Computers and biomedical research, an international journal最新文献_第2页

Disease Management Research Using Event Graphs 使用事件图的疾病管理研究

Computers and biomedical research, an international journal Pub Date : 2000-08-01 DOI: 10.1006/cbmr.2000.1545

H.G. Allore , L.W. Schruben

引用次数: 5

The Reliability Issue of Computer-Aided Breast Cancer Diagnosis 计算机辅助乳腺癌诊断的可靠性问题

Computers and biomedical research, an international journal Pub Date : 2000-08-01 DOI: 10.1006/cbmr.2000.1546

Boris Kovalerchuk , Evangelos Triantaphyllou , James F. Ruiz , Vetle I. Torvik , Evgeni Vityaev

引用次数: 20

A Decentralized Multichannel Length Transformation Algorithm and Its Parallel Implementation for Real-Time ECG Monitoring 心电实时监测的分散多通道长度变换算法及其并行实现

Computers and biomedical research, an international journal Pub Date : 2000-08-01 DOI: 10.1006/cbmr.2000.1544

A. Koulouris, G. Papakonstantinou, P. Tsanakas

引用次数: 2

A Closed-Loop Model of the Canine Cardiovascular System That Includes Ventricular Interaction 包括心室相互作用的犬心血管系统闭环模型

Computers and biomedical research, an international journal Pub Date : 2000-08-01 DOI: 10.1006/cbmr.2000.1543

J.B. Olansen , J.W. Clark , D. Khoury , F. Ghorbel , A. Bidani

{"title":"A Closed-Loop Model of the Canine Cardiovascular System That Includes Ventricular Interaction","authors":"J.B. Olansen , J.W. Clark , D. Khoury , F. Ghorbel , A. Bidani","doi":"10.1006/cbmr.2000.1543","DOIUrl":"10.1006/cbmr.2000.1543","url":null,"abstract":"<div><p>A closed-loop model of cardiopulmonary circulation has been developed for the study of right–left ventricular interaction under physiologically normal and altered conditions. The core model provides insight into the effects of ventricular interaction and pericardial mechanics on hemodynamics. The complete model contains realistic descriptions of (a) the interacting ventricular free walls and septum, (b) the atria, (c) the pericardium, and (d) the systemic and pulmonary vascular loads. The current analysis extends previous work on ventricular interaction and pericardial influence under isolated heart conditions to loading conditions imposed by a closed-loop model of the circulation. A nonlinear least-squares parameter identification method (Levenberg–Marquardt algorithm) is used, together with parameter sensitivity analysis, to estimate the values of key parameters associated with the ventricular and circulation models. Pressure measurements taken at several anatomical locations in the circulation during open-chest experiments on dogs are used as data in the identification process. The complete circulatory model, including septal and pericardial coupling, serves as a virtual testbed for assessing the global affects of localized mechanical or hemodynamic alterations. Studies of both <em>direct</em> and <em>series</em> ventricular interaction, as well as the effect of the pericardium on cardiac performance, are accomplished with this model. Alterations in model parameter values are used to predict the impact of disease and/or clinical interventions on steady-state hemodynamic performance. Additionally, a software package titled CardioPV has been developed to integrate the complete model with data acquisition tools and a sophisticated graphical user interface. The complete software package enables users to collect experimental data, use the data to estimate model parameters, and view the model outputs in an online setting.</p></div>","PeriodicalId":75733,"journal":{"name":"Computers and biomedical research, an international journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2000-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/cbmr.2000.1543","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21782950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 96

Accuracy of Two Dipolar Inverse Algorithms Applying Reciprocity for Forward Calculation 应用互易进行正演计算的两种偶极逆算法的精度

Computers and biomedical research, an international journal Pub Date : 2000-06-01 DOI: 10.1006/cbmr.1999.1538

Päivi Laarne , Jari Hyttinen , Silke Dodel , Jaakko Malmivuo , Hannu Eskola

{"title":"Accuracy of Two Dipolar Inverse Algorithms Applying Reciprocity for Forward Calculation","authors":"Päivi Laarne , Jari Hyttinen , Silke Dodel , Jaakko Malmivuo , Hannu Eskola","doi":"10.1006/cbmr.1999.1538","DOIUrl":"10.1006/cbmr.1999.1538","url":null,"abstract":"<div><p>Two inverse algorithms were applied for solving the EEG inverse problem assuming a single dipole as a source model. For increasing the efficiency of the forward computations the lead field approach based on the reciprocity theorem was applied. This method provides a procedure to calculate the computationally heavy forward problem by a single solution for each EEG lead. A realistically shaped volume conductor model with five major tissue compartments was employed to obtain the lead fields of the standard 10–20 EEG electrode system and the scalp potentials generated by simulated dipole sources. A least-squares method and a probability-based method were compared in their performance to reproduce the dipole source based on the reciprocal forward solution. The dipole localization errors were 0 to 9 mm and 2 to 22 mm without and with added noise in the simulated data, respectively. The two different inverse algorithms operated mainly very similarly. The lead field method appeared applicable for the solution of the inverse problem and especially useful when a number of sources, e.g., multiple EEG time instances, must be solved.</p></div>","PeriodicalId":75733,"journal":{"name":"Computers and biomedical research, an international journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2000-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/cbmr.1999.1538","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21703546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 32

Fractal Texture Analysis of Perfusion Lung Scans 肺灌注扫描的分形纹理分析

Computers and biomedical research, an international journal Pub Date : 2000-06-01 DOI: 10.1006/cbmr.2000.1542

Georgia D. Tourassi , Erik D. Frederick , Neal F. Vittitoe , R.Edward Coleman

引用次数: 15

Optimizing Drug Regimens in Cancer Chemotherapy by an Efficacy–Toxicity Mathematical Model 用疗效-毒性数学模型优化肿瘤化疗药物方案

Computers and biomedical research, an international journal Pub Date : 2000-06-01 DOI: 10.1006/cbmr.2000.1540

Athanassios Iliadis , Dominique Barbolosi

{"title":"Optimizing Drug Regimens in Cancer Chemotherapy by an Efficacy–Toxicity Mathematical Model","authors":"Athanassios Iliadis , Dominique Barbolosi","doi":"10.1006/cbmr.2000.1540","DOIUrl":"10.1006/cbmr.2000.1540","url":null,"abstract":"<div><p>In cancer chemotherapy, it is important to design treatment strategies that ensure a desired rate of tumor cell kill without unacceptable toxicity. To optimize treatment, we used a mathematical model describing the pharmacokinetics of anticancer drugs, antitumor efficacy, and drug toxicity. This model was associated with constraints on the allowed plasma concentrations, drug exposure, and leukopenia. Given a schedule of drug administrations, the mathematical model optimized the drug doses that can minimize the tumor burden while limiting toxicity at the level of the white blood cells. The main result is that <em>the optimal drug administration is an initial high-dose chemotherapy up to saturation of constraints associated with normal cell toxicity and a maintenance continuous infusion at a moderate rate</em>. Data related to etoposide investigations were used in a feasibility study. Simulations with the optimized protocol showed better performances than usual clinical protocols. Model-based optimal drug doses provide for greater cytoreduction, while limiting the risk of unacceptable toxicity.</p></div>","PeriodicalId":75733,"journal":{"name":"Computers and biomedical research, an international journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2000-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/cbmr.2000.1540","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21703468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 90

3-D Reconstruction from Tomographic Data Using 2-D Active Contours 利用二维活动轮廓线对层析数据进行三维重建

Computers and biomedical research, an international journal Pub Date : 2000-06-01 DOI: 10.1006/cbmr.2000.1541

Ronald Chung , Chi-kin Ho

引用次数: 12

The Polysomnogram Assay: A Method to Represent the Overnight Polysomnogram in a Condensed Format 多导睡眠图测定:一种以浓缩格式表示夜间多导睡眠图的方法

Computers and biomedical research, an international journal Pub Date : 2000-04-01 DOI: 10.1006/cbmr.1999.1537

Anton Bartolo , Bradley D. Clymer , Joseph A. Golish , Richard C. Burgess

{"title":"The Polysomnogram Assay: A Method to Represent the Overnight Polysomnogram in a Condensed Format","authors":"Anton Bartolo , Bradley D. Clymer , Joseph A. Golish , Richard C. Burgess","doi":"10.1006/cbmr.1999.1537","DOIUrl":"10.1006/cbmr.1999.1537","url":null,"abstract":"<div><p>We present the polysomnogram assay (PSGA), a new representation format for the polysomnogram (PSG), designed to assist in the interpretation of overnight PSG studies. The technique condenses the PSG record by a factor of 30 while preserving the ability to portray PSG features of diagnostic relevance, including sleep architecture, arousals, movement, leg jerks, cyclic alternating pattern, and increased breathing effort. The PSGA patterns associated with these events are described and illustrated by examples. The new format considerably reduces the effort required to evaluate sleep quality and continuity, making it more practicable for the polysomnographer to interpret the entire overnight PSG study. The compressed time scale also facilitates analysis of relatively long PSG episodes and allows assessment of signal activity surrounding critical PSG events. The PSGA appears capable of improving identification of arousals, leg jerks, and upper airway resistance, and may be especially amenable for automatic analysis of PSG data.</p></div>","PeriodicalId":75733,"journal":{"name":"Computers and biomedical research, an international journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2000-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/cbmr.1999.1537","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21697959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

IMM/Scrub: A Domain-Specific Tool for the Deduplication of Vaccination History Records in Childhood Immunization Registries IMM/Scrub:用于儿童免疫登记中疫苗接种历史记录重复数据删除的特定领域工具

Computers and biomedical research, an international journal Pub Date : 2000-04-01 DOI: 10.1006/cbmr.1999.1534

Perry L. Miller, Sandra J. Frawley, Frederick G. Sayward

{"title":"IMM/Scrub: A Domain-Specific Tool for the Deduplication of Vaccination History Records in Childhood Immunization Registries","authors":"Perry L. Miller, Sandra J. Frawley, Frederick G. Sayward","doi":"10.1006/cbmr.1999.1534","DOIUrl":"10.1006/cbmr.1999.1534","url":null,"abstract":"<div><p>IMM/Scrub is a pilot tool developed to assist in the deduplication of vaccination history records in childhood immunization registries. This problem is complicated by a number of factors including that fact that: (1) some doses are numbered and some are not, (2) doses may have different dose numbers, (3) doses may specify different preparations within a vaccine series, (4) one dose may indicate a combination vaccine and the other dose may specify one component of that combination, (5) two doses may have slightly different dates, and (6) combinations of any of these problems may occur together. IMM/Scrub is designed to help detect 10 different types of vaccination dose duplicates and also allows the user to specify flexibly the conditions in which a duplicate dose might be automatically eliminated. In addition, IMM/Scrub is linked to the IMM/Serve immunization forecasting program, which can provide additional assistance in the data cleaning process. The paper describes (1) the design of the current pilot implementation of IMM/Scrub, (2) the lessons learned during its implementation, and (3) our preliminary experience applying it to data from three immunization databases, from a state, a metropolitan area, and an academic medical center.</p></div>","PeriodicalId":75733,"journal":{"name":"Computers and biomedical research, an international journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2000-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/cbmr.1999.1534","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21697960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4