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Studies on vasculitis. I. Immunoglobulins, 1C, C-reactive protein, and bacterial antigens in cutaneous vasculitis lesions. 血管炎的研究。1 .皮肤血管炎病变中的免疫球蛋白、1C、c反应蛋白和细菌抗原。
Clinical allergy Pub Date : 1971-03-01 DOI: 10.1111/j.1365-2222.1971.tb02451.x
W E Parish
{"title":"Studies on vasculitis. I. Immunoglobulins, 1C, C-reactive protein, and bacterial antigens in cutaneous vasculitis lesions.","authors":"W E Parish","doi":"10.1111/j.1365-2222.1971.tb02451.x","DOIUrl":"https://doi.org/10.1111/j.1365-2222.1971.tb02451.x","url":null,"abstract":"The lesions of several cutaneous vascular diseases, examined by immunofluorescence, contained γG, γA, γM and β1C globulins. Acetone‐fixed sections of some lesions contained C‐reactive protein. Antigens of streptococci, Candida, Mycobacteriwn tuberculosis and staphylococci were also found, sometimes combined with IgG indicating the formation of bacterial antigen‐antibody complexes. There was indirect evidence of the formation of complexes in vivo in that the patients had rheumatoid and anti‐IgG factors and immunoconglutinin in their sera more frequently than normal persons.","PeriodicalId":75708,"journal":{"name":"Clinical allergy","volume":"1 1","pages":"97-109"},"PeriodicalIF":0.0,"publicationDate":"1971-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1365-2222.1971.tb02451.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15506292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 65
The experimental inhibition of reagin-mediated reactions. 实验性抑制reagin介导的反应。
Clinical allergy Pub Date : 1971-03-01 DOI: 10.1111/j.1365-2222.1971.tb02445.x
D R Stanworth
{"title":"The experimental inhibition of reagin-mediated reactions.","authors":"D R Stanworth","doi":"10.1111/j.1365-2222.1971.tb02445.x","DOIUrl":"https://doi.org/10.1111/j.1365-2222.1971.tb02445.x","url":null,"abstract":"Introduction Recent studies facilitated by the availability of a myeloma form of IgE have provided important new information about the mechanism of hypersensitivity reactions of the immediate-type. Consequently, a clearer insight is being obtained into those immunoiogical events which initiate the release of pharmacological mediators: events which, until recently, had been mainly investigated in experimental anaphylaxis systems involving sensitization by antibodies of the IgG type. It seems to be an appropriate time, at the inception of a new journal of Clinical Allergy, to attempt to assess the relevance of these new developments to the clinician; and to consider ways in which they could possibly be exploited to achieve the more effective control of allergic conditions in humans. First, however, it is necessary to define the terms of reference.","PeriodicalId":75708,"journal":{"name":"Clinical allergy","volume":"1 1","pages":"25-35"},"PeriodicalIF":0.0,"publicationDate":"1971-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1365-2222.1971.tb02445.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15227277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 24
Antibodies in some chronic fibrosing lung diseases. I. Non organ-specific autoantibodies. 一些慢性纤维化肺疾病的抗体。1 .非器官特异性自身抗体。
Clinical allergy Pub Date : 1971-03-01 DOI: 10.1111/j.1365-2222.1971.tb02450.x
M Turner-Warwick, P Haslam
{"title":"Antibodies in some chronic fibrosing lung diseases. I. Non organ-specific autoantibodies.","authors":"M Turner-Warwick, P Haslam","doi":"10.1111/j.1365-2222.1971.tb02450.x","DOIUrl":"https://doi.org/10.1111/j.1365-2222.1971.tb02450.x","url":null,"abstract":"Autoantibodies to nuclear and cytoplasmic constitutents and to denatured γ‐globulin have been studied in patients with different types of chronic fibrosing lung disease. The prevalence of these antibodies is increased in cryptogenic fibrosing alveolitis but the incidence in extrinsic allergic alveolitis is similar to previous published reports on random populations and a control group included in this series of asbestos workers with normal chest radiographs. In asbestosis there was a lesser increase in ANF and rheumatoid factors but no significant increase in antibodies to cytoplasmic constituents. No evidence of organ‐specific autoantibodies to lung have been demonstrated in any group. The presence of non organ‐specific autoantibodies cannot necessarily be attributed to a non‐specific consequence of all types of chronic destructive pulmonary fibrosis because of their differential distribution in different lung diseases.","PeriodicalId":75708,"journal":{"name":"Clinical allergy","volume":"1 1","pages":"83-95"},"PeriodicalIF":0.0,"publicationDate":"1971-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1365-2222.1971.tb02450.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16042539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 83
The changing prevalence of asthma in school children. 学龄儿童哮喘患病率的变化。
Clinical allergy Pub Date : 1971-03-01 DOI: 10.1111/j.1365-2222.1971.tb02447.x
J M Smith, L K Harding, G Cumming
{"title":"The changing prevalence of asthma in school children.","authors":"J M Smith, L K Harding, G Cumming","doi":"10.1111/j.1365-2222.1971.tb02447.x","DOIUrl":"https://doi.org/10.1111/j.1365-2222.1971.tb02447.x","url":null,"abstract":"A study of the prevalence of asthma in school children in Birmingham which was first carried out in 1956–57 was repeated in 1968–69. There has been an increase in the prevalence of definitely diagnosed asthma from 1.8% to 2.3%, not including an even higher number of children (3.2%) with wheezing. A considerably higher prevalence in boys than in girls was again found both for definite asthma and for wheezing but the tendency to recovery in boys with definite asthma was slight whereas there was a marked recovery in cases of wheezing which almost certainly represented mild asthma.","PeriodicalId":75708,"journal":{"name":"Clinical allergy","volume":"1 1","pages":"57-61"},"PeriodicalIF":0.0,"publicationDate":"1971-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1365-2222.1971.tb02447.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16241590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 134
Platinum sensitivity: treatment by specific hyposensitization. 铂敏感性:通过特异性减敏治疗。
Clinical allergy Pub Date : 1971-03-01 DOI: 10.1111/j.1365-2222.1971.tb02449.x
G M Levene, C D Calnan
{"title":"Platinum sensitivity: treatment by specific hyposensitization.","authors":"G M Levene, C D Calnan","doi":"10.1111/j.1365-2222.1971.tb02449.x","DOIUrl":"https://doi.org/10.1111/j.1365-2222.1971.tb02449.x","url":null,"abstract":"An analytical chemist developed respiratory tract and cutaneous allergy to complex salts of platinum in the course of his work.","PeriodicalId":75708,"journal":{"name":"Clinical allergy","volume":"1 1","pages":"75-82"},"PeriodicalIF":0.0,"publicationDate":"1971-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1365-2222.1971.tb02449.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16097051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 29
Changes in nasal airways resistance on antigenic challenge in allergic rhinitis. 变应性鼻炎患者鼻气道对抗原攻击的抵抗变化。
Clinical allergy Pub Date : 1971-03-01 DOI: 10.1111/j.1365-2222.1971.tb02448.x
G Taylor, P R Shivalkar
{"title":"Changes in nasal airways resistance on antigenic challenge in allergic rhinitis.","authors":"G Taylor, P R Shivalkar","doi":"10.1111/j.1365-2222.1971.tb02448.x","DOIUrl":"https://doi.org/10.1111/j.1365-2222.1971.tb02448.x","url":null,"abstract":"The nasal airways resistance changes occurring after challenge with graded doses of antigen have been measured in sixty‐five sensitive subjects. The degree of nasal sensitivity has been compared with skin sensitivity and no clear positive quantitative correlation was found. This lack of correlation is considered to indicate the importance of local IgE production in allergic rhinitis. Some subjects show evidence of local desensitization after several antigen challenges. Possible mechanisms are discussed.","PeriodicalId":75708,"journal":{"name":"Clinical allergy","volume":"1 1","pages":"63-73"},"PeriodicalIF":0.0,"publicationDate":"1971-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1365-2222.1971.tb02448.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16241591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 71
Clinical significance of specific IgE to common allergens. I. Relationship of specific IgE against Dermatophagoides spp. and grass pollen to skin and nasal tests and history. 常见过敏原特异性IgE的临床意义。1 .抗棘球绦虫和草花粉特异性IgE与皮肤和鼻腔试验及病史的关系。
Clinical allergy Pub Date : 1971-03-01 DOI: 10.1111/j.1365-2222.1971.tb02446.x
B Stenius, L Wide, W M Seymour, V Holford-Strevens, J Pepys
{"title":"Clinical significance of specific IgE to common allergens. I. Relationship of specific IgE against Dermatophagoides spp. and grass pollen to skin and nasal tests and history.","authors":"B Stenius, L Wide, W M Seymour, V Holford-Strevens, J Pepys","doi":"10.1111/j.1365-2222.1971.tb02446.x","DOIUrl":"https://doi.org/10.1111/j.1365-2222.1971.tb02446.x","url":null,"abstract":"Serological measurements of specific IgE to Dermatophagoides farinae, D. pteronyssinus and grass pollen showed statistically highly significant correlations with prick test reactions, the sizes of weals elicited, nasal tests and the clinical history. In subjects with negative prick tests, intracutaneous tests gave reactions which were not associated with specific IgE or reactions to nasal tests. Highly significant correlations were also found between total IgE values and prick test reactions to the allergens tested and to 48/80 but not to histamine; there was a negative correlation with reactions to anti‐IgE serum. The reactions to prick tests identified almost all subjects with specific IgE.","PeriodicalId":75708,"journal":{"name":"Clinical allergy","volume":"1 1","pages":"37-55"},"PeriodicalIF":0.0,"publicationDate":"1971-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1365-2222.1971.tb02446.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15227278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 161
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