Environmental quality and safety最新文献

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Environmental effects of the herbicide, paraquat. 除草剂百草枯对环境的影响。
Environmental quality and safety Pub Date : 1975-01-01
A Calderbank
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引用次数: 0
Benefit of risk evaluations in modern toxicology. 风险评估在现代毒理学中的益处。
Environmental quality and safety Pub Date : 1975-01-01
F Coulston
{"title":"Benefit of risk evaluations in modern toxicology.","authors":"F Coulston","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75827,"journal":{"name":"Environmental quality and safety","volume":"4 ","pages":"194-9"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12369712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Environmental problems related to herbicidal use in Japan. 日本除草剂使用的环境问题。
Environmental quality and safety Pub Date : 1975-01-01
S Matsunaka, S Kuwatsuka
{"title":"Environmental problems related to herbicidal use in Japan.","authors":"S Matsunaka, S Kuwatsuka","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75827,"journal":{"name":"Environmental quality and safety","volume":"4 ","pages":"149-59"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12369709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inhibition of hepatic drug-metabolizing enzymes by thiophaophate insecticides and its toxicological evaluation. 硫磷类杀虫剂对肝脏药物代谢酶的抑制作用及其毒理学评价。
Environmental quality and safety Pub Date : 1975-01-01
M Uchiyama, T Yochida, K Homma, T Hongo
{"title":"Inhibition of hepatic drug-metabolizing enzymes by thiophaophate insecticides and its toxicological evaluation.","authors":"M Uchiyama,&nbsp;T Yochida,&nbsp;K Homma,&nbsp;T Hongo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Thiophosphate insecticides, fenitrothion, diazinon and methylparathion, inhibit hepatic drug-metabolizing enzyme activity which was assayed using aminopyrine and aniline as substrates. About 50% inhibition was observed 4 hrs after the injection of fenitrothion into mice in a dose of 25 mg/kg. The addition in vitro of thiophosphates into a reaction mixture of drug metabolizing enzyme also produced an effective inhibition and IC50 was around 10(-5)M for fenitrothion. DDVP and oxygenated metabolite of fenitrothion did not show any inhibiting effect either in vitro or in vivo. The inhibition of thiophosphates in vitro was competitive while the kinetics of in vivo inhibition was shown as non-competitive. The drug metabolism in the rat liver preparation was also inhibited by thiophosphate in vitro, but in vivo treatment to male rats resulted in only slight inhibition. Female rats exhibited the similar response as mice. The administration of fenitrothion to mice prolonged the hexobarbital sleeping time and, consequently, suppressed the oxidative metabolism of parathion in liver preparation. These effects reveal that the biological half life of thiophosphate insecticides could be altered by the mode of administration or by co-existing thiophosphates.</p>","PeriodicalId":75827,"journal":{"name":"Environmental quality and safety","volume":"4 ","pages":"109-16"},"PeriodicalIF":0.0,"publicationDate":"1975-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12369895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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