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Letter: Asthma due to inhaled chemicals. 信:吸入化学物质引起的哮喘。
Clinical allergy Pub Date : 1975-09-01
G M Halpern
{"title":"Letter: Asthma due to inhaled chemicals.","authors":"G M Halpern","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75708,"journal":{"name":"Clinical allergy","volume":"5 3","pages":"351-2"},"PeriodicalIF":0.0,"publicationDate":"1975-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12360325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigations of allergic status and blood counts in Chinese patients receiving daily or intermittent rifampicin in Hong Kong. 在香港每日或间歇性接受利福平治疗的中国患者的过敏状态和血液计数调查。
Clinical allergy Pub Date : 1975-06-01
{"title":"Investigations of allergic status and blood counts in Chinese patients receiving daily or intermittent rifampicin in Hong Kong.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In a controlled trial in Hong Bong, 575 Chinese patients with pulmonary tuberculosis whose treatment with first-line regimens had failed were allocated at random to the following retreatment regimens of chemotherapy. (1) Rifampicin plus ethambutol daily (ER7). (2) Rifampicin plus ethambutol twice a week (ER2). (3) Rifampicin plus ethambutol once a week (ER1). (4) Rifampicin plus ethambutol daily for 2 months and then once a week (ER7ER1). (5) Ethionamide plus pyrazinamide plus cycloserine daily for 6 months and then ethionamide plus pyrazinamide daily (EtZC), as a control regimen. Answers to a questionnaire on allergic disease, the results of prick tests with standard allergens, ABO blood grouping, size of tuberculin response during chemotherapy, and a rifampicin patch test showed no associations with the occurrence of adverse reactions to daily or intermittent rifampicin. Mantoux testing during chemotherapy provided no evidence of an immunosuppressive effect of rifampicin. Mean platelet counts at 12 months were significantly lower than those at 3 months on the two once-weekly regimens (ER1, ER7ER1) and on the control regimen (EtZC), although still within normal limits. At 3 months, but not at 12 months, mean platelet counts on the two once-weekly regimens were significantly lower 6 hr after a dose of the regimen than they were before the dose.</p>","PeriodicalId":75708,"journal":{"name":"Clinical allergy","volume":"5 2","pages":"189-99"},"PeriodicalIF":0.0,"publicationDate":"1975-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12275488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter: Rhinitis and nasal polyps in asthma. 信:哮喘中的鼻炎和鼻息肉。
Clinical allergy Pub Date : 1974-09-01
G J Archer
{"title":"Letter: Rhinitis and nasal polyps in asthma.","authors":"G J Archer","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75708,"journal":{"name":"Clinical allergy","volume":"4 3","pages":"323-4"},"PeriodicalIF":0.0,"publicationDate":"1974-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15527155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A controlled clinical trial of small daily doses of rifampicin in the prevention of adverse reactions to the drug in a once-weekly regimen of chemotherapy. A Hong Kong Tuberculosis Treatment Services-British Medical Research Council Investigation. 在每周一次的化疗方案中，每日小剂量利福平预防药物不良反应的对照临床试验。香港结核病治疗服务处与英国医学研究理事会的调查。
Clinical allergy Pub Date : 1974-03-01
{"title":"A controlled clinical trial of small daily doses of rifampicin in the prevention of adverse reactions to the drug in a once-weekly regimen of chemotherapy. A Hong Kong Tuberculosis Treatment Services-British Medical Research Council Investigation.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75708,"journal":{"name":"Clinical allergy","volume":"4 1","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"1974-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15920789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The airways response to phenylephrine after blockade of alpha and beta receptors in extrinsic bronchial asthma. 外源性支气管哮喘阻断α和β受体后气道对苯肾上腺素的反应。
Clinical allergy Pub Date : 1973-12-01 DOI: 10.1111/j.1365-2222.1973.tb01351.x
K R Patel, J W Kerr
{"title":"The airways response to phenylephrine after blockade of alpha and beta receptors in extrinsic bronchial asthma.","authors":"K R Patel,&nbsp;J W Kerr","doi":"10.1111/j.1365-2222.1973.tb01351.x","DOIUrl":"https://doi.org/10.1111/j.1365-2222.1973.tb01351.x","url":null,"abstract":"Phenylephrine, a powerful alpha receptor stimulant, has been shown to cause a significant fall in the FEV1 and SGaw in six patients with extrinsic bronchial asthma after prior beta blockade with propranolol. In contrast, propranolol or phenylephrine after prior beta blockade failed to effect a significant change in the FEV1 and SGaw in five normal subjects. The phenylephrine effect can be completely inhibited by alpha receptor blocking drugs, phenoxybenzamine and thymoxamine. These observations suggest that the bronchomotor tone in asthma is largely controlled by the sympathetic activity and that there are alpha receptors in the human airways which in the presence of beta blockade can be stimulated to give bronchoconstriction.","PeriodicalId":75708,"journal":{"name":"Clinical allergy","volume":"3 4","pages":"439-48"},"PeriodicalIF":0.0,"publicationDate":"1973-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1365-2222.1973.tb01351.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15258547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 55
Allergy to snake venom: the use of radioimmunoassay for the detection of IgE antibodies against antigens not suitable for cutaneous tests. 对蛇毒过敏:使用放射免疫分析法检测针对不适合皮肤试验的抗原的IgE抗体。
Clinical allergy Pub Date : 1973-12-01 DOI: 10.1111/j.1365-2222.1973.tb01345.x
J F Kelly, R Patterson
{"title":"Allergy to snake venom: the use of radioimmunoassay for the detection of IgE antibodies against antigens not suitable for cutaneous tests.","authors":"J F Kelly,&nbsp;R Patterson","doi":"10.1111/j.1365-2222.1973.tb01345.x","DOIUrl":"https://doi.org/10.1111/j.1365-2222.1973.tb01345.x","url":null,"abstract":"A case of a severe immediate‐type respiratory reaction to rattlesnake venom is reported. Reaginic antibody to the snake venom was demonstrated in the patient's serum by long latency passive cutaneous anaphylaxis in a monkey. IgE antibody against the venom was demonstrated in the patient's serum by a solid phase radioimmunoassay.","PeriodicalId":75708,"journal":{"name":"Clinical allergy","volume":"3 4","pages":"385-8"},"PeriodicalIF":0.0,"publicationDate":"1973-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1365-2222.1973.tb01345.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15313398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
The effect of frequent administration of sodium cromoglycate to asthmatic children who previously responded poorly. 频繁给药cromoglycate钠对既往反应不良的哮喘儿童的影响。
Clinical allergy Pub Date : 1973-12-01 DOI: 10.1111/j.1365-2222.1973.tb01347.x
P König, S Godfrey
{"title":"The effect of frequent administration of sodium cromoglycate to asthmatic children who previously responded poorly.","authors":"P König,&nbsp;S Godfrey","doi":"10.1111/j.1365-2222.1973.tb01347.x","DOIUrl":"https://doi.org/10.1111/j.1365-2222.1973.tb01347.x","url":null,"abstract":"The effect of an increased frequency of administration of sodium cromoglycate (SCG) was studied in twenty‐four asthmatic children who had previously responded poorly to 3–4 capsules per day. Six out of seven children who were assessed clinically alone improved when their dose was raised to 6 capsules daily. When a diary score and bronchodilator consumption were recorded, the more frequent administration of SCG gave significantly better results in eleven of seventeen children. However, only five of the twelve children given peak flow meters to use twice daily at home showed objective improvement.","PeriodicalId":75708,"journal":{"name":"Clinical allergy","volume":"3 4","pages":"395-402"},"PeriodicalIF":0.0,"publicationDate":"1973-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1365-2222.1973.tb01347.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15313400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Relationship between rifampicin-dependent antibody scores, serum rifampicin concentrations and symptoms in patients with adverse reactions to intermittent rifampicin treatment. 间歇性利福平治疗不良反应患者的利福平依赖性抗体评分、血清利福平浓度与症状的关系
Clinical allergy Pub Date : 1973-12-01 DOI: 10.1111/j.1365-2222.1973.tb01342.x
M G O'Mahony, C W Kar
{"title":"Relationship between rifampicin-dependent antibody scores, serum rifampicin concentrations and symptoms in patients with adverse reactions to intermittent rifampicin treatment.","authors":"M G O'Mahony,&nbsp;C W Kar","doi":"10.1111/j.1365-2222.1973.tb01342.x","DOIUrl":"https://doi.org/10.1111/j.1365-2222.1973.tb01342.x","url":null,"abstract":"Twelve patients receiving intermittent treatment with rifampicin for pulmonary tuberculosis, who had developed rifampicin‐dependent antibodies were studied. Ten of the twelve patients had also developed adverse reactions to the drug at the time the study was done. After a dose of the drug, blood samples were taken from each patient at regular intervals for the assessment of rifampicin‐dependent antibodies by a semi‐quantitative method, and for the measurement of serum rifampicin concentrations. Clinical details of any adverse reactions which occurred were also recorded at these set times. Serum rifampicin concentrations were at their highest from 1 to 12 hr after a dose, and during this same period the rifampicin‐dependent antibody score was reduced. Adverse reactions, when they occurred, coincided with the period of high serum rifampicin concentration and low antibody score. Whether or not these findings are of immunological significance is discussed.","PeriodicalId":75708,"journal":{"name":"Clinical allergy","volume":"3 4","pages":"353-62"},"PeriodicalIF":0.0,"publicationDate":"1973-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1365-2222.1973.tb01342.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15881081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
Photo-inactivated allergens. II. Clinical experience with house dust allergen in pulmonary function tests and in immunotherapy. Photo-inactivated过敏原。2屋尘过敏原在肺功能检查和免疫治疗中的临床经验。
Clinical allergy Pub Date : 1973-12-01 DOI: 10.1111/j.1365-2222.1973.tb01353.x
E Hénocq, M Garcelon, L Berrens
{"title":"Photo-inactivated allergens. II. Clinical experience with house dust allergen in pulmonary function tests and in immunotherapy.","authors":"E Hénocq,&nbsp;M Garcelon,&nbsp;L Berrens","doi":"10.1111/j.1365-2222.1973.tb01353.x","DOIUrl":"https://doi.org/10.1111/j.1365-2222.1973.tb01353.x","url":null,"abstract":"Purified house dust allergen irradiated with UV‐light loses its capacity to elicit immediate type skin and bronchial provocation reactions in the majority of asthmatic patients. However, in some patients both immediate and/or late bronchial reactions were observed to the active house dust and its inactivated counterpart.","PeriodicalId":75708,"journal":{"name":"Clinical allergy","volume":"3 4","pages":"461-9"},"PeriodicalIF":0.0,"publicationDate":"1973-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1365-2222.1973.tb01353.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15881083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
A fine structure study of some cellular components in allergic reactions. 1. Degranulation of human mast cells in allergic asthma and perennial rhinitis. 过敏反应中某些细胞成分的精细结构研究。1. 过敏性哮喘和常年性鼻炎的肥大细胞脱颗粒。
Clinical allergy Pub Date : 1973-12-01 DOI: 10.1111/j.1365-2222.1973.tb01349.x
C M Trotter, T S Orr
{"title":"A fine structure study of some cellular components in allergic reactions. 1. Degranulation of human mast cells in allergic asthma and perennial rhinitis.","authors":"C M Trotter,&nbsp;T S Orr","doi":"10.1111/j.1365-2222.1973.tb01349.x","DOIUrl":"https://doi.org/10.1111/j.1365-2222.1973.tb01349.x","url":null,"abstract":"Tissues from patients with allergic asthma or perennial rhinitis have been examined and normal mast cell ultrastructure described. Degranulating mast cells are shown in nasal and bronchiolar tissue, with attention focused on granules, microfilaments and labyrinth and pore formations.","PeriodicalId":75708,"journal":{"name":"Clinical allergy","volume":"3 4","pages":"411-25"},"PeriodicalIF":0.0,"publicationDate":"1973-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1365-2222.1973.tb01349.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15881082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 53
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