Controversial opinions are expressed regarding the appearance of rebound insomnia or anxiety. It seems that those authors who believe in the existence of rebound relate it either to therapy with high doses of drugs or to hypnotics with short to intermediate half-life.","PeriodicalId":75943,"journal":{"name":"International pharmacopsychiatry","volume":"17 4","pages":"194-237"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000468579","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17203175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 21
A study on the pharmacological and biochemical profile of clocapramine. 氯氯帕明的药理学和生化特征研究。
International pharmacopsychiatry Pub Date : 1982-01-01 DOI: 10.1159/000468561
M Kurihara, T Tsumagari, M Setoguchi, T Fukuda
{"title":"A study on the pharmacological and biochemical profile of clocapramine.","authors":"M Kurihara,&nbsp;T Tsumagari,&nbsp;M Setoguchi,&nbsp;T Fukuda","doi":"10.1159/000468561","DOIUrl":"https://doi.org/10.1159/000468561","url":null,"abstract":"<p><p>Clocapramine was introduced into clinical use as a successor to carpipramine which is designated as a \"désinhibiteur' by Deniker et al. Pharmacological and biochemical studies were carried out in order to elucidate the central action of clocapramine. Antidopaminergic activity of clocapramine was more potent than that of carpipramine. Clocapramine did not show any imipramine-like action; on the other hand, carpipramine partially did. We discuss the correlation between the preclinical findings so far obtained and clinical disinhibitory activity.</p>","PeriodicalId":75943,"journal":{"name":"International pharmacopsychiatry","volume":"17 2","pages":"73-90"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000468561","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17192018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
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