Studies on vasculitis. I. Immunoglobulins, 1C, C-reactive protein, and bacterial antigens in cutaneous vasculitis lesions.

Abstract

The lesions of several cutaneous vascular diseases, examined by immunofluorescence, contained γG, γA, γM and β1C globulins. Acetone‐fixed sections of some lesions contained C‐reactive protein. Antigens of streptococci, Candida, Mycobacteriwn tuberculosis and staphylococci were also found, sometimes combined with IgG indicating the formation of bacterial antigen‐antibody complexes. There was indirect evidence of the formation of complexes in vivo in that the patients had rheumatoid and anti‐IgG factors and immunoconglutinin in their sera more frequently than normal persons.