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[Hepatitis B associated membraneous glomerulonephritis: healing following drug-induced reactivation of hepatitis]. [乙型肝炎相关膜性肾小球肾炎:药物诱导肝炎再活化后的愈合]。
Helvetica paediatrica acta Pub Date : 1989-06-01
O Tönz, G P Ramelli, J O Gebbers
{"title":"[Hepatitis B associated membraneous glomerulonephritis: healing following drug-induced reactivation of hepatitis].","authors":"O Tönz,&nbsp;G P Ramelli,&nbsp;J O Gebbers","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We report on a 7-year-old boy with nephrotic syndrome due to a membranous glomerulonephritis. The disease was caused by a persistent hepatitis B antigenemia without formation of antibodies. It was possible to show diffuse deposits of HBs antigen in the glomerular basement membrane and the mesangium by immunohistology. Therapy with cyclophosphamide resulted in an acute exacerbation of the hepatitis and, consequently, in a seroconversion. Subsequently, the nephrotic syndrome and the HBs antigenemia disappeared, and the hepatitis healed.</p>","PeriodicalId":75904,"journal":{"name":"Helvetica paediatrica acta","volume":"43 5-6","pages":"539-47"},"PeriodicalIF":0.0,"publicationDate":"1989-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13885623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Fecal chymotrypsin concentration in childhood. Normal values, specificity, sensitivity]. 儿童粪便凝乳胰蛋白酶浓度。正常值，特异性，敏感性]。
Helvetica paediatrica acta Pub Date : 1989-06-01
J Henker, S Hackbarth, C Sprössig
{"title":"[Fecal chymotrypsin concentration in childhood. Normal values, specificity, sensitivity].","authors":"J Henker,&nbsp;S Hackbarth,&nbsp;C Sprössig","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The determination of fecal chymotrypsin is a suitable noninvasive screening test for the evaluation of exocrine pancreatic function. Using a photometric assay we found a specificity of 87.5% and a sensitivity of 80%. Beyond the first year of life the lowest limit of normal values is 72 micrograms chymotrypsin/g stool. The method is reproducible, and a 72-hour stool collection is unnecessary when several fecal chymotrypsin determinations in spot stool samples are performed.</p>","PeriodicalId":75904,"journal":{"name":"Helvetica paediatrica acta","volume":"43 5-6","pages":"397-404"},"PeriodicalIF":0.0,"publicationDate":"1989-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13885699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Botulism in infancy]. [婴儿肉毒中毒]。
Helvetica paediatrica acta Pub Date : 1989-06-01
E Gautier, A Gallusser, P A Despland
{"title":"[Botulism in infancy].","authors":"E Gautier,&nbsp;A Gallusser,&nbsp;P A Despland","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The authors describe a case of botulism in a 3-month-old infant infected with Clostridium botulinum type A. Symptomatology developed within four days, persisted for two weeks, then regressed. Symptoms were paresis of face muscles, hyporeactive pupils, loss of succion and deglutition, axial hypotonia, weakness of peripheral muscles, lability of the autonomic nervous system with acute episodes of bradycardia and constipation. Anomalies of the electroen-cephalogram and of the auditory evoked responses suggest that the toxin penetrated the central nervous system. Treatment was symptomatic, without need for assisted ventilation. It was not possible to detect the source of infection.</p>","PeriodicalId":75904,"journal":{"name":"Helvetica paediatrica acta","volume":"43 5-6","pages":"521-30"},"PeriodicalIF":0.0,"publicationDate":"1989-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13806285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiology of urinary tract infections and vesico-ureteral reflux in children. 儿童尿路感染和膀胱输尿管反流的流行病学研究。
Helvetica paediatrica acta Pub Date : 1989-06-01
G Messi, L Peratoner, L Paduano, A G Marchi
{"title":"Epidemiology of urinary tract infections and vesico-ureteral reflux in children.","authors":"G Messi,&nbsp;L Peratoner,&nbsp;L Paduano,&nbsp;A G Marchi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The purpose of this study was to assess the incidence of symptomatic urinary tract infection (U.T.I.) and malformations, such as vesico-ureteral reflux (V.U.R.), in the Trieste area. Data were collected in the framework of a survey based on the application of a protocol on urinary infections between 1979 and 1983. The U.T.I. incidence was found to be 1.38% of the 0-14-year-old residents, with a higher frequency in females (2.36%) than in males (0.46%). As regards V.U.R., the incidence in the population studied turned out to be 0.25%, with a females/males ratio of 4:1. Striking differences in incidence data were observed according to the age of U.T.I. and V.U.R. diagnosis and to the infection level (cystitis or pyelonephritis). The incidence of renal scarring resulted to be extremely low, which can be ascribed to the early diagnosis in our cases.</p>","PeriodicalId":75904,"journal":{"name":"Helvetica paediatrica acta","volume":"43 5-6","pages":"389-96"},"PeriodicalIF":0.0,"publicationDate":"1989-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13926291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Authentic recombinant human growth hormone. Results of a multicenter clinical trial in patients with growth hormone deficiency. 真正的重组人类生长激素。生长激素缺乏症患者的多中心临床试验结果。
Helvetica paediatrica acta Pub Date : 1989-06-01
L H Rasmussen, M Zachmann, P Nilsson
{"title":"Authentic recombinant human growth hormone. Results of a multicenter clinical trial in patients with growth hormone deficiency.","authors":"L H Rasmussen,&nbsp;M Zachmann,&nbsp;P Nilsson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>197 patients with growth hormone deficiency (144 boys, 53 girls, age 1.5-19.5 [mean 11 +/- 3.6], bone age 0.3-15 [mean 8.9 +/- 3.5] years) were treated for one year with authentic recombinant human growth hormone (r-hGH, Norditropin] in several European paediatric centers. 107 patients were newly treated (group A), and 90 transferred from pituitary or methionine hGH (groups B and C). In 19 of the latter, treatment was interrupted for 6 months (group B), in the others, it was changed without interruption (group C). The dosage was 0.45 +/- 0.2 IU/kg/week given s.c. 6-7 times a week. Height velocity increased from 4.1 +/- 2.4 to 8.3 +/- 2.5 (group A), 2.6 +/- 1.8 to 8.3 +/- 2.3 (group B), and 6.2 +/- 2.7 to 6.8 +/- 2.2 cm/year (group C). Few patients complained of local discomfort at the injection site, but this disappeared after changing metacresol in the solvent to 0.9% benzyl alcohol. Only 3 patients developed antibodies to hGH in low titers, which did not interfere with growth. No changes in E. coli protein antibodies were observed. It is concluded that r-hGH is an efficient and safe treatment for children with growth hormone deficiency.</p>","PeriodicalId":75904,"journal":{"name":"Helvetica paediatrica acta","volume":"43 5-6","pages":"443-8"},"PeriodicalIF":0.0,"publicationDate":"1989-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13806284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Proteus syndrome. A contribution to the further differential diagnosis of congenital local gigantism]. (普罗透斯综合症。对先天性局部巨人症进一步鉴别诊断的贡献[j]。
Helvetica paediatrica acta Pub Date : 1989-06-01
B O Trappe, E Rupprecht, E Bosselmann, M Schaeper, K Mohnike, J Gedschold
{"title":"[Proteus syndrome. A contribution to the further differential diagnosis of congenital local gigantism].","authors":"B O Trappe,&nbsp;E Rupprecht,&nbsp;E Bosselmann,&nbsp;M Schaeper,&nbsp;K Mohnike,&nbsp;J Gedschold","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Four sporadically occurring characteristic cases of the Proteus syndrome are described. All patients show the main features of the disease, consisting of hemihypertrophy, partial gigantism of hands and/or feet with soft-tissue hypertrophy, plane naevi, subcutaneous tumours, and cranial anomalies. There is a remarkable polymorphism of the symptoms. Anamnestic, clinical and paraclinical findings are shown in tables. Based on a survey of the literature, the main aspects of genetics and of differential diagnosis are discussed.</p>","PeriodicalId":75904,"journal":{"name":"Helvetica paediatrica acta","volume":"43 5-6","pages":"473-82"},"PeriodicalIF":0.0,"publicationDate":"1989-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13885617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful treatment of superior vena cava syndrome with urokinase in an infant with a central venous catheter. 尿激酶成功治疗婴儿上腔静脉综合征中心静脉导管。
Helvetica paediatrica acta Pub Date : 1989-06-01
M K Caglar, J Tolboom
{"title":"Successful treatment of superior vena cava syndrome with urokinase in an infant with a central venous catheter.","authors":"M K Caglar,&nbsp;J Tolboom","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An infant with superior vena cava syndrome due to thrombus formation in the superior vena cava, sourced from a central venous line, was treated with urokinase. It was used in a loading dose of 250,000 units/1.73 m2/15 min, followed by continuous infusion of 125,000 units/1.73 m2/h for three days. After two days of urokinase treatment, the clinical signs of superior vena cava syndrome completely disappeared. No bleeding complication was observed.</p>","PeriodicalId":75904,"journal":{"name":"Helvetica paediatrica acta","volume":"43 5-6","pages":"483-6"},"PeriodicalIF":0.0,"publicationDate":"1989-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13644676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[43 years of Helvetica Paediatrica Acta--retrospect and prospects]. [Helvetica儿科学报43年回顾与展望]。
Helvetica paediatrica acta Pub Date : 1989-06-01
A Fanconi
{"title":"[43 years of Helvetica Paediatrica Acta--retrospect and prospects].","authors":"A Fanconi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75904,"journal":{"name":"Helvetica paediatrica acta","volume":"43 5-6","pages":"357-62"},"PeriodicalIF":0.0,"publicationDate":"1989-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13806283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk factors associated with the development of peri-intraventricular haemorrhage and periventricular leukomalacia. 与脑室周围出血和脑室周围白质软化相关的危险因素。
Helvetica paediatrica acta Pub Date : 1989-06-01
D Tzogalis, C L Fawer, Y Wong, A Calame
{"title":"Risk factors associated with the development of peri-intraventricular haemorrhage and periventricular leukomalacia.","authors":"D Tzogalis,&nbsp;C L Fawer,&nbsp;Y Wong,&nbsp;A Calame","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>81 preterm infants of 34 weeks' gestation or less were prospectively and sequentially examined by means of real-time ultrasound in order to identify which clinical risk factors might be associated with the development of peri-intraventricular haemorrhage (PVH) and periventricular leukomalacia (PVL). Infants were allocated in three groups: group A (n = 44): with normal scans; group B (n = 24): with isolated PVH, and group C (n = 13): with PVL. 28 obstetrical and neonatal factors were compared within the three groups using two methods of statistical analysis (2 x 2 chi 2 analysis and multivariate logistic regression analysis). Hyaline membrane disease, acidosis, pneumothorax and Apgar score at 10 min were statistically associated with PVH. The multivariate logistic regression analysis showed that need for resuscitation, hyaline membrane disease, acidosis and gestational age were the most important factors. Gestational age, seizures, hyaline membrane disease, apnoea with hypoxaemia and bradycardia were strongly associated with PVL. These results suggest that a low gestational age, the need for resuscitation and a respiratory distress syndrome with its consequences might lead to PVH, whereas a low gestational age, hypoxaemia and cardiocirculatory disturbances might decrease cerebral perfusion and result into PVL.</p>","PeriodicalId":75904,"journal":{"name":"Helvetica paediatrica acta","volume":"43 5-6","pages":"363-76"},"PeriodicalIF":0.0,"publicationDate":"1989-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13885080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Auditory brainstem responses and ultrasound changes in a high-risk infants population. 高危婴儿人群的听觉脑干反应和超声变化。
Helvetica paediatrica acta Pub Date : 1989-06-01
C Guinard, C L Fawer, P A Despland, A Calame
{"title":"Auditory brainstem responses and ultrasound changes in a high-risk infants population.","authors":"C Guinard,&nbsp;C L Fawer,&nbsp;P A Despland,&nbsp;A Calame","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>50 neonates were selected in a high perinatal risk population and examined by means of cerebral ultrasound (US) and auditory brainstem responses (ABR). They were allocated in 5 groups according to their US diagnosis (normal scans, isolated peri-intraventricular haemorrhage, large haemorrhage with associated lesions, hypoxic-ischaemic lesions in term neonates, miscellaneous disorders). ABR abnormalities were found in 40% of the infants. They were more frequent in neonates with cerebral lesions. Furthermore, the more extensive the cerebral lesions, the more severe the ABR abnormalities. Most of the ABR changes were of audiological type (severe: threshold greater than 80 dB [14%]; moderate: threshold less than or equal to 80 dB [20%]), whereas neurological abnormalities were rare (6%). The prognostic value of ABR appears in this study to depend on the possible recovery in the neonatal period. Severe hearing loss was associated either with an early death or with major handicaps. ABR represent the method of first choice for the detection of hearing loss in the Neonatal Unit, while they seemed to be of limited value in assessing brainstem function.</p>","PeriodicalId":75904,"journal":{"name":"Helvetica paediatrica acta","volume":"43 5-6","pages":"377-88"},"PeriodicalIF":0.0,"publicationDate":"1989-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13885696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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