International pharmacopsychiatry最新文献_第10页

Tranylcypromine isomers in the treatment of Parkinson's disease. Biochemical effects. 三酰环丙氨酸异构体在帕金森病治疗中的应用。生化效应。

International pharmacopsychiatry Pub Date : 1981-01-01 DOI: 10.1159/000468471

G P Reynolds, P Riederer

引用次数: 6

Dopamine antagonist properties of atypical neuroleptics may be revealed following mesolimbic denervation. 非典型抗精神病药的多巴胺拮抗剂特性可以在中脑边缘去神经支配后发现。

International pharmacopsychiatry Pub Date : 1981-01-01 DOI: 10.1159/000468470

V Nohria, B Costall, R J Naylor

引用次数: 2

Benzodiazepine withdrawal phenomena. 苯二氮卓类戒断现象。

International pharmacopsychiatry Pub Date : 1981-01-01 DOI: 10.1159/000468500

C Hallstrom, M Lader

引用次数: 123

[Metabolism and excretion of the neuroleptic drug perazine in healthy volunteers]. [健康志愿者抗精神病药物佩拉嗪的代谢和排泄]。

International pharmacopsychiatry Pub Date : 1981-01-01 DOI: 10.1159/000468497

J. Schley, E. Riedel, B. Müller-Oerlinghausen

引用次数: 5

Long-term application of haloperidol: effects on dopamine and acetylcholine receptors. 氟哌啶醇长期应用:对多巴胺和乙酰胆碱受体的影响。

International pharmacopsychiatry Pub Date : 1981-01-01 DOI: 10.1159/000468489

G Stock, P Kummer

{"title":"Long-term application of haloperidol: effects on dopamine and acetylcholine receptors.","authors":"G Stock, P Kummer","doi":"10.1159/000468489","DOIUrl":"https://doi.org/10.1159/000468489","url":null,"abstract":"Rats were injected daily with haloperidol, 0.5 mg/kg i.p., or pimozide, 2 mg/kg i.p., for a period of 8 or 16 days, respectively. 24 h after the last injection of haloperidol, these rats were challenged with gamma-butyrolactone (GBL) in doses of 200-750 mg/kg i.p. In haloperidol-treated rats, higher doses of GBL are needed in order to increase the rate of dopa accumulation. This finding demonstrates the development of supersensitivity of dopamine (DA) autoreceptors towards endogenously released DA. Pimozide had no effect on the increased rate of dopa accumulation induced by increasing doses of GBL. From this data it is concluded that pimozide in our model is mainly active on postsynaptic DA receptors and haloperidol is active on pre- and postsynaptic DA receptors. In rats treated chronically with daily injections of haloperidol, benztropine, in a dose of 50 mg/kg, induced a decrease in dopa accumulation which was more marked than the decrease seen with benztropine, 50 mg/kg in animals treated with a single injection of haloperidol only. The opiate antagonist, naloxone at a dose of 10 mg/kg, had no effect on these results. Benztropine, 50 mg/kg i.p., had no effect on the increased rate of dopa accumulation induced by GBL, 400 mg/kg. The data support the hypothesis that in parallel to the development of supersensitive postsynaptic DA receptors, there is a development of subsensitivity in cholinergic receptors within the nigro-neostriatal system. Further the results show that a new DA-acetylcholine equilibrium is reached during long-term haloperidol treatment. The implications of these findings in regard to extrapyramidal side effects during long-term neuroleptic treatment are briefly discussed.","PeriodicalId":75943,"journal":{"name":"International pharmacopsychiatry","volume":"16 3","pages":"144-53"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000468489","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17850799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Drug interactions in psychiatric practice. 精神病学实践中的药物相互作用。

International pharmacopsychiatry Pub Date : 1981-01-01 DOI: 10.1159/000468482

M Ragheb

引用次数: 7

Drug fever due to nomifensine treatment in patients with endogenous depression. 药物发热因诺非芬治疗的内源性抑郁症患者。

International pharmacopsychiatry Pub Date : 1981-01-01 DOI: 10.1159/000468476

J L Nielsen, N O Lund

引用次数: 12

Follow-up study of 281 schizophrenic patients treated with high dosage fluphenazine decanoate. 高剂量癸酸氟那嗪治疗281例精神分裂症患者的随访研究。

International pharmacopsychiatry Pub Date : 1981-01-01 DOI: 10.1159/000468493

S Steiner, C Nagy

引用次数: 1

Acute effects of disulfiram on anxiety levels of chronic alcoholics. 双硫仑对慢性酗酒者焦虑水平的急性影响。

International pharmacopsychiatry Pub Date : 1981-01-01 DOI: 10.1159/000468474

S Snyder, M Keeler

引用次数: 8

Effects of long-term administration of anticonvulsant drugs on chromosomes in man. 长期服用抗惊厥药物对人染色体的影响。

International pharmacopsychiatry Pub Date : 1981-01-01 DOI: 10.1159/000468468

Y Matsushima, H Hazama, R Kawahara

{"title":"Effects of long-term administration of anticonvulsant drugs on chromosomes in man.","authors":"Y Matsushima, H Hazama, R Kawahara","doi":"10.1159/000468468","DOIUrl":"https://doi.org/10.1159/000468468","url":null,"abstract":"Effects of long=term administration of anticonvulsant drugs on chromosomes in epileptic mothers and their children were examined. Specimens from peripheral lymphocytes were prepared by incubation for 3 days and colchicine treatment. Results obtained were as follows: (1) The incidence of abnormal cells in epileptic mother group over 9 years of drug administration was significantly higher than in the group below 9 years. (2) Most of chromosome abnormalities found in subjects were of comparatively simple morphological aberrations such as gaps or breaks. The incidence of the chromosome-type abnormalities was significantly higher in the patient group than in the control group. (3) Chromosome abnormality of children showed a positive correlation with that of mothers but was not significant. (4) The incidence of chromosome abnormality in children was reduced along with aging. (5) These observations could be interpreted to suggest that chromosome abnormality appearing in children born from epileptic mothers under drug therapy was probably formed by direct effects of anticonvulsant drugs on the fetal hematopoietic system.","PeriodicalId":75943,"journal":{"name":"International pharmacopsychiatry","volume":"16 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000468468","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18311074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1