Current developments in psychopharmacology最新文献

Anticonvulsant drugs, behavior, and cognitive abilities. 抗惊厥药物，行为和认知能力。

Current developments in psychopharmacology Pub Date : 1981-01-01 DOI: 10.1007/978-94-011-8123-5_3

M Trimble

引用次数: 26

Behavioral effects of opiates: a pharmacogenetic analysis. 阿片类药物对行为的影响:药理学分析。

Current developments in psychopharmacology Pub Date : 1981-01-01 DOI: 10.1007/978-94-011-8123-5_2

A Oliverio, C Castellano

{"title":"Behavioral effects of opiates: a pharmacogenetic analysis.","authors":"A Oliverio, C Castellano","doi":"10.1007/978-94-011-8123-5_2","DOIUrl":"https://doi.org/10.1007/978-94-011-8123-5_2","url":null,"abstract":"A number of studies are reviewed in relation to a pharmacogenetic approach to the effect of opiates. The behavioral effects of morphine and heroin in different species or strains of animals are considered. In particular, a number of behavioral, neurophysiological, and biochemical correlates of the opiates in different inbred strains of mice are cited. Recent studies concerning the effects of opiates on behavior have utilized the C57BL/6J and the DBA/2J strains, which are characterized by different brain levels and turnover of cholinergic and adrenergic mediators. It has been shown that the effects of opiates on running activity and on analgesia are strain-dependent, and a negative correlation is evident between the two measures in the strains considered. Experiments carried out on mice with septal lesions and on normal mice have confirmed that the motor and analgesic effects of morphine in the mouse are two distinct phenomena, which may be explained through different neurophysiological and biochemical models. Differences between the strains considered have also been observed when the ECoG response to morphine administration has been investigated. The results of these experiments have suggested: 1. The existence of a correlation between behavioral activation and sleep-like ECoG patterns. 2. The existence of a similarity between the effects of the anticholinergic drugs and those of morphine, since a dissociation between ECoG and behavior became evident following morphine administration. Some studies have also suggested that the environmental factors play an important role in determining the stimulating effects of morphine. This effect was absent in \"experience\" mice (i.e., in subjects already tested in the apparatus), as compared with naive \"inexperienced\" animals.","PeriodicalId":75756,"journal":{"name":"Current developments in psychopharmacology","volume":"6 ","pages":"45-64"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18061808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Comparative psychopharmacology. 比较精神药理学。

Current developments in psychopharmacology Pub Date : 1981-01-01 DOI: 10.1007/978-94-011-8123-5_1

K Y Lagerspetz

引用次数: 1

Nicotine and smoking. 尼古丁和吸烟。

Current developments in psychopharmacology Pub Date : 1981-01-01 DOI: 10.1007/978-94-011-8123-5_5

R Kumar, M Lader

引用次数: 31

Chronopharmacological studies of neuroleptics. 抗精神病药的时间药理学研究。

Current developments in psychopharmacology Pub Date : 1981-01-01 DOI: 10.1007/978-94-011-8123-5_7

H Nagayama, A Takagi, R Takahashi

{"title":"Chronopharmacological studies of neuroleptics.","authors":"H Nagayama, A Takagi, R Takahashi","doi":"10.1007/978-94-011-8123-5_7","DOIUrl":"https://doi.org/10.1007/978-94-011-8123-5_7","url":null,"abstract":"Studies were carried out to clarify the mechanism of appearance and the laws controlling the appearance of such phenomena as circadian fluctuation in the effects of neuroleptics. A detailed review was initially made of previous studies on drugs closely related to neuroleptics; then data obtained by the authors was analyzed. Significant circadian fluctuation was found in the effect of chlorpromazine, haloperidol, and tetrabenazine, varying with the time of administration, with the kind of drug, and even with the dose of the same drug. There was also circadian fluctuation in lethality rate, which was seen to be a phenomenon controlled by a law different from that controlling circadian fluctuation in the effect of a drug. Circadian fluctuation in the effect of a drug was regulated externally by clock time, setting the light-dark rhythm of the raising environment. Different times of administration of a drug did not affect chronological changes in the blood level or intracerebral concentration of a drug after administration. From these results, it was assumed that this phenomenon might be induced by the circadian rhythm of drug sensitivity of a brain where the drug acts.","PeriodicalId":75756,"journal":{"name":"Current developments in psychopharmacology","volume":"6 ","pages":"191-214"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17178644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

The antidepressant effect of lithium. 锂的抗抑郁作用。

Current developments in psychopharmacology Pub Date : 1981-01-01 DOI: 10.1007/978-94-011-8123-5_6

A Arieli, E Lepkifker

引用次数: 26

Drug-induced tardive dyskinesia. 药物引起的迟发性运动障碍。

Current developments in psychopharmacology Pub Date : 1981-01-01 DOI: 10.1007/978-94-011-8123-5_4

H Itoh

{"title":"Drug-induced tardive dyskinesia.","authors":"H Itoh","doi":"10.1007/978-94-011-8123-5_4","DOIUrl":"https://doi.org/10.1007/978-94-011-8123-5_4","url":null,"abstract":"Drug-induced tardive dyskinesia, which occurs in the course of long-term administration of psychotropic drugs, especially neuroleptics, and persists for years even after drug removal, began to be reported in the late 1950s. Since then, more than 100 investigations on this subjects have been described. And it is estimated that 10 to 30 percent of long-term hospitalized psychiatric patients in Europe and North America exhibit tardive dyskinesia, whereas 5 to 20 percent of patients exhibit this syndrome in Japan. These findings suggest that the manifestation of tardive dyskinesia will become a serious problem in the investigation of psychotropic drug treatment. The author presents a review of the symptomatology, etiological factors, differential diagnosis, prognosis, and management of this syndrome. Results of the author's studies in the cross-national survey and on the reversibility of tardive dyskinesia are also described. In connection with biochemical theory of the etiology of tardive dyskinesia, a variety of therapeutic investigations have been carried out, but no successful therapy could be found among them. Therefore, the author stresses that the early diagnosis of dyskinetic symptoms, possible removal of responsible drugs, and preventive care in daily psychotropic drug treatment are regarded as extremely important in the management of this syndrome.","PeriodicalId":75756,"journal":{"name":"Current developments in psychopharmacology","volume":"6 ","pages":"93-126"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17178645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

The effects of D-amphetamine on dopaminergic regulated mechanisms of physiological and behavioral thermoregulation. d -安非他明对多巴胺能调节生理和行为体温调节机制的影响。

Current developments in psychopharmacology Pub Date : 1979-01-01

S Yehuda

引用次数: 0

Metabolism and functions of histamine in the brain. 大脑中组胺的代谢和功能。

Current developments in psychopharmacology Pub Date : 1979-01-01

J C Schwartz, G Barbin, M Baudry, M Garbarg, M P Martres, H Pollard, M Verdiere

引用次数: 0

Psychobiological interactions and schizophrenia. 心理生物相互作用与精神分裂症。

Current developments in psychopharmacology Pub Date : 1979-01-01

D Shore

引用次数: 0