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Immunitat und Infektion最新文献

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[New experimental therapies for type I allergy]. [I型过敏的新实验疗法]。
Immunitat und Infektion Pub Date : 1994-06-01
H Renz
{"title":"[New experimental therapies for type I allergy].","authors":"H Renz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>CD4+ T cells play a central role in the development of the immediate-type allergic response. It was shown that T cells from allergic patients exhibit an imbalance on the level of cytokine production which is characterized by increased IL-4- and decreased IFN-gamma production. Different strategies were developed to therapeutically interfere on various levels of the immunological dysregulation. In this article, the use of the immunomodulatory and immunosuppressive drugs methotrexate, cyclosporine, and intravenous immunoglobulin (IVIG) will be discussed. Furthermore, new experimental therapeutic approaches will be presented which are aimed to selectively interfere on the level of cytokine production and regulation. A different approach targets the functional activity of allergen-specific T cells whose functions could be modulated in an animal model system by subcutaneous treatment with peptides.</p>","PeriodicalId":75925,"journal":{"name":"Immunitat und Infektion","volume":"22 3","pages":"113-20"},"PeriodicalIF":0.0,"publicationDate":"1994-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18924190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Molecular characterization of allergens]. [过敏原的分子表征]。
Immunitat und Infektion Pub Date : 1994-06-01
W M Becker
{"title":"[Molecular characterization of allergens].","authors":"W M Becker","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Allergenic source material consists of a great number of single components of which only a small number is IgE-reactive. Since allergenic source material is the basis of diagnostics and immunotherapy, there is a strong interest in identification, characterization and quantification of allergens. A further reason of interest is to explain the pathomechanism of the type I allergy. The structure of allergens is of central importance, because only a small number of antigens are allergens and the structure of these components is essential in giving rise to symptoms. The process and further prospects of molecular characterization of allergens are described and grass pollen allergens are used as paradigm. Allergies are an excellent model to study the meaning of specificity in immunologic disorders.</p>","PeriodicalId":75925,"journal":{"name":"Immunitat und Infektion","volume":"22 3","pages":"82-7"},"PeriodicalIF":0.0,"publicationDate":"1994-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18530138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[New perspectives in molecular allergology]. [分子过敏学的新视角]。
Immunitat und Infektion Pub Date : 1994-06-01
M Schlaak
{"title":"[New perspectives in molecular allergology].","authors":"M Schlaak","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75925,"journal":{"name":"Immunitat und Infektion","volume":"22 3","pages":"81"},"PeriodicalIF":0.0,"publicationDate":"1994-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18924194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Clinical diagnosis of malaria and amoebiasis]. 疟疾和阿米巴病的临床诊断。
Immunitat und Infektion Pub Date : 1994-04-01
G D Burchard
{"title":"[Clinical diagnosis of malaria and amoebiasis].","authors":"G D Burchard","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In all patients with fever after returning from tropical countries malaria must be excluded. Amebic liver abscess is an important differential diagnosis, especially in patients with pain in the right epigastrium. In all patients with diarrhea after returning from tropical countries amebic colitis is an important differential diagnosis. The diagnosis of malaria is based on microscopical demonstration of the parasite in blood slides. In patients with Plasmodium falciparum malaria the extent of organ complications has to be checked. The diagnosis of intestinal amebiasis rests on parasitological stool examination. Amebic liver abscess is diagnosed by demonstration of the liver abscess in imaging techniques and verification by finding specific antibodies.</p>","PeriodicalId":75925,"journal":{"name":"Immunitat und Infektion","volume":"22 2","pages":"39-41"},"PeriodicalIF":0.0,"publicationDate":"1994-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18955365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Passive immunotherapy with Venimmun for the prevention of habitual abortion--early pregnancy factor, placenta protein 12, placenta protein 14, tumor necrosis factor alpha--parameters for monitoring immunotherapy]. 【静脉免疫预防习惯性流产被动免疫治疗——早孕因子、胎盘蛋白12、胎盘蛋白14、肿瘤坏死因子α——免疫治疗监测参数】。
Immunitat und Infektion Pub Date : 1994-04-01
T Römer, W Straube, M Meisel
{"title":"[Passive immunotherapy with Venimmun for the prevention of habitual abortion--early pregnancy factor, placenta protein 12, placenta protein 14, tumor necrosis factor alpha--parameters for monitoring immunotherapy].","authors":"T Römer,&nbsp;W Straube,&nbsp;M Meisel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In a study it was investigated to what extent the early pregnancy factor, the placental proteins 12 and 14 and tumor necrosis factor alpha are suited to control and select patients with habitual abortions for immunotherapy. Immunotherapy shows good clinical results. Placental protein 12 ist not suited for selecting patients. Placental protein 14 shows typical changes after the application of polyvalent immunoglobulin and could be an important prognostic factor. Tumor necrosis factor alpha seems to be useful for selecting patients for immunotherapy, because in cases of habitual abortions this factor can be a sign for immunological causes. In the late phase of pregnancy, early pregnancy factor is also an indicator for disturbances of pregnancy.</p>","PeriodicalId":75925,"journal":{"name":"Immunitat und Infektion","volume":"22 2","pages":"55-7"},"PeriodicalIF":0.0,"publicationDate":"1994-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18955370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[New chemotherapeutics against malarial parasites]. [针对疟疾寄生虫的新化疗药物]。
Immunitat und Infektion Pub Date : 1994-04-01
W Presber
{"title":"[New chemotherapeutics against malarial parasites].","authors":"W Presber","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>New findings on the molecular biology of plasmodia have led to new approaches for the development of chemotherapeutics. Trials to circumvent the relative toxicity of individual substances by a combination of active agents have been successful in several cases, and there will be more of those combinations in the future. An additional advantage of combinations can be the improvement of activity. In some cases, antiparasitic side effects of long known drugs with low toxicity such as imipramine can be used to decrease or overcome resistance. And, last but not least, ideas or in some cases new drugs will come from the traditional medicine.</p>","PeriodicalId":75925,"journal":{"name":"Immunitat und Infektion","volume":"22 2","pages":"48-52"},"PeriodicalIF":0.0,"publicationDate":"1994-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18955368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Chemoimmunotherapy of malignancies of the gastrointestinal tract]. 胃肠道恶性肿瘤的化学免疫治疗。
Immunitat und Infektion Pub Date : 1994-04-01
C Lersch, T Gain, R Lorenz, M Classen
{"title":"[Chemoimmunotherapy of malignancies of the gastrointestinal tract].","authors":"C Lersch,&nbsp;T Gain,&nbsp;R Lorenz,&nbsp;M Classen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Stimulation of the immune response could be obtained in outpatients with inoperable locally advanced or metastasizing gastrointestinal tumors (n = 56), who were palliatively treated with cyclophosphamide (cy), 350 mg/m2 i.v., thymostimulin, echinacin i.m. and in part additionally with epirubicin, 15 mg/m2 i.v. At present, outpatients with pancreatic (n = 7) or colon carcinomas (n = 1) receive interleukin 2 (IL-2) intralesionally, 2 x 10(5) Cetus units (CU), days 3, 5 and 7 after cy, and by portable continuous infusion systems i.v., 3 x 10(5) CU/day, days 3-8 after cy. Subsets of lymphocytes slightly decreased in the patients' peripheral blood, recall antigen reactivity slightly increased. Patients' mean survival time was 5.7 +/- 1.7 months.</p>","PeriodicalId":75925,"journal":{"name":"Immunitat und Infektion","volume":"22 2","pages":"58-9"},"PeriodicalIF":0.0,"publicationDate":"1994-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18532875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Wellcome starts model experiment: training for young HIV-physicians]. [惠康启动模型实验:培训年轻艾滋病医生]。
Immunitat und Infektion Pub Date : 1994-04-01
{"title":"[Wellcome starts model experiment: training for young HIV-physicians].","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75925,"journal":{"name":"Immunitat und Infektion","volume":"22 2","pages":"VIII"},"PeriodicalIF":0.0,"publicationDate":"1994-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18955364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Therapy for malaria and amoebiasis]. [治疗疟疾和阿米巴病]。
Immunitat und Infektion Pub Date : 1994-04-01
G D Burchard
{"title":"[Therapy for malaria and amoebiasis].","authors":"G D Burchard","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Treatment of malaria depends on the infecting Plasmodium species. In Plasmodium falciparum malaria the treatment also depends on whether chloroquine resistances occur and whether the course is uncomplicated or complicated. Uncomplicated cases are cared for with chloroquine and with mefloquine or halofantrine when the patient comes from areas with chloroquine resistances. Patients with complicated Plasmodium falciparum malaria must get chinine and doxycycline. A careful fluid balance is extremely important in order to prevent noncardiac pulmonary edemas. Luminal infections with pathogenic Entamoeba histolytica are treated with diloxanide furoate, luminal infections with non-pathogenic Entamoeba histolytica (= E. dispar) do not have to be treated. If differentiation is not possible, all asymptomatic cyst passers must get treatment. Patients with invasive amebiasis (amebic colitis and amebic liver abscess) have to be treated with metronidazole, followed by diloxanide furoate.</p>","PeriodicalId":75925,"journal":{"name":"Immunitat und Infektion","volume":"22 2","pages":"45-7"},"PeriodicalIF":0.0,"publicationDate":"1994-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18955367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Abbott TestPack Chlamydia--a reliable test system for the immediate diagnosis of Chlamydia]. [雅培TestPack衣原体——一种即时诊断衣原体的可靠检测系统]。
Immunitat und Infektion Pub Date : 1994-04-01
{"title":"[Abbott TestPack Chlamydia--a reliable test system for the immediate diagnosis of Chlamydia].","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75925,"journal":{"name":"Immunitat und Infektion","volume":"22 2","pages":"VI-VIII"},"PeriodicalIF":0.0,"publicationDate":"1994-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18955362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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