American Journal of Phytomedicine and Clinical Therapeutics最新文献_第4页

Identification and characterization of microbial community of anaerobic digested poultry litter 厌氧消化禽粪微生物群落的鉴定与表征

American Journal of Phytomedicine and Clinical Therapeutics Pub Date : 2021-08-23 DOI: 10.4314/JOPAT.V20I1.7

Stella Suanu Leh-Togi Zobeashia, P. O. Abioye, U. Ijah, O. A. Oyewole

{"title":"Identification and characterization of microbial community of anaerobic digested poultry litter","authors":"Stella Suanu Leh-Togi Zobeashia, P. O. Abioye, U. Ijah, O. A. Oyewole","doi":"10.4314/JOPAT.V20I1.7","DOIUrl":"https://doi.org/10.4314/JOPAT.V20I1.7","url":null,"abstract":"Livestock farming have resulted in the release of excessive wastes which, contains abundant organic matter and microbial population. The need to develop an alternative and sustainable methods to minimize the waste generated and it effects on the environment led to the application of anaerobic digestion (AD) for the treatment of waste and generation of methane gas. The study focused on investigation of the microbiome involve in AD of poultry litter and was conducted using poultry litter as organic substrate under batch conditions at hydraulic retention time (HRT) of fifty-six (56) days in fifteen (15) liter fabricated digesters at 37OC. The pH, total solid (TS), moisture content (MC) total ammonia nitrogen, volatile solid (VS) was assessed before and after digestion while the microbial community diversity was analyzed using 16S rRNA amplicon-based next-generation sequencing (NGS). The results indicated a pH of 7.91±0.04 before digestion and 7.33±0.06 after digestion and a TS value of 56.40±0.6% before digestion and 6.30±0.34% after digestion. A collective biogas yield of 5.21±21.00 bars were recorded. The characterization of biogas analyzed with non-dispersive infrared (NDIR) gas analyzer (gas board 3100p) revealed a percentage methane content of 50.31±1.33. The microbial community indicate Bacteroidetes (46.37%), Firmicutes (48.37%), Proteobacteria (8.17%), as the most dominant phylum. This study suggests the importance of molecular analysis as a fundamental tool to gain insight and deeper understanding of anaerobic digester performances.","PeriodicalId":7592,"journal":{"name":"American Journal of Phytomedicine and Clinical Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79850571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complementary Therapeutic Effect of Polyherbal Supplement (Gasca D™) on Newly Diagnosed Type 2 Diabetic Patients on Lifestyle Modification: A Randomised Cohort Clinical Trial 多草药补充剂(Gasca D™)对新诊断的2型糖尿病患者生活方式改变的补充治疗效果:一项随机队列临床试验

American Journal of Phytomedicine and Clinical Therapeutics Pub Date : 2021-08-23 DOI: 10.4314/jopat.v20i1.6

S. I. Ibrahim, N. Kabir, D. Ibrahim, Amina Umar Abdullahi, Chedi Bashir, Y. Fakhraddeen

{"title":"Complementary Therapeutic Effect of Polyherbal Supplement (Gasca D™) on Newly Diagnosed Type 2 Diabetic Patients on Lifestyle Modification: A Randomised Cohort Clinical Trial","authors":"S. I. Ibrahim, N. Kabir, D. Ibrahim, Amina Umar Abdullahi, Chedi Bashir, Y. Fakhraddeen","doi":"10.4314/jopat.v20i1.6","DOIUrl":"https://doi.org/10.4314/jopat.v20i1.6","url":null,"abstract":"Our previous studies have shown that Gasca D™; a polyherbal formulation made from three well known antidiabetic plants in Nigeria, possess anti-hyperglycemic, body weight and blood lipid lowering potentials in rats. In view of this, the present study was therefore designed to evaluate the complementary therapeutic efficacy of Gasca D™ supplementation with lifestyle modification in a clinical setting. The randomized cohort trial was conducted in sixty (60) newly diagnosed type 2 diabetic patients on life style modification as first-line therapy who willingly volunteered to participate. The subjects that satisfy our inclusion criteria were randomly assigned into Gasca D™ (GG) and lifestyle (LG) groups. The GG group received 2000 mg Gasca D™ capsules daily over a twelve weeks period whereas the LG group received none. Biochemical estimates were conducted on subjects to evaluate the safety and efficacy of the polyherbal supplement at the end of the intervention period. Mean fasting blood sugar (FBS) showed a decrease of 23.4% (p < 0.05) in the GG group contrary to a 9.6% mean FBS observed in the LG (p < 0.05) group. Variation in glycosylated hemoglobin (HbA1c) was in line with that of FBS. Safety of Gasca D™ was demonstrated by a normal renal and liver function profile in both groups. Our finding suggests that, Gasca D™ can successfully be used as an effective and safe complementary nutraceutical for the control of hyperglycemia in type 2 diabetic patients on life style modification.","PeriodicalId":7592,"journal":{"name":"American Journal of Phytomedicine and Clinical Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83619690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of Parkia biglobosa Stem Bark in the Treatment of Burn Wounds 枇杷皮治疗烧伤创面的疗效观察

American Journal of Phytomedicine and Clinical Therapeutics Pub Date : 2021-08-23 DOI: 10.4314/jopat.v20i1.5

Builders F. Philip, Akissaa H. Shedrack, Boma B. Mohammed, Builders Modupe

{"title":"Efficacy of Parkia biglobosa Stem Bark in the Treatment of Burn Wounds","authors":"Builders F. Philip, Akissaa H. Shedrack, Boma B. Mohammed, Builders Modupe","doi":"10.4314/jopat.v20i1.5","DOIUrl":"https://doi.org/10.4314/jopat.v20i1.5","url":null,"abstract":"Burns are a major health challenge all over the world. Among the Hausa and Fulani people of Nigeria the bark of Pakia biglobosa is used as folk medicine for treating wounds by the application of the finely powdered bark to the open wounds. The aim of this study is to corroborate the folk claims of the wound healing ability of P. biglobosa and the benefits of formulating it into an emulgel. The powder and the extract of the stem bark of P. biglobosa formulated as an emulgel were investigated for burn wound healing activities and compared with I% silver sulfadiazine cream (Dermazin®) on Wister Albino rats. Also, the skin irritation and physicochemical properties of the emulgel were determined. Herbal emulgel showed good quality in relation to compendia and non-compendia tests. The emulgels were smooth, none gritty to touch and odourless as well as having varying colour shades of reddish brown consistent with the concentration of the extract. The formulations also showed no skin irritation and a concentration dependent wound healing activity. The emulgel containing 2.5% w/w of the herbal extract showed superior burn wound healing relative to the finely powdered stem bark, while the emulgel containing 5% w/w of the extract showed wound healing activity comparable to Dermazin®. The finely powdered stem bark of P. biglobosa showed effective wound healing activities and the emulgel formulation enhanced the wound healing activity. The results thus, corroborates the folk use of P. biglobosa stem bark for treating burn wounds.","PeriodicalId":7592,"journal":{"name":"American Journal of Phytomedicine and Clinical Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75084561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The ameliorative effect of the solvent extracts of Ocimum basilicum against acetaminophen-induced liver damage in albino rats 罗勒溶剂提取物对对乙酰氨基酚所致白化大鼠肝损伤的改善作用

American Journal of Phytomedicine and Clinical Therapeutics Pub Date : 2021-08-23 DOI: 10.4314/JOPAT.V20I1.4

T. Asala, M. Abatan, S. A. Salami, Oluwatosin. O. Baba-Onoja, Olatunde. B. Akanbi, A. Rowaiye, Benjamin. O. Ocheja, G. Ada

{"title":"The ameliorative effect of the solvent extracts of Ocimum basilicum against acetaminophen-induced liver damage in albino rats","authors":"T. Asala, M. Abatan, S. A. Salami, Oluwatosin. O. Baba-Onoja, Olatunde. B. Akanbi, A. Rowaiye, Benjamin. O. Ocheja, G. Ada","doi":"10.4314/JOPAT.V20I1.4","DOIUrl":"https://doi.org/10.4314/JOPAT.V20I1.4","url":null,"abstract":"This study was designed to evaluate the protective activities of 4 different Ocimum basilicum L whole plant extracts against acute acetaminophen-induced liver damage in albino rats. A total of 42 rats were divided into 7 groups comprising the control (acetaminophen, water, and silymarin treated) groups and OB-treated (chloroform, diethylether, ethylacetate, and methanol extract) groups. Each treatment group was made up of 6 rats, with 3 replicates of 2 rats each. At the end of the treatment period, blood samples were collected to investigate the activities of liver enzymes, and liver tissue was harvested for histological analysis. Rats pre-treated with OB extracts showed decreased (p<0.05) ALT, AST, and ALP activities when compared with the silymarin-treated and positive control groups. Serum urea decreased (p<0.05) in OB-treated groups compared to the control groups and least (p<0.05) activity was seen in rats pre-treated with diethyl ether and methanol extracts. Rats pre-treated with OB extract (except diethyl ether extract) showed decreased (p<0.05) creatinine activity in comparison with the positive control group. The decreased value of serum total bilirubin and D bilirubin in rats pretreated with OB methanol extract was comparable to those of negative control. Histopathological examination revealed hepatic tissue necrosis in the acetaminophen-induced rats and varying degrees of injury and amelioration in other groups. The results from of all the solvent extracts of OB whole plant suggest significant hepatoprotective and antioxidant activities with the methanolic extract having higher hepatoprotective activity than the standard, Silymarin, and other solvent extracts.","PeriodicalId":7592,"journal":{"name":"American Journal of Phytomedicine and Clinical Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80086163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Ethnobotanical survey of anti-malarial plants used in Ilorin metropolis, Nigeria 尼日利亚伊洛林大都市区抗疟疾植物的民族植物学调查

American Journal of Phytomedicine and Clinical Therapeutics Pub Date : 2021-08-23 DOI: 10.4314/JOPAT.V20I1.3

A. O. Ibrahim, K. Adelakun, A. S. Adedeji, S. Alaye, O. Oyediran

{"title":"Ethnobotanical survey of anti-malarial plants used in Ilorin metropolis, Nigeria","authors":"A. O. Ibrahim, K. Adelakun, A. S. Adedeji, S. Alaye, O. Oyediran","doi":"10.4314/JOPAT.V20I1.3","DOIUrl":"https://doi.org/10.4314/JOPAT.V20I1.3","url":null,"abstract":"An ethnobotanical survey of medicinal plants used in the treatment of malaria in Ilorin, Kwara State, Nigeria was carried out between March and June, 2019. Ethno-botanical data were collected by oral interview with the aid of a semi-structured questionnaire administered to forty-seven (47) herb sellers. The respondents were aware of the signs and symptoms of malaria and could readily distinguish the ailments from other feverish symptoms and conditions. Symptoms reported include body weakness, high body temperature (hot skin), loss of appetite, coldness, mouth bitterness, headache, coloured eyes (yellow), sleepless night and urine colouration (yellowish). From the study, a total of thirteen (13) plant species belonging to nine (9) families including Aannonaceae, Aapocynaceae, Rrubiaceae, Oochnaaceae were described as being used for the treatment of malaria. The plant parts used were leaves, root, stem bark and seed with roots being the most used plant part. It was also observed that recipes were made from combination of different parts from more than one plant species including bark, root and leaves while some were made from single plant part. The most preferred mode of administration was oral, while decoction and infusion were the most preferred method of preparation. However, the study observed that Picralima nitida, Enanchia chloranta and Morinda nucida were the frequently mentioned plants. Hence, these plant species could be considered as promising candidates for further scientific validation in the search for new, effective and affordable antimalarial drugs.","PeriodicalId":7592,"journal":{"name":"American Journal of Phytomedicine and Clinical Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82514632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Consumers’ Perception on Safety and Microbiological Assessment of Sanitary Pads Sold in The Federal Capital Territory (FCT), Nigeria 消费者对尼日利亚联邦首都地区(FCT)销售的卫生巾的安全性和微生物评估的看法

American Journal of Phytomedicine and Clinical Therapeutics Pub Date : 2021-08-23 DOI: 10.4314/jopat.v20i1.1

M. Aboh, M. Ekpo, F. Khalid-Salako, P. Oladosu

{"title":"Consumers’ Perception on Safety and Microbiological Assessment of Sanitary Pads Sold in The Federal Capital Territory (FCT), Nigeria","authors":"M. Aboh, M. Ekpo, F. Khalid-Salako, P. Oladosu","doi":"10.4314/jopat.v20i1.1","DOIUrl":"https://doi.org/10.4314/jopat.v20i1.1","url":null,"abstract":"Urinary tract infections (UTI) a known public health problem is common in females. The objectives of this study were to assess consumers’ knowledge on possible contamination of sanitary pads, determine the quality of some commercial brands of sanitary pads and evaluate the effect of different storage conditions on their integrity. To assess consumers’ knowledge on possible contamination of sanitary pads, determine the quality of some commercial brands of sanitary pads and evaluate the effect of different storage conditions on their integrity. A cross-sectional analysis of 500 female respondents was done by a close ended, structured, interviewer dispensed inquiry form through stratified random sampling. Ten brands of sanitary pads were stored at conditions to simulate possible storage habits of consumers and at different time intervals (0, 1, 7, 14, 21 and 28 days) samples were assessed for total bacterial count (TBC) and total fungal count (TFC) via the pour plate method. Standard methods were used to isolate and identify pathogens. Results revealed that 69.4 % of respondents stored their pads in sealed enclosures, 11.8 % were not aware of the dangers of poor storage and 51.4 % agreed that poor storage could result in microbial contamination. The results on microbial burden revealed that none of the pads were contaminated at the beginning of the study (Day 0). The presence of microorganisms (B. subtilis, S. aureus and Mucor spp) were observed after 24h of storage, especially in samples with open packages and stored in open shelves, followed closely by those unsealed in enclosed environments. These microbial growths can therefore be attributed to the storage conditions of the sanitary pads. Sanitary pads can harbour pathogenic microorganisms; there is a need to properly store them and once opened use them within 14 days to prevent environmental contamination.","PeriodicalId":7592,"journal":{"name":"American Journal of Phytomedicine and Clinical Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78979484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Editorial of phytomedicine and clinical therapeutics (issn: 2321-2748) 植物医学与临床治疗学编辑(issn: 2321-2748)

American Journal of Phytomedicine and Clinical Therapeutics Pub Date : 2021-01-01 DOI: 10.36648/2321-2748.21.9.15

Vinay Kumar

引用次数: 0

Classification and Bioactivity Prediction of Essential Oil-Producing Plants 精油植物分类及生物活性预测

American Journal of Phytomedicine and Clinical Therapeutics Pub Date : 2021-01-01 DOI: 10.36648/2321-2748.21.9.36

K. Smith

引用次数: 0

Application of Microfluidic Technology in Pharmaceutical Analysis 微流控技术在药物分析中的应用

American Journal of Phytomedicine and Clinical Therapeutics Pub Date : 2021-01-01 DOI: 10.36648/2321-2748.21.9.33

Chilukuri Revathi Sreelekha, N. Sahoo

{"title":"Application of Microfluidic Technology in Pharmaceutical Analysis","authors":"Chilukuri Revathi Sreelekha, N. Sahoo","doi":"10.36648/2321-2748.21.9.33","DOIUrl":"https://doi.org/10.36648/2321-2748.21.9.33","url":null,"abstract":"Microfluidic gadgets existing one-of-a-kind benefits for the development of effective medication provider bits, cell-free healthy protein synthesis systems, and also rapid strategies for straight drug testing. Contrasted to bulk approaches, by effectively controlling the geometries of the produced chip and the circulation rates of multiphase fluids, microfluidic modern technology makes it possible for the generation of very stable, consistent, mono dispersed particles with greater encapsulation performance. Given that the existing preclinical versions are inefficient drug displays for anticipating clinical outcomes, microfluidic systems might use a more rapid as well as affordable choice. The development of pharmaceutical logical methods represents one of the most significant aspects of medication growth. Recent advancements in micro fabrication and microfluidics can provide brand-new techniques for drug analysis, including medicine screening, active testing as well as the study of metabolic process. Microfluidic chip innovations, such as lab-on-a-chip innovation, three-dimensional (3D) cell society, organs-on-chip as well as bead methods, have actually all been created swiftly.","PeriodicalId":7592,"journal":{"name":"American Journal of Phytomedicine and Clinical Therapeutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80816055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial Note on Chlorophyll biosynthesis, crucial to life on Earth 叶绿素生物合成对地球上的生命至关重要

American Journal of Phytomedicine and Clinical Therapeutics Pub Date : 2021-01-01 DOI: 10.36648/2321-2748.21.9.13

S. Michel

引用次数: 0