International journal of nuclear medicine and biology最新文献_第5页

4369369 X or gamma radiation detector, particularly for radiology and a radiological apparatus comprising such a detector X射线或伽马射线探测器，尤指用于放射学和包含这种探测器的放射学设备

International journal of nuclear medicine and biology Pub Date : 1985-01-01 DOI: 10.1016/0047-0740(85)90039-7

引用次数: 0

4473544 Radio-iodine-labelled omega phenyl fatty acids 4473544放射性碘标记的欧米茄苯基脂肪酸

International journal of nuclear medicine and biology Pub Date : 1985-01-01 DOI: 10.1016/0047-0740(85)90204-9

引用次数: 0

4427647 Method and reagent for making a radiopharmaceutical composition based on pertechnetate 4427647用于制造基于高技术酸盐的放射性药物组合物的方法和试剂

International journal of nuclear medicine and biology Pub Date : 1985-01-01 DOI: 10.1016/0047-0740(85)90196-2

引用次数: 0

Isopropyl alcohol is a cause of stomach activity on oxidronate bone scans 异丙醇是氧化骨扫描显示胃部活动的一个原因

International journal of nuclear medicine and biology Pub Date : 1985-01-01 DOI: 10.1016/0047-0740(85)90183-4

Erma M. Peterson, James W. Ryan, William B. Martin

引用次数: 0

Modified rapid radiometric method for detection of Mycobacterium tuberculosis from sputum samples 改进快速放射法检测痰液中结核分枝杆菌

International journal of nuclear medicine and biology Pub Date : 1985-01-01 DOI: 10.1016/0047-0740(85)90190-1

D.H. Shah , M.N. Devdhar , R.D. Ganatra , P.N. Kale , S.S. Virdi , M.D. Deshmukh

引用次数: 7

In vivo kinetics and thrombus accumulation of 67ga-labeled urokinase 67ga标记尿激酶的体内动力学和血栓积聚

International journal of nuclear medicine and biology Pub Date : 1985-01-01 DOI: 10.1016/0047-0740(85)90012-9

Yoshiro Ohmomo, Akira Yokoyama, Yuko Yamauchi, Kazuko Horiuchi, Hideo Saji, Chiaki Tanaka, Kanji Torizuka

{"title":"In vivo kinetics and thrombus accumulation of 67ga-labeled urokinase","authors":"Yoshiro Ohmomo, Akira Yokoyama, Yuko Yamauchi, Kazuko Horiuchi, Hideo Saji, Chiaki Tanaka, Kanji Torizuka","doi":"10.1016/0047-0740(85)90012-9","DOIUrl":"10.1016/0047-0740(85)90012-9","url":null,"abstract":"<div>Highly purified high and low molecular weight urokinase (H-UK and L-UK) were labeled with 67Ga using deferoxamine (DF) as a bifunctional chelating agent. The labeling efficiency was 91.7% for the H-UK, and 90.4% for the L-UK, respectively. The 67Ga labeled UK (67Ga-DF-UK) fully retained the enzymatic activity of the parent UK. Studies on the in vivo behavior of the 67Ga labeled UK in rabbits showed a very rapid blood clearance with half-life of 4 min (67Ga-DF-L-UK) to 8 min (67Ga-DF-H-UK Studies carried out in rabbits with induced thrombi in the femoral vein showed thrombus-to-blood 67Ga-DF-UK activity ratios, 2 h after injection, of 2.00–3.08 for the H-UK, and 0.84–1.65 for the L-UK, respectively, with thrombi aged 4 to 3 days. A dose effect of the 67Ga-DF-H-UK on its thrombus accumulation was observed. Gel chromatographic analysis of plasma samples withdrawn from those animals injected with this radiopharmaceutical revealed a reduction of the 67Ga-DF-UK effectiveness due to complexation with protein inhibitors. This led to formation of high molecular weight complexes which was reflected in the very fast blood clearance. Its implication in thrombus accumulation is discussed. In conclusion, usefulness of DF for labeling UK with 67Ga or 68Ga with no alteration of UK enzymatic properties was demonstrated. The use of 67Ga-DF-UK as a diagnostic or therapeutic radiopharmaceutical is promising.</div>","PeriodicalId":75939,"journal":{"name":"International journal of nuclear medicine and biology","volume":"12 1","pages":"Pages 47-52"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0047-0740(85)90012-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15121476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Production of 123I as iodide by distillation 以碘化物形式蒸馏生产123I

International journal of nuclear medicine and biology Pub Date : 1985-01-01 DOI: 10.1016/0047-0740(85)90014-2

M. Anwar Qureshl, L. Mcisaac, D. Schlyer, H.B. Hupf, Farouk A.H. Al-Watban, David Lewall

引用次数: 4

Scintigraphic visualisation of extrahepatic portal circulation in patients with portal hypertension using 99mTc-tin-colloid and 99mTc-HIDA 用99mtc -锡胶体和99mtc - hda显像观察门静脉高压症患者的肝外门静脉循环

International journal of nuclear medicine and biology Pub Date : 1985-01-01 DOI: 10.1016/0047-0740(85)90015-4

Mousa H.S. Al-Hussoni, Malik N. Jasim, Amira H. Shubbar

引用次数: 1

Transmembrane transport of iron from extracellular transferrin by lymphoma cells 淋巴瘤细胞胞外转铁蛋白的铁跨膜运输

International journal of nuclear medicine and biology Pub Date : 1985-01-01 DOI: 10.1016/0047-0740(85)90017-8

Anthony F. Almeida , Graeme R. Boniface, Uwe K. Terner, Antoine A. Noujaim

引用次数: 0

Comparative radiopharmacokinetics of 18F-5-fluorouracil administered i.v. to rats bearing a mammary tumor 18f -5-氟尿嘧啶在乳腺肿瘤大鼠体内的比较放射药代动力学

International journal of nuclear medicine and biology Pub Date : 1985-01-01 DOI: 10.1016/0047-0740(85)90005-1

Jashovam Shani , Randall C. Manaka , David Young , Jordan L. Cohen , Walter Wolf

{"title":"Comparative radiopharmacokinetics of 18F-5-fluorouracil administered i.v. to rats bearing a mammary tumor","authors":"Jashovam Shani , Randall C. Manaka , David Young , Jordan L. Cohen , Walter Wolf","doi":"10.1016/0047-0740(85)90005-1","DOIUrl":"10.1016/0047-0740(85)90005-1","url":null,"abstract":"<div>In an attempt to compare the efficacy of various 5-fluorouracil (5-FU) regimens, we studied the kinetics of 18F-labeled and unlabeled 5-FU in rats. 18F-5-FU was synthesized in our laboratory and was administered in tracer doses to Fischer rats bearing either the 13762 or the R3230 mammary adenocarcinoma, and to Sprague-Dawley rats bearing the Walker-256 carcinosarcoma, with or without pre-treatment with a therapeutic dose of unlabeled 5-FU. In addition, the non-radioactive 5-FU was administered to control rats of both strains. All animals were followed for 70 min either by measuring their 18F blood levels continuously using an extracorporeal blood-loop, or by determining their 5-FU blood levels at discrete time intervals. The biphasic kinetic profile was characterized by determining α and β rate constants and their corresponding half-lives. Differences in 18F elimination, as measured by the area under the curve during the elimination phase, were observed between the pre-treated 13762-bearing rats and the untreated group bearing the same tumor. as well as the pre-treated non-tumored controls and both W-256-bearing groups. Such differences could reveal changes in the ability of those rats to metabolize 5-FU, and hence correlate to the level of active metabolite(s) available to their tumor sites.</div>","PeriodicalId":75939,"journal":{"name":"International journal of nuclear medicine and biology","volume":"12 1","pages":"Pages 9-12"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0047-0740(85)90005-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15122126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4