{"title":"Pathology of pituitary adenomas.","authors":"K Kovacs, E Horvath","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A new pituitary classification has been developed, based on the histologic, histochemical, immunocytologic and electron microscopic investigation of 207 pituitary adenomas removed surgically from male and female patients of various ages and different clinical symptomatology. Based principally on cytogenesis, the classification attempts to correlate the morphologic features of the tumor cells with their secretory activities, the clinical history, symptomatology, and biochemical findings. The classification consists of the following eight entities: 1) growth hormone cell adenoma; 2) prolactin cell adenoma; 3) mixed growth hormone cell-prolactin cell adenoma; 4) acidophil stem cell adenoma; 5) corticotroph cell adenoma; 6) thyrotroph cell adenoma; 7) gonadotroph cell adenoma; 8) undifferentiated cell adenoma, including oncocytoma. Prolactin adenomas were found to be the most frequently occurring pituitary adenoma type.</p>","PeriodicalId":75651,"journal":{"name":"Bulletin of the Los Angeles neurological societies","volume":"42 3-4","pages":"92-110"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11442458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical pituitary disorders.","authors":"C Ezrin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The pituitary gland is really a confederation of several relatively independent endocrine glands gathered together in close relationship to the hypothalamus which exerts considerable governing control. Each of these sub-glands of the pituitary should be considered separately in every case of pituitary disease. While such an approach is mandatory in dealing with laboratory investigation, it also is profitable in considering clinical and therapeutic aspects of each case to ensure that nothing is overlooked.</p>","PeriodicalId":75651,"journal":{"name":"Bulletin of the Los Angeles neurological societies","volume":"42 3-4","pages":"81-91"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11442457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Radiology of the adult sella turcica.","authors":"J S Teal","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Radiographic changes of the sella turcica or pituitary fossa reflect multiple disease processes of intracranial, cranial and systemic origin. Their value as diagnostic aids is related to the fact that the development of the fossa depends somewhat upon that of the pituitary gland, which it partially encloses. Further, many vascular and neural structures about the base of the brain lie close to the fossa. Also, it is vulnerable to increased intracranial pressure. The ease of radiographic demonstration of the sellar components from many planes and angles allows early recognition of pathologic alterations. Radiographic anatomy, both normal and abnormal, will be discussed, as well special diagnostic procedures such as computed tomography, angiography and cerebral pneumography.</p>","PeriodicalId":75651,"journal":{"name":"Bulletin of the Los Angeles neurological societies","volume":"42 3-4","pages":"111-74"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11441742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J A Linfoot, J S Nakagawa, E Wiedemann, J Lyman, C Chong, J Garcia, J H Lawrence
{"title":"Heavy particle therapy: pituitary tumors.","authors":"J A Linfoot, J S Nakagawa, E Wiedemann, J Lyman, C Chong, J Garcia, J H Lawrence","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Therapy with 910 MeV alpha particles provides a treatment with no mortality and an extremely low morbidity and has been highly successful in the control of pituitary hormone hypersecretion and tumor growth. It is possible to deliver radiation doses to the pituitary gland that are sufficiently high to inhibit or destroy the tumor cells that cause abnormal secretory activity without damaging the surrounding structures. The data demonstrate the effectiveness of this form of treatment in acromegaly, non-functioning pituitary tumors, prolactin secreting adenomas, Cushing's disease and Nelson's syndrome.</p>","PeriodicalId":75651,"journal":{"name":"Bulletin of the Los Angeles neurological societies","volume":"42 3-4","pages":"175-89"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11441743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pathology of pituitary adenomas.","authors":"K. Kovacs, É. Horváth","doi":"10.1159/000413924","DOIUrl":"https://doi.org/10.1159/000413924","url":null,"abstract":"A new pituitary classification has been developed, based on the histologic, histochemical, immunocytologic and electron microscopic investigation of 207 pituitary adenomas removed surgically from male and female patients of various ages and different clinical symptomatology. Based principally on cytogenesis, the classification attempts to correlate the morphologic features of the tumor cells with their secretory activities, the clinical history, symptomatology, and biochemical findings. The classification consists of the following eight entities: 1) growth hormone cell adenoma; 2) prolactin cell adenoma; 3) mixed growth hormone cell-prolactin cell adenoma; 4) acidophil stem cell adenoma; 5) corticotroph cell adenoma; 6) thyrotroph cell adenoma; 7) gonadotroph cell adenoma; 8) undifferentiated cell adenoma, including oncocytoma. Prolactin adenomas were found to be the most frequently occurring pituitary adenoma type.","PeriodicalId":75651,"journal":{"name":"Bulletin of the Los Angeles neurological societies","volume":"7 3 1","pages":"92-110"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79706103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Surgery of the pituitary gland.","authors":"M H Weiss","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Increasing diagnostic sophistication among endocrinologists has continually expanded the horizon of surgical treatment of adenohypophyseal problems. This advancement in endocrinology has been paralleled by improvement in the technical sophistication of neurosurgeons which has resulted in an increasingly aggressive approach to these serious disorders. Neurosurgical treatment is clearly able to provide resolution of significant physical disorders with minimal sequelae. The apparent potential for transsphenoidal approaches to the sella turcica as described within this paper has intrigued a number of neurosurgeons throughout this century. Their continuing interest has carried this procedure to a secure position in the management of many of these complex problems. This paper describes the author's experience with 132 consecutive transsphenoidal hypophysectomies.</p>","PeriodicalId":75651,"journal":{"name":"Bulletin of the Los Angeles neurological societies","volume":"42 3-4","pages":"190-200"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11442456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dystonia musculorum deformans--a status report.","authors":"J H Menkes","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":75651,"journal":{"name":"Bulletin of the Los Angeles neurological societies","volume":"41 4","pages":"184-8"},"PeriodicalIF":0.0,"publicationDate":"1976-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11246537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A simple method for continuous pressure recording.","authors":"R Levinthal","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A relatively simple, nonoperative, percutaneous procedure for recording continuous cerebrospinal fluid pressure was carried out on 12 patients at UCLA Hospital. The experience with pressure recording in these patients has demonstrated no mortality or permanent sequelae and the technical character of the records has been excellent. This technique could make continuous pressure recording more easily available to the average practioner. Other uses for this procedure are also suggested.</p>","PeriodicalId":75651,"journal":{"name":"Bulletin of the Los Angeles neurological societies","volume":"41 4","pages":"148-53"},"PeriodicalIF":0.0,"publicationDate":"1976-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12213131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B L Crue, J J Pinsky, D C Agnew, A K Malyon, A Felsööry, B Kenton, M L Apuzzo
{"title":"What is a pain center?","authors":"B L Crue, J J Pinsky, D C Agnew, A K Malyon, A Felsööry, B Kenton, M L Apuzzo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The authors present the concept that a multi-disciplinary interdepartmental pain center should include: 1) an initial out-patient pain clinic, 2) an inpatient pain service for diagnosis of pain problems and treatment of patients with intractable pain, including pain from cancer, 3) a psychotherapeutically-oriented chronic benign Pain Unit, 4) facilities for clinical and basic pain research, and 5) affiliations for an adequate teaching program.</p>","PeriodicalId":75651,"journal":{"name":"Bulletin of the Los Angeles neurological societies","volume":"41 4","pages":"160-7"},"PeriodicalIF":0.0,"publicationDate":"1976-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12213135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tumor immunology: a neurosurgical perspective. II. The immunology of glial neoplasms.","authors":"M L Apuzzo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The research thus far on the relation of the immune system to gliomas has shown that a glioma associated antigen does exist. Small quantities of glioma associated antibodies probably circulate within the patient's serum but there is definite evidence of depression of the cell-mediated vanguard of the immune response. This depression is caused by a blocking factor that may be present as an antigen, antibody, or antigen-antibody complex. Both active and passive immunotherapeutic techniques have been employed in a small number of patients with little success. Considerable understanding of the alteration of the immune system is necessary before a rational approach toward immunotherapy of gliomas may be undertaken. However, it is apparent that reductive therapy consisting of surgery, radiation, and chemotherapy will be necessary before the immune system will be effective against the tumor burden.</p>","PeriodicalId":75651,"journal":{"name":"Bulletin of the Los Angeles neurological societies","volume":"41 4","pages":"176-83"},"PeriodicalIF":0.0,"publicationDate":"1976-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11296137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}