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[Mutations in the PIG-A gene lead to GPI-deficiency in paroxysmal nocturnal hemoglobinuria]. [猪- a基因突变导致阵发性夜间血红蛋白尿gpi缺乏]。
Immunitat und Infektion Pub Date : 1994-08-01
T Ostendorf, J Schubert, R E Schmidt
{"title":"[Mutations in the PIG-A gene lead to GPI-deficiency in paroxysmal nocturnal hemoglobinuria].","authors":"T Ostendorf,&nbsp;J Schubert,&nbsp;R E Schmidt","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by the deficiency of glycosylphosphatidylinositol-(GPI-)-anchored surface molecules on blood cells. The biochemical basis of this deficiency is the lack of the first GPI biosynthesis intermediate GlcNAc-PI in the deficient cells corresponding to that in Thy-1- mouse lymphoma mutants of the class A. Recently, the responsible gene (PIG-A gene) has been cloned. Here, PIG-A transcripts in T-, NK- and EBV-transformed B cell lines of different PNH patients have been analyzed. In contrast to the uniform biochemical defect, these molecular analyses reveal heterogenous mutations of the PIG-A gene in different PNH patients.</p>","PeriodicalId":75925,"journal":{"name":"Immunitat und Infektion","volume":"22 4","pages":"154-5"},"PeriodicalIF":0.0,"publicationDate":"1994-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18923460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Important study demonstrates anew the utility of early AZT therapy]. [重要的研究再次证明了早期AZT治疗的效用]。
Immunitat und Infektion Pub Date : 1994-08-01
{"title":"[Important study demonstrates anew the utility of early AZT therapy].","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75925,"journal":{"name":"Immunitat und Infektion","volume":"22 4","pages":"III"},"PeriodicalIF":0.0,"publicationDate":"1994-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18924197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Relationship between secretory IgA in pancreatic secretions, in pancreatic tissue, and in the serum of patients with chronic pancreatitis]. [慢性胰腺炎患者胰腺分泌物、胰腺组织和血清中IgA分泌的关系]。
Immunitat und Infektion Pub Date : 1994-08-01
J Emmrich, P Conradi, M Seyfarth, S Liebe
{"title":"[Relationship between secretory IgA in pancreatic secretions, in pancreatic tissue, and in the serum of patients with chronic pancreatitis].","authors":"J Emmrich,&nbsp;P Conradi,&nbsp;M Seyfarth,&nbsp;S Liebe","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In five patients with chronic pancreatitis we found secretory IgA (sIgA) in the pancreatic juice. In four control persons this was seen only in one case. In pancreatic tissue of three patients with chronic pancreatitis we detected both, IgA and secretory component by immunohistology. We suggest that sIgA in the pancreatic juice was partly produced in the pancreas.</p>","PeriodicalId":75925,"journal":{"name":"Immunitat und Infektion","volume":"22 4","pages":"161-2"},"PeriodicalIF":0.0,"publicationDate":"1994-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18923463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Systemic B-cell response in the mouse after mucosal immunization with measles virus]. [麻疹病毒粘膜免疫后小鼠全身b细胞反应]。
Immunitat und Infektion Pub Date : 1994-06-01
C P Muller, N H Brons
{"title":"[Systemic B-cell response in the mouse after mucosal immunization with measles virus].","authors":"C P Muller,&nbsp;N H Brons","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The respiratory tract represents both the port of entrance of the measles virus (MV) and an important target tissue for measles complications. Therefore, mucosal immunization could be an attractive alternative to the current subcutaneous route. We studied the virus-specific IgA and IgG antibody response in the serum after intranasal and intragastric immunization with MV in the mouse model under non-replicating conditions. Hemagglutination-inhibiting antibodies, mostly without virus-neutralizing activity were found after intranasal immunization. No virus-specific antibodies were detected after intragastric immunization.</p>","PeriodicalId":75925,"journal":{"name":"Immunitat und Infektion","volume":"22 3","pages":"125-6"},"PeriodicalIF":0.0,"publicationDate":"1994-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18924193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Human basophilic granulocytes and mast cells: mediators between allergic inflammation and the specific immune system]. 人嗜碱性粒细胞和肥大细胞:过敏性炎症和特异性免疫系统之间的介质。
Immunitat und Infektion Pub Date : 1994-06-01
S C Bischoff
{"title":"[Human basophilic granulocytes and mast cells: mediators between allergic inflammation and the specific immune system].","authors":"S C Bischoff","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Basophils and mast cells represent important effector cells in allergic inflammation. Furthermore, these cell types are suggested to play a role in the pathogenesis of other forms of chronic inflammation and in the maintenance of tissue homeostasis. Recent studies provided new information on the morphology, development, distribution and effector function of the histamine-containing cells. Particularly the identification of new surface membrane molecules such as CD40 ligand on basophils or c-kit on mast cells, and of new triggering agents and modulators of mediator release such as IL-3, IL-5, GM-CSF and nerve growth factor (for basophils) or c-kit ligand (for mast cells) allows a better understanding of the regulation of these cell types. The regulating cytokines are produced by lymphocytes and tissue cells. On the same time, membrane proteins and soluble mediators of basophils and mast cells regulate tissue and immune functions. Thus, basophils and mast cells are not only effectors but also regulators of inflammation. It is, therefore, tempting to speculate that both cell types play an important role as mediator cells between the unspecific effector level and the specific antigen-recognizing cells of the host immune defense system. This review is mostly restricted to the human system.</p>","PeriodicalId":75925,"journal":{"name":"Immunitat und Infektion","volume":"22 3","pages":"93-103"},"PeriodicalIF":0.0,"publicationDate":"1994-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18924196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Roche begins phase III study with a new AIDS medication]. 罗氏开始艾滋病新药的III期研究。
Immunitat und Infektion Pub Date : 1994-06-01
{"title":"[Roche begins phase III study with a new AIDS medication].","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75925,"journal":{"name":"Immunitat und Infektion","volume":"22 3","pages":"VI"},"PeriodicalIF":0.0,"publicationDate":"1994-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18926045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Enhanced antibody production by lung lymphocytes after oral immunization with Bordetella pertussis surface antigens]. [口服百日咳博德氏杆菌表面抗原免疫后肺淋巴细胞产生抗体增强]。
Immunitat und Infektion Pub Date : 1994-06-01
M Frühwirth, H Ellemunter, C Ruedl, H Wolf
{"title":"[Enhanced antibody production by lung lymphocytes after oral immunization with Bordetella pertussis surface antigens].","authors":"M Frühwirth,&nbsp;H Ellemunter,&nbsp;C Ruedl,&nbsp;H Wolf","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The purpose of our study was to evaluate the effect of oral vaccination with Bordetella pertussis surface antigens on the immune response at the site of antigen application. We orally immunized female BALB/c mice on five consecutive days and repeated this procedure after a free interval of 10 days. Lymphocytes of the lung (LL), Peyer's patches (PPL) and lamina propria of the gut (LPL) were isolated and the immunoglobulin secretion rate was measured with time-resolved immunofluorescence. Oral immunization was found to enhance the IgA secretion rate by 69.9% in LL compared to unimmunized animals. The IgG synthesis in LL was increased by 28.1% and the IgM synthesis by 14.1%. In addition, an improvement of 47.8% was observed for the IgG secretion in LPL and PPL. Thus, our results demonstrate a strong local immune response after oral immunization with Bordetella pertussis.</p>","PeriodicalId":75925,"journal":{"name":"Immunitat und Infektion","volume":"22 3","pages":"121-2"},"PeriodicalIF":0.0,"publicationDate":"1994-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18924191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The Th1/Th2 concept--its importance for regulation of IgE]. [Th1/Th2概念——其对IgE调节的重要性]。
Immunitat und Infektion Pub Date : 1994-06-01
H Haas, M Schlaak
{"title":"[The Th1/Th2 concept--its importance for regulation of IgE].","authors":"H Haas,&nbsp;M Schlaak","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>T helper type 2 (TH2) cells are a major source of interleukin- (IL-)4 which plays a critical role in the induction of the IgE synthesis. Their counterplayers, the T helper type 1 (TH1) cells produce interferon- (IFN-)gamma which inhibits the IL-4-induced IgE synthesis. Thus, the TH2/TH1 ratio plays an important role in the regulation of the IgE synthesis. Moreover, IL-4 seems to be the crucial factor controlling the switch of T helper precursor (THp) cells to the TH2 phenotype. However, the primary cellular source of IL-4 that skews an immune response towards the TH2 phenotype is not yet known. For future prophylactic and therapeutic interventions, e.g. in allergy, it will be crucial to know the type of cell involved and the factors that are activating this cell, i.e. the exact mechanism that is controlling the switch to the TH2 phenotype.</p>","PeriodicalId":75925,"journal":{"name":"Immunitat und Infektion","volume":"22 3","pages":"88-93"},"PeriodicalIF":0.0,"publicationDate":"1994-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18924195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Functional IgG subclass determinations in patients with suspected humoral immune defects using the LIBA technique]. [用LIBA技术测定疑似体液免疫缺陷患者的功能IgG亚类]。
Immunitat und Infektion Pub Date : 1994-06-01
H I Joller-Jemelka, P W Joller, E Montano, P J Grob
{"title":"[Functional IgG subclass determinations in patients with suspected humoral immune defects using the LIBA technique].","authors":"H I Joller-Jemelka,&nbsp;P W Joller,&nbsp;E Montano,&nbsp;P J Grob","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In patients with recurrent infections, \"intrinsic\" asthma and lymphoma the specific binding capacity of IgG subclass 2 against pneumococcus was determined by line-immuno-binding-assay (LIBA). The results show that LIBA represents a simple and specific test system suitable as diagnostic parameter in patients with a suspected humoral defect.</p>","PeriodicalId":75925,"journal":{"name":"Immunitat und Infektion","volume":"22 3","pages":"123-4"},"PeriodicalIF":0.0,"publicationDate":"1994-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18924192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Cell biology and function of eosinophilic granulocytes in immunologic inflammation]. [细胞生物学和嗜酸性粒细胞在免疫性炎症中的功能]。
Immunitat und Infektion Pub Date : 1994-06-01
C Kroegel, W Luttmann, G Zeck-Kapp, H Matthys, A Kapp, J C Virchow
{"title":"[Cell biology and function of eosinophilic granulocytes in immunologic inflammation].","authors":"C Kroegel,&nbsp;W Luttmann,&nbsp;G Zeck-Kapp,&nbsp;H Matthys,&nbsp;A Kapp,&nbsp;J C Virchow","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In recent years, increasing evidence has accumulated to suggest that the eosinophil represents a potent cytotoxic effector cell which plays a key role in the pathogenesis of pulmonary diseases as well as other human disorders. Beside contributing to antiparasitic host defense, eosinophils can prove detrimental to a number of host organs and tissues via release of their preformed basic proteins as well as de novo generated lipid mediators or oxygen radicals. Eosinophil effector functions are stimulated by certain lipid mediators and cytokines released by other cells in the course of active disease. In addition to their effector functions, eosinophils may have other functions in immune responses. Synthesis and expression of class II proteins of the major histocompatibility complex (MHC) may enable eosinophils to serve as antigen-presenting cells, i.e. to the antigens that appear at mucosal surfaces. In addition to collaborative interactions with lymphocytes, CD4-expressing eosinophils may elaborate cytokines that can effect cells within their tissue milieu. In conclusion, the evolving understanding of eosinophils indicates that eosinophils may not only serve as end-stage effector cells but also interact cooperatively with other cellular tissue elements in related diseases.</p>","PeriodicalId":75925,"journal":{"name":"Immunitat und Infektion","volume":"22 3","pages":"104-13"},"PeriodicalIF":0.0,"publicationDate":"1994-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18924189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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