Ceskoslovenska fysiologie最新文献_第6页

Short review of some properties of muscular proteins. 肌肉蛋白的一些特性的简要回顾。

Ceskoslovenska fysiologie Pub Date : 2008-01-01

P Makovický, P Makovický, F Jílek

引用次数: 0

[Methamphetamine--a drug of pregnant female drug addicts]. [甲基苯丙胺——怀孕女性吸毒成瘾者的毒品]。

Ceskoslovenska fysiologie Pub Date : 2008-01-01

Romana Slamberová, Petra Charousová

引用次数: 0

[What are the mechanisms of drug addiction?]. 药物成瘾的机制是什么?

Ceskoslovenska fysiologie Pub Date : 2008-01-01

R Slamberová

引用次数: 0

[What is new in the research of psychostimulats drug addiction?]. 精神刺激药物成瘾研究有什么新进展?

Ceskoslovenska fysiologie Pub Date : 2008-01-01

R Slamberová, L Hrubá, B Schutová

引用次数: 0

[Chronobiology and practical medicine]. [时间生物学和实用医学]。

Ceskoslovenska fysiologie Pub Date : 2008-01-01

P Svorc, I Bracoková, I Bacová, E Svorcová

{"title":"[Chronobiology and practical medicine].","authors":"P Svorc, I Bracoková, I Bacová, E Svorcová","doi":"","DOIUrl":"","url":null,"abstract":"In present time, to classify the healthy as potencional possibility of the organism to accept variable environment influences without the break of the biological important functions is not satisfactory. Examples from the different field of the clinical medicine refer to importance of the knowledge's of the circadian rhythmicity concerning many diseases, symptoms or significant remissions. Therefore, clinical trials considering the biological variability differ from the convectional studies by assumption that biology of patient is dynamic, that time of the diagnostic test running is significant and that drugs can influence safety and therapeutic effect in the dependence on the day-time. In paper, it is showed on some examples from the clinical practice that respection of the chronobiological principles may play the important role in the medical diagnostics as well as in therapy and may improve accuracy of the whatever functional examination. For terms, which are often used in the chronobiological texts, no suitable terms were available and therefore it was necessary to introduce the descriptive phrases, which would be accepted by specialists in the field. Many of the introduced terms are still unknown to many investigators and physicians who might benefit from the application of chronobiologic principles to their work.","PeriodicalId":75688,"journal":{"name":"Ceskoslovenska fysiologie","volume":"57 1","pages":"4-9"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27537475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[The role of endothelium and nitric oxide in the regulation of vascular tone]. [内皮和一氧化氮在血管张力调节中的作用]。

Ceskoslovenska fysiologie Pub Date : 2008-01-01

A Púzserová, J Kopincová, I Bernátová

{"title":"[The role of endothelium and nitric oxide in the regulation of vascular tone].","authors":"A Púzserová, J Kopincová, I Bernátová","doi":"","DOIUrl":"","url":null,"abstract":"Vascular system is a large complex of tubes with different diameters which are able to perceive changes of endogenous milieu, to integrate and modulate signals of intercellular communication and to respond and adapt by a local production of different kinds of mediators affecting vascular structure and function. For a long time, it has been assumed that the main determinant of vasomotor function was the nervous system and the monolayer of endothelial cells was only a physical barrier between the vessel wall and blood. However, the first publications in 1960s and 70s indicated that endothelium is not only a passive barrier. Endothelium features autocrine, paracrine and endocrine activities. Vascular endothelium plays an important role in the regulation of vascular tone, blood pressure and blood flow beside central regulation of nervous system. The existence of endothelium-derived relaxing factor (EDRF) was found out by Furchgott and Zawadzki (1980) who showed that acetylcholine induced relaxation of the rabbit aorta only in the presence of intact endothelium. Nowadays, nitric oxide (NO), previously known as EDRF, is considered one of the crucial endothelium-derived vasorelaxing substances participating in the regulation of basal vascular tone, vascular resistance and thus in the regulation of blood pressure. Arterial bed is dilated continuously as a consequence of constant production of NO. Any damage of endothelium modifies regulatory functions of endothelial cells. These conditions are characterised as endothelial dysfunction associated with imbalance between vasodilating and vasoconstricting factors, pro- and anticoagulation factors and factors stimulating and inhibiting growth and proliferation of cells. However, cellular mechanisms which are involved in the development of endothelial dysfunction, are still not well-known.","PeriodicalId":75688,"journal":{"name":"Ceskoslovenska fysiologie","volume":"57 2-3","pages":"53-60"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28150125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Regulation and significance of non-quantal acetylcholine release at neuromuscular synapse]. [神经肌肉突触非定量乙酰胆碱释放的调控及意义]。

Ceskoslovenska fysiologie Pub Date : 2008-01-01

F Vyskocil

引用次数: 0

[Nature of non-quantal acetylcholine release at neuromuscular synapse]. [神经肌肉突触非定量乙酰胆碱释放的性质]。

Ceskoslovenska fysiologie Pub Date : 2008-01-01

F Vyskocil

引用次数: 0

[5/6 nephrectomy as an experimental model of chronic renal failure and adaptation to reduced nephron number]. [5/6肾切除术作为慢性肾功能衰竭和适应肾细胞数量减少的实验模型]。

Ceskoslovenska fysiologie Pub Date : 2008-01-01

P Kujal, Z Vernerová

引用次数: 0

[Testosterone--effects, metabolism and genetic determination]. [睾丸激素——影响、代谢和基因决定]。

Ceskoslovenska fysiologie Pub Date : 2008-01-01

E Schmidtová

{"title":"[Testosterone--effects, metabolism and genetic determination].","authors":"E Schmidtová","doi":"","DOIUrl":"","url":null,"abstract":"Testosterone (C19H28O2), the main testicular hormone, is 19-carbonic steroid substance with -OH group in position 17. Precursor for its synthesis is cholesterol, or possibly androstendione released by adrenal cortex. Testosterone is produced in smooth endoplasmatic reticulum of Leydig cells of testes. Apart from testes it is also produced in adrenal cortex, liver, kidneys, in fat and muscle tissue, even though in smaller extent--around 5% (Bidlingmaier, F. et al., 1986). Approximately 4-9 mg (13.9-31.2 nmol/l) of testosterone is daily produced in healthy men. Absolute majority, around 99% from overall plasmatic testosterone is bound to albumin, erythrocytes, but mainly to sex hormone binding globulin (SHBG) (Diver, M.J. et al., 2003). Only small proportion (1-2%) of testosterone circulates as free fraction (Ostatníková, D., 2003). Production and secretion of the main androgen in testes is regulated by well known and accepted axis of hypothalamus, hypophysis and testes. Testosterone and its metabolite dihydrotestosterone can influence the expression of genes, development of masculine type of habitus and behavior, acting via androgen receptor (AR) (Zitzmann, M. and Nieschlag, E., 2003). Testosterone can affect also via its metabolites, whose production is conditioned by enzymes. In peripheral tissues is testosterone converted via aromatase to estradiol and via 5alpha-reductase to dihydrotestosterone (Weber, K.S. et al., 1999).","PeriodicalId":75688,"journal":{"name":"Ceskoslovenska fysiologie","volume":"57 2-3","pages":"61-75"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28150126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0