Cancer clinical trials最新文献_第5页

Adriamycin plus vincristine alone or with dibromodulcitol or ICRF-159 in metastatic breast cancer. 阿霉素单独加长春新碱或与二溴调醇或ICRF-159治疗转移性乳腺癌。

Cancer clinical trials Pub Date : 1981-01-01

F J Cummings, R Gelman, D C Tormey, W DeWys, J Glick

{"title":"Adriamycin plus vincristine alone or with dibromodulcitol or ICRF-159 in metastatic breast cancer.","authors":"F J Cummings, R Gelman, D C Tormey, W DeWys, J Glick","doi":"","DOIUrl":"","url":null,"abstract":"A total of 268 patients with metastatic breast cancer were prospectively randomized to receive Adriamycin-vincristine (AV) alone, AV plus dibromodulcitol (AVD), or AV plus ICRF-159 (AVI). Two hundred thirty were eligible and had received prior chemotherapy. The objective response rates were 27%, 23%, and 16% for AV, AVD and AVI, respectively, and an additional 44% had stabilization of disease. Duration of responses ranged from 4.1 to 4.6 months and the times to treatment failure from 2.9 to 3.8 months. Median survivals ranged from 7.1 to 8.3 months. Performance status and the presence of liver or brain metastases were significant prognostic variables for outcome. These studies show that AVI is inferior to AV with respect to survival when prognostic variables are taken into account in a multivariate model, whereas AVD which utilizes a lower dose of Adriamycin appears to have comparable antitumor activity to AV. This does not appear to offer any benefit to patients previously treated with chemotherapy, as in this trial, but it may be an advantage to previously untreated patients since Adriamycin can be administered to responding patients over a longer period of time before an unacceptable total cumulative dose is reached.","PeriodicalId":75672,"journal":{"name":"Cancer clinical trials","volume":"4 3","pages":"253-60"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18072612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The pathologic effects of fractionated fast neutrons or photons on canine liver. 分异快中子或光子对犬肝脏的病理影响。

Cancer clinical trials Pub Date : 1981-01-01

B C Zook, E W Bradley, G W Casarett, R A Hitzelberg, C C Rogers

{"title":"The pathologic effects of fractionated fast neutrons or photons on canine liver.","authors":"B C Zook, E W Bradley, G W Casarett, R A Hitzelberg, C C Rogers","doi":"","DOIUrl":"","url":null,"abstract":"Thirty-nine adult male purebred beagles received either fast neutron or photon irradiation to the right thorax to determine the effects on pulmonary tissue. The right half of the liver was included in the field of radiation. Twenty-four dogs (six/group) received fast neutrons with a mean energy of 15 MeV to total doses of 1000, 1500, 2250, or 3375 rads in four fractions per week for 6 weeks. Fifteen dogs received 3000, 4500, or 6750 total rads of photons (five dogs/group) in an identical fractionation pattern. All neutron-irradiated dogs receiving 3375 and 2250 rads and one receiving 1500 rads developed clinical signs, hepatic enzyme, and bilirubin elevations, and the dogs died or were euthanized in extremis on postirradiation day 47-291. Signs of liver injury, other than enzyme changes, have not developed to date (1200-1300 days) in the remaining dogs, except in one 6750-rad photon dog that died of hepatic failure on postirradiation day 708. At necropsy, the irradiated right lobes of the liver were atrophic and the nonirradiated left lobes underwent compensatory hypertrophy. Hepatic arterioles and bile ducts were injured in every dog, but no obstructive lesions were observed in hepatic veins. Portal fibroplasia, bile retention, and proliferation of bile ductules was common; the latter two changes also occurred in the nonirradiated lobes. No qualitative differences were observed between hepatic lesions in neutron- versus photon-irradiated dogs. The relative biological effectiveness of fast neutrons for liver damage appears to be no less than 4.5.","PeriodicalId":75672,"journal":{"name":"Cancer clinical trials","volume":"4 1","pages":"47-65"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18228873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A system for determining the pharmacology of indirect radiation sensitizer drugs on multicellular spheroids. 一种测定多细胞球体间接辐射增敏药物药理学的系统。

Cancer clinical trials Pub Date : 1981-01-01

N Kaufman, H I Bicher, F W Hetzel, M Brown

{"title":"A system for determining the pharmacology of indirect radiation sensitizer drugs on multicellular spheroids.","authors":"N Kaufman, H I Bicher, F W Hetzel, M Brown","doi":"","DOIUrl":"","url":null,"abstract":"We have characterized some of the physiology of multicellular spheroids of different sizes grown from Chinese hamster lung fibroblast (V79) cells. Among the parameters studied were oxygen tension distributions within the spheroid. This was achieved using ultramicroelectrodes with tip diameters of 1-5 mu and a perfusion system whereby environmental conditions such as flow, temperature, and chemical makeup of the milieu could be measured and controlled. Plateau pO2 values of less than 10 mm Hg were consistently obtained from spheroids under various conditions. We were able to modify these distributions by use of indirect radiation sensitizer drugs such as mechlorethamine HCl (mustargen) at nontoxic doses. We have also made determinations of the inhibitory capacities of several other drugs on the respiration rate of constituent cells of multicellular spheroids in single-cell suspensions. We have concluded that there are indeed hypoxic cells in spheroids whose radioresistance may be modified by essentially nontoxic levels of indirect radiosensitizer drugs and that the system described shows great promise for screening agents which may modify radiation response.","PeriodicalId":75672,"journal":{"name":"Cancer clinical trials","volume":"4 2","pages":"199-204"},"PeriodicalIF":0.0,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18262298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bone, muscle, soft tissue workshop. 骨、肌肉、软组织车间。

Cancer clinical trials Pub Date : 1981-01-01

L W Brady, H Suit

引用次数: 0

Flow cytometric analysis of bone marrow in a patient with resistant neuroblastoma. 1例耐药神经母细胞瘤患者骨髓流式细胞术分析。

Cancer clinical trials Pub Date : 1981-01-01

L Helson, F Traganos, D Miller

引用次数: 0

Phase I study of aziridinylbenzoquinone (NSC 182986). aziridinylbenzoquinone (NSC 182986)的一期研究。

Cancer clinical trials Pub Date : 1981-01-01

A Y Bedikian, G P Bodey, M A Burgess, E J Freireich