Clinical allergy最新文献_第2页

Action of tiaramide in nasal allergen challenge. 甲酰胺在鼻腔过敏原攻击中的作用。

Clinical allergy Pub Date : 1983-11-01

U Pipkorn

引用次数: 0

Hyaline ascospores as a cause of the epidemic of asthma deaths in the 1960s. 透明子囊孢子是20世纪60年代哮喘死亡流行的一个原因。

Clinical allergy Pub Date : 1983-05-01

J F Ackroyd, J S Fry

引用次数: 0

Histamine, neutrophil chemotactic factor and circulating basophil levels following exercise in asthmatic and control subjects. 哮喘和对照组运动后的组胺、中性粒细胞趋化因子和循环嗜碱性粒细胞水平。

Clinical allergy Pub Date : 1982-10-01 DOI: 10.1111/j.1365-2222.1982.tb03296.x

D J Morgan, M J Phillips, I Moodley, E V Elliott, R J Davies

{"title":"Histamine, neutrophil chemotactic factor and circulating basophil levels following exercise in asthmatic and control subjects.","authors":"D J Morgan, M J Phillips, I Moodley, E V Elliott, R J Davies","doi":"10.1111/j.1365-2222.1982.tb03296.x","DOIUrl":"https://doi.org/10.1111/j.1365-2222.1982.tb03296.x","url":null,"abstract":"<p><p>Significant increase in the maximum post-exercise values of plasma histamine (PH), whole blood histamine (WBH) and neutrophil chemotactic factor (NCF) occurred in arterial blood within the first hour after exercise in asthmatic patients. However, similar changes in PH and WBH also occurred in the control group. Significant increases in circulating basophil counts following exercise were found in both groups, which closely mirrored the changes in PH and NCF, and there was a highly significant correlation between rises in WBH and basophil counts (P less than 0.001). When plasma histamine as assayed in venous blood using a more sensitive and specific double isotope radio enzymatic assay no significant alteration in plasma histamine levels was detected in either the asthmatic or the control group. We conclude that there is no evidence from these studies to support the suggestion that mast cell mediator release is involved in the pathogenesis of exercise-induced asthma, and that any observed changes in levels of PH and NCF after exercise may be related to changes in levels of circulating basophils.</p>","PeriodicalId":75708,"journal":{"name":"Clinical allergy","volume":"12 Suppl ","pages":"29-37"},"PeriodicalIF":0.0,"publicationDate":"1982-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17807155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Ketotifen in childhood allergic disease. 酮替芬在儿童过敏性疾病中的作用。

Clinical allergy Pub Date : 1982-10-01 DOI: 10.1111/j.1365-2222.1982.tb03295.x

J O Warner, S J Goldsworthy

{"title":"Ketotifen in childhood allergic disease.","authors":"J O Warner, S J Goldsworthy","doi":"10.1111/j.1365-2222.1982.tb03295.x","DOIUrl":"https://doi.org/10.1111/j.1365-2222.1982.tb03295.x","url":null,"abstract":"Introduction Attempts to develop an orally active sodium cromoglycate (SCG)-like compound have been as intense and competitive as was the search for the 'Holy Grail'. The development of SCG was the outcome of exhaustive studies of the constituents of Khellin, utilizing challenge tests in human asthma (Cox, 1967). It did not arise from a fundamental understanding of the aetiology of asthma. In many respects the clinical success of SCG in allergic disorders has retarded the development of new drugs for these conditions. Identification of the in vitro mast cell stabilizing properties of SCG led to the assumption that this property accounted for its action (Cox, 1971). Several orally active mast cell stabilizing compounds have been made, but few have achieved clinical success. However, it is now evident that SCG operates by mechanisms other than or in addition to mast cell stabilization (Altounyan, 1980). Clinical experience suggests that SCG is particularly effective in young children, but its use in this age group is limited by the need for administration by inhalation (Geller-Bernstein & Sneh, 1980). Thus an orally absorbed systemically active compound would be valuable in the treatment of childhood asthma, and may also control allergic rhinitis and conjunctivitis. Unfortunately orally administered drugs may not be as effective as those given by inhalation because intra-luminal events, including mast cell degranulation are probably important in the initiation of allergic reactions (Davies & Phillips, 1982).","PeriodicalId":75708,"journal":{"name":"Clinical allergy","volume":"12 Suppl ","pages":"21-7"},"PeriodicalIF":0.0,"publicationDate":"1982-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1365-2222.1982.tb03295.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17866246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

T lymphocyte substances controlling eosinophilia. The spontaneous synthesis by asthmatic human bronchial T lymphocytes of a substance stimulating eosinophil activities and expression of complement receptors. 控制嗜酸性细胞的T淋巴细胞物质。哮喘患者支气管T淋巴细胞自发合成一种刺激嗜酸性粒细胞活动和补体受体表达的物质

Clinical allergy Pub Date : 1982-10-01

W E Parish

引用次数: 0

Control of mediator release from mast cells. 肥大细胞释放介质的控制。

Clinical allergy Pub Date : 1982-10-01 DOI: 10.1111/j.1365-2222.1982.tb03293.x

S T Holgate, M K Church

{"title":"Control of mediator release from mast cells.","authors":"S T Holgate, M K Church","doi":"10.1111/j.1365-2222.1982.tb03293.x","DOIUrl":"https://doi.org/10.1111/j.1365-2222.1982.tb03293.x","url":null,"abstract":"An acute inflammatory response occumng 5 to 10 min following contact with a specific antigen identifies the type I or immediate hypersensitivity reaction. The response is initiated by a calcium-dependent non-cytotoxic secretion from mast cells of granule-associated preformed mediators and newly generated mediators of inflammation. The secondary recruitment of other cells such as eosinophils and neutrophils by mast cell chemotactic factors contribute further to the ensuing inflammatory tissue reaction (Austen, 1979). Mast cells of man (Colman & Godfrey, 1981) and most animal species (Metzger, 1978) have in excess of 1-6 x 108 receptors on their cell surface which specifically bind IgE through high affinity association with the C4 domain of the Fc fragment (KI 108-1010 mol-I) . The availability of rat peritoneal mast cells in dispersed and purified form together with tissue culture techniques to propagate the related rat basophil leukaemia (RBL) cell line has enabled the biochemical characteristics of the IgE-Fc receptor to be studied in detail. The IgE-Fc receptor of RE3L cells has been isolated and characterized as a glycoprotein of 95000 mol. wt (Metzger, 1978) which has immunochemical identity with corresponding receptors of rat mast serosal mast cells (Conrad er al., 1979). The receptor complex of the RBL cell is composed of at least two ionically linked sub-units, alpha and beta, with estimated molecular weights of 45000 and 55000 respectively (Conrad et al., 1979). Only the cell surface alpha sub-unit has the high affinity binding site for IgE, while the beta sub-unit, buried in the phospholipid plasma membrane, may serve to couple the signal to intracellular mechanisms responsible for secretion (Pecoud & Conrad, 1981). The binding of IgE to mast cell Fc receptors is slow, becoming maximum after 1-6 hr of passive","PeriodicalId":75708,"journal":{"name":"Clinical allergy","volume":"12 Suppl ","pages":"5-13"},"PeriodicalIF":0.0,"publicationDate":"1982-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1365-2222.1982.tb03293.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17247765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

A current view of pigeon fancier's lung. A model for pulmonary extrinsic allergic alveolitis. 鸽友肺的近观。肺外源性过敏性肺泡炎模型。

Clinical allergy Pub Date : 1982-10-01

G Boyd, C P McSharry, S W Banham, P P Lynch

引用次数: 0

Advances in Allergy. 过敏的进展。

Clinical allergy Pub Date : 1982-10-01 DOI: 10.1111/j.1365-2222.1982.tb03292.x

M H Lessof

引用次数: 0

XI International Congress of Allergology and Clinical Immunology. Papers presented to the British Society for Allergy and Clinical Immunology. 第十一届国际变态反应学和临床免疫学大会。提交给英国过敏和临床免疫学学会的论文。

Clinical allergy Pub Date : 1982-10-01

引用次数: 0

Calcium antagonists in experimental asthma. 实验性哮喘中的钙拮抗剂。

Clinical allergy Pub Date : 1982-10-01 DOI: 10.1111/j.1365-2222.1982.tb03294.x

K R Patel, J W Kerr

{"title":"Calcium antagonists in experimental asthma.","authors":"K R Patel, J W Kerr","doi":"10.1111/j.1365-2222.1982.tb03294.x","DOIUrl":"https://doi.org/10.1111/j.1365-2222.1982.tb03294.x","url":null,"abstract":"Introduction The release of histamine from mast cells following antigen-IgE binding is dependent on increased permeability to calcium ions through specific calcium channels in the cell membrane. The secretion of mediators from mast cells can also be initiated by calcium ionophore A23187, or by direct injection of calcium ions into the cell, even in the absence of antigen. The release of mediators is thus regulated by extra and intracellular levels of calcium ions (Mongar & Foreman, 1979). It has been proposed that the anti-allergic drug sodium cromoglycate may prevent mediator release by blocking the calcium channels of mast cells (Foreman & Garland, 1976). Calcium ions are also involved in smooth muscle contraction and other secretory processes. Thus, inhibition of calcium ion influx should be beneficial in allergic asthma which involves both the increased bronchial hyper-reactivity and the release of mast cell mediators. Verapamil and nifedipine selectively inhibit calcium ion influx across the cell membrane. In vitro, verapamil and nifedipine have been reported to inhibit anaphylaxis in the airway smooth muscle (Weiss & Markowicz, 1981) and also to prevent the release of platelet-activating factor and slow reacting substance of anaphylaxis from human neutrophils (Cerrina et al., 1981). In addition, both these drugs suppress calcium-dependent smooth muscle excitation and contraction, and are also capable of neutralizing the vasoconstrictor effect of histamine, serotonin, ergotamine and acetylcholine (Fleckenstein-Griin et al., 1978). We have investigated the effect of verapamil and nifedipine in exercise-induced asthma and also on the histamine bronchial reactivity in patients with allergic asthma.","PeriodicalId":75708,"journal":{"name":"Clinical allergy","volume":"12 Suppl ","pages":"15-20"},"PeriodicalIF":0.0,"publicationDate":"1982-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18155615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9